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UMC Repository: Recent submissions

  • Adherence to guideline recommendations for coronary angiography in a poor South-East Asian setting: Impact on short- and medium-term clinical outcomes 
    Qanitha, Andriany; Uiterwaal, Cuno S.P.M.; Henriques, Jose P.S.; Mappangara, Idar; Amir, Muzakkir; Saing, Sumarsono G.; de Mol, Bastianus A.J.M. (Nature Publishing Group, 2019-12-01)
    In South-East Asian populations and particularly in Indonesia, access to coronary angiography (CAG) is limited. We aimed to assess the adherence for undergoing CAG for indicated patients, according to the guideline ...
  • Hyperosmolar Therapy in Pediatric Severe Traumatic Brain Injury-A Systematic Review 
    Stopa, Brittany M.; Dolmans, Rianne G.F.; Broekman, Marike L.D.; Gormley, William B.; Mannix, Rebekah; Izzy, Saef (Lippincott Williams & Wilkins, 2019-12-01)
    OBJECTIVES: Traumatic brain injury is a leading cause of hospital visits for children. Hyperosmolar therapy is often used to treat severe traumatic brain injury. Hypertonic saline is used predominantly, yet there remains ...
  • In Vitro Human Liver Model of Nonalcoholic Steatohepatitis by Coculturing Hepatocytes, Endothelial Cells, and Kupffer Cells 
    Suurmond, Ceri Anne E.; Lasli, Soufian; van den Dolder, Floor W.; Ung, Aly; Kim, Han Jun; Bandaru, Praveen; Lee, Kang Ju; Cho, Hyun Jong; Ahadian, Samad; Ashammakhi, Nureddin; Dokmeci, Mehmet R.; Lee, Junmin; Khademhosseini, Ali (John Wiley & Sons Inc., 2019-12-01)
    The liver has a complex and unique microenvironment with multiple cell–cell interactions and internal vascular networks. Although nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with ...
  • Impact of preventive screening and lifestyle interventions in women with a history of preeclampsia: A micro-simulation study 
    Lagerweij, G R; Brouwers, L; De Wit, G A; Moons, Kgm; Benschop, L; Maas, Ahem; Franx, A; Wermer, Marieke J H; Roeters Van Lennep, Jeanine E.; van Rijn, B B; Koffijberg, H (Oxford University Press, 2020-09)
    BACKGROUND: Preeclampsia is a female-specific risk factor for the development of future cardiovascular disease. Whether early preventive cardiovascular disease risk screenings combined with risk-based lifestyle interventions ...
  • In pursuit of the normal progressor: the holy grail for ALS clinical trial design? 
    van Eijk, Ruben P A; van Den Berg, Leonard H (Informa Healthcare, 2020-01-02)
  • Analysis of FUS, PFN2, TDP-43, and PLS3 as potential disease severity modifiers in spinal muscular atrophy 
    Wadman, Renske I; Jansen, Marc D; Curial, Chantall A D; Groen, Ewout J N; Stam, Marloes; Wijngaarde, Camiel A; Medic, Jelena; Sodaar, Peter; van Eijk, Kristel R; Huibers, Manon M H; van Kuik, Joyce; Lemmink, Henny H; van Rheenen, Wouter; Veldink, Jan Herman; van den Berg, Leonard H; van der Pol, W Ludo (Lippincott Williams & Wilkins, 2020-02)
    Objective: To investigate mutations in genes that are potential modifiers of spinal muscular atrophy (SMA) severity. Methods: We performed a hypothesis-based search into the presence of variants in fused in sarcoma (FUS), ...
  • Primary lateral sclerosis: consensus diagnostic criteria 
    Delegates of the 2nd International PLS Conference (BMJ Publishing Group, 2020-04)
    Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system. Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is clinical, after exclusion of structural, ...
