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Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Hartman, Robin J G; Kapteijn, Daniek M C; Haitjema, Saskia; Bekker, Mireille N; Mokry, Michal; Pasterkamp, Gerard; Civelek, Mete; den Ruijter, Hester M (Nature Publishing Group, 2020-07-23)

Sex differences in endothelial cell (EC) biology may reflect intrinsic differences driven by chromosomes or sex steroid exposure and gender differences accumulated over life. We analysed EC gene expression data from boy-girl ...
Reducing uncertainty: motivations and consequences of seeking a second opinion in oncology

Lehmann, Vicky; Smets, Ellen M A; de Jong, Maxime; de Vos, Filip Y F; Kenter, Gemma G; Stouthard, Jacqueline M; Hillen, Marij A (Informa Healthcare, 2020-12-01)

BACKGROUND: Cancer patients increasingly seek second opinion (SO) consultations, but there is scarce empirical evidence to substantiate medical and psychological benefits for patients. This is the first study to examine ...
Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study

Groen, M H A; Slieker, F J B; Vink, A; de Borst, G J; Simons, M V; Ebbini, E S; Utrecht, University; Hazenberg, C E V B; van Es, R (Informa Healthcare, 2020-01-01)

PURPOSE: High-intensity focused ultrasound (HIFU) is a potential noninvasive thermal ablation method for the treatment of peripheral artery disease. Dual-mode ultrasound arrays (DMUA) offer the possibility of simultaneous ...
Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017

Trzcionkowska, Kasia; Vehmeijer, Wouter B H J; Kerkhoff, Frank T; Bauer, Noel J C; Bennebroek, Carlien A M; Dijk, Peter H; Dijkman, Koen P; van den Dungen, Frank A M; Eggink, Cathrien A; Feenstra, Robert P G; Groenendaal, Floris; van Heijst, Arno F; van der Hoeven, Mark A H B M; Kornelisse, Rene F; Kraal-Biezen, Elke; Lopriore, Enrico; Onland, Wes; Renardel de Lavalette, Victor W; van Rijn, Laurentius J; Schuerman, Frank A B A; Simonsz, Huibert J; Voskuil-Kerkhof, Elsbeth S M; Witlox, Ruben S G M; Termote, Jacqueline U M; Schalij-Delfos, Nicoline E (Wiley-Blackwell, 2021-02)

Purpose: Compare patients treated for Retinopathy of Prematurity (ROP) in two consecutive periods. Methods: Retrospective inventory of anonymized neonatal and ophthalmological data of all patients treated for ROP from 2010 ...
MEN1-related pancreatic NETs: identification of unmet clinical needs and future directives: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: MEN1-related pancreatic NETs: identification of unmet clinical needs and future directives

Pieterman, C R C; Sadowski, S M; Maxwell, J E; Katz, M H G; Lines, K E; Heaphy, C M; Tirosh, A; Blau, J E; Perrier, N D; Lewis, M A; Metzcar, J P; Halperin, D M; Thakker, R V; Valk, G D (BioScientifica Ltd., 2020-08)

The PanNET Working Group of the 16th International Multiple Endocrine Neoplasia Workshop (MEN2019) convened in Houston, TX, USA, 27-29 March 2019 to discuss key unmet clinical needs related to PanNET in the context of MEN1, ...
Prognostic factors for the outcome of nonfunctioning pancreatic neuroendocrine tumors in MEN1: a systematic review of literature

Sadowski, S M; Pieterman, C R C; Perrier, N D; Triponez, F; Valk, G D (BioScientifica Ltd., 2020-06)

Metastatic duodenopancreatic neuro-endocrine tumors (dpNETs) are the most important disease-related cause of death in patients with multiple endocrine neoplasia type 1 (MEN1). Nonfunctioning pNETs (NF-pNETs) are highly ...
Surgery for multiple endocrine neoplasia type 1-related insulinoma: long-term outcomes in a large international cohort

van Beek, D J; Nell, S; Verkooijen, H M; Borel Rinkes, I H M; Valk, G D; Vriens, M R; (on behalf of the DutchMEN study group); the International MEN1 Insulinoma Study Group (John Wiley & Sons Inc., 2020-10)

BACKGROUND: Insulinomas are found in 10-15 per cent of patients with multiple endocrine neoplasia type 1 (MEN1) and lead to life-threatening hypoglycaemia. Surgical outcome and the optimal surgical strategy for MEN1-related ...
Clinical management of neuroendocrine neoplasms (NENs)

Casey, Ruth T; Valk, Gerlof D; Schalin-Jäntti, Camilla; Grossman, Ashley B; Thakker, Rajesh V (Oxford University Press, 2020-08)

In viral pandemics, most specifically Covid-19, many patients with neuroendocrine neoplasms (NENs), including phaeochromocytomas, paragangliomas and medullary thyroid carcinoma, may develop Covid-19 in a mild or severe ...
Blood Molecular Genomic Analysis Predicts the Disease Course of Gastroenteropancreatic Neuroendocrine Tumor Patients: a validation study of the predictive value of the NETest®

van Treijen, Mark J C; van der Zee, Dennis; Heeres, Birthe C; Staal, Femke C R; Vriens, Menno R; Saveur, Lisette J; Verbeek, Wieke H M; Korse, Catharina M; Maas, Monique; Valk, Gerlof D; Tesselaar, Margot (S. Karger AG, 2021-06)

Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for ...
PSMA PET/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy

Mohan, Vineet; Vogel, Wouter V; Valk, Gerlof D; de Boer, Jan P; Lam, Marnix G E H; de Keizer, Bart (SAGE Publications Inc., 2020-07-04)

