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Now showing items 17861-17880 of 40729

Ticagrelor Versus Clopidogrel in Older Patients with NSTE-ACS Using Oral Anticoagulation: A Sub-Analysis of the POPular Age Trial

Gimbel, Marieke E; Tavenier, Anne H; Bor, Wilbert; Hermanides, Renicus S; de Vrey, Evelyn; Heestermans, Ton; Gin, Melvyn Tjon Joe; Waalewijn, Reinier; Hofma, Sjoerd; den Hartog, Frank; Jukema, Wouter; von Birgelen, Clemens; Voskuil, Michiel; Kelder, Johannes; Deneer, Vera; Ten Berg, Jurriën M (Multidisciplinary Digital Publishing Institute (MDPI), 2020-10-12)

There are no randomised data on which antiplatelet agent to use in elderly patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) and an indication for oral anticoagulation (OAC). The randomised POPular Age ...
Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study

Ubiquitous Pharmacogenomics Consortium (Lippincott Williams & Wilkins, 2020-08)

OBJECTIVES: Pharmacogenetic panel-based testing represents a new model for precision medicine. A sufficiently powered prospective study assessing the (cost-)effectiveness of a panel-based pharmacogenomics approach to guide ...
Genetic variants as predictors of toxicity and response in patients with non-small cell lung cancer undergoing first-line platinum-based chemotherapy: Design of the multicenter PGxLUNG study

de Jong, Corine; Herder, Gerarda J.M.; Deneer, Vera H.M. (Blackwell Publishing Asia Pty Ltd, 2020-12)

Introduction: Platinum–based chemotherapy is currently the most frequently applied first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) without targetable mutations or high PD-L1 expression. ...
Effect ofCYP3A4*22 andPPAR-alpha Genetic Variants on Platelet Reactivity in Patients Treated with Clopidogrel and Lipid-Lowering Drugs Undergoing Elective Percutaneous Coronary Intervention

ICPC investigators (Multidisciplinary Digital Publishing Institute (MDPI), 2020-09-11)

This study aims to determine whether genetic variants that influence CYP3A4 expression are associated with platelet reactivity in clopidogrel-treated patients undergoing elective percutaneous coronary intervention (PCI), ...
Effect of Adding Ticagrelor to Standard Aspirin on Saphenous Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting (POPular CABG): A Randomized, Double-Blind, Placebo-Controlled Trial

Willemsen, Laura M.; Janssen, Paul W.A.; Peper, Joyce; Soliman-Hamad, Mohamed A.; van Straten, Albert H.M.; Klein, Patrick; Hackeng, Chris M.; Sonker, Uday; Bekker, Margreet W.A.; von Birgelen, Clemens; Brouwer, Marc A.; van der Harst, Pim; Vlot, Eline A.; Deneer, Vera H.M.; Chan Pin Yin, Dean R.P.P.; Gimbel, Marieke E.; Beukema, Kasper F.; Daeter, Edgar J.; Kelder, Johannes C.; Tijssen, Jan G.P.; Rensing, Benno J.W.M.; van Es, Hendrik W.; Swaans, Martin J.; Ten Berg, Jurrien M. (Lippincott Williams and Wilkins, 2020-11-10)

BACKGROUND: Approximately 15% of saphenous vein grafts (SVGs) occlude during the first year after coronary artery bypass graft surgery (CABG) despite aspirin use. The POPular CABG trial (The Effect of Ticagrelor on Saphenous ...
Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa: modelling to inform treatment guidelines

Phillips, Andrew N.; Bansi-Matharu, Loveleen; Venter, Francois; Havlir, Diane; Pozniak, Anton; Kuritzkes, Daniel R.; Wensing, Annemarie; Lundgren, Jens D.; Pillay, Deenan; Mellors, John; Cambiano, Valentina; Jahn, Andreas; Apollo, Tsitsi; Mugurungi, Owen; Ripin, David; Da Silva, Juliana; Raizes, Elliot; Ford, Nathan; Siberry, George K.; Gupta, Ravindra K.; Barnabas, Ruanne; Revill, Paul; Cohn, Jennifer; Calmy, Alexandra; Bertagnolio, Silvia (Elsevier, 2020-03)

Background: The integrase inhibitor dolutegravir is being considered in several countries in sub-Saharan Africa instead of efavirenz for people initiating antiretroviral therapy (ART) because of superior tolerability and ...
Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