  • Non-reversible tissue fixation retains extracellular vesicles for in situ imaging 
    Gupta, Mrinali P.; Tandalam, Sangeetha; Ostrager, Shariss; Lever, Alexander S.; Fung, Angus R.; Hurley, David D.; Alegre, Gemstonn B.; Espinal, Jasmin E.; Remmel, H. Lawrence; Mukherjee, Sushmita; Levine, Benjamin M.; Robins, Russell P.; Molina, Henrik; Dill, Brian D.; Kenific, Candia M.; Tuschl, Thomas; Lyden, David; D’Amico, Donald J.; Pena, John T.G. (Nature Research, 2019-12-01)
    Extracellular vesicles (EVs) are secreted nanosized particles with many biological functions and pathological associations. The inability to image EVs in fixed tissues has been a major limitation to understanding their ...
  • Reported adverse drug reactions in women and men: Aggregated evidence from globally collected individual case reports during half a century 
    Watson, Sarah; Caster, Ola; Rochon, Paula A.; den Ruijter, Hester (Elsevier, 2019-12-01)
    Background: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Reports on differences in reporting patterns between women and men exist nationally. The goal of the present study was to assess ...
  • Learning to detect lymphocytes in immunohistochemistry with deep learning 
    Swiderska-Chadaj, Zaneta; Pinckaers, Hans; van Rijthoven, Mart; Balkenhol, Maschenka; Melnikova, Margarita; Geessink, Oscar; Manson, Quirine; Sherman, Mark; Polonia, Antonio; Parry, Jeremy; Abubakar, Mustapha; Litjens, Geert; van der Laak, Jeroen; Ciompi, Francesco (Elsevier, 2019-12-01)
    The immune system is of critical importance in the development of cancer. The evasion of destruction by the immune system is one of the emerging hallmarks of cancer. We have built a dataset of 171,166 manually annotated ...
  • Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients 
    Castelijns, Bas; Baak, Mirna L.; Timpanaro, Ilia S.; Wiggers, Caroline R.M.; Vermunt, Marit W.; Shang, Peng; Kondova, Ivanela; Geeven, Geert; Bianchi, Valerio; de Laat, Wouter; Geijsen, Niels; Creyghton, Menno P. (Nature Publishing Group, 2020-01-16)
    Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and underlie the emergence of the human brain or its unique ...
  • Snake Venom Gland Organoids 
    Post, Yorick; Puschhof, Jens; Beumer, Joep; Kerkkamp, Harald M.; de Bakker, Merijn A.G.; Slagboom, Julien; de Barbanson, Buys; Wevers, Nienke R.; Spijkers, Xandor M.; Olivier, Thomas; Kazandjian, Taline D.; Ainsworth, Stuart; Iglesias, Carmen Lopez; van de Wetering, Willine J.; Heinz, Maria C.; van Ineveld, Ravian L.; van Kleef, Regina G.D.M.; Begthel, Harry; Korving, Jeroen; Bar-Ephraim, Yotam E.; Getreuer, Walter; Rios, Anne C.; Westerink, Remco H.S.; Snippert, Hugo J.G.; van Oudenaarden, Alexander; Peters, Peter J.; Vonk, Freek J.; Kool, Jeroen; Richardson, Michael K.; Casewell, Nicholas R.; Clevers, Hans (Elsevier, 2020-01-23)
    Wnt dependency and Lgr5 expression define multiple mammalian epithelial stem cell types. Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids that recapitulate essential features of the ...
  • Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features 
    Dumont, Marie; Gamba, Riccardo; Gestraud, Pierre; Klaasen, Sjoerd; Worrall, Joseph T.; De Vries, Sippe G.; Boudreau, Vincent; Salinas-Luypaert, Catalina; Maddox, Paul S.; Lens, Susanne M.A.; Kops, Geert J.P.L.; McClelland, Sarah E.; Miga, Karen H.; Fachinetti, Daniele (Springer Science and Business Media Deutschland GmbH, 2020-01-15)
    Intrinsic genomic features of individual chromosomes can contribute to chromosome-specific aneuploidy. Centromeres are key elements for the maintenance of chromosome segregation fidelity via a specialized chromatin marked ...
