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Now showing items 18821-18840 of 40729

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

ENIGMA Bipolar Disorder Working Group (Wiley-Liss Inc., 2022-01)

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied ...
Heritability of specific cognitive functions and associations with schizophrenia spectrum disorders using CANTAB: a nation-wide twin study

Lemvigh, Cecilie K; Brouwer, Rachel M; Pantelis, Christos; Jensen, Maria H; Hilker, Rikke W; Legind, Christian S; Anhøj, Simon J; Robbins, Trevor W; Sahakian, Barbara J; Glenthøj, Birte Y; Fagerlund, Birgitte (Cambridge University Press, 2022-04)

BACKGROUND: Many cognitive functions are under strong genetic control and twin studies have demonstrated genetic overlap between some aspects of cognition and schizophrenia. How the genetic relationship between specific ...
The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study

Soesanti, Frida; Idris, Nikmah S; Klipstein-Grobusch, Kerstin; Hendarto, Aryono; Grobbee, Diederick E; Uiterwaal, Cuno S P M (BioMed Central, 2020-08-20)

BACKGROUND: To date, there is limited evidence on the effect of antenatal exposure to non-organophosphate household pesticides on infant health. Our hypothesis is that antenatal exposure to non-organophosphate household ...
MTX intolerance in children and adolescents with juvenile idiopathic arthritis

Hügle, Boris; van Dijkhuizen, E H Pieter (Oxford University Press, 2020-07-01)

MTX is the medication most commonly used for antirheumatic treatment in juvenile idiopathic arthritis. It has high efficacy, is usually well tolerated and has an excellent safety profile. However, frequently intolerance ...
Consensus Statement on the Management of Waldenström Macroglobulinemia Patients During the COVID-19 Pandemic

Talaulikar, Dipti; Advani, Ranjana H; Branagan, Andrew R; Buske, Christian; Dimopoulos, Meletios A; D'Sa, Shirley; Kersten, Maria J; Leblond, Veronique; Minnema, Monique C; Owen, Roger G; Palomba, Maria Lia; Tedeschi, Alessandra; Trotman, Judith; Varettoni, Marzia; Vos, Josephine M; Treon, Steven P; Kastritis, Efstathios; Castillo, Jorge J (Wolters Kluwer Health, 2020-08)

In the light of the COVID-19 pandemic, the International Workshop on Waldenström Macroglobulinemia (IWWM) Treatment Recommendations Panel felt the need to provide a consensus statement for the management of Waldenström ...
Broad proteomic screen reveals shared serum proteomic signature in patients with psoriatic arthritis and psoriasis without arthritis

Leijten, Emmerik; Tao, Weiyang; Pouw, Juliette; van Kempen, Tessa; Olde Nordkamp, Michel; Balak, Deepak; Tekstra, J; Muñoz-Elías, Ernesto; DePrimo, Samuel; Drylewicz, Julia; Pandit, Aridaman; Boes, Marianne; Radstake, Timothy (Oxford University Press, 2021-02-01)

OBJECTIVE: To identify novel serum proteins involved in the pathogenesis of PsA as compared with healthy controls, psoriasis (Pso) and AS, and to explore which proteins best correlated to major clinical features of the ...
Recently Evolved Enhancers Emerge with High Interindividual Variability and Less Frequently Associate with Disease

Castelijns, Bas; Baak, Mirna L; Geeven, Geert; Vermunt, Marit W; Wiggers, Caroline R M; Timpanaro, Ilia S; Kondova, Ivanela; de Laat, Wouter; Creyghton, Menno P (Cell Press, 2020-06-23)

Mutations in non-coding regulatory DNA such as enhancers underlie a wide variety of diseases including developmental disorders and cancer. As enhancers rapidly evolve, understanding their function and configuration in ...
Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation

van Ouwerkerk, Antoinette F; Hall, Amelia W; Kadow, Zachary A; Lazarevic, Sonja; Reyat, Jasmeet S; Tucker, Nathan R; Nadadur, Rangarajan D; Bosada, Fernanda M; Bianchi, Valerio; Ellinor, Patrick T; Fabritz, Larissa; Martin, James F; de Laat, Wouter; Kirchhof, Paulus; Moskowitz, Ivan P; Christoffels, Vincent M (Lippincott Williams & Wilkins, 2020-06-19)

Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, ...
SKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport

Jongsma, Marlieke Lm; Bakker, Jeroen; Cabukusta, Birol; Liv, Nalan; van Elsland, Daphne; Fermie, Job; Akkermans, Jimmy Ll; Kuijl, Coenraad; van der Zanden, Sabina Y; Janssen, Lennert; Hoogzaad, Denise; van der Kant, Rik; Wijdeven, Ruud H; Klumperman, Judith; Berlin, Ilana; Neefjes, Jacques (Springer Science and Business Media Deutschland GmbH, 2020-03-16)

The endolysosomal system fulfils a myriad of cellular functions predicated on regulated membrane identity progressions, collectively termed maturation. Mature or "late" endosomes are designated by small membrane-bound ...
Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening

Omta, Wienand A; van Heesbeen, Roy G; Shen, Ian; de Nobel, Jacob; Robers, Desmond; van der Velden, Lieke M; Medema, René H; Siebes, Arno P J M; Feelders, Ad J; Brinkkemper, Sjaak; Klumperman, Judith S; Spruit, Marco René; Brinkhuis, Matthieu J S; Egan, David A (Society for Laboratory Automation and Screening (SLAS), 2020-07)

