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UMC Repository: Recent submissions

  • ADAMTS-13 and bleeding phenotype in von Willebrand disease 
    WiN Study Group (Elsevier, 2020-11)
    Background: The bleeding phenotype of von Willebrand disease (VWD) varies highly between patients and can only partly be explained by von Willebrand factor (VWF) parameters. By cleaving large VWF multimers into smaller, ...
  • Sentinel node biopsy in patients with melanoma improves the accuracy of staging when added to clinicopathological features of the primary tumor 
    El Sharouni, M A; Stodell, M D; Ahmed, T; Suijkerbuijk, K P M; Cust, A E; Witkamp, A J; Sigurdsson, V; van Diest, P J; Scolyer, R A; Thompson, J F; van Gils, C H; Lo, S N (Oxford University Press, 2021-03)
    BACKGROUND: It has been claimed, without supporting evidence, that knowledge of sentinel node (SN) status does not provide more accurate prognostic information than basic clinicopathological features of a primary cutaneous ...
  • Public involvement in the governance of population-level biomedical research: Unresolved questions and future directions 
    Erikainen, Sonja; Friesen, Phoebe; Rand, Leah; Jongsma, Karin; Dunn, Michael; Sorbie, Annie; McCoy, Matthew; Bell, Jessica; Burgess, Michael; Chen, Haidan; Chico, Vicky; Cunningham-Burley, Sarah; Darbyshire, Julie; Dawson, Rebecca; Evans, Andrew; Fahy, Nick; Finlay, Teresa; Frith, Lucy; Goldenberg, Aaron; Hinton, Lisa; Hoppe, Nils; Hughes, Nigel; Koenig, Barbara; Lignou, Sapfo; McGowan, Michelle; Parker, Michael; Prainsack, Barbara; Shabani, Mahsa; Staunton, Ciara; Thompson, Rachel; Varnai, Kinga; Vayena, Effy; Williams, Oli; Williamson, Max; Chan, Sarah; Sheehan, Mark (BMJ Publishing Group, 2021-07-01)
    Population-level biomedical research offers new opportunities to improve population health, but also raises new challenges to traditional systems of research governance and ethical oversight. Partly in response to these ...
  • Recommendations from a James Lind Alliance priority setting partnership - a qualitative interview study 
    Jongsma, Karin; van Seventer, Juliette; Verwoerd, Anouk; van Rensen, Annemiek (BioMed Central Ltd., 2020-11-19)
    Background: The James Lind Alliance (JLA) offers a method for research priority setting with patients, clinicians and carers. The method is increasingly used but publications primarily discuss the outcome of such projects, ...
  • ARGX-117, a therapeutic complement inhibiting antibody targeting C2 
    Van de Walle, Inge; Silence, Karen; Budding, Kevin; Van de Ven, Liesbeth; Dijkxhoorn, Kim; de Zeeuw, Elisabeth; Yildiz, Cafer; Gabriels, Sofie; Percier, Jean-Michel; Wildemann, Johanna; Meeldijk, Jan; Simons, Peter J; Boon, Louis; Cox, Linda; Holgate, Rob; Urbanus, Rolf; Otten, Henny G; Leusen, Jeanette H W; Blanchetot, Christophe; de Haard, Hans; Hack, C Erik; Boross, Peter (Mosby Inc., 2021-04)
    Background: Activation of the classical and lectin pathway of complement may contribute to tissue damage and organ dysfunction of antibody-mediated diseases and ischemia-reperfusion conditions. Complement factors are being ...
  • Small steps, big change. Forging a public-private health insurance system in the Netherlands 
    Bertens, R. M.; Vonk, R. A.A. (Elsevier Limited, 2020-12)
    Context: History helps us to better understand the particulars of the form and functions of institutions. In this paper we present the case study of the evolution of health care financing in the Netherlands over the past ...
  • Mortality, life expectancy and causes of death of persons with hemophilia in the Netherlands 2001-2018 
    Hassan, Shermarke; Monahan, Rory C; Mauser-Bunschoten, Evelien P; van Vulpen, Lize F D; Eikenboom, Jeroen; Beckers, Erik A M; Hooimeijer, Louise; Ypma, Paula F; Nieuwenhuizen, Laurens; Coppens, Michiel; Schols, Saskia E M; Leebeek, Frank W G; Smit, Cees; Driessens, Mariëtte H; le Cessie, Saskia; van Balen, Erna C; Rosendaal, Frits R; van der Bom, Johanna G; Gouw, Samantha C (Wiley-Blackwell, 2021-03)
    BACKGROUND: Treatment of patients with hemophilia has advanced over the past decades, but it is unknown whether this has resulted in a normal life expectancy in the Netherlands. OBJECTIVE: This observational cohort study ...
