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UMC Repository: Recent submissions

  • How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases 
    ter Haar, N. M.; Jansen, M. H.A.; Frenkel, J. F.; Vastert, S. J. (Academic Press Inc., 2020-10)
    IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate ...
  • Potential Use of Extracellular Vesicles Generated by Microbubble-Assisted Ultrasound as Drug Nanocarriers for Cancer Treatment 
    Yuana, Yuana; Balachandran, Banuja; van der Wurff-Jacobs, Kim M G; Schiffelers, Raymond M; Moonen, Chrit T (Multidisciplinary Digital Publishing Institute (MDPI), 2020-04-02)
    Extracellular vesicles (EVs)-carrying biomolecules derived from parental cells have achieved substantial scientific interest for their potential use as drug nanocarriers. Ultrasound (US) in combination with microbubbles ...
  • Local release of siRNA using polyplex-loaded thermosensitive hydrogels 
    Fliervoet, Lies A L; Zhang, Heyang; van Groesen, Emma; Fortuin, Kyra; Duin, Naut J C B; Remaut, Katrien; Schiffelers, Raymond M; Hennink, Wim E; Vermonden, Tina (Royal Society of Chemistry, 2020-05-14)
    One of the challenges for the clinical translation of RNA interference (RNAi)-based therapies concerns the deposition of therapeutically effective doses of the nucleic acids, like siRNA, at a local tissue level without ...
  • Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model 
    Varela-Moreira, Aida; van Straten, Demian; van Leur, Heleen F; Ruiter, Ruud W J; Deshantri, Anil K; Hennink, Wim E; Fens, Marcel H A M; Groen, Richard W J; Schiffelers, Raymond M (Elsevier, 2020-12)
    Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib ...
  • Endothelial cell targeting by crgd-functionalized polymeric nanoparticles under static and flow conditions 
    Martínez-Jothar, Lucía; Barendrecht, Arjan D.; de Graaff, Anko M.; Oliveira, Sabrina; van Nostrum, Cornelus F.; Schiffelers, Raymond M.; Hennink, Wim E.; Fens, Marcel H.A.M. (Multidisciplinary Digital Publishing Institute, 2020-07-10)
    Since αvβ3 integrin is a key component of angiogenesis in health and disease, Arg-Gly-Asp (RGD) peptide-functionalized nanocarriers have been investigated as vehicles for targeted delivery of drugs to the αvβ3 integrin-o ...
  • Delivering the power of nanomedicine to patients today 
    Germain, Matthieu; Caputo, Fanny; Metcalfe, Su; Tosi, Giovanni; Spring, Kathleen; Åslund, Andreas K O; Pottier, Agnes; Schiffelers, Raymond; Ceccaldi, Alexandre; Schmid, Ruth (Elsevier, 2020-10-10)
    The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified diagnostic technologies suitable for use in the field and for delivering ...
  • Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain 
    Dekker, Mirthe; Waissi, Farahnaz; van Bennekom, Joelle; Silvis, Max J M; Timmerman, Nathalie; Bank, Ingrid E M; Walter, Joan E; Mueller, Christian; Schoneveld, A H; Schiffelers, Raymond M; Pasterkamp, Gerard; Grobbee, Diederick E; de Winter, Robbert J; Mosterd, A; de Kleijn, Dominique P V; Timmers, Leo (Nature Publishing Group, 2020-12-01)
    Diagnosing stable ischemic heart disease (IHD) is challenging, especially in females. Currently, no blood test is available. Plasma extracellular vesicles (EV) are emerging as potential biomarker source. We therefore aimed ...
  • Dexamethasone nanomedicines for COVID-19 
    Lammers, Twan; Sofias, Alexandros Marios; van der Meel, Roy; Schiffelers, Raymond; Storm, Gert; Tacke, Frank; Koschmieder, Steffen; Brümmendorf, Tim H; Kiessling, Fabian; Metselaar, Josbert M (Nature Publishing Group, 2020-08-01)
  • The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy 
    Francia, Valentina; Schiffelers, Raymond M; Cullis, Pieter R; Witzigmann, Dominik (American Chemical Society, 2020-09)
    Gene therapy holds great potential for treating almost any disease by gene silencing, protein expression, or gene correction. To efficiently deliver the nucleic acid payload to its target tissue, the genetic material needs ...
  • Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro 
    Patras, Laura; Fens, Marcel H A M; Vader, Pieter; Barendrecht, Arjan; Sesarman, Alina; Banciu, Manuela; Schiffelers, Raymond (Multidisciplinary Digital Publishing Institute (MDPI), 2020-09-01)
    Extracellular vesicles (EV) secreted in the tumour microenvironment (TME) are emerging as major antagonists of anticancer therapies by orchestrating the therapeutic outcome through altering the behaviour of recipient cells. ...
  • Cellular and molecular mechanism of cardiac regeneration: A comparison of newts, zebrafish, and mammals 
    de Wit, Lousanne; Fang, Juntao; Neef, Klaus; Xiao, Junjie; Doevendans, Pieter A.; Schiffelers, Raymond M.; Lei, Zhiyong; Sluijter, Joost P.G. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-09)
    Cardiovascular disease is the leading cause of death worldwide. Current palliative treatments can slow the progression of heart failure, but ultimately, the only curative treatment for end-stage heart failure is heart ...
  • Clinical, Pathology, Genetic, and Molecular Features of Colorectal Tumors in Adolescents and Adults 25 Years or Younger 
    de Voer, Richarda M; Diets, Illja J; van der Post, Rachel S; Weren, Robbert D A; Kamping, Eveline J; de Bitter, Tessa J J; Elze, Lisa; Verhoeven, Rob H A; Vink-Börger, Elisa; Eijkelenboom, Astrid; Mensenkamp, Arjen; Nagtegaal, Iris D; Jongmans, Marjolijn C J; Ligtenberg, Marjolijn J L (W.B. Saunders, 2021-08)
    BACKGROUND & AIMS: Colorectal cancers (CRCs) are rare in adolescents and adults ages 25 years or younger. We analyzed clinical, pathology, and molecular features of colorectal tumors from adolescents and young adults in ...
  • Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia 
    Waanders, Esmé; Gu, Zhaohui; Dobson, Stephanie M; Antić, Željko; Crawford, Jeremy Chase; Ma, Xiaotu; Edmonson, Michael N; Payne-Turner, Debbie; van der Vorst, Maartje; Jongmans, Marjolijn C J; McGuire, Irina; Zhou, Xin; Wang, Jian; Shi, Lei; Pounds, Stanley; Pei, Deqing; Cheng, Cheng; Song, Guangchun; Fan, Yiping; Shao, Ying; Rusch, Michael; McCastlain, Kelly; Yu, Jiangyan; van Boxtel, Ruben; Blokzijl, Francis; Iacobucci, Ilaria; Roberts, Kathryn G; Wen, Ji; Wu, Gang; Ma, Jing; Easton, John; Neale, Geoffrey; Olsen, Scott R; Nichols, Kim E; Pui, Ching-Hon; Zhang, Jinghui; Evans, William E; Relling, Mary V; Yang, Jun J; Thomas, Paul G; Dick, John E; Kuiper, Roland P; Mullighan, Charles G (NLM (Medline), 2020-07)
    Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood cancer-related death. Prior studies have shown clonal mutations at relapse often arise from relapse-fated subclones that exist at diagnosis. ...
  • Natural gene therapy in hematopoietic disorders: GATA too 
    Jongmans, Marjolijn C; Kuiper, Roland P (Elsevier, 2020-08-20)
    In this issue of Blood, Catto et al1 describe for the first time the occurrence of somatic genetic rescue (SGR) in an asymptomatic individual carrying a pathogenic germline mutation in GATA2. The authors hypothesize that ...
  • Imaging tests for the diagnosis of COVID-19 
    McInnes, Matthew D.F.; Leeflang, Mariska M.G.; Salameh, Jean Paul; McGrath, Trevor A.; van der Pol, Christian B.; Frank, Robert A.; Prager, Ross; Hare, Samanjit S.; Dennie, Carole; Spijker, René; Deeks, Jonathan J.; Dinnes, Jacqueline; Jenniskens, Kevin; Korevaar, Daniël A.; Cohen, Jérémie F.; Van den Bruel, Ann; Takwoingi, Yemisi; van de Wijgert, Janneke; Damen, Johanna A.A.G.; Hooft, Lotty (John Wiley & Sons Inc., 2020-06-02)
    Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. The primary objective is to determine the diagnostic accuracy of chest imaging (computed tomography (CT), chest X-ray and ...
  • Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis 
    Kreuzberger, Nina; Damen, Johanna AAG; Trivella, Marialena; Estcourt, Lise J; Aldin, Angela; Umlauff, Lisa; Vazquez-Montes, Maria Dla; Wolff, Robert; Moons, Karel GM; Monsef, Ina; Foroutan, Farid; Kreuzer, Karl-Anton; Skoetz, Nicole (John Wiley & Sons Inc., 2020-07-31)
    BACKGROUND: Chronic lymphocytic leukaemia (CLL) is the most common cancer of the lymphatic system in Western countries. Several clinical and biological factors for CLL have been identified. However, it remains unclear which ...
  • Enterococcus faecium: From microbiological insights to practical recommendations for infection control and diagnostics 
    Zhou, Xuewei; Willems, Rob J.L.; Friedrich, Alexander W.; Rossen, John W.A.; Bathoorn, Erik (BioMed Central Ltd., 2020-08-10)
    Early in its evolution, Enterococcus faecium acquired traits that allowed it to become a successful nosocomial pathogen. E. faecium inherent tenacity to build resistance to antibiotics and environmental stressors that ...
  • Reduced parenchymal cerebral blood flow is associated with greater progression of brain atrophy: The SMART-MR study 
    UCC-SMART Study Group (SAGE Publications Inc., 2021-06-01)
    Global cerebral hypoperfusion may be involved in the aetiology of brain atrophy; however, long-term longitudinal studies on this relationship are lacking. We examined whether reduced cerebral blood flow was associated with ...
  • Suboptimal Dosing of Fluconazole in Critically III Patients: Time To Rethink Dosing 
    Muilwijk, Eline W; de Lange, Dylan W; Schouten, Jeroen A; Wasmann, Roeland E; Ter Heine, Rob; Burger, David M; Colbers, Angela; Haas, Pieter J; Verweij, Paul E; Pickkers, Peter; Brüggemann, Roger J (American Society for Microbiology, 2020-09-21)
    Fluconazole is frequently used for the treatment of invasive Candida infections in critically ill patients. However, alterations in renal functions might influence fluconazole clearance. Therefore, our objective was to ...
  • Therapy limitation in octogenarians in German intensive care units is associated with a longer length of stay and increased 30 days mortality: A prospective multicenter study 
    Bruno, Raphael Romano; Wernly, Bernhard; Beil, Michael; Muessig, Johanna M; Rahmel, Tim; Graf, Tobias; Meybohm, Patrick; Schaller, Stefan J; Allgäuer, Sebastian; Franz, Marcus; Westphal, Julian Georg; Barth, Eberhard; Ebelt, Henning; Fuest, Kristina; Horacek, Michael; Schuster, Michael; Dubler, Simon; Schering, Stefan; Wolff, Georg; Steiner, Stephan; Rabe, Christian; Dieck, Thorben; Lauten, Alexander; Sacher, Anne Lena; Brenner, Thorsten; Bloos, Frank; Jánosi, Rolf A; Simon, Philipp; Utzolino, Stefan; Kelm, Malte; De Lange, Dylan W; Guidet, Bertrand; Flaatten, Hans; Jung, Christian (Elsevier, 2020-12)
    Purpose: The approach to limit therapy in very old intensive care unit patients (VIPs) significantly differs between regions. The focus of this multicenter analysis is to illuminate, whether the Clinical Frailty Scale (CFS) ...