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Now showing items 18801-18820 of 40729

Clinical spectrum, prognosis and estimated prevalence of DNAJB11-kidney disease

Genkyst Study Group, Genomics England Research Consortium (Elsevier, 2020-08)

Monoallelic mutations of DNAJB11 were recently described in seven pedigrees with atypical clinical presentations of autosomal dominant polycystic kidney disease. DNAJB11 encodes one of the main cofactors of the endoplasmic ...
The CARDIA-trial protocol: a multinational, prospective, randomized, clinical trial comparing transthoracic esophagectomy with transhiatal extended gastrectomy in adenocarcinoma of the gastroesophageal junction (GEJ) type II

Leers, Jessica M; Knepper, Laura; van der Veen, Arjen; Schröder, Wolfgang; Fuchs, Hans; Schiller, Petra; Hellmich, Martin; Zettelmeyer, Ulrike; Brosens, Lodewijk A A; Quaas, Alexander; Ruurda, Jelle P; van Hillegersberg, Richard; Bruns, Christiane J (BioMed Central, 2020-08-20)

BACKGROUND: Adenocarcinoma of the gastroesophageal junction (GEJ) Siewert type II can be resected by transthoracic esophagectomy or transhiatal extended gastrectomy. Both allow for a complete tumor resection, yet there is ...
Ustekinumab is associated with superior effectiveness outcomes compared to vedolizumab in Crohn's disease patients with prior failure to anti-TNF treatment

Biemans, Vince B C; van der Woude, C Janneke; Dijkstra, Gerard; van der Meulen-de Jong, Andrea E; Löwenberg, Mark; de Boer, Nanne K; Oldenburg, Bas; Srivastava, Nidhi; Jansen, Jeroen M; Bodelier, Alexander G L; West, Rachel L; de Vries, Annemarie C; Haans, Jeoffrey J L; de Jong, Dirk; Hoentjen, Frank; Pierik, Marieke J; Dutch Initiative on Crohn and Colitis (ICC) (Wiley-Blackwell, 2020-07-01)

BACKGROUND: Both vedolizumab and ustekinumab can be considered for the treatment of Crohn's disease (CD) when anti-TNF treatment fails. However, head-to-head trials are currently not available or planned. AIM: To compare ...
From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke

Arrarte Terreros, Nerea; Tolhuisen, Manon L.; Bennink, E; de Jong, Hugo; Beenen, Ludo F. M.; Majoie, Charles B.L.M.; van Bavel, Ed (Elsevier Limited, 2020-10-09)

Thrombus permeability determines blood flow through the occluding thrombus in acute ischemic stroke (AIS) patients. The quantification of thrombus permeability is challenging since it cannot be directly measured nor derived ...
Cisplatin and carboplatin pharmacokinetics in a pediatric patient with hepatoblastoma receiving peritoneal dialysis

Nijstad, A Laura; van Eijkelenburg, Natasha K A; Kraal, Kathelijne C J M; Meijs, Marieke J M; de Kanter, Clara T M M; Lilien, Marc R; Huitema, Alwin D R (Springer-Verlag, 2020-09)

PURPOSE: Cisplatin and carboplatin are frequently used drugs in the treatment of pediatric hepatoblastoma. Dosing guidelines for these drugs in children requiring peritoneal dialysis are lacking. Here, we describe the case ...
Infliximab Level Between Venous and Capillary Blood Using Novel Device Strongly Correlate in Paediatric Inflammatory Bowel Disease Patients

Zijlstra, Marieke; Jongsma, Maria Myrthe Elisabeth; de Vries, Annick; Schaap, Tiny; Bloem, Karien; de Ridder, Lissy (Lippincott Williams & Wilkins, 2021-01-01)

Objectives: Blood to measure infliximab (IFX) levels is typically obtained with venipuncture. Dried blood sampling (DBS), using capillary blood obtained from a finger prick, would be an alternative to measure IFX blood ...
Raising the Cut-Off Level of Anti-Tissue Transglutaminase Antibodies to Detect Celiac Disease Reduces the Number of Small Bowel Biopsies in Children with Type 1 Diabetes: A Retrospective Study

Wessels, Margreet; Velthuis, Anouk; van Lochem, Ellen; Duijndam, Eline; Hoorweg-Nijman, Gera; de Kruijff, Ineke; Wolters, Victorien; Berghout, Eveline; Meijer, Jos; Bokma, Jan Alle; Mul, Dick; van der Velden, Janielle; Roovers, Lian; Mearin, M Luisa; van Setten, Petra (Mosby Inc., 2020-08)

OBJECTIVE: To study the optimal cut-off value for anti-tissue transglutaminase type 2 IgA antibodies (TG2A) in serum to select for diagnostic small bowel biopsies for celiac disease in children with type 1 diabetes mellitus. ...
Infliximab in young paediatric IBD patients: it is all about the dosing

Paediatric IBD Porto group of ESPGHAN (Springer-Verlag, 2020-12)

Infliximab (IFX) is administered intravenously using weight-based dosing (5 mg/kg) in inflammatory bowel disease (IBD) patients. Our hypothesis is that especially young children need a more intensive treatment regimen than ...
Potential of ileal bile acid transporter inhibition as a therapeutic target in Alagille syndrome and progressive familial intrahepatic cholestasis

Kamath, Binita M; Stein, Philip; Houwen, Roderick H J; Verkade, Henkjan J (Wiley-Blackwell, 2020-08)

Alagille syndrome (ALGS) and progressive familial intrahepatic cholestasis (PFIC) are rare, inherited cholestatic liver disorders that manifest in infants and children and are associated with impaired bile flow (ie ...
p.P1379S, a benign variant with reduced ATP7B protein level in Wilson Disease