There has been an increase in the use of machine learning and artificial intelligence (AI) for the analysis of image-based cellular screens. The accuracy of these analyses, however, is greatly dependent on the quality of ...
Integrated super resolution fluorescence microscopy and transmission electron microscopy

Mohammadian, Sajjad; Agronskaia, Alexandra V; Blab, Gerhard A; van Donselaar, Elly G; de Heus, Cecilia; Liv, Nalan; Klumperman, Judith; Gerritsen, Hans C (Elsevier, 2020-08)

In correlative light and electron microscopy (CLEM), the capabilities of fluorescence microscopy (FM) and electron microscopy (EM) are united. FM combines a large field of view with high sensitivity for detecting fluorescence, ...
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells

Jain Goyal, Manu; Zhao, Xiyan; Bozhinova, Mariya; Andrade-López, Karla; de Heus, Cecilia; Schulze-Dramac, Sandra; Müller-McNicoll, Michaela; Klumperman, Judith; Béthune, Julien (Life Science Alliance, LLC, 2020-09)

Coat protein complex I (COPI)-coated vesicles mediate membrane trafficking between Golgi cisternae as well as retrieval of proteins from the Golgi to the endoplasmic reticulum. There are several flavors of the COPI coat ...
Wiskott-Aldrich syndrome protein restricts cGAS-STING activation by dsDNA immune complexes

Piperno, Giulia Maria; Naseem, Asma; Silvestrelli, Giulia; Amadio, Roberto; Caronni, Nicoletta; Cervantes Luevano, Karla Evelia; Liv, Nalan; Klumperman, Judith; Colliva, Andrea; Ali, Hashim; Graziano, Francesca; Benaroch, Philippe; Haecker, Hans; Hanna, Richard N; Benvenuti, Federica (American Society for Clinical Investigation, 2020-09-03)

Dysregulated sensing of self-nucleic acid is a leading cause of autoimmunity in multifactorial and monogenic diseases. Mutations in Wiskott-Aldrich syndrome protein (WASp), a key regulator of cytoskeletal dynamics in immune ...
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes

Scales, Suzie J; Gupta, Nidhi; De Mazière, Ann M; Posthuma, George; Chiu, Cecilia P; Pierce, Andrew A; Hötzel, Kathy; Tao, Jianhua; Foreman, Oded; Koukos, Georgios; Oltrabella, Francesca; Klumperman, Judith; Lin, WeiYu; Peterson, Andrew S (Wolters Kluwer Health, 2020-09)

BACKGROUND: APOL1 is found in human kidney podocytes and endothelia. Variants G1 and G2 of the APOL1 gene account for the high frequency of nondiabetic CKD among African Americans. Proposed mechanisms of kidney podocyte ...
Valuing Healthcare Goods and Services: A Systematic Review and Meta-Analysis on the WTA-WTP Disparity

Rotteveel, Adriënne H; Lambooij, Mattijs S; Zuithoff, Nicolaas P A; van Exel, Job; Moons, Karel G M; de Wit, G Ardine (Adis International Ltd, 2020-05)

OBJECTIVE: The objective of this systematic review was to review the available evidence on the disparity between willingness to accept (WTA) and willingness to pay (WTP) for healthcare goods and services. METHODS: A tiered ...
Antithrombotic management of patients with atrial fibrillation-Dutch anticoagulant initiatives anno 2020

Chu, G; Seelig, J; Trinks-Roerdink, E M; Geersing, G J; Rutten, F H; de Groot, J R; Huisman, M V; Hemels, M E W (Bohn Stafleu van Loghum, 2020-08-01)

In recent years, as more and more experience has been gained with prescribing direct oral anticoagulants (DOACs), new research initiatives have emerged in the Netherlands to improve the safety and appropriateness of DOAC ...
Ranking Preventive Interventions from Different Policy Domains: What Are the Most Cost-Effective Ways to Improve Public Health?

van der Vliet, Nina; Suijkerbuijk, Anita W M; de Blaeij, Adriana T; de Wit, G Ardine; van Gils, Paul F; Staatsen, Brigit A M; Maas, Rob; Polder, Johan J (Multidisciplinary Digital Publishing Institute (MDPI), 2020-03-02)

It is widely acknowledged that in order to promote public health and prevent diseases, a wide range of scientific disciplines and sectors beyond the health sector need to be involved. Evidence-based interventions, beyond ...
Time trends in the use and appropriateness of natriuretic peptide testing in primary care: an observational study

Valk, Mark; Hoes, Arno W; Mosterd, Arend; Broekhuizen, Brenda; Zuithoff, Nicolaas; Rutten, Frans H (Royal College of General Practitioners, 2020-10)

BACKGROUND: Diagnosing heart failure (HF) is difficult, relying on medical history, symptoms, and signs only. Clinical guidelines recommend natriuretic peptides (NPs) as an additional diagnostic test, notably to exclude ...
Effectiveness and cost-effectiveness of stratified blended physiotherapy in patients with non-specific low back pain: Study protocol of a cluster randomized controlled trial

Koppenaal, Tjarco; Arensman, Remco M.; Van Dongen, Johanna M.; Ostelo, Raymond W.J.G.; Veenhof, Cindy; Kloek, Corelien J.J.; Pisters, Martijn F. (BioMed Central, 2020-04-22)

Background: Patient education, advice on returning to normal activities and (home-based) exercise therapy are established treatment options for patients with non-specific low back pain (LBP). However, the effectiveness of ...
Kan psychotherapie voor PTSS veranderingen van het DNA herstellen?

Vinkers, Christiaan; Geuze, Elbert; Boks, Marco (Uitgeverij Boom, 2020-01-01)

Now showing items 18821-18840 of 40729