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UMC Repository: Recent submissions

  • No benefit of HDL mimetic CER-001 on carotid atherosclerosis in patients with genetically determined very low HDL levels 
    Zheng, Kang H.; Kaiser, Yannick; van Olden, Casper C.; Santos, Raul D.; Dasseux, Jean Louis; Genest, Jacques; Gaudet, Daniel; Westerink, Jan; Keyserling, Constance; Verberne, Hein J.; Leitersdorf, Eran; Hegele, Robert A.; Descamps, Olivier S.; Hopkins, Paul; Nederveen, Aart J.; Stroes, Erik S.G. (Elsevier, 2020-10)
    Background and aims: Infusion of high-density lipoprotein (HDL) mimetics failed to induce regression of atherosclerosis in recent randomized clinical trials. However, patients in these previous trials had normal levels of ...
  • Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) in patients with type 1 diabetes mellitus: A systematic review and meta-analysis 
    De Vries, Marieke; Westerink, Jan; Kaasjager, Karin H.A.H.; De Valk, Harold W. (The Endocrine Society, 2020-12-01)
    Context: Nonalcoholic fatty liver disease (NAFLD) prevalence is high, especially in patients with obesity and type 2 diabetes, and is expected to rise steeply in the coming decades. Objective: We estimated NAFLD prevalence ...
  • Magnetic resonance imaging for diagnosis of recurrent ipsilateral deep vein thrombosis 
    van Dam, Lisette F.; Dronkers, Charlotte E.A.; Gautam, Gargi; Eckerbom, Åsa; Ghanima, Waleed; Gleditsch, Jostein; von Heijne, Anders; Hofstee, Herman M.A.; Hovens, Marcel M.C.; Huisman, Menno V.; Kolman, Stan; Mairuhu, Albert T.A.; Nijkeuter, Mathilde; van de Ree, Marcel A.; van Rooden, Cornelis J.; Westerbeek, Robin E.; Westerink, Jan; Westerlund, Eli; Kroft, Lucia J.M.; Klok, Frederikus A. (American Society of Hematology, 2020-04-16)
    The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) is challenging, because persistent intravascular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography. Magnetic resonance ...
  • Efficacy of Tocilizumab Monotherapy Versus Tocilizumab and Methotrexate Combination Therapy in the Prevention of Radiographic Progression in Rheumatoid Arthritis: An Analysis Using Individual Patient Data From Multiple Clinical Trials 
    Verhoeven, Maxime M A; Tekstra, Janneke; Jacobs, Johannes W G; Bijlsma, Johannes W J; van Laar, Jacob M; Pethö-Schramm, Attila; Borm, Michelle E A; Lafeber, Floris P J; Welsing, Paco M J (John Wiley & Sons Inc., 2022-06)
    OBJECTIVE: To compare the effects of preventing radiographic progression (in its 3 components) of tocilizumab (TCZ) monotherapy with those of TCZ and methotrexate (MTX) in combination therapy (TCZ + MTX), and to evaluate ...
  • A feasibility study on two tailored interventions to improve adherence in adults with haemophilia 
    Hoefnagels, Anne; Fischer, Kathelijn; Bos, Ruud; Driessens, Mariette H E; Meijer , Stephan; Schutgens, Roger E; Schrijvers, Marlies (2020-12-01)
    Introduction: Haemophilia is a congenital bleeding disorder mainly affecting males. To prevent bleeding, patients need to perform regular intravenous injections (prophylaxis) throughout life. Non-adherence often occurs. ...
  • Ideal Cardiovascular Health Index and Its Determinants in a Rural South African Population 
    Ketelaar, E J; Vos, A G; Godijk, N G; Scheuermaier, K; Devillé, W; Tempelman, H; Coutinho, R A; Venter, W D F; Grobbee, D E; Klipstein-Grobusch, K (Elsevier Science & Technology, 2020-11-25)
    Background: The ideal cardiovascular health index (CVHI) is a measure to summarize cardiovascular (CV) health, and includes smoking, body-mass index, physical activity, blood pressure, glucose, total cholesterol, and diet. ...