Connell, Bridgette J.; Hermans, Lucas E.; Wensing, Annemarie M.J.; Schellens, Ingrid; Schipper, Pauline J.; van Ham, Petra M.; de Jong, Dorien T.C.M.; Otto, Sigrid; Mathe, Tholakele; Moraba, Robert; Borghans, José A.M.; Papathanasopoulos, Maria A.; Kruize, Zita; Venter, Francois W.D.; Kootstra, Neeltje A.; Tempelman, Hugo; Tesselaar, Kiki; Nijhuis, Monique (Nature Publishing Group, 2020-09-28)

HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early infection. A switch to X4-tropism often occurs during ...
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report

Gupta, Ravindra Kumar; Peppa, Dimitra; Hill, Alison L.; Gálvez, Cristina; Salgado, Maria; Pace, Matthew; McCoy, Laura E.; Griffith, Sarah A.; Thornhill, John; Alrubayyi, Aljawharah; Huyveneers, Laura E.P.; Nastouli, Eleni; Grant, Paul; Edwards, Simon G.; Innes, Andrew J.; Frater, John; Nijhuis, Monique; Wensing, Anne Marie J.; Martinez-Picado, Javier; Olavarria, Eduardo (Elsevier Ltd, 2020-05)

BACKGROUND: The London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); remission was reported at 18 months after analytical ...
Drug level testing as a strategy to determine eligibility for drug resistance testing after failure of ART: a retrospective analysis of South African adult patients on second-line ART

Hermans, Lucas E.; Steegen, Kim; ter Heine, Rob; Schuurman, Rob; Tempelman, Hugo A.; Moraba, Robert; van Maarseveen, Erik; Nijhuis, Monique; Pillay, Taryn; Legg-E’Silva, Derryn; Snyman, Tracy; Schapiro, Jonathan M.; Burger, David M.; Carmona, Sergio; Wensing, Annemarie M.J. (International AIDS Society, 2020-06-01)

Introduction: When protease inhibitor (PI)-based second-line ART fails, guidelines recommend drug resistance testing and individualized third-line treatment. However, PI-resistant viral strains are rare and drug resistance ...
Risk factors for loss to follow-up from antiretroviral therapy programmes in low-income and middle-income countries

Frijters, Elise M.; Hermans, Lucas E.; Wensing, Annemarie M.J.; Devillé, Walter L.J.M.; Tempelman, Hugo A.; De Wit, John B.F. (Lippincott Williams & Wilkins, 2020-07-15)

INTRODUCTION: Loss to follow-up (LTFU) rates from antiretroviral treatment (ART) programmes in low- and middle-income countries (LMIC) are high, leading to poor treatment outcomes and onward transmission of HIV. Knowledge ...
Formalin fixation for optimal concordance of programmed death-ligand 1 immunostaining between cytologic and histologic specimens from patients with non-small cell lung cancer

Koomen, Bregje; van der Starre-Gaal, Jose; Vonk, Judith; von der Thüsen, Jan; van der Meij, Jacqueline; Monkhorst, Kim; Willems, Stefan; Timens, Wim; 't Hart, Nils (Wiley-Blackwell, 2021-04)

Background: Immunohistochemical staining of programmed death-ligand 1 (PD-L1) is used to determine which patients with non-small cell lung cancer (NSCLC) may benefit most from immunotherapy. Therapeutic management of many ...
Liver Steatosis and Diarrhea After Liver Transplantation for Progressive Familial Intrahepatic Cholestasis Type 1: Can Biliary Diversion Solve These Problems?

Knisely, A S; Houwen, Roderick H J (Lippincott Williams & Wilkins, 2021-03-01)
Glioblastoma hijacks microglial gene expression to support tumor growth

Maas, Sybren L.N.; Abels, Erik R.; Van De Haar, Lieke L.; Zhang, Xuan; Morsett, Liza; Sil, Srinjoy; Guedes, Joana; Sen, Pritha; Prabhakar, Shilpa; Hickman, Suzanne E.; Lai, Charles P.; Ting, David T.; Breakefield, Xandra O.; Broekman, Marike L.D.; El Khoury, Joseph (BioMed Central, 2020-04-16)

Background: Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to pathogens, toxins, and tumors. Glioblastoma cells ...
GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma

Abels, Erik R.; Maas, Sybren L.N.; Tai, Eric; Ting, David T.; Broekman, Marike L.D.; Breakefield, Xandra O.; El Khoury, Joseph (Nature Publishing Group, 2020-06-18)

Monocytes, macrophages and microglia make up a large part of the glioma environment and have an important role in maintaining and propagating glioma progression. Targeting these cells to inhibit their tumor-promoting effect ...
Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

Suwala, Abigail K.; Stichel, Damian; Schrimpf, Daniel; Kloor, Matthias; Wefers, Annika K.; Reinhardt, Annekathrin; Maas, Sybren L.N.; Kratz, Christian P.; Schweizer, Leonille; Hasselblatt, Martin; Snuderl, Matija; Abedalthagafi, Malak Sameer J.; Abdullaev, Zied; Monoranu, Camelia M.; Bergmann, Markus; Pekrun, Arnulf; Freyschlag, Christian; Aronica, Eleonora; Kramm, Christof M.; Hinz, Felix; Sievers, Philipp; Korshunov, Andrey; Kool, Marcel; Pfister, Stefan M.; Sturm, Dominik; Jones, David T.W.; Wick, Wolfgang; Unterberg, Andreas; Hartmann, Christian; Dodgshun, Andrew; Tabori, Uri; Wesseling, Pieter; Sahm, Felix; von Deimling, Andreas; Reuss, David E. (Springer, 2021-01)

Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known to occur in recurrent IDH-mutant gliomas as ...
Orally administered 5-aminolevulinic acid for isolation and characterization of circulating tumor-derived extracellular vesicles in glioblastoma patients

Maas, Sybren L.N.; van Solinge, Thomas S.; Schnoor, Rosalie; Yekula, Anudeep; Senders, Joeky T.; de Vrij, Jeroen; Robe, Pierre; Carter, Bob S.; Balaj, Leonora; Arkesteijn, Ger J.A.; Nolte-’T Hoen, Esther N.M.; Broekman, Marike L.D. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-11-07)

Background: In glioblastoma (GB), tissue is required for accurate diagnosis and subtyping. Tissue can be obtained through resection or (stereotactic) biopsy, but these invasive procedures provide risks for patients. ...
Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression

van Solinge, Thomas S.; Abels, Erik R.; van de Haar, Lieke L.; Hanlon, Killian S.; Maas, Sybren L.N.; Schnoor, Rosalie; de Vrij, Jeroen; Breakefield, Xandra O.; Broekman, Marike L.D. (Frontiers Media S. A., 2020-11-12)

Introduction: Glioma cells exert influence over the tumor-microenvironment in part through the release of extracellular vesicles (EVs), membrane-enclosed structures containing proteins, lipids, and RNAs. In this study, we ...
Language in schizophrenia: relation with diagnosis, symptomatology and white matter tracts

de Boer, J N; van Hoogdalem, M; Mandl, R C W; Brummelman, J; Voppel, A E; Begemann, M J H; van Dellen, E; Wijnen, F N K; Sommer, I E C (Nature Publishing Group, 2020-12-01)

Language deviations are a core symptom of schizophrenia. With the advances in computational linguistics, language can be easily assessed in exact and reproducible measures. This study investigated how language characteristics ...
Volume Increase of the Dentate Gyrus Induced by Electroconvulsive Therapy: Shedding Light on the Clinical Relevance of Plasticity in the Hippocampus

Takamiya, Akihiro; Nuninga, Jasper O; Mandl, René C W; Sommer, Iris E C; Mimura, Masaru; Kishimoto, Taishiro (Lippincott Williams & Wilkins, 2019-12-01)
Multimodal assessment of white matter microstructure in antipsychotic-naïve schizophrenia patients and confounding effects of recreational drug use

Raghava, Jayachandra M; Mandl, René C W; Nielsen, Mette Ø; Fagerlund, Birgitte; Glenthøj, Birte Y; Rostrup, Egill; Ebdrup, Bjørn H (Springer New York, 2021-02)

Cerebral white matter (WM) aberrations in schizophrenia have been linked to multiple neurobiological substrates but the underlying mechanisms remain unknown. Moreover, antipsychotic treatment and substance use constitute ...

Now showing items 17861-17880 of 40729