GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma

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GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma
 
Abels, Erik R.; Maas, Sybren L.N.; Tai, Eric; Ting, David T.; Broekman, Marike L.D.; Breakefield, Xandra O.; El Khoury, Joseph
(2020) Scientific Reports, volume 10, issue 1, pp. 1 - 11
(Article)
Abstract
Monocytes, macrophages and microglia make up a large part of the glioma environment and have an important role in maintaining and propagating glioma progression. Targeting these cells to inhibit their tumor-promoting effect and reprogramming them into an anti-tumor phenotype is a potential therapeutic approach for glioma. In this study we ... read more
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Keywords: Animals, Biomarkers/metabolism, Brain Neoplasms/immunology, Cell Line, Tumor, Cytokines/metabolism, Databases, Factual, Disease Models, Animal, Glioma/immunology, Lymphocytes, Tumor-Infiltrating/cytology, Macrophages/cytology, Mice, Mice, Inbred C57BL, Monocytes/cytology, Transplantation, Homologous, Up-Regulation, User-Computer Interface, Journal Article, Research Support, N.I.H., Extramural
DOI: https://doi.org/10.1038/s41598-020-66728-w
ISSN: 2045-2322
Publisher: Nature Publishing Group
Note: Funding Information: We thank the Massachusetts General Hospital, Department of Pathology Flow and Image Cytometry Research Core. All members of the Breakefield, Tannous, Maguire, Bragg and El Khoury labs that suggested ideas during lab meetings are very much appreciated. We thank Ms. Suzanne McDavitt for skilled editorial assistance. Sybren Maas acknowledges support from the Dutch Nijbakker-Morra travel stipend and the Dutch Cancer Society (KWF) travel grant. Xandra Breakefield acknowledges NIH NCI CA179563, CA069246 and CA232103 grants for funding used to perform this research. U19 CA179563 is supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director. Joseph El Khoury is funded by NIH grants 1RF1 AG051506 and R01 AI119065. Generation of vectors used in this study was supported by the NIH NS045776 grant. The MGH Department of Pathology Flow and Image Cytometry Research Core obtained support from the NIH Shared Instrumentation program with grants 1S10OD012027-01A1, 1S10OD016372-01, 1S10RR020936-01, and 1S10RR023440-01A1. Publisher Copyright: © 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
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