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UMC Repository: Recent submissions

  • Efficacy and Safety of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis With and Without Fever at Baseline: Results from an Open-label, Active Treatment Extension Study 
    Paediatric Rheumatology International Trials Organisation (PRINTO), the Pediatric Rheumatology Collaborative Study Group (PRCSG) (John Wiley & Sons Inc., 2020-12)
    Objective: To evaluate the long-term efficacy and safety of canakinumab and explore prediction of response in patients with systemic juvenile idiopathic arthritis (JIA) with or without fever at treatment initiation. Methods: ...
  • Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study 
    Tabor, David E; Fernandes, Fiona; Langedijk, Annefleur C; Wilkins, Deidre; Lebbink, Robert Jan; Tovchigrechko, Andrey; Ruzin, Alexey; Kragten-Tabatabaie, Leyla; Jin, Hong; Esser, Mark T; Bont, Louis J; Abram, Michael E; INFORM-RSV Study Group (American Society for Microbiology, 2021-01)
    Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to ...
  • Genetic testing and surveillance in infantile myofibromatosis: a report from the SIOPE Host Genome Working Group 
    Hettmer, Simone; Dachy, Guillaume; Seitz, Guido; Agaimy, Abbas; Duncan, Catriona; Jongmans, Marjolijn; Hirsch, Steffen; Kventsel, Iris; Kordes, Uwe; de Krijger, Ronald R; Metzler, Markus; Michaeli, Orli; Nemes, Karolina; Poluha, Anna; Ripperger, Tim; Russo, Alexandra; Smetsers, Stephanie; Sparber-Sauer, Monika; Stutz, Eveline; Bourdeaut, Franck; Kratz, Christian P; Demoulin, Jean-Baptiste (Springer Netherlands, 2021-10)
    Infantile myofibromatosis (IM), which is typically diagnosed in young children, comprises a wide clinical spectrum ranging from inconspicuous solitary soft tissue nodules to multiple disseminated tumors resulting in ...
  • Repairing the heart: State-of the art delivery strategies for biological therapeutics 
    Yang, Qiangbing; Fang, Juntao; Lei, Zhiyong; Sluijter, Joost P G; Schiffelers, Raymond (Elsevier, 2020-05)
    Myocardial infarction (MI) is one of the leading causes of mortality worldwide. It is caused by an acute imbalance between oxygen supply and demand in the myocardium, usually caused by an obstruction in the coronary arteries. ...
  • A post-insertion strategy for surface functionalization of bacterial and mammalian cell-derived extracellular vesicles 
    Jiang, Linglei; Luirink, Joen; Kooijmans, Sander A A; van Kessel, Kok P M; Jong, Wouter; van Essen, Max; Seinen, Cor W; de Maat, Steven; de Jong, Olivier G; Gitz-François, Jerney F F; Hennink, Wim E; Vader, Pieter; Schiffelers, Raymond M (Elsevier, 2021-04)
    Extracellular vesicles (EVs) are nanoparticles which are released by cells from all three domains of life: Archaea, Bacteria and Eukarya. They can mediate cell-cell communication by transferring cargoes such as proteins ...
  • Bleeding severity in patients with rare bleeding disorders: real-life data from the RBiN study 
    Saes, Joline L; Verhagen, Marieke J A; Meijer, Karina; Cnossen, Marjon H; Schutgens, Roger E G; Peters, Marjolein; Nieuwenhuizen, Laurens; van der Meer, Felix J M; Kruis, Ilmar C; van Heerde, Waander L; Schols, Saskia E M (The American Society of Hematology, 2020-10-16)
    Patients with hereditary rare bleeding disorders (RBDs) present with diverse hemorrhagic symptoms. Correlation between factor activity levels and clinical bleeding severity is poor for most RBDs. Threshold factor activity ...