Yi, Fan; Poskanzer, Sheri A; Myers, Candace T; Thies, Jenny; Collins, Christopher J; Dayuha, Remwilyn; Duong, Phi; Houwen, Roderick; Hahn, Si Houn (Springer Berlin, 2020-07)

Background: Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by inherited defects in the ATP7B gene and results in toxic accumulation of copper in various organs. We previously reported a ...
Development and validation of a gas chromatography–mass spectrometry method to analyze octanoate enrichments at low concentrations in human plasma

van Harskamp, Dewi; Knottnerus, Suzan J.G.; Visser, Gepke; van Goudoever, Johannes B.; Schierbeek, Henk (Springer-Verlag, 2020-09-01)

A new method for accurately analyzing octanoate enrichment in plasma was developed and validated. Samples were derivatized directly in plasma by transesterification with isobutanol and were analyzed by gas chromatography-mass ...
Ethical challenges for pediatric liver organoid transplantation

Schneemann, Sarah A; Boers, Sarah N; van Delden, Johannes J M; Nieuwenhuis, Edward E S; Fuchs, Sabine A; Bredenoord, Annelien L (American Association for the Advancement of Science, 2020-07-15)

Liver organoid transplantation may be a less invasive alternative to liver transplant, but is it ethically acceptable to include children with liver disease in a first-in-human clinical trial of this new intervention?
European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides – the SHARE initiative: This is a correction to: Rheumatology, Volume 58, Issue 4, April 2019, Pages 656–671, https://doi.org/10.1093/rheumatology/key322

De Graeff, Nienke; Groot, Noortje; Brogan, Paul; Ozen, Seza; Avcin, Tadej; Bader-Meunier, Brigitte; Dolezalova, Pavla; Feldman, Brian M.; Kone-Paut, Isabelle; Lahdenne, Pekka; Marks, Stephen D.; McCann, Liza; Pilkington, Clarissa; Ravelli, Angelo; Van Royen, Annet; Uziel, Yosef; Vastert, Bas; Wulffraat, Nico; Kamphuis, Sylvia; Beresford, Michael W. (Oxford University Press, 2020-04)
The Patient and Parent Perspective on Methotrexate in Recent Juvenile Idiopathic Arthritis Guidelines: Comment on the Article by Ringold et al

Schoemaker, Casper G.; Wulffraat, Nico M.; Vastert, Sebastiaan J. (John Wiley & Sons Inc., 2020-06-01)
Treating juvenile idiopathic arthritis to target: What is the optimal target definition to reach all goals?

Schoemaker, Casper G.; Swart, Joost F.; Wulffraat, Nico M. (BioMed Central Ltd., 2020-04-16)

In 2018, an international Task Force formulated recommendations for treating Juvenile Idiopathic Arthritis (JIA) to target. The Task Force has not yet resolved three issues. The first issue is the lack of a single "best" ...
Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in patients with childhood systemic lupus erythematosus: a real-world interventional multi-centre study

Rotstein Grein, Ingrid Herta; Pinto, Natalia Ferreira; Lobo, Aline; Groot, Noortje; Sztajnbok, Flavio; da Silva, Clóvis Artur Almeida; Paim Marques, Luciana B.; Appenzeller, Simone; Islabão, Aline Garcia; Magalhães, Claudia Saad; de Almeida, Rozana Gasparello; Bica, Blanca; Fraga, Melissa; da Fraga, Aline Coelho Moreira; dos Santos, Maria Carolina; Robazzi, Teresa; Terreri, Maria Teresa RA; Bandeira, Marcia; Pasmans, Hella; Schepp, Rutger; van der Klis, Fiona; de Roock, Sytze; Wulffraat, Nico; Pileggi, Gecilmara (SAGE Publications Ltd, 2020-07-01)

Objective: This study aimed to assess the safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccination in childhood-onset systemic lupus erythematosus (cSLE) patients. Methods: Volunteer cSLE ...
Presumed Risk Factors and Biomarkers for Severe Respiratory Syncytial Virus Disease and Related Sequelae: Protocol for an Observational Multicenter, Case-Control Study From the Respiratory Syncytial Virus Consortium in Europe (RESCEU)

Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators (Oxford University Press, 2020-11-01)

Respiratory syncytial virus (RSV) is the leading viral pathogen associated with acute lower respiratory tract infection and hospitalization in children < 5 years of age worldwide. While there are known clinical risk factors ...
Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe

Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators (Oxford University Press, 2020-11-01)

Background. Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although prematurity and cardiopulmonary disease are risk factors for severe disease, the majority of infants ...
A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells

Ormel, Paul R.; Böttcher, Chotima; Gigase, Frederieke A.J.; Missall, Roy D.; van Zuiden, Welmoed; Fernández Zapata, M. Camila; Ilhan, Dilara; de Goeij, Michelle; Udine, Evan; Sommer, Iris E.C.; Priller, Josef; Raj, Towfique; Kahn, René S.; Hol, Elly M.; de Witte, Lot D. (Academic Press Inc., 2020-11)

Different lines of evidence support a causal role for microglia in the pathogenesis of schizophrenia. However, how schizophrenia patient-derived microglia are affected at the phenotypic and functional level is still largely ...
The role of client empathy in treatment outcome in a sample of adolescents referred to forensic youth psychiatric services

de Wied, Minet; van der Graaff, Jolien; de Rooij, Guido; Scheepers, Floor; Hoekstra, Pieter J.; Branje, Susan; van de Schoot, Rens (Elsevier, 2020-11)

Starting from the assumption that empathy is crucial in the therapeutic process, the current study explored whether client empathy before treatment relates to treatment outcome, whether client empathy is subject to change ...

Now showing items 18801-18820 of 40729