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UMC Repository: Recent submissions

  • An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo 
    Man, Joyce C.K.; Mohan, Rajiv A.; Boogaard, Malou van den; Hilvering, Catharina R.E.; Jenkins, Catherine; Wakker, Vincent; Bianchi, Valerio; Laat, Wouter de; Barnett, Phil; Boukens, Bastiaan J.; Christoffels, Vincent M. (Nature Publishing Group, 2019-12-01)
    Mutations and variations in and around SCN5A, encoding the major cardiac sodium channel, influence impulse conduction and are associated with a broad spectrum of arrhythmia disorders. Here, we identify an evolutionary ...
  • Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture 
    Giobbe, Giovanni Giuseppe; Crowley, Claire; Luni, Camilla; Campinoti, Sara; Khedr, Moustafa; Kretzschmar, Kai; De Santis, Martina Maria; Zambaiti, Elisa; Michielin, Federica; Meran, Laween; Hu, Qianjiang; van Son, Gijs; Urbani, Luca; Manfredi, Anna; Giomo, Monica; Eaton, Simon; Cacchiarelli, Davide; Li, Vivian S.W.; Clevers, Hans; Bonfanti, Paola; Elvassore, Nicola; De Coppi, Paolo (Nature Publishing Group, 2019-12-01)
    Organoids have extensive therapeutic potential and are increasingly opening up new avenues within regenerative medicine. However, their clinical application is greatly limited by the lack of effective GMP-compliant systems ...
  • A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out 
    Hoeksma, Jelmer; Misset, Tim; Wever, Christie; Kemmink, Johan; Kruijtzer, John; Versluis, Kees; Liskamp, Rob M.J.; Boons, Geert Jan; Heck, Albert J.R.; Boekhout, Teun; den Hertog, Jeroen (Nature Publishing Group, 2019-12-01)
    There is a constant need for new therapeutic compounds. Fungi have proven to be an excellent, but underexplored source for biologically active compounds with therapeutic potential. Here, we combine mycology, embryology and ...
  • Insulin-like growth factor-II and bioactive proteins containing a part of the E-domain of pro-insulin-like growth factor-II 
    van Doorn, Jaap (Wiley-Blackwell, 2020-07-01)
    Insulin-like growth factor (IGF)-II is considered to function as an important fetal growth factor, which is structurally and functionally related to IGF-I and proinsulin. At least in vitro, IGF-II actions are mediated ...
  • Cost-effectiveness of screening program for chronic q fever, the netherlands 
    De Boer, Pieter T.; De Lange, Marit M.A.; Wielders, Cornelia C.H.; Dijkstra, Frederika; Van Roeden, Sonja E.; Bleeker-Rovers, Chantal P.; Oosterheert, Jan Jelrik; Schneeberger, Peter M.; Van Der Hoek, Wim (Centers for Disease Control and Prevention (CDC), 2020-02)
    In the aftermath of a large Q fever (QF) epidemic in the Netherlands during 2007-2010, new chronic QF (CQF) patients continue to be detected. We developed a health-economic decision model to evaluate the cost-effectiveness ...
  • Supervisors' pedagogies for supporting interns to learn intra- and interprofessional collaboration: a qualitative and quantitative ego network analysis 
    de Groot, Esther; van den Broek, Mirte; Fokkens, Janneke T; Witte, Janneke A M; Damoiseaux, Roger A M J; Zwart, Dorien (Informa Healthcare, 2021-03-04)
    This work aims to understand intra- and interprofessional networks of general practitioners (GPs) and ear, nose, and throat specialists (ENT specialists), and in what manner supervisors in these specialties involve interns ...
  • A Bayesian meta-analysis on early tobacco exposure and vascular health: From childhood to early adulthood 
    Georgiopoulos, Georgios; Oikonomou, Dimitrios; Pateras, Konstantinos; Masi, Stefano; Magkas, Nikolaos; Delialis, Dimitrios; Ajdini, Erold; Vlachou, Victoria; Stamatelopoulos, Kimon; Charakida, Marietta (Oxford University Press, 2021-11-01)
    Background: Smoking has been consistently associated with increased cardiovascular risk in adults. Although exposure to tobacco products often starts in early life, evidence for the possible adverse effects on the ...
  • In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium 
    Yvernogeau, Laurent; Gautier, Rodolphe; Petit, Laurence; Khoury, Hanane; Relaix, Frédéric; Ribes, Vanessa; Sang, Helen; Charbord, Pierre; Souyri, Michèle; Robin, Catherine; Jaffredo, Thierry (Nature Research, 2019-11-01)
    It is well established that haematopoietic stem and progenitor cells (HSPCs) are generated from a transient subset of specialized endothelial cells termed haemogenic, present in the yolk sac, placenta and aorta, through ...
  • The Clinical Picture and Severity of Invasive Meningococcal Disease Serogroup W Compared With Other Serogroups in the Netherlands, 2015-2018 
    Loenenbach, Anna D; van der Ende, Arie; de Melker, Hester E; Sanders, Elisabeth A M; Knol, Mirjam J (Oxford University Press, 2020-05-15)
    Background. An increase in invasive meningococcal disease (IMD) serogroup W (IMD-W) cases caused by sequence type-11 clonal complex (cc11) was observed from October 2015 in the Netherlands. We compared the clinical picture ...
  • Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling 
    Akbari, Soheil; Sevinç, Gülben Gürhan; Ersoy, Nevin; Basak, Onur; Kaplan, Kubra; Sevinç, Kenan; Ozel, Erkin; Sengun, Berke; Enustun, Eray; Ozcimen, Burcu; Bagriyanik, Alper; Arslan, Nur; Önder, Tamer Tevfik; Erdal, Esra (Cell Press, 2019-10-08)
    Organoid technologies have become a powerful emerging tool to model liver diseases, for drug screening, and for personalized treatments. These applications are, however, limited in their capacity to generate functional ...