  • Early Onset of Coronary Artery Calcification in Women with Previous Preeclampsia 
    Benschop, Laura; Brouwers, Laura; Zoet, Gerbrand A.; Meun, Cindy; Boersma, Eric; Budde, Ricardo P.J.; Fauser, Bart C.J.M.; De Groot, Christianne M.J.; Van Der Schouw, Yvonne T.; Maas, Angela H.E.M.; Velthuis, Birgitta K.; Linstra, Katie M.; Kavousi, Maryam; Duvekot, Johannes J.; Franx, Arie; Steegers, Eric; Van Rijn, Bas B.; Van Lennep, Jeanine E.Roeters (Lippincott Williams & Wilkins, 2020-11-01)
    Background: Preeclampsia, coronary artery calcification (CAC), and atherosclerotic plaque are risk factors for the development of cardiovascular disease. We determined at what age CAC becomes apparent on coronary computed ...
  • Renal tumors of childhood—A histopathologic pattern-based diagnostic approach 
    Ooms, Ariadne H.A.G.; Vujanić, Gordan M.; D’hooghe, Ellen; Collini, Paola; L’herminé-Coulomb, Aurore; Vokuhl, Christian; Graf, Norbert; van den Heuvel-Eibrink, Marry M.; de Krijger, Ronald R. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-03-19)
    Renal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. ...
  • Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas 
    Wallace, Paal W.; Conrad, Catleen; Brückmann, Sascha; Pang, Ying; Caleiras, Eduardo; Murakami, Masanori; Korpershoek, Esther; Zhuang, Zhengping; Rapizzi, Elena; Kroiss, Matthias; Gudziol, Volker; Timmers, Henri J.L.M.; Mannelli, Massimo; Pietzsch, Jens; Beuschlein, Felix; Pacak, Karel; Robledo, Mercedes; Klink, Barbara; Peitzsch, Mirko; Gill, Anthony J.; Tischler, Arthur S.; de Krijger, Ronald R.; Papathomas, Thomas; Aust, Daniela; Eisenhofer, Graeme; Richter, Susan (John Wiley & Sons Inc., 2020-08-01)
    Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours with a hereditary background in over one-third of patients. Mutations in succinate dehydrogenase (SDH) genes increase the risk for PPGLs and ...
  • Characteristics and outcome of children with renal cell carcinoma: A narrative review 
    van der Beek, Justine N.; Geller, James I.; de Krijger, Ronald R.; Graf, Norbert; Pritchard-Jones, Kathy; Drost, Jarno; Verschuur, Arnauld C.; Murphy, Dermot; Ray, Satyajit; Spreafico, Filippo; Dzhuma, Kristina; Littooij, Annemieke S.; Selle, Barbara; Tytgat, Godelieve A.M.; van den Heuvel-Eibrink, Marry M. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-07-03)
    Pediatric renal cell carcinoma (RCC) is a rare type of kidney cancer, most commonly occurring in teenagers and young adolescents. Few relatively large series of pediatric RCC have been reported. Knowledge of clinical ...
  • Data set for the reporting of pheochromocytoma and paraganglioma: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting 
    Thompson, Lester D.R.; Gill, Anthony J.; Asa, Sylvia L.; Clifton-Bligh, Roderick J.; de Krijger, Ronald R.; Kimura, Noriko; Komminoth, Paul; Lack, Ernest E.; Lenders, Jacques W.M.; Lloyd, Ricardo V.; Papathomas, Thomas G.; Sadow, Peter M.; Tischler, Arthur S. (W.B. Saunders, 2021-04)
    Background and objectives: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit to develop evidence-based, internationally agreed-upon standardized data sets for each anatomic site, to be used ...
  • Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up† 
    ESMO Guidelines Committee (Oxford University Press, 2020-11)
  • Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma 
    Wellens, Lianne M.; Deken, Marion M.; Sier, Cornelis F.M.; Johnson, Hannah R.; de la Jara Ortiz, Fàtima; Bhairosingh, Shadhvi S.; Houvast, Ruben D.; Kholosy, Waleed M.; Baart, Victor M.; Pieters, Annique M.M.J.; de Krijger, Ronald R.; Molenaar, Jan J.; Wehrens, Ellen J.; Dekkers, Johanna F.; Wijnen, Marc H.W.A.; Vahrmeijer, Alexander L.; Rios, Anne C. (Nature Publishing Group, 2020-10-19)
    Neuroblastoma resection represents a major challenge in pediatric surgery, because of the high risk of complications. Fluorescence-guided surgery (FGS) could lower this risk by facilitating discrimination of tumor from ...
  • The diagnostic value of magnetic resonance imaging in differentiating benign and malignant pediatric ovarian tumors 
    Janssen, Carlijn L.; Littooij, Annemieke S.; Fiocco, Marta; Huige, Josephine C.B.; de Krijger, Ronald R.; Hulsker, Caroline C.C.; Goverde, Angelique J.; Zsiros, József; Mavinkurve-Groothuis, Annelies M.C. (Springer-Verlag, 2021-03)
    BACKGROUND: The diagnostic workup of ovarian tumors in children and adolescents is challenging because preserving fertility, in addition to oncological safety, is of particular importance in this population. Therefore, a ...
