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Now showing items 19901-19920 of 40729

Dementia with Lewy Bodies: A Clinicopathologic Series of False-positive Cases

Netherlands Brain Bank (Lippincott Williams and Wilkins Ltd., 2020)

Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease. Here we present a clinicopathologic series of false-positive DLB cases. Patients were enrolled ...
Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

Shahmoradian, Sarah H.; Lewis, Amanda J.; Genoud, Christel; Hench, Jürgen; Moors, Tim E.; Navarro, Paula P.; Castaño-Díez, Daniel; Schweighauser, Gabriel; Graff-Meyer, Alexandra; Goldie, Kenneth N.; Sütterlin, Rosmarie; Huisman, Evelien; Ingrassia, Angela; Gier, Yvonne de; Rozemuller, Annemieke J.M.; Wang, Jing; Paepe, Anne De; Erny, Johannes; Staempfli, Andreas; Hoernschemeyer, Joerg; Großerüschkamp, Frederik; Niedieker, Daniel; El-Mashtoly, Samir F.; Quadri, Marialuisa; Van IJcken, Wilfred F.J.; Bonifati, Vincenzo; Gerwert, Klaus; Bohrmann, Bernd; Frank, Stephan; Britschgi, Markus; Stahlberg, Henning; Van de Berg, Wilma D.J.; Lauer, Matthias E. (Nature Research, 2019-07-01)

Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy bodies and Lewy neurites: neuronal inclusions ...
Global Heart: The Prime Journal for Global Cardiovascular Research Findings, Implementation and Interpretation

Grobbee, Diederick E. (Elsevier Science & Technology, 2019-03-01)
Corrigendum to “2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk” (Atherosclerosis (2019) 290 (140–205), (S0021915019314595), (10.1016/j.atherosclerosis.2019.08.014))

Task Force Members; ESC National Cardiac Societies; ESC Committee for Practice Guidelines (CPG) (Elsevier, 2020-02-01)

In row 4 of Table 3, ‘should’ should read as ‘may’; In 4.2.1, paragraph 3, ‘should’ should read ‘may’ to read ‘Overall, CAC score assessment with CT may be considered in individuals … ’ Also in the second row of ‘Recommendations ...
The new Primary Care and Risk Factor Management (PCRFM) nucleus of the European Association of Preventive Cardiology: A call for action

on behalf of all PCRFM nucleus members (Oxford University Press, 2020-08)
Patients' and public views and attitudes towards the sharing of health data for research: A narrative review of the empirical evidence

Kalkman, Shona; Van Delden, Johannes; Banerjee, Amitava; Tyl, Benoît; Mostert, Menno; Van Thiel, Ghislaine (BMJ Publishing Group, 2022-01-01)

Introduction: International sharing of health data opens the door to the study of the so-called 'Big Data', which holds great promise for improving patient-centred care. Failure of recent data sharing initiatives indicates ...
Influence of mental stress and environmental toxins on circadian clocks - implications for redox regulation of the heart and cardioprotection

Li, Huige; Kilgallen, Aoife B; Münzel, Thomas; Wolf, Eva; Lecour, Sandrine; Schulz, Rainer; Daiber, Andreas; Van Laake, Linda W (John Wiley & Sons Inc., 2020-12)

Risk factors in the environment such as air pollution and mental stress contribute to the development of chronic non-communicable disease. Air pollution was identified as the leading health risk factor in the physical ...
Added value of inflammatory markers to vital signs to predict mortality in patients suspected of severe infection

Takada, Toshihiko; Hoogland, Jeroen; Yano, Tetsuhiro; Fujii, Kotaro; Fujiishi, Ryuto; Miyashita, Jun; Takeshima, Taro; Hayashi, Michio; Azuma, Teruhisa; Moons, Karel G M (W.B. Saunders, 2020-07)

Objective: To evaluate the added value of inflammatory markers to vital signs to predict mortality in patients suspected of severe infection. Methods: This study was conducted at an acute care hospital (471-bed capacity). ...
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Honkoop, Hessel; de Bakker, Dennis Em; Aharonov, Alla; Kruse, Fabian; Shakked, Avraham; Nguyen, Phong D; de Heus, Cecilia; Garric, Laurence; Muraro, Mauro J; Shoffner, Adam; Tessadori, Federico; Peterson, Joshua Craiger; Noort, Wendy; Bertozzi, Alberto; Weidinger, Gilbert; Posthuma, George; Grun, Dominic; van der Laarse, Willem J; Klumperman, Judith; Jaspers, Richard T; Poss, Kenneth D; van Oudenaarden, Alexander; Tzahor, Eldad; Bakkers, Jeroen (eLife Sciences Publications, 2019-12-23)

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation ...
Discontinuation Rates of Antidepressant Use by Dutch Soldiers

Janssen, Debbie G.A.; Vermetten, Eric; Egberts, Toine C.G.; Heerdink, Eibert R. (Oxford University Press, 2019-12-01)

INTRODUCTION: Soldiers have a higher risk for developing psychiatric disorders that require treatment; often with antidepressants. However, antidepressants as well as the psychiatric disorder, may influence military readiness ...
Reproducibility and construct validity of the utrecht mixing ability Test to obtain masticatory performance outcome in patients with condylar mandibular fractures

