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UMC Repository: Recent submissions

  • Prospective practice survey of management of cetuximab-related skin reactions 
    Lugtenberg, R T; Boers-Doets, C B; Witteveen, P O; van Herpen, C M L; Wymenga, A N M; de Groot, J W B; Hoeben, A; Del Grande, C; van Doorn, B; Koldenhof, J J; Driessen, C M L; Gelderblom, H (Springer-Verlag, 2021-07)
    PURPOSE: Evidence-based guidelines on how to prevent or treat cetuximab-related skin reactions are lacking and multiple care and management strategies are used. The main purpose of the present study is to gain information ...
  • Short-term surgical complications after radical hysterectomy-A nationwide cohort study 
    Wenzel, Hans H B; Kruitwagen, Roy F P M; Nijman, Hans W; Bekkers, Ruud L M; van Gorp, Toon; de Kroon, Cornelis D; van Lonkhuijzen, Luc R C W; Massuger, Leon F A G; Smolders, Ramon G V; van Trommel, Nienke E; Yigit, Refika; Zweemer, Ronald P; van der Aa, Maaike A (Wiley-Blackwell, 2020-07)
    INTRODUCTION: Centralization has, among other aspects, been argued to have an impact on quality of care in terms of surgical morbidity. Next, monitoring quality of care is essential in identifying areas of improvement. ...
  • Survival of patients with early-stage cervical cancer after abdominal or laparoscopic radical hysterectomy: a nationwide cohort study and literature review 
    Wenzel, Hans H B; Smolders, Ramon G V; Beltman, Jogchum J; Lambrechts, Sandrina; Trum, Hans W; Yigit, Refika; Zusterzeel, Petra L M; Zweemer, Ronald P; Mom, Constantijne H; Bekkers, Ruud L M; Lemmens, Valery E P P; Nijman, Hans W; Van der Aa, Maaike A (Elsevier Limited, 2020-07)
    Aim: Recently, the safety of laparoscopic radical hysterectomy (LRH) has been called into question in early-stage cervical cancer. This study aimed to evaluate overall survival (OS) and disease-free survival (DFS) in ...
  • EULAR recommendations for the management of antiphospholipid syndrome in adults 
    Tektonidou, Maria G; Andreoli, Laura; Limper, Marteen; Amoura, Zahir; Cervera, Ricard; Costedoat-Chalumeau, Nathalie; Cuadrado, Maria Jose; Dörner, Thomas; Ferrer-Oliveras, Raquel; Hambly, Karen; Khamashta, Munther A; King, Judith; Marchiori, Francesca; Meroni, Pier Luigi; Mosca, Marta; Pengo, Vittorio; Raio, Luigi; Ruiz-Irastorza, Guillermo; Shoenfeld, Yehuda; Stojanovich, Ljudmila; Svenungsson, Elisabet; Wahl, Denis; Tincani, Angela; Ward, Michael M (Elsevier, 2019-10)
    The objective was to develop evidence-based recommendations for the management of antiphospholipid syndrome (APS) in adults. Based on evidence from a systematic literature review and expert opinion, overarching principles ...
  • Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the EULAR recommendations for the management of antiphospholipid syndrome in adults 
    Tektonidou, Maria G; Andreoli, Laura; Limper, Marteen; Tincani, Angela; Ward, Michael M (BMJ Publishing Group, 2019)
    Objective: To perform a systematic literature review (SLR) informing the European Lmmendations for the management of antiphospholipid syndrome (APS) in adults. Methods: A SLR through January 2018 was performed. Research ...
  • The immunologic etiology of psychiatric manifestations in systemic lupus erythematosus: A narrative review on the role of the blood brain barrier, antibodies, cytokines and chemokines 
    Deijns, Sander J; Broen, Jasper C A; Kruyt, Nyika D; Schubart, Chris D; Andreoli, Laura; Tincani, Angela; Limper, Maarten (Elsevier, 2020-08)
    INTRODUCTION: The aim of this narrative review is to provide an overview of the literature on the possible immunologic pathophysiology of psychiatric manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE). ...