  • D-dimer in COVID-19: A Guide With Pitfalls 
    Schutgens, Roger E (Wolters Kluwer Health, 2020-08)
  • Development of a clinical prediction rule for sepsis in primary care: protocol for the TeSD-IT study 
    Loots, Feike J; Hopstaken, Rogier; Jenniskens, Kevin; Frederix, Geert W J; van de Pol, Alma C; Van den Bruel, Ann; Oosterheert, Jan Jelrik; van Zanten, Arthur R H; Smits, Marleen; Verheij, Theo J M (2020)
    Background: Early recognition and treatment of sepsis is crucial to prevent detrimental outcomes. General practitioners (GPs) are often the first healthcare providers to encounter seriously ill patients. The aim of this ...
  • Molecular epidemiology and clinical impact of rhinovirus infections in adults during three epidemic seasons in 11 European countries (2007-2010) 
    Zlateva, Kalina T.; Van Rijn, Anneloes L.; Simmonds, Peter; Coenjaerts, Frank E.J.; Van Loon, Anton M.; Verheij, Theo J.M.; De Vries, Jutte J.C.; Little, Paul; Butler, Christopher C.; Van Zwet, Erik W.; Goossens, Herman; Ieven, Margareta; Claas, Eric C.J. (BMJ Publishing Group, 2020-10-01)
    BACKGROUND: Differences in clinical impact between rhinovirus (RVs) species and types in adults are not well established. The objective of this study was to determine the epidemiology and clinical impact of the different ...
  • Comparing Conventional Chemotherapy to Chronomodulated Chemotherapy for Cancer Treatment: Protocol for a Systematic Review 
    Kilgallen, Aoife B; Štibler, Urška; Printezi, Markella I; Putker, Marrit; Punt, Cornelis J A; Sluijter, Joost P G; May, Anne M; van Laake, Linda W (JMIR Publications Inc., 2020-10-21)
    Background: Chronomodulated chemotherapy aims to achieve maximum drug safety and efficacy by adjusting the time of treatment to an optimal biological time as determined by the circadian clock. Although it is a promising ...
  • Consensus treatment recommendations from the tenth International Workshop for Waldenström Macroglobulinaemia 
    Castillo, Jorge J; Advani, Ranjana H; Branagan, Andrew R; Buske, Christian; Dimopoulos, Meletios A; D'Sa, Shirley; Kersten, Marie José; Leblond, Veronique; Minnema, Monique C; Owen, Roger G; Palomba, M Lia; Talaulikar, Dipti; Tedeschi, Alessandra; Trotman, Judith; Varettoni, Marzia; Vos, Josephine M; Treon, Steven P; Kastritis, Efstathios (Lancet Publishing Group, 2020-11)
    Waldenström macroglobulinaemia is an indolent B-cell lymphoma with clearly defined criteria for diagnosis, initiation of therapy, and response, which was established by consensus panels at previous International Workshops ...
  • A systematic review on brain injury and altered brain development in moderate-late preterm infants" (vol 148, 105094, 2020) 
    Boswinkel, Vivian; Nijboer-Oosterveld, Jacqueline; Nijholt, Ingrid M; Edens, Mireille A; Mulder-de Tollenaer, Susanne M; Boomsma, Martijn F; de Vries, Linda S; van Wezel-Meijler, Gerda (Elsevier Ireland Ltd, 2021-04)
    In the initial published version of this systematic review, the authors stated: “None of the included studies reported on cerebellar hemorrhage” (last sentence below section ‘3.7. Other abnormalities’ on page 7). The authors ...
  • Association of early skin breaks and neonatal thalamic maturation: A modifiable risk? 
    Duerden, Emma G; Grunau, Ruth E; Chau, Vann; Groenendaal, Floris; Guo, Ting; Chakravarty, M Mallar; Benders, Manon; Wagenaar, Nienke; Eijsermans, Rian; Koopman, Corine; Synnes, Anne; Vries, Linda de; Miller, Steven P (Lippincott Williams & Wilkins, 2020-12-15)
    OBJECTIVE: To test the hypothesis that a strategy of prolonged arterial line (AL) and central venous line (CVL) use is associated with reduced neonatal invasive procedures and improved growth of the thalamus in extremely ...
  • Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis 
    Vonk, Jet M J; Twait, Emma L; Scholten, Rob J P M; Geerlings, Mirjam I (Elsevier Ireland Ltd, 2020-12)
    Previous research suggests the presence of subtle semantic decline in early stages of Alzheimer's disease. This study investigated associations between amyloid burden, a biomarker for Alzheimer's disease, and tasks of ...
  • ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization 
    Project MinE ALS Sequencing Consortium (Oxford University Press, 2020)
    Increasingly, repeat expansions are being identified as part of the complex genetic architecture of amyotrophic lateral sclerosis. To date, several repeat expansions have been genetically associated with the disease: ...
  • Intragenic and structural variation in the SMN locus and clinical variability in spinal muscular atrophy 
    Wadman, Renske I; Jansen, Marc D; Stam, Marloes; Wijngaarde, Camiel A; Curial, Chantall A D; Medic, Jelena; Sodaar, Peter; Schouten, Jan; Vijzelaar, Raymon; Lemmink, Henny H; van den Berg, Leonard H; Groen, Ewout J N; van der Pol, W Ludo (Oxford University Press, 2020)
    Clinical severity and treatment response vary significantly between patients with spinal muscular atrophy. The approval of therapies and the emergence of neonatal screening programmes urgently require a more detailed ...
  • Blood metal levels and amyotrophic lateral sclerosis risk: a prospective cohort 
    Peters, Susan; Broberg, Karin; Gallo, Valentina; Levi, Michael; Kippler, Maria; Vineis, Paolo; Veldink, Jan; van den Berg, Leonard; Middleton, Lefkos; Travis, Ruth C; Bergmann, Manuela M; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Elbaz, Alexis; Vlaar, Tim; Mancini, Francesca; Kühn, Tilman; Katzke, Verena; Agudo, Antonio; Goñi, Fernando; Gómez, Jesús-Humberto; Rodríguez-Barranco, Miguel; Merino, Susana; Barricarte, Aurelio; Trichopoulou, Antonia; Jenab, Mazda; Weiderpass, Elisabete; Vermeulen, Roel (John Wiley & Sons Inc., 2021-01)
    Objective: Metals have been suggested as a risk factor for amyotrophic lateral sclerosis (ALS), but only retrospective studies are available to date. We compared metal levels in prospectively collected blood samples from ...
  • On predictions in critical care: The individual prognostication fallacy in elderly patients 
    Beil, Michael; Sviri, Sigal; Flaatten, Hans; De Lange, Dylan W; Jung, Christian; Szczeklik, Wojciech; Leaver, Susannah; Rhodes, Andrew; Guidet, Bertrand; van Heerden, P Vernon (Elsevier, 2021-02)
    Predicting the future course of critical conditions involves personal experience, heuristics and statistical models. Although these methods may perform well for some cases and population averages, they suffer from substantial ...
  • Toxicological analysis of azide and cyanide for azide intoxications using gas chromatography 
    Bruin, M A C; Dekker, D; Venekamp, N; Tibben, M; Rosing, H; de Lange, D W; Beijnen, J H; Huitema, A D R (Wiley-Blackwell, 2021-03)
    Azide is a highly toxic chemical agent to human being. Accidental, but also intentional exposure to azide occurs. To be able to confirm azide ingestion, we developed a method to identify and quantify azide in biological ...
  • Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life 
    Initiative on Crohns and Colitis (ICC) (BMJ Publishing Group, 2021-07)
    OBJECTIVE: The aim of this study was to describe the long-term health outcomes of children born to mothers with inflammatory bowel disease (IBD) and to assess the impact of maternal IBD medication use on these outcomes. ...