Weinberg, Florine M.; Vermaire, Jorine A.; Forouzanfar, Tymour; Rosenberg, Antoine J.W.P.; Speksnijder, Caroline M. (Wiley-Blackwell, 2020-04)

Objective: This study assessed the test-retest reproducibility of the Utrecht mixing ability test (MAT) and the construct validity of the MAT in relation to the Mandibular Function Impairment Questionnaire (MFIQ) in patients ...
Adherence to the Dutch dietary guidelines and 15-year incidence of heart failure in the EPIC-NL cohort

Harbers, Marjolein C; de Kroon, A Marleen; Boer, Jolanda M A; Asselbergs, Folkert W; Geleijnse, Johanna M; Verschuren, W M Monique; van der Schouw, Yvonne T; Sluijs, Ivonne (Springer Science and Business Media Deutschland GmbH, 2020-12)

PURPOSE: A healthy diet may contribute to the primary prevention of heart failure (HF), but evidence is still inconclusive. We aimed to study the association between adherence to the Dutch dietary guidelines and incidence ...
Fraser syndrome without cryptophthalmos: Two cases

Boussion, S; Lyonnet, S; Van Der Zwaag, B; Vogel, M J; Smol, T; Mezel, A; Manouvrier-Hanu, S; Vincent-Delorme, C; Vanlerberghe, C (Elsevier Masson SAS, 2020-04)

Fraser syndrome (MIM#219000) is an autosomal recessive disorder, characterized by the association of cryptophthtalmos, syndactyly of the four extremities, urinary tract abnormalities and laryngo-tracheal anomalies. This ...
Combining deep learning and 3D contrast source inversion in MR-based electrical properties tomography

Leijsen, Reijer; van den Berg, Cornelis; Webb, Andrew; Remis, Rob; Mandija, Stefano (John Wiley & Sons Inc., 2022-04)

Magnetic resonance electrical properties tomography (MR-EPT) is a technique used to estimate the conductivity and permittivity of tissues from MR measurements of the transmit magnetic field. Different reconstruction methods ...
Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification

Bach, Frances C; de Rooij, Kim M; Riemers, Frank M; de Jong, Willem A M; Zhang, Ying; Creemers, Laura B; Chan, Danny; Le Maitre, Christine; Tryfonidou, Marianna A (Wiley-Blackwell Publishing Ltd, 2019-12)

Parathyroid hormone-related protein (PTHrP) and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) ...
GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity

Vila-Bedmar, Rocío; Cruces-Sande, Marta; Arcones, Alba C; Willemen, Hanneke L D M; Prieto, Patricia; Moreno-Indias, Isabel; Díaz-Rodríguez, Daniel; Francisco, Sara; Jaén, Rafael I; Gutiérrez-Repiso, Carolina; Heijnen, Cobi J; Boscá, Lisardo; Fresno, Manuel; Kavelaars, Annemieke; Mayor, Federico; Murga, Cristina (Springer Science and Business Media Deutschland GmbH, 2020-12)

Macrophages are key effector cells in obesity-associated inflammation. G protein-coupled receptor kinase 2 (GRK2) is highly expressed in different immune cell types. Using LysM-GRK2+/- mice, we uncover that a reduction of ...
Clinical effect of lumacaftor/ivacaftor in F508del homozygous CF patients with FEV1 ≥ 90% predicted at baseline

Aalbers, B L; de Winter-de Groot, K M; Arets, H G M; Hofland, R W; de Kiviet, A C; van Oirschot-van de Ven, M M M; Kruijswijk, M A; Schotman, S; Michel, S; van der Ent, C K; Heijerman, H G M (Elsevier, 2020-07)

Objective: The first available CFTR modulator combination for homozygous F508del patients, lumacaftor/ivacaftor, has not been tested in patients with percentage predicted (pp)FEV1 > 90 in the phase III trials. The objective ...
Differentiation and activation of eosinophils in the human bone marrow during experimental human endotoxemia

Hassani, Marwan; Leijte, Guus; Bruse, Niklas; Kox, Matthijs; Pickkers, Peter; Vrisekoop, Nienke; Koenderman, Leo (Oxford University Press, 2020-11)

Acute infection is characterized by eosinopenia. However, the underlying mechanism(s) are poorly understood and it is unclear whether decreased mobilization/production of eosinophils in the bone marrow (BM) and/or increased ...
Amylin as a Potential Link between Type 2 Diabetes and Alzheimer Disease

Despa, Florin; Goldstein, Larry B; Biessels, Geert Jan (John Wiley & Sons Inc., 2020-03)
Applying evidence-based medicine in general practice: a video-stimulated interview study on workplace-based observation

Welink, Lisanne S; Van Roy, Kaatje; Damoiseaux, Roger A M J; Suijker, Hilde A; Pype, Peter; de Groot, Esther; Bartelink, Marie-Louise E L (BioMed Central, 2020-01-08)

BACKGROUND: Evidence-based medicine (EBM) in general practice involves applying a complex combination of best-available evidence, the patient's preferences and the general practitioner's (GP) clinical expertise in ...

Now showing items 19901-19920 of 40729