  • Evaluating international Haemophilia Joint Health Score (HJHS) results combined with expert opinion: Options for a shorter HJHS 
    Kuijlaars, Isolde A R; van der Net, Janjaap; Feldman, Brian M; Aspdahl, Magnus; Bladen, Melanie; de Boer, Wypke; Cuesta-Barriuso, Rubén; Matlary, Ruth E D; Funk, Sharon M; Hilliard, Pamela; John, Judy A; Kempton, Christine L; de Kleijn, Piet; Manco-Johnson, Marilyn; Petrini, Pia; Poonnoose, Pradeep; St-Louis, Jean; Thomas, Sylvia; Timmer, Merel A; Trakymiene, Sonata Saulyte; van Vlimmeren, Leo; Fischer, Kathelijn (Wiley-Blackwell, 2020-11)
    INTRODUCTION: The Hemophilia Joint Health Score (HJHS) was developed to detect early changes in joint health in children and adolescents with haemophilia. The HJHS is considered by some to be too time consuming for clinical ...
  • Working nights and lower leisure-time physical activity associate with chronic pain in Southern African long-distance truck drivers: A cross-sectional study 
    Wadley, Antonia L; Iacovides, Stella; Roche, Johanna; Scheuermaier, Karine; Venter, W D Francois; Vos, Alinda G; Lalla-Edward, Samanta T (Public Library of Science, 2020-12)
    BACKGROUND: In South Africa, the trucking industry employs over 70,000 people and the prevalence of chronic pain in this occupational group was reported at 10%. We investigated factors associated with chronic pain in truck ...
  • Polygenic Risk Scores for Genetic Counseling in Psychiatry: Lessons Learned from other Fields of Medicine 
    Eeltink, E; van der Horst, M Z; Zinkstok, J R; Aalfs, C M; Luykx, J J (Elsevier Limited, 2021-02)
    Polygenic risk scores (PRS) may aid in the identification of individuals at-risk for psychiatric disorders, treatment optimization, and increase in prognostic accuracy. PRS may also add significant value to genetic counseling. ...
  • The leukocyte non-coding RNA landscape in critically ill patients with sepsis 
    MARS Consortium (eLife Sciences Publications, 2020-12-11)
    The extent of non-coding RNA alterations in patients with sepsis and their relationship to clinical characteristics, soluble mediators of the host response to infection, as well as an advocated in vivo model of acute ...
  • Single-cell derived tumor organoids display diversity in HLA class I peptide presentation 
    Demmers, Laura C; Kretzschmar, Kai; Van Hoeck, Arne; Bar-Epraïm, Yotam E; van den Toorn, Henk W P; Koomen, Mandy; van Son, Gijs; van Gorp, Joost; Pronk, Apollo; Smakman, Niels; Cuppen, Edwin; Clevers, Hans; Heck, Albert J R; Wu, Wei (Nature Publishing Group, 2020-12-01)
    Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte antigen (HLA) peptide ligands are promising ...
  • Pan-cancer landscape of homologous recombination deficiency 
    Nguyen, Luan; W M Martens, John; Van Hoeck, Arne; Cuppen, Edwin (Nature Publishing Group, 2020-12-01)
    Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous ...
  • Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE) 
    Samsom, Kris G; Bosch, Linda J W; Schipper, Luuk J; Roepman, Paul; de Bruijn, Ewart; Hoes, Louisa R; Riethorst, Immy; Schoenmaker, Lieke; van der Kolk, Lizet E; Retèl, Valesca P; Frederix, Geert W J; Buffart, Tineke E; van der Hoeven, Jacobus J M; Voest, Emile E; Cuppen, Edwin; Monkhorst, Kim; Meijer, Gerrit A (BioMed Central, 2020-12)
    BACKGROUND: 'Precision oncology' can ensure the best suitable treatment at the right time by tailoring treatment towards individual patient and comprehensive tumour characteristics. In current molecular pathology, diagnostic ...