  • The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale 
    Tschiderer, Lena; Seekircher, Lisa; Klingenschmid, Gerhard; Izzo, Raffaele; Baldassarre, Damiano; Iglseder, Bernhard; Calabresi, Laura; Liu, Jing; Price, Jackie F.; Bae, Jang Ho; Brouwers, Frank P.; De Groot, Eric; Schmidt, Caroline; Bergström, Göran; Aşçi, Gülay; Gresele, Paolo; Okazaki, Shuhei; Kapellas, Kostas; Landecho, Manuel F.; Sattar, Naveed; Agewall, Stefan; Zou, Zhi Yong; Byrne, Christopher D.; Nanayakkara, Prabath W.B.; Papagianni, Aikaterini; Witham, Miles D.; Bernal, Enrique; Ekart, Robert; Van Agtmael, Michiel A.; Neves, Mario F.; Sato, Eiichi; Ezhov, Marat; Walters, Matthew; Olsen, Michael H.; Stolić, Radojica; Zozulińska-Ziółkiewicz, Dorota A.; Hanefeld, Markolf; Staub, Daniel; Nagai, Michiaki; Nieuwkerk, Pythia T.; Huisman, Menno V.; Kato, Akihiko; Honda, Hirokazu; Parraga, Grace; Magliano, Dianna; Gabriel, Rafael; Rundek, Tatjana; Espeland, Mark A.; Beulens, Joline W.J.; Bots, Michiel L. (S. Karger AG, 2020-09-01)
    Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, ...
  • Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas 
    Brosens, Erwin; Felix, Janine F.; Boerema-de Munck, Anne; de Jong, Elisabeth M.; Lodder, Elisabeth M.; Swagemakers, Sigrid; Buscop-van Kempen, Marjon; de Krijger, Ronald R.; Wijnen, Rene M.H.; van IJcken, Wilfred F.J.; van der Spek, Peter; de Klein, Annelies; Tibboel, Dick; Rottier, Robbert J. (Public Library of Science, 2020-11)
    Esophageal atresia (EA) and tracheoesophageal fistula (TEF) are relatively frequently occurring foregut malformations. EA/TEF is thought to have a strong genetic component. Not much is known regarding the biological processes ...
  • Supporting a teacher identity in health professions education: AMEE Guide No. 132 
    van Lankveld, Thea; Thampy, Harish; Cantillon, Peter; Horsburgh, Jo; Kluijtmans, Manon (Informa Healthcare, 2021-02-01)
    This guide provides an understanding of what teacher identity is and how it can be developed and supported. Developing a strong teacher identity in the context of health professions education is challenging, because teachers ...
  • Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation 
    Weng, Lu Chen; Hall, Amelia Weber; Choi, Seung Hoan; Jurgens, Sean J.; Haessler, Jeffrey; Bihlmeyer, Nathan A.; Grarup, Niels; Lin, Honghuang; Teumer, Alexander; Li-Gao, Ruifang; Yao, Jie; Guo, Xiuqing; Brody, Jennifer A.; Müller-Nurasyid, Martina; Schramm, Katharina; Verweij, Niek; van den Berg, Marten E.; van Setten, Jessica; Isaacs, Aaron; Ramírez, Julia; Warren, Helen R.; Padmanabhan, Sandosh; Kors, Jan A.; de Boer, Rudolf A.; van der Meer, Peter; Sinner, Moritz F.; Waldenberger, Melanie; Psaty, Bruce M.; Taylor, Kent D.; Völker, Uwe; Kanters, Jørgen K.; Li, Man; Alonso, Alvaro; Perez, Marco V.; Vaartjes, Ilonca; Bots, Michiel L.; Huang, Paul L.; Heckbert, Susan R.; Lin, Henry J.; Kornej, Jelena; Munroe, Patricia B.; van Duijn, Cornelia M.; Asselbergs, Folkert W.; Stricker, Bruno H.; van der Harst, Pim; Kääb, Stefan; Peters, Annette; Sotoodehnia, Nona; Rotter, Jerome I.; Mook-Kanamori, Dennis O. (Lippincott Williams & Wilkins, 2020-10-01)
    BACKGROUND: The P-wave duration (PWD) is an electrocardiographic measurement that represents cardiac conduction in the atria. Shortened or prolonged PWD is associated with atrial fibrillation (AF). We used exome-chip data ...
  • Measuring effects on intima-media thickness: an evaluation of rosuvastatin in Chinese subjects with subclinical atherosclerosis—design, rationale, and methodology of the METEOR-China study 
    Wang, Yilong; Wang, Anxin; Li, Hongwei; Li, Zhanquan; Hu, Bo; Li, Xiaogang; Zheng, Huaguang; Fu, Lu; Hu, Hongtao; Nie, Zhiyu; Qin, Yulin; Zhao, Bilian; Wei, Di; Karlson, Björn W.; Bots, Michiel L.; Chen, Yundai; Wang, Yongjun (BioMed Central, 2020-11-11)
    BACKGROUND: The beneficial effect of statins on atherosclerosis and cardiovascular outcomes has been well established. The Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin (METEOR) global study ...