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Now showing items 19021-19040 of 40729

A single neural network for cone-beam computed tomography-based radiotherapy of head-and-neck, lung and breast cancer

Maspero, Matteo; Houweling, Antonetta C.; Savenije, Mark H.F.; van Heijst, Tristan C.F.; Verhoeff, Joost J.C.; Kotte, Alexis N.T.J.; van den Berg, Cornelis A.T. (Elsevier, 2020-04)

Background and purpose Adaptive radiotherapy based on cone-beam computed tomography (CBCT) requires high CT number accuracy to ensure accurate dose calculations. Recently, deep learning has been proposed for fast CBCT ...
Network Meta-analysis for the Diagnostic Approach to Pathologic Nipple Discharge

Filipe, Mando D.; Patuleia, Susanna I.S.; de Jong, Valentijn M.T.; Vriens, Menno R.; van Diest, Paul J.; Witkamp, Arjen J. (Elsevier, 2020-12)

Pathologic nipple discharge (PND) is one of the most common breast-related complaints for referral because of its supposed association with breast cancer. The aim of this network meta-analysis (NMA) was to compare the ...
Impact of delays on effectiveness of contact tracing strategies for COVID-19: a modelling study

Kretzschmar, Mirjam E; Rozhnova, Ganna; Bootsma, Martin C J; van Boven, Michiel; van de Wijgert, Janneke H H M; Bonten, Marc J M (Elsevier Limited, 2020-08)

BACKGROUND: In countries with declining numbers of confirmed cases of COVID-19, lockdown measures are gradually being lifted. However, even if most physical distancing measures are continued, other public health measures ...
Medullary Pancreatic Carcinoma Due to Somatic POLE Mutation: A Distinctive Pancreatic Carcinoma With Marked Long-Term Survival

Kryklyva, Valentyna; Ter Linden, Esther; Kroeze, Leonie I; de Voer, Richarda M; van der Kolk, B Marion; Stommel, Martijn W J; Hermans, John J; Luchini, Claudio; Wood, Laura D; Hruban, Ralph H; Nagtegaal, Iris D; Ligtenberg, Marjolijn J L; Brosens, Lodewijk A A (Lippincott Williams & Wilkins, 2020-08)

Medullary pancreatic carcinoma (MPC) is a rare histological variant of pancreatic ductal adenocarcinoma (PDAC). Because of its rarity, data on the molecular background of MPC are limited. Previous studies have shown that ...
Epithelial-mesenchymal transition in undifferentiated carcinoma of the pancreas with and without osteoclast-like giant cells

Mattiolo, Paola; Fiadone, Giulia; Paolino, Gaetano; Chatterjee, Deyali; Bernasconi, Riccardo; Piccoli, Paola; Parolini, Claudia; El Aidi, Mouad; Sperandio, Nicola; Malleo, Giuseppe; Salvia, Roberto; Brosens, Lodewijk A; Wood, Laura D; Scarpa, Aldo; Lawlor, Rita T; Luchini, Claudio (Springer-Verlag, 2021-02)

Undifferentiated carcinoma (UC) and undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) are peculiar variants of pancreatic ductal adenocarcinoma (PDAC), characterized by hypercellularity and absence of ...
Results from the Netherlands' 2018 Report Card and Report Card+ on physical activity for children and youth with and without chronic medical condition

Dutch Physical Activity Report Card Study Group (Elsevier, 2020-08)

Objective: The objective of this study was to summarize the results of the 2018 the Netherlands' Physical Activity Report Card (PARC) for children and youth as well as for children and youth with a chronic medical condition ...
Sleep quantity and its relation with physical activity in children with cerebral palsy; insights using actigraphy

Smit, Denise J M; Zwinkels, Maremka; Takken, Tim; Hulst, Raquel Y; de Groot, Janke F; Lankhorst, Kristel; Verschuren, Olaf (John Wiley & Sons Inc., 2020-10)

AIM: To objectively assess the sleep quantity, and explore the relationships between sleep quantity and quality, and physical activity and sedentary behaviour in children and adolescents with cerebral palsy (CP). METHODS: ...
6-Minute Push Test in Youth Who Have Spina Bifida and Who Self-Propel a Wheelchair: Reliability and Physiologic Response

Damen, Karlijn M S; Takken, Tim; de Groot, Janke F; Backx, Frank J G; Radder, Bob; Roos, Irene C P M; Bloemen, Manon A T (Oxford University Press, 2020-10)

Objective. Despite the common occurrence of lower levels of physical activity and physical fitness in youth with spina bifida (SB) who use a wheelchair, there are very few tests available to measure and assess these levels. ...
Oseltamivir bij infectie door een humaan coronavirus: Post-hocanalyse van gegevens uit 2016-2018

van der Velden, Alike; Goossens, Herman; Cianci, Daniela; Bongard, Emily; Saville, Benjamin; Ieven, Margareta; Verheij, Th J.M.; Butler, C. C.; Coenen, S. (Bohn Stafleu van Loghum, 2020-08-01)

In een onderzoek tijdens 3 griepseizoenen tussen 2016 en 2018 bleek dat patiënten met griepachtige klachten een dag sneller herstelden wanneer oseltamivir werd toegevoegd aan de gebruikelijke zorg. Een nadere analyse laat ...
Introducing simulated IK1 into human iPSC-cardiomyocytes using dynamic clamp on an automated patch clamp system