  • Endometrial scratching in women with one failed IVF/ICSI cycle-outcomes of a randomised controlled trial (SCRaTCH) 
    van Hoogenhuijze, N E; Mol, F; Laven, J S E; Groenewoud, E R; Traas, M A F; Janssen, C A H; Teklenburg, G; de Bruin, J P; van Oppenraaij, R H F; Maas, J W M; Moll, E; Fleischer, K; van Hooff, M H A; de Koning, C H; Cantineau, A E P; Lambalk, C B; Verberg, M; van Heusden, A M; Manger, A P; van Rumste, M M E; van der Voet, L F; Pieterse, Q D; Visser, J; Brinkhuis, E A; den Hartog, J E; Glas, M W; Klijn, N F; van der Meer, S; Bandell, M L; Boxmeer, J C; van Disseldorp, J; Smeenk, J; van Wely, M; Eijkemans, M J C; Torrance, H L; Broekmans, F J M (Oxford University Press, 2021-01-01)
    STUDY QUESTION: Does endometrial scratching in women with one failed IVF/ICSI treatment affect the chance of a live birth of the subsequent fresh IVF/ICSI cycle? SUMMARY ANSWER: In this study, 4.6% more live births were ...
  • Accurate prediction of peanut allergy in one-third of adults using a validated Ara h 2 cutoff 
    Kansen, Hannah M; van Erp, Francine C; Knulst, André C; Ehlers, Anna M; Lyons, Sarah A; Knol, Edward F; Meijer, Yolanda; Otten, Henny G; van der Ent, Cornelis K; Le, Thuy-My (2021-04)
    BACKGROUND: The diagnostic value of peanut components is extensively studied in children, but to a lesser extent in adults with suspected peanut allergy. The use of peanut components in daily practice may reduce the need ...
  • Correction: Antigenic evolution of viruses in host populations 
    Rouzine, Igor M; Rozhnova, Ganna (Public Library of Science, 2020-08)
    In the Time to the most recent common ancestor subsection of the Results, there is an error in the equation. The notation N in parentheses is incorrect. It should read N inf. Please view the complete, correct equation ...
  • Forecasting the pandemic: the role of mathematical models 
    Gomes, Manuel Carmo; Nunes, Ana; Nogueira, João; Rebelo, Carlota; Viana, João; Rozhnova, Ganna (CELOM, 2020-11-02)
  • The Coronary Sinus Reducer; 5-year Dutch experience 
    Silvis, M J M; Dekker, M; Zivelonghi, C; Agostoni, P; Stella, P R; Doevendans, P A; de Kleijn, D P V; van Kuijk, J P; Leenders, G E; Timmers, L (Bohn Stafleu van Loghum, 2021-04)
    Background: Refractory angina is a growing and major health-care problem affecting millions of patients with coronary artery disease worldwide. The Coronary Sinus Reducer (CSR) is a device that may be considered for the ...
  • Coronary sinus anatomical features: Description and procedural implications during coronary sinus Reducer implantation 
    Wilgenhof, Adriaan; Zivelonghi, Carlo; Verheye, Stefan; Vermeersch, Paul; Scott, Benjamin; Convens, Carl; Timmers, Leo; Leenders, Geert; Kuijk, Jan Peter Van; Stella, Pieter; Agostoni, Pierfrancesco (Wiley-Liss Inc., 2021-06-01)
    OBJECTIVES: We hypothesized that some coronary sinus (CS) anatomies allow a more straightforward CS Reducer (CSR) implantation. BACKGROUND: Recent decades have seen a rise in patients with chronic angina. When complete ...
  • Prophylactic versus therapeutic left ventricular unloading during extracorporeal membrane oxygenation, better safe than sorry? 
    van der Wal, Pieter S; van Steenwijk, Myrthe P J; Montenij, Leon J; Donker, Dirk W; Meuwese, Christiaan L (Pioneer Bioscience Publishing Company (PBPC), 2020-11)