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UMC Repository: Recent submissions

  • Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs 
    Wienke, Judith; Brouwers, Laura; van der Burg, Leone M; Mokry, Michal; Scholman, Rianne C; Nikkels, Peter G J; van Rijn, Bas B; van Wijk, Femke (American Society for Clinical Investigation, 2020-09-17)
    Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic fetus. We investigated the elusive transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy. ...
  • Biomarker profiles of endothelial activation and dysfunction in rare systemic autoimmune diseases: implications for cardiovascular risk 
    Dutch Juvenile Myositis Consortium (Oxford University Press, 2021-02-01)
    OBJECTIVES: Vasculopathy is an important hallmark of systemic chronic inflammatory connective tissue diseases (CICTD) and is associated with increased cardiovascular risk. We investigated disease-specific biomarker profiles ...
  • Invasive coronary physiology: a Dutch tradition 
    van de Hoef, T. P.; de Waard, G. A.; Meuwissen, M.; Voskuil, M.; Chamuleau, S. A.J.; van Royen, N.; Piek, J. J. (Bohn Stafleu van Loghum, 2020-08)
    Invasive coronary physiology has been applied since the early days of percutaneous transluminal coronary angioplasty, and has become a rapidly emerging field of research. Many physiology indices have been developed, tested ...
  • Conversion of STOPP/START version 2 into coded algorithms for software implementation: A multidisciplinary consensus procedure 
    Huibers, Corlina J A; Sallevelt, Bastiaan T G M; de Groot, Dominique A; Boer, Maarten J; van Campen, Jos P C M; Davids, Cathelijn J; Hugtenburg, Jacqueline G; Vermeulen Windsant-Van den Tweel, Annemieke M A; van Hout, Hein P J; van Marum, Rob J; Meulendijk, Michiel C (Elsevier Ireland Ltd, 2019-05)
    BACKGROUND: The rapid digitalization of medical practice has attracted growing interest in developing software applications for clinical guidelines and explicit screening tools to detect potentially inappropriate prescribing, ...
  • 'Optimising PharmacoTherapy In the multimorbid elderly in primary CAre' (OPTICA) to improve medication appropriateness: study protocol of a cluster randomised controlled trial 
    Jungo, Katharina Tabea; Rozsnyai, Zsofia; Mantelli, Sophie; Floriani, Carmen; Löwe, Axel Lennart; Lindemann, Fanny; Schwab, Nathalie; Meier, Rahel; Elloumi, Lamia; Huibers, Corlina Johanna Alida; Sallevelt, Bastiaan Theodoor Gerard Marie; Meulendijk, Michiel C; Reeve, Emily; Feller, Martin; Schneider, Claudio; Bhend, Heinz; Bürki, Pius M; Trelle, S; Spruit, Marco; Schwenkglenks, Matthias; Rodondi, Nicolas; Streit, Sven (BMJ Publishing Group, 2019-09-01)
    INTRODUCTION: Multimorbidity and polypharmacy are major risk factors for potentially inappropriate prescribing (eg, overprescribing and underprescribing), and systematic medication reviews are complex and time consuming. ...
  • Extravasation of an antibody-drug conjugate: A case report of epidermal necrosis after trastuzumab-emtansine extravasation 
    Sallevelt, Bastiaan T G M; Teunis, Teun; Agterof, Mariette J; van den Broek, Marcel P H (Wiley-Blackwell, 2020-08)
    WHAT IS KNOWN AND OBJECTIVE: Trastuzumab-emtansine is an antibody-drug conjugate developed to decrease off-target toxicity. According to the product label, reactions secondary to extravasation are mild or moderate. CASE ...
  • Systemic exposure of oxaliplatin and docetaxel in gastric cancer patients with peritonitis carcinomatosis treated with intraperitoneal hyperthermic chemotherapy 
    Koemans, W J; van der Kaaij, R T; Wassenaar, E C E; Grootscholten, C; Boot, H; Boerma, D; Los, M; Imhof, O; Schellens, J H M; Rosing, H; Huitema, A D R; van Sandick, J W (W.B. Saunders Ltd, 2021-02)
    In the PERISCOPE I study, gastric cancer patients with limited peritoneal dissemination were treated with systemic chemotherapy followed by (sub)total gastrectomy, cytoreductive surgery and hyperthermic intraperitoneal ...
  • In-Hospital Production of Medicines: Preparing for Disruption 
    Kalkman, Shona; Arentshorst, Marlous; Hoekman, Jarno; Boon, Wouter; Uijtendaal, Esther; van Thiel, Ghislaine; Moors, Ellen (Elsevier Limited, 2020-10)
    In-hospital production of affordable medicines holds potential to address problems of drug accessibility. However, expanding the scope of magistral preparation to include high-cost drugs and complex biologicals gives rise ...