  • Strategies to reduce the use of low-value medical tests in primary care: a systematic review 
    Takada, Toshihiko; Heus, Pauline; van Doorn, Sander; Naaktgeboren, Christiana A.; Weenink, Jan-Willem; van Dulmen, Simone A.; Hooft, Lotty (Royal College of General Practitioners, 2020-12-01)
    BACKGROUND: It is recognised that medical tests are overused in primary care; however, it is unclear how best to reduce their use. AIM: To identify which strategies are effective in reducing the use of low-value medical ...
  • Data on sex differences in one-year outcomes of out-of-hospital cardiac arrest patients without ST-segment elevation 
    Spoormans, Eva M.; Lemkes, Jorrit S.; Janssens, Gladys N.; van der Hoeven, Nina W.; Jewbali, Lucia S.D.; Dubois, Eric A.; van de Ven, Peter M.; Meuwissen, Martijn; Rijpstra, Tom A.; Bosker, Hans A.; Blans, Michiel J.; Bleeker, Gabe B.; Baak, Remon; Vlachojannis, Georgios J.; Eikemans, Bob J.W.; van der Harst, Pim; van der Horst, Iwan C.C.; Voskuil, Michiel; van der Heijden, Joris J.; Beishuizen, Albertus; Stoel, Martin; Camaro, Cyril; van der Hoeven, Hans; Henriques, José P.; Vlaar, Alexander P.J.; Vink, Maarten A.; van den Bogaard, Bas; Heestermans, Ton A.C.M.; de Ruijter, Wouter; Delnoij, Thijs S.R.; Crijns, Harry J.G.M.; Jessurun, Gillian A.J.; Oemrawsingh, Pranobe V.; Gosselink, Marcel T.M.; Plomp, Koos; Magro, Michael; Elbers, Paul W.G.; Appelman, Yolande; van Royen, Niels (Elsevier, 2020-12)
    Sex differences in out-of-hospital cardiac arrest (OHCA) patients are increasingly recognized. Although it has been found that post-resuscitated women are less likely to have significant coronary artery disease (CAD) than ...
  • Modeling human embryogenesis: embryo-like structures spark ethical and policy debate: embryo-like structures spark ethical and policy debate 
    Pereira Daoud, Ana M; Popovic, Mina; Dondorp, Wybo J; Trani Bustos, Marc; Bredenoord, Annelien L; Chuva de Sousa Lopes, Susana M; van den Brink, Susanne C; Roelen, Bernard A J; de Wert, Guido M W R; Heindryckx, Björn (Oxford University Press, 2020-11-01)
    BACKGROUND: Studying the human peri-implantation period remains hindered by the limited accessibility of the in vivo environment and scarcity of research material. As such, continuing efforts have been directed towards ...
  • Young@Heart: empowering the next generation of cardiovascular researchers 
    Hoes, M F; Te Riele, A S J M; Gladka, M M; Westenbrink, B D; van Hout, G P J; van den Hoogenhof, M M G; Ghigo, A; Bollini, S; Purcell, N H; Sohaib, S M A; Kardys, I; Kuster, D W D (Bohn Stafleu van Loghum, 2020-08-01)
    In recognition of the increasing health burden of cardiovascular disease, the Dutch CardioVascular Alliance (DCVA) was founded with the ambition to lower the cardiovascular disease burden by 25% in 2030. To achieve this, ...
  • Spatial transcriptomics of nematodes identifies sperm cells as a source of genomic novelty and rapid evolution 
    Rödelsperger, Christian; Ebbing, Annabel; Sharma, Devansh Raj; Okumura, Misako; Sommer, Ralf J; Korswagen, Hendrik C (Oxford University Press, 2021-01-04)
    Divergence of gene function and expression during development can give rise to phenotypic differences at the level of cells, tissues, organs, and ultimately whole organisms. To gain insights into the evolution of gene ...
  • Mathematical model of colorectal cancer initiation 
    Paterson, Chay; Clevers, Hans; Bozic, Ivana (National Academy of Sciences, 2020-08-25)
    Quantifying evolutionary dynamics of cancer initiation and progression can provide insights into more effective strategies of early detection and treatment. Here we develop a mathematical model of colorectal cancer initiation ...
  • Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo 
    Miao, Yi; Ha, Andrew; de Lau, Wim; Yuki, Kanako; Santos, António J M; You, Changjiang; Geurts, Maarten H; Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Peng, Weng Chuan; Senlice, Ramazan; Piani, Carol; Buikema, Jan W; Gbenedio, Oghenekevwe M; Vallon, Mario; Yuan, Jenny; de Haan, Sanne; Hemrika, Wieger; Rösch, Kathrin; Dang, Luke T; Baker, David; Ott, Melanie; Depeille, Philippe; Wu, Sean M; Drost, Jarno; Nusse, Roeland; Roose, Jeroen P; Piehler, Jacob; Boj, Sylvia F; Janda, Claudia Y; Clevers, Hans; Kuo, Calvin J; Garcia, K Christopher (Cell Press, 2020-11-05)
    Modulation of Wnt signaling has untapped potential in regenerative medicine due to its essential functions in stem cell homeostasis. However, Wnt lipidation and Wnt-Frizzled (Fzd) cross-reactivity have hindered translational ...
  • Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish 
    Hoeksma, Jelmer; van der Zon, Gerard C M; Ten Dijke, Peter; den Hertog, Jeroen (Company of Biologists Ltd, 2020-09-24)
    Zebrafish models are well-established tools for investigating the underlying mechanisms of diseases. Here, we identified cercosporamide, a metabolite from the fungus Ascochyta aquiliqiae, as a potent bone morphogenetic ...
  • Human-Derived Model Systems in Gynecological Cancer Research 
    Lõhmussaar, Kadi; Boretto, Matteo; Clevers, Hans (Cell Press, 2020-12)
    The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics ...
  • The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of Heart Failure with Preserved Ejection Fraction 
    Withaar, Coenraad; Meems, Laura M G; Markousis-Mavrogenis, George; Boogerd, Cornelis J; Silljé, Herman H W; Schouten, E Marloes; Dokter, Martin M; Voors, Adriaan A; Westenbrink, B Daan; Lam, Carolyn S P; de Boer, Rudolf A (Oxford University Press, 2021-08-01)
    AIMS: Heart failure with preserved ejection fraction (HFpEF) is a multifactorial disease that constitutes several distinct phenotypes, including a common cardiometabolic phenotype with obesity and type 2 diabetes mellitus. ...
  • Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells 
    Pleguezuelos-Manzano, Cayetano; Puschhof, Jens; van den Brink, Stieneke; Geurts, Veerle; Beumer, Joep; Clevers, Hans (John Wiley & Sons Inc., 2020-09-01)
    Human intestinal organoids derived from adult stem cells are miniature ex vivo versions of the human intestinal epithelium. Intestinal organoids are useful tools for the study of intestinal physiology as well as many disease ...
  • Vps13 is required for timely removal of nurse cell corpses 
    Faber, Anita I E; van der Zwaag, Marianne; Schepers, Hein; Eggens-Meijer, Ellie; Kanon, Bart; IJsebaart, Carmen; Kuipers, Jeroen; Giepmans, Ben N G; Freire, Raimundo; Grzeschik, Nicola A; Rabouille, Catherine; Sibon, Ody C M (Company of Biologists Ltd, 2020-10-29)
    Programmed cell death and consecutive removal of cellular remnants is essential for development. During late stages of Drosophila melanogaster oogenesis, the small somatic follicle cells that surround the large nurse cells ...
  • 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/beta-catenin pathway activation 
    Cho, Yong-Hee; Ro, Eun Ji; Yoon, Jeong-Su; Mizutani, Tomohiro; Kang, Dong-Woo; Park, Jong-Chan; Il Kim, Tae; Clevers, Hans; Choi, Kang-Yell (Nature Publishing Group, 2020-12-01)
    5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC ...
  • How chromosome topologies get their shape: views from proximity ligation and microscopy methods 
    Huang, