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UMC Repository: Recent submissions

  • High-frequency metabolite profiling and the incidence of recurrent cardiac events in patients with post-acute coronary syndrome 
    Vroegindewey, Maxime M.; van den Berg, Victor J.; Oemrawsingh, Rohit M.; Kardys, Isabella; Asselbergs, Folkert W.; van der Harst, Pim; Kietselaer, Bas; Lenderink, Timo; Akkerhuis, K. Martijn; Boersma, Eric (Informa Healthcare, 2020-04-02)
    Purpose: The aim of this study was to study temporal changes in metabolite profiles in patients with post-acute coronary syndrome (ACS), in particular prior to the development of recurrent ACS (reACS). Methods: BIOMArCS ...
  • Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours 
    van de Vegte, Yordi J; Said, M Abdullah; Rienstra, Michiel; van der Harst, Pim; Verweij, Niek (Nature Publishing Group, 2020-04-21)
    Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure ...
  • Stabilization patterns and variability of hs-CRP, NT-proBNP and ST2 during 1 year after acute coronary syndrome admission: results of the BIOMArCS study 
    BIOMArCS Investigators (Walter de Gruyter GmbH, 2020-12)
    Details of the biological variability of high-sensitivity C-reactive protein (hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and ST2 are currently lacking in patients with acute coronary syndrome ...
  • Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure 
    Huang, Yisong; Ollikainen, Miina; Muniandy, Maheswary; Zhang, Tao; van Dongen, Jenny; Hao, Guang; van der Most, Peter J; Pan, Yue; Pervjakova, Natalia; Sun, Yan V; Hui, Qin; Lahti, Jari; Fraszczyk, Eliza; Lu, Xueling; Sun, Dianjianyi; Richard, Melissa A; Willemsen, Gonneke; Heikkila, Kauko; Mateo Leach, Irene; Mononen, Nina; Kähönen, Mika; Hurme, Mikko A; Raitakari, Olli T; Drake, Amanda J; Perola, Markus; Nuotio, Marja-Liisa; Huang, Yunfeng; Khulan, Batbayar; Räikkönen, Katri; Wolffenbuttel, Bruce H R; Zhernakova, Alexandra; Fu, Jingyuan; Zhu, Haidong; Dong, Yanbin; van Vliet-Ostaptchouk, Jana V; Franke, Lude; Eriksson, Johan G; Fornage, Myriam; Milani, Lili; Lehtimäki, Terho; Vaccarino, Viola; Boomsma, Dorret I; van der Harst, Pim; de Geus, Eco J C; Salomaa, Veikko; Li, Shengxu; Chen, Wei; Su, Shaoyong; Wilson, James; Snieder, Harold; Kaprio, Jaakko; Wang, Xiaoling (Lippincott Williams & Wilkins, 2020-07)
    We conducted an epigenome-wide association study meta-analysis on blood pressure (BP) in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA methylation data from peripheral leukocytes were ...
  • Good taste or gut feeling?: A new method in rats shows oro-sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns 
    Roelofs, Theresia J M; Luijendijk, Mieneke C M; van der Toorn, Annette; Camps, Guido; Smeets, Paul A M; Dijkhuizen, Rick M; Adan, Roger A H (John Wiley & Sons Inc., 2021-07)
    Satiation is influenced by a variety of signals including gastric distention and oro-sensory stimulation. Here we developed a high-field (9.4 T) functional magnetic resonance imaging (fMRI) protocol to test how oro-sensory ...
  • Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis 
    Alencar, Gabriel F; Owsiany, Katherine M; K, Santosh; Sukhavasi, Katyayani; Mocci, Giuseppe; Nguyen, Anh; Williams, Corey M; Shamsuzzaman, Sohel; Mokry, Michal; Henderson, Christopher A; Haskins, Ryan; Baylis, Richard A; Finn, Aloke V; McNamara, Coleen A; Zunder, Eli R; Venkata, Vamsidhar; Pasterkamp, Gerard; Björkegren, Johan; Bekiranov, Stefan; Owens, Gary K (Lippincott Williams & Wilkins, 2020-11-24)
    Background: Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we have a limited understanding of the identity, origin, ...