  • Delay in Treatment of Neonatal Seizures: A Retrospective Cohort Study 
    Apers, Wievineke M J; de Vries, Linda S; Groenendaal, Floris; Toet, Mona C; Weeke, Lauren C (S. Karger AG, 2021-01)
    Introduction: Neonatal seizures are common and caused by a variety of underlying disorders. There is increasing evidence that neonatal seizures result in further brain damage. Objective: To describe the time interval between ...
  • Increased Use of Therapeutic Hypothermia in Infants with Milder Neonatal Encephalopathy due to Presumed Perinatal Asphyxia 
    Parmentier, Corline E.J.; de Vries, Linda; Toet, MC; van Haastert, Inge-Lot; Koopman-Esseboom, C; Weeke, Lauren; Groenendaal, Floris (S. Karger AG, 2020-12)
    INTRODUCTION: Adverse outcomes have been reported in infants with mild neonatal encephalopathy (NE). Increasing clinical experience with the application of therapeutic hypothermia (TH) may have resulted in the treatment ...
  • No Need for Sternal Fixation in Traumatic Sternovertebral Fractures: Outcomes of a 10-Year Retrospective Cohort Study 
    Klei, Dorine S.; Öner, F. Cumhur; Leenen, Luke P.H.; van Wessem, Karlijn J.P. (SAGE Publications Inc., 2021-04)
    Study Design: Retrospective cohort study. Objectives: Combined sternal and spinal fractures are rare traumatic injuries and present a high risk of spinal and thoracic wall instability. Limited research has addressed the ...
  • Development and reliability of the AOSpine CROST (Clinician Reported Outcome Spine Trauma): a tool to evaluate and predict outcomes from clinician’s perspective 
    Sadiqi, Said; Muijs, Sander P.J.; Renkens, Jeroen J.M.; Post, Marcel W.; Benneker, Lorin M.; Chapman, Jens R.; Kandziora, Frank; Schnake, Klaus J.; Vialle, Emiliano N.; Vaccaro, Alexander R.; Oner, F. Cumhur (Springer-Verlag, 2020-10)
    Purpose: To report on the development of AOSpine CROST (Clinician Reported Outcome Spine Trauma) and results of an initial reliability study. Methods: The AOSpine CROST was developed using an iterative approach of multiple ...
  • Regional and experiential differences in surgeon preference for the treatment of cervical facet injuries: a case study survey with the AO Spine Cervical Classification Validation Group 
    AO Spine Cervical Classification Validation Group (Springer-Verlag, 2021-02)
    Purpose: The management of cervical facet dislocation injuries remains controversial. The main purpose of this investigation was to identify whether a surgeon’s geographic location or years in practice influences their ...
  • Optimizing patients' functional status during daily nursing care interventions: A systematic review 
    Verstraten, Carolien C.J.M.M.; Metzelthin, Silke F.; Schoonhoven, Lisette; Schuurmans, Marieke J.; de Man-van Ginkel, Janneke M. (John Wiley & Sons Inc., 2020-09-01)
    Patients often experience a functional decline due to physical inactivity during illness. Nurses can influence the physical activity of patients while assisting them with activities of daily living. The purpose of this ...
  • Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency 
    Ghosh, Sujal; Köstel Bal, Sevgi; Edwards, Emily S J; Pillay, Bethany; Jimenez-Heredia, Raúl; Rao, Geetha; Erol Cipe, Funda; Salzer, Elisabeth; Zoghi, Samaneh; Abolhassani, Hassan; Momen, Tooba; Gostick, Emma; Price, David A; Zhang, Yu; Oler, Andrew J; Gonzaga-Jauregui, Claudia; Erman, Baran; Metin, Ayse; Ilhan, Inci; Haskologlu, Sule; Islamoglu, Candan; Baskin, Kubra; Ceylaner, Serdar; Yilmaz, Ebru; Unal, Ekrem; Karakukcu, Musa; Berghuis, Dagmar; Cole, Theresa; Gupta, Aditya Kumar; Hauck, Fabian; Hoepelman, Andy; Baris, Safa; Karakoc-Aydiner, Elif; Ozen, Ahmet; Kager, Leo; Holzinger, Dirk; Paulussen, Michael; Krüger, Renate; Meisel, Roland; Oommen, Prasad Thomas; Morris, Emma C; Neven, Benedicte; Worth, Austen J J; van Montfrans, Joris M; Fraaij, Pieter; Choo, Sharon; Dogu, Figen; Davies, E Graham; Burns, Siobhan; Dueckers, Gregor; Perez Becker, Ruy; von Bernuth, Horst; Latour, Sylvain; Faraci, Maura; Gattorno, Marco; Su, Helen; Pan-Hammarström, Qiang; Hammarström, Lennart; Lenardo, Michael J; Ma, Cindy S; Niehues, Tim; Aghamohammadi, Asghar; Rezaei, Nima; Ikinciogullari, Aydan; Tangye, Stuart G; Lankester, Arjan C; Boztug, Kaan (Elsevier, 2020-12-03)
    Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie inborn errors of immunity (IEIs) characterized predominantly by Epstein-Barr virus (EBV)-associated immune dysregulation, such as chronic viremia, ...
  • Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score 
    Inborn Errors, Clinical, and Registry Working Parties of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiencies (Mosby Inc., 2020-05)
    Background: Recent findings strongly support hematopoietic stem cell transplantation (HSCT) in patients with severe presentation of LPS-responsive beige-like anchor protein (LRBA) deficiency, but long-term follow-up and ...
  • Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis 
    Depla, A L; de Wit, L; Steenhuis, T J; Slieker, M G; Voormolen, D N; Scheffer, P G; de Heus, R; van Rijn, B B; Bekker, M N (John Wiley & Sons Inc., 2021-04)
    Objective: Maternal diabetes in pregnancy is associated with structural anomalies of the fetal heart, as well as hypertrophy and functional impairment. This systematic review and meta-analysis aimed to estimate the effect ...
  • Cost and impact of early diagnosis in primary immunodeficiency disease: A literature review 
    Elsink, Kim; van Montfrans, Joris M.; van Gijn, Mariëlle E.; Blom, Maartje; van Hagen, P. Martin; Kuijpers, T. W.; Frederix, Geert W.J. (Academic Press Inc., 2020-04)
    Background: New, innovative, costly diagnostic methods for patients with primary immunodeficiencies (PID) demand upfront insight into their potential cost savings and added value for individual patients. As such, high ...
  • Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: Analysis by the Pharmachild Safety Adjudication Committee 
    Giancane, Gabriella; Swart, Joost F.; Castagnola, Elio; Groll, Andreas H.; Horneff, Gerd; Huppertz, Hans Iko; Lovell, Daniel J.; Wolfs, Tom; Herlin, Troels; Dolezalova, Pavla; Sanner, Helga; Susic, Gordana; Sztajnbok, Flavio; Maritsi, Despoina; Constantin, Tamas; Vargova, Veronika; Sawhney, Sujata; Rygg, Marite; Oliveira, Sheila K.; Cattalini, Marco; Bovis, Francesca; Bagnasco, Francesca; Pistorio, Angela; Martini, Alberto; Wulffraat, Nico; Ruperto, Nicolino; Cuttica, Ruben; Garay, Stella Maris; Brunner, Jurgen; Emminger, Wolfgang; Appenzeller, Simone; Len, Claudio; Saad Magalhaes, Claudia; Telcharova-Mihaylovska, Albena; Harjacek, Miroslav; Jelusic, Marija; Estmann, Anne; Nielsen, Susan; Herrera Mora, Cristina; Gervais, Elisabeth; Koné-Paut, Isabelle; Quartier, Pierre; Foeldvari, Ivan; Horneff, Gerd; Lutz, Thomas; Minden, Kirsten; Tzaribachev, Nikolay; Trachana, Maria; Tsitsami, Elena; Vougiouka, Olga; Orban, Ilonka; Harel, Liora; Hashkes, Philip; Uziel, Yosef; Cimaz, Rolando; Civino, Adele; Consolini, Rita; D'Angelo, Gianfranco; De Benedetti, Fabrizio; Filocamo, Giovanni; Fueri, Elena; Gallizzi, Romina; Maggio, Maria Cristina; Magnolia, Maria Greca; Miniaci, Angela; Montin, Davide; Olivieri, Alma Nunzia; Pastore, Serena; Rigante, Donato; Zulian, Francesco; Rumba-Rozenfelde, Ingrida; Stanevicha, Valda; Panaviene, Violeta; Rodriguez Lozano, Ana Luisa; Rubio-Perez, Nadina; Vega Cornejo, Gabriel; Hoppenreijs, Esther; Kamphuis, Sylvia; Flato, Berit; Nordal, Ellen Berit; Abdwani, Reem; Miraval, Tatiana; Paz Gastanaga, Maria Eliana; Smolewska, Elzbieta; Ailioaie, Constantin; Cochino, Alexis Virgil; Laday, Matilda; Lazar, Calin; Alexeeva, Ekaterina; Chasnyk, Vyacheslav; Keltsev, Vladimir; Suwairi, Wafaa Mohammed Saad; Vijatov-Djuric, Gordana; Vojinovic, Jelena; Arkachaisri, Thaschawee; Koskova, Elena; Avcin, Tadej; Ally, Mahmood; Van Rensburg, Christa Janse; Louw, Ingrid; Lopez, Jordi Anton; Boteanu, Alina Lucica; Calvo Penades, Inmaculada; De Inocencio, Jaime; Mesa-Del-Castillo, Pablo; Moreno, Estefania; Remesal, Agustin; Hofer, Michael; Gok, Faysal; Ozen, Seza; Ramanan, Athimalaipet; Pallotti, Chiara; Villa, Luca (BioMed Central Ltd., 2020-04-07)
    Background: To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). ...
  • Proceedings from the 2ndNext Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019 
    NextGen 2019 Participants (BioMed Central Ltd., 2020-07-15)
    For reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall disease control, children with Systemic Juvenile Idiopathic Arthritis (SJIA) ...