Stoelzle-Feix, Sonja; Becker, Nadine; Obergrussberger, Alison; de Boer, Teun; Goversen, Birgit; van Veen, Toon A.; Fertig, Niels (Elsevier, 2019-09)
Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

Lei, Chon Lok; Clerx, Michael; Whittaker, Dominic G.; Gavaghan, David J.; de Boer, Teun P.; Mirams, Gary R. (The Royal Society, 2020-06-12)

Mathematical models of ion channels, which constitute indispensable components of action potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a previous study, we fitted cell-specific ...
Anticholinergic drug exposure at intensive care unit admission affects the occurrence of delirium. A prospective cohort study

Vondeling, Ariël M.; Knol, Wilma; Egberts, Toine C.G.; Slooter, Arjen J.C. (Elsevier, 2020-08)

Background: Anticholinergic drugs may increase the risk of delirium in non-critically ill patients, but it is unclear whether exposure to these drugs is also a risk factor for Intensive Care Unit (ICU) delirium. In this ...
Opportunities for changes in the drug product design to enhance medication safety in older people: Evaluation of a national public portal for medication incidents

Karapinar-Çarkit, Fatma; van den Bemt, Patricia M.L.A.; Sadik, Mariam; van Soest, Brigit; Knol, Wilma; van Hunsel, Florence; van Riet-Nales, Diana A. (Wiley-Blackwell, 2020-10)

Aims: Medication safety requires urgent attention in hospital pharmacy. This study evaluated the medication-related problems/errors as reported to the Dutch medication incident registry and disseminated for information to ...
The distinct traits of the UNC13A polymorphism in amyotrophic lateral sclerosis

Tan, Harold H G; Westeneng, Henk-Jan; van der Burgh, Hannelore K; van Es, Michael A; Bakker, Leonhard A; van Veenhuijzen, Kevin; van Eijk, Kristel R; van Eijk, Ruben P A; Veldink, Jan H; van den Berg, Leonard H (John Wiley & Sons Inc., 2020-10)

OBJECTIVE: The rs12608932 single nucleotide polymorphism in UNC13A is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) susceptibility, and may underlie differences in treatment response. ...
A placebo-controlled trial to investigate the safety and efficacy of Penicillin G/Hydrocortisone in patients with ALS (PHALS trial)

Van Es, Michael A; Van Eijk, Ruben P A; Bunte, Tommy M; Van Den Berg, Leonard H (Informa Healthcare, 2020-10-01)

Objective: A recent case-series described patients with ALS to improve and/or stabilize after treatment with intravenous high-dose Penicillin G/Hydrocortisone (PenGH). In this study, we determine the safety and efficacy ...
The Beginning of Genomic Therapies for ALS

Hardiman, Orla; van den Berg, Leonard H (Massachussetts Medical Society, 2020-07-09)
TRICALS: creating a highway toward a cure

van Eijk, Ruben P A; Kliest, Tessa; McDermott, Christopher J; Roes, Kit C B; Van Damme, Philip; Chio, Adriano; Weber, Markus; Ingre, Caroline; Corcia, Philippe; Povedano, Mònica; Reviers, Evy; van Es, Michael A; Al-Chalabi, Ammar; Hardiman, Orla; van den Berg, Leonard H (Informa Healthcare, 2020-10-01)

A change in our current approach toward drug development is required to improve the likelihood of finding effective treatment for patients with amyotrophic lateral sclerosis (ALS). The aim of the Treatment Research Initiative ...
Association between C reactive protein and microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes: the RODAM study

Hayfron-Benjamin, Charles Frederick; Maitland-van der Zee, Anke H; van den Born, Bert-Jan; Amoah, Albert G B; Meeks, Karlijn A C; Klipstein-Grobusch, Kerstin; Schulze, Matthias B; Spranger, Joachim; Danquah, Ina; Smeeth, Liam; Beune, Erik J A J; Mockenhaupt, Frank; Agyemang, Charles O (BMJ Publishing Group, 2020-07-14)

INTRODUCTION: Although inflammation assessed by elevated C reactive protein (CRP) concentration is known to be associated with risk of cardiovascular disease, its association with microvascular and macrovascular dysfunction ...
Predicting sustained ventricular arrhythmias in dilated cardiomyopathy: a meta-analysis and systematic review

Sammani, Arjan; Kayvanpour, Elham; Bosman, Laurens P; Sedaghat-Hamedani, Farbod; Proctor, Tanja; Gi, Weng-Tein; Broezel, Alicia; Jensen, Katrin; Katus, Hugo A; Te Riele, Anneline S J M; Meder, Benjamin; Asselbergs, Folkert W (John Wiley & Sons Inc., 2020-08)

AIMS: Patients with non-ischaemic dilated cardiomyopathy (DCM) are at increased risk of sudden cardiac death. Identification of patients that may benefit from implantable cardioverter-defibrillator implantation remains ...
Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples

Berendsen, Sharon; Frijlink, Elselien; Kroonen, Jèrôme; Spliet, Wim G M; van Hecke, Wim; Seute, Tatjana; Snijders, Tom J; Robe, Pierre A (Oxford University Press, 2019-05-01)

Background: The antiepileptic drug valproic acid (VPA) inhibits histone deacetylase in glioblastoma cells in vitro, which influences several oncogenic pathways and decreases glioma cell proliferation. The clinical relevance ...

Now showing items 19021-19040 of 40729