  • The hemodynamic effect of different left ventricular unloading techniques during veno-arterial extracorporeal life support: a systematic review and meta-analysis 
    Meuwese, Christiaan Lucas; de Haan, Marloes; Zwetsloot, Peter-Paul; Braithwaite, Sue; Ramjankhan, Faiz; van der Heijden, Joris; Hermens, Jeannine; Cremer, Olaf; Broomé, Michael; Donker, Dirk Wilhelm (SAGE Publications Ltd, 2020-10-01)
    BACKGROUND: Pulmonary edema and left ventricular thrombosis may arise during veno-arterial extracorporeal life support due to an increase in cardiac load. This mechanical stress can be reduced through different left ...
  • Cell Type Purification by Single-Cell Transcriptome-Trained Sorting 
    Baron, Chloé S.; Barve, Aditya; Muraro, Mauro J.; van der Linden, Reinier; Dharmadhikari, Gitanjali; Lyubimova, Anna; de Koning, Eelco J.P.; van Oudenaarden, Alexander (Elsevier, 2019-10-03)
    Much of current molecular and cell biology research relies on the ability to purify cell types by fluorescence-activated cell sorting (FACS). FACS typically relies on the ability to label cell types of interest with ...
  • A rectal cancer organoid platform to study individual responses to chemoradiation 
    Rectal cancer organoid platform (Nature Research, 2019-10-01)
    Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation and surgery to optimize outcomes for individual patients. No accurate model of RC exists to answer fundamental research questions ...
  • The molecular basis of monopolin recruitment to the kinetochore 
    Plowman, Rebecca; Singh, Namit; Tromer, Eelco C.; Payan, Angel; Duro, Eris; Spanos, Christos; Rappsilber, Juri; Snel, Berend; Kops, Geert J.P.L.; Corbett, Kevin D.; Marston, Adele L. (Springer Science and Business Media Deutschland GmbH, 2019-09-01)
    The monopolin complex is a multifunctional molecular crosslinker, which in S. pombe binds and organises mitotic kinetochores to prevent aberrant kinetochore-microtubule interactions. In the budding yeast S. cerevisiae, ...
  • Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells 
    Han, Seungmin; Fink, Juergen; Jörg, David J.; Lee, Eunmin; Yum, Min Kyu; Chatzeli, Lemonia; Merker, Sebastian R.; Josserand, Manon; Trendafilova, Teodora; Andersson-Rolf, Amanda; Dabrowska, Catherine; Kim, Hyunki; Naumann, Ronald; Lee, Ji Hyun; Sasaki, Nobuo; Mort, Richard Lester; Basak, Onur; Clevers, Hans; Stange, Daniel E.; Philpott, Anna; Kim, Jong Kyoung; Simons, Benjamin D.; Koo, Bon Kyoung (Cell Press, 2019-09-05)
    The gastric corpus epithelium is the thickest part of the gastrointestinal tract and is rapidly turned over. Several markers have been proposed for gastric corpus stem cells in both isthmus and base regions. However, the ...
  • T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation 
    Fu, Ya Yuan; Egorova, Anastasiya; Sobieski, Catherine; Kuttiyara, Jason; Calafiore, Marco; Takashima, Shuichiro; Clevers, Hans; Hanash, Alan M. (Cell Press, 2019-07-16)
    The key sites within the gastrointestinal tract where T cells mediate effector responses and their impact on intestinal stem cells remain unclear. Using 3D microscopy, Fu et al. visualize T cell spatial localization within ...
  • A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas 
    van Gurp, Léon; Muraro, Mauro J.; Dielen, Tim; Seneby, Lina; Dharmadhikari, Gitanjali; Gradwohl, Gerard; van Oudenaarden, Alexander; de Koning, Eelco J.P. (Company of Biologists Ltd, 2019-06-01)
    During pancreatic development, endocrine cells appear from the pancreatic epithelium when Neurog3-positive cells delaminate and differentiate into α-, β-, γ- and δ-cells. The mechanisms involved in this process are still ...
  • YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo 
    Monroe, Tanner O.; Hill, Matthew C.; Morikawa, Yuka; Leach, John P.; Heallen, Todd; Cao, Shuyi; Krijger, Peter H.L.; de Laat, Wouter; Wehrens, Xander H.T.; Rodney, George G.; Martin, James F. (Cell Press, 2019-03-25)
    Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with poor renewal capacity, an integral reason underlying organ failure in disease and aging. Among the least renewable cells in the ...
  • Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses 
    Fakhiri, Julia; Schneider, Marc A.; Puschhof, Jens; Stanifer, Megan; Schildgen, Verena; Holderbach, Stefan; Voss, Yannik; El Andari, Jihad; Schildgen, Oliver; Boulant, Steeve; Meister, Michael; Clevers, Hans; Yan, Ziying; Qiu, Jianming; Grimm, Dirk (Cell Press, 2019-03-15)
    Parvoviruses are highly attractive templates for the engineering of safe, efficient, and specific gene therapy vectors, as best exemplified by adeno-associated virus (AAV). Another candidate that currently garners increasing ...
  • An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance 
    Li, Ningning; Babaei-Jadidi, Roya; Lorenzi, Federica; Spencer-Dene, Bradley; Clarke, Philip; Domingo, Enric; Tulchinsky, Eugene; Vries, Robert G.J.; Kerr, David; Pan, Yihang; He, Yulong; Bates, David O.; Tomlinson, Ian; Clevers, Hans; Nateri, Abdolrahman S. (Nature Publishing Group, 2019-02-19)
    Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial–mesenchymal ...