INTRODUCTION: Xerostomia is a well-known complication after iodine-131 (131I) therapy for thyroid carcinoma. It is currently insufficiently understood how the dose and biodistribution of 131I relates to salivary gland ...
General Anesthesia or Conscious Sedation for Transfemoral Aortic Valve Replacement with the SAPIEN 3 Transcatheter Heart Valve

Neumann, Franz-Josef; Redwood, Simon; Abdel-Wahab, Mohamed; Lefèvre, Thierry; Frank, Derk; Eltchaninoff, Hélène; Caussin, Christophe; Stella, Pieter R; Hovorka, Tomas; Baumgartner, Helmut; Tarantini, Giuseppe; Wendler, Olaf; Treede, Hendrik (International Heart Journal Association, 2020-07)

Differences in the benefits of conscious sedation (CS) and general anesthesia (GA) during transfemoral aortic valve implantation (TAVI) are unclear.We aimed to assess differences in procedural and clinical outcomes based ...
Five-Year Outcome of Laparoscopic Fundoplication in Pediatric GERD Patients: a Multicenter, Prospective Cohort Study

Stellato, Rebecca K; Colmer, Nadia; Tytgat, Stefaan H A; van der Zee, David C; van de Peppel-Mauritz, Femke A; Lindeboom, Maud Y A (Springer New York, 2021-06)

Background: Gastroesophageal reflux disease (GERD) is a common disease in children. When drug treatment fails, laparoscopic anti-reflux surgery (LARS) is considered. Short-term follow-up studies report high success rates; ...
Conditional safety margins for less conservative peak local SAR assessment: A probabilistic approach

Meliadò, Ettore Flavio; Sbrizzi, Alessandro; van den Berg, Cornelis A T; Steensma, Bart R; Luijten, Peter R; Raaijmakers, Alexander J E (John Wiley & Sons Inc., 2020-12-01)

PURPOSE: The introduction of a linear safety factor to address peak local specific absorption rate (pSAR10g ) uncertainties (eg, intersubject variation, modeling inaccuracies) bears one considerable drawback: It often ...
High-resolution in vivo MR-STAT using a matrix-free and parallelized reconstruction algorithm

van der Heide, Oscar; Sbrizzi, Alessandro; Luijten, Peter R; van den Berg, Cornelis A T (John Wiley & Sons Inc., 2020-04-01)

MR-STAT is a recently proposed framework that allows the reconstruction of multiple quantitative parameter maps from a single short scan by performing spatial localisation and parameter estimation on the time-domain data ...
A Reflectivity Measure to Quantify Bruch's Membrane Calcification in Patients with Pseudoxanthoma Elasticum Using Optical Coherence Tomography

Risseeuw, Sara; Bennink, E; Poirot, Maarten; de Jong, Pim; Spiering, Wilko; Imhof, Saskia; van Leeuwen, R; Ossewaarde-van Norel, J (Association for Research in Vision and Ophthalmology Inc., 2020-07)

Purpose: Progressive calcification of Bruch's membrane (BM) causes considerable visual morbidity in patients with pseudoxanthoma elasticum (PXE). Since calcification is hyperreflective on optical coherence tomography (OCT), ...
ESHRE guideline: ovarian stimulation for IVF/ICSI†

Ovarian Stimulation, The Eshre Guideline Group On; Bosch, Ernesto; Broer, Simone; Griesinger, Georg; Grynberg, Michael; Humaidan, Peter; Kolibianakis, Estratios; Kunicki, Michal; La Marca, Antonio; Lainas, George; Le Clef, Nathalie; Massin, Nathalie; Mastenbroek, Sebastiaan; Polyzos, Nikolaos; Sunkara, Sesh Kamal; Timeva, Tanya; Töyli, Mira; Urbancsek, Janos; Vermeulen, Nathalie; Broekmans, Frank (2020)

STUDY QUESTION: What is the recommended management of ovarian stimulation, based on the best available evidence in the literature? SUMMARY ANSWER: The guideline development group formulated 84 recommendations answering 18 ...
Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration

Krouwels, Anita; Iljas, Juvita D; Kragten, Angela H M; Dhert, Wouter J A; Öner, F Cumhur; Tryfonidou, Marianna A; Creemers, Laura B (Multidisciplinary Digital Publishing Institute (MDPI), 2020-04-14)

Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the intervertebral disc, can be stimulated by growth factors. Bone morphogenetic proteins (BMPs) hold great promise. Although BMP2 and ...
Lessons Learned from 23 Years of Experience in Testing Visual Fields of Neurologically Impaired Children

Portengen, Brendan L.; Koenraads, Yvonne; Imhof, Saskia M.; Porro, Giorgio L. (Informa Healthcare, 2020-11-01)

We sought to investigate the reliability of standard conventional perimetry (SCP) in neurologically impaired (NI) children using the examiner-based assessment of reliability scoring system and to determine the difference ...
Intoxicated persons showing challenging behavior demand complexity interventions: a pilot study at the interface of the ER and the complexity intervention unit

Verheesen, Stefan M H; Ten Doesschate, Freek; van Schijndel, Maarten A; van der Gaag, Rutger Jan; Cahn, Wiepke; van Waarde, Jeroen A (D. Steinkopff-Verlag, 2021-08)

Intoxicated persons showing challenging behavior (IPCBs) under influence of alcohol and/or drugs frequently have trouble finding appropriate acute care. Often IPCBs are stigmatized being unwilling or unable to accept help. ...
Association of schizophrenia polygenic risk score with data-driven cognitive subtypes: A six-year longitudinal study in patients, siblings and controls

GROUP Investigators (Elsevier, 2020-09)

Cross-sectional studies have shown that the polygenic risk score for schizophrenia (PRSSCZ) may influence heterogeneity in cognitive performance although evidence from family-based longitudinal study is limited. This study ...

Now showing items 18961-18980 of 40729