  • Identification and transfer of spatial transcriptomics signatures for cancer diagnosis 
    Yoosuf, Niyaz; Navarro, José Fernández; Salmén, Fredrik; Ståhl, Patrik L.; Daub, Carsten O. (BioMed Central Ltd., 2020-01-13)
    Background: Distinguishing ductal carcinoma in situ (DCIS) from invasive ductal carcinoma (IDC) regions in clinical biopsies constitutes a diagnostic challenge. Spatial transcriptomics (ST) is an in situ capturing method, ...
  • Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer 
    Yao, Ye; Xu, Xiaoya; Yang, Lifeng; Zhu, Ji; Wan, Juefeng; Shen, Lijun; Xia, Fan; Fu, Guoxiang; Deng, Yun; Pan, Mengxue; Guo, Qiang; Gao, Xiaoxue; Li, Yuanchuang; Rao, Xinxin; Zhou, Yi; Liang, Liping; Wang, Yaqi; Zhang, Jing; Zhang, Hui; Li, Guichao; Zhang, Lixing; Peng, Junjie; Cai, Sanjun; Hu, Chen; Gao, Jianjun; Clevers, Hans; Zhang, Zhen; Hua, Guoqiang (Cell Press, 2020-01-02)
    Accumulating evidence indicates that patient-derived organoids (PDOs) can predict drug responses in the clinic, but the ability of PDOs to predict responses to chemoradiation in cancer patients remains an open question. ...
  • Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100 
    Capponi, Simona; Stöffler, Nadja; Irimia, Manuel; Van Schaik, Frederik M.A.; Ondik, Mercedes M.; Biniossek, Martin L.; Lehmann, Lisa; Mitschke, Julia; Vermunt, Marit W.; Creyghton, Menno P.; Graybiel, Ann M.; Reinheckel, Thomas; Schilling, Oliver; Blencowe, Benjamin J.; Crittenden, Jill R.; Timmers, H. Th Marc (Landes Bioscience, 2020-01-02)
    Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34ʹ ...
  • Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion 
    Van Es, Johan H.; Wiebrands, Kay; López-Iglesias, Carmen; Van De Wetering, Marc; Zeinstra, Laura; Van Den Born, Maaike; Korving, Jeroen; Sasaki, Nobuo; Peters, Peter J.; Van Oudenaarden, Alexander; Clevers, Hans (National Academy of Sciences, 2019-12-26)
    Cycling intestinal Lgr5+ stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt bottoms. Paneth cells providemultiple secreted (e.g.,Wnt, EGF) aswell as surfacebound (Notch ligand) ...
  • Tumor organoid–T-cell coculture systems 
    Cattaneo, Chiara M.; Dijkstra, Krijn K.; Fanchi, Lorenzo F.; Kelderman, Sander; Kaing, Sovann; van Rooij, Nienke; van den Brink, Stieneke; Schumacher, Ton N.; Voest, Emile E. (Springer Nature, 2020-01-01)
    T cells are key players in cancer immunotherapy, but strategies to expand tumor-reactive cells and study their interactions with tumor cells at the level of an individual patient are limited. Here we describe the generation ...
  • Prenatal exposure to PCBs and neurological and sexual/pubertal development from birth to adolescence 
    Berghuis, Sietske Annette; Roze, Elise (Mosby Inc., 2019-06-01)
    Several chemical compounds are resistant to degradation and end up in the food chain. One group of these chemicals is polychlorinated biphenyls (PCBs) which are used as flame retardants and plasticizers. Although PCBs were ...
  • A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart 
    Asp, Michaela; Giacomello, Stefania; Larsson, Ludvig; Wu, Chenglin; Fürth, Daniel; Qian, Xiaoyan; Wärdell, Eva; Custodio, Joaquin; Reimegård, Johan; Salmén, Fredrik; Österholm, Cecilia; Ståhl, Patrik L.; Sundström, Erik; Åkesson, Elisabet; Bergmann, Olaf; Bienko, Magda; Månsson-Broberg, Agneta; Nilsson, Mats; Sylvén, Christer; Lundeberg, Joakim (Elsevier, 2019-12-12)
    The process of cardiac morphogenesis in humans is incompletely understood. Its full characterization requires a deep exploration of the organ-wide orchestration of gene expression with a single-cell spatial resolution. ...