  • Microinjection induces changes in the transcriptome of bovine oocytes 
    Tan, Minjie; van Tol, Helena T A; Mokry, Michal; Stout, Tom A E; Roelen, Bernard A J (Nature Publishing Group, 2020-07-08)
    Gene knockdown techniques are widely used to examine the function of specific genes or proteins. While a variety of techniques are available, a technique commonly used on mammalian oocytes is mRNA knockdown by microinjection ...
  • H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts 
    Pei, Jiayi; Harakalova, Magdalena; Treibel, Thomas A; Lumbers, R Thomas; Boukens, Bastiaan J; Efimov, Igor R; van Dinter, Jip T; González, Arantxa; López, Begoña; El Azzouzi, Hamid; van den Dungen, Noortje; van Dijk, Christian G M; Krebber, Merle M; den Ruijter, Hester M; Pasterkamp, Gerard; Duncker, Dirk J; Nieuwenhuis, Edward E S; de Weger, Roel; Huibers, Manon M; Vink, Aryan; Moore, Jason H; Moon, James C; Verhaar, Marianne C; Kararigas, Georgios; Mokry, Michal; Asselbergs, Folkert W; Cheng, Caroline (Springer-Verlag, 2020-07-14)
    Background: H3K27ac histone acetylome changes contribute to the phenotypic response in heart diseases, particularly in end-stage heart failure. However, such epigenetic alterations have not been systematically investigated ...
  • Sodium thiosulfate improves renal function and oxygenation in L-NNA-induced hypertension in rats 
    Nguyen, Isabel T N; Klooster, Astrid; Minnion, Magdalena; Feelisch, Martin; Verhaar, Marianne C; van Goor, Harry; Joles, Jaap A (Elsevier, 2020-08)
    Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, ...
  • Screening for cardiovascular disease risk using traditional risk factor assessment or coronary artery calcium scoring: the ROBINSCA trial 
    van der Aalst, Carlijn M; Denissen, Sabine J A M; Vonder, Marleen; Gratama, Jan Willem C; Adriaansen, Henk J; Kuijpers, Dirkjan; Vliegenthart, Rozemarijn; van Lennep, Jeanine E Roeters; van der Harst, Pim; Braam, Richard L; van Dijkman, Paul R M; van Bruggen, Rykel; Oudkerk, Matthijs; de Koning, Harry J (Oxford University Press, 2020-10-20)
    Aims: Screening for a high cardiovascular disease (CVD) risk followed by preventive treatment can potentially reduce coronary heart disease-related morbidity and mortality. ROBINSCA (Risk Or Benefit IN Screening for ...
  • Sex-Based Differences in Unrecognized Myocardial Infarction 
    van der Ende, M Yldau; Juarez-Orozco, Luis Eduardo; Waardenburg, Ingmar; Lipsic, Erik; Schurer, Remco A J; van der Werf, Hindrik W; Benjamin, Emelia J; van Veldhuisen, Dirk Jan; Snieder, Harold; van der Harst, Pim (Wiley-Blackwell, 2020-07-07)
    Background Myocardial infarction is an important cause of morbidity and mortality in both men and women. Atypical or the absence of symptoms, more prevalent among women, may contribute to unrecognized myocardial infarctions ...
  • The Impact of Strategic White Matter Hyperintensity Lesion Location on Language 
    Hilal, Saima; Biesbroek, J Matthijs; Vrooman, Henri; Chong, Eddie; Kuijf, Hugo J; Venketasubramanian, Narayanaswamy; Cheng, Ching-Yu; Wong, Tien Yin; Biessels, Geert Jan; Chen, Christopher (Lippincott Williams & Wilkins, 2021-02)
    OBJECTIVE: The impact of white matter hyperintensities (WMH) on language possibly depends on lesion location through disturbance of strategic white matter tracts. We examined the impact of WMH location on language in elderly ...
  • Modeling to Predict Factor VIII Levels Associated with Zero Bleeds in Patients with Severe Hemophilia A Initiated on Tertiary Prophylaxis 
    Chowdary, Pratima; Fischer, Kathelijn; Collins, Peter W; Cotterill, Amy; Konkle, Barbara A; Blanchette, Victor; Pipe, Steven W; Berntorp, Erik; Wolfsegger, Martin; Engl, Werner; Spotts, Gerald (Schattauer GmbH, 2020-05-01)
    BACKGROUND:  Factor VIII (FVIII) trough levels > 1 IU/dL in patients with severe hemophilia A receiving regular prophylaxis may optimize bleed protection. OBJECTIVES:  In this post hoc analysis of patients receiving tertiary ...
  • Clinical outcomes in hemophilia: Towards development of a core set of standardized outcome measures for research 
    Dover, Saunya; Blanchette, Victor S; Srivastava, Alok; Fischer, Kathelijn; Abad, Audrey; Feldman, Brian M (Elsevier, 2020-05)
    Introduction: A lack of uniformity in the choice of outcome measurement in hemophilia care and research has led to studies with incomparable results. We identified a need to define core outcome measures for use in research ...
  • Comments to "Frailty is associated with hospital readmission in geriatric patients a prognostic study": Assessment of frailty in geriatric patients: let's keep it simple 
    Bruno, Raphael Romano; Wernly, Bernhard; Guidet, Bertrand; Flaatten, Hans; De Lange, Dylan W; Jung, Christian (Springer Science and Business Media Deutschland GmbH, 2020-10-01)
  • Diffusion tensor imaging reveals changes in non-fat infiltrated muscles in Late Onset Pompe Disease 
    Rehmann, R; Froeling, M; Rohm, M; Forsting, J; Kley, R A; Schmidt-Wilcke, T; Karabul, N; Meyer-Frießem, C H; Vollert, J; Tegenthoff, M; Vorgerd, M; Schlaffke, L (John Wiley & Sons Inc., 2020-10-01)
    MRI is a helpful tool for monitoring disease progression in late-onset Pompe disease (LOPD). Our study aimed to evaluate if muscle diffusion tensor imaging (mDTI) shows alterations in muscles of LOPD patients with <10% ...
  • Diffusion tensor imaging of the anterior cruciate ligament graft following reconstruction: a longitudinal study 
    Van Dyck, Pieter; Billiet, Thibo; Desbuquoit, Damien; Verdonk, Peter; Heusdens, Christiaan H; Roelant, Ella; Sijbers, Jan; Froeling, Martijn (Springer-Verlag, 2020-12-01)
    OBJECTIVE: To longitudinally monitor remodeling of human autograft following anterior cruciate ligament (ACL) reconstruction with DTI. METHODS: Twenty-eight patients underwent DTI follow-up at 3, 8, and 14 months after ...
  • The mutational impact of culturing human pluripotent and adult stem cells 
    Kuijk, Ewart; Jager, Myrthe; van der Roest, Bastiaan; Locati, Mauro D; Van Hoeck, Arne; Korzelius, Jerome; Janssen, Roel; Besselink, Nicolle; Boymans, Sander; van Boxtel, Ruben; Cuppen, Edwin (Nature Publishing Group, 2020-12-01)
    Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we determined all mutations in individual ...
  • Sperm DNA damage causes genomic instability in early embryonic development 
    Middelkamp, Sjors; van Tol, Helena T A; Spierings, Diana C J; Boymans, Sander; Guryev, Victor; Roelen, Bernard A J; Lansdorp, Peter M; Cuppen, Edwin; Kuijk, Ewart W (American Association for the Advancement of Science, 2020-04)
    Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, we examined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of ...
  • Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses 
    de Witte, Chris Jenske; Espejo Valle-Inclan, Jose; Hami, Nizar; Lõhmussaar, Kadi; Kopper, Oded; Vreuls, Celien Philomena Henrieke; Jonges, Geertruida Nellie; van Diest, Paul; Nguyen, Luan; Clevers, Hans; Kloosterman, Wigard Pieter; Cuppen, Edwin; Snippert, Hugo Johannes Gerhardus; Zweemer, Ronald Peter; Witteveen, Petronella Oda; Stelloo, Ellen (Cell Press, 2020-06-16)
    There remains an unmet need for preclinical models to enable personalized therapy for ovarian cancer (OC) patients. Here we evaluate the capacity of patient-derived organoids (PDOs) to predict clinical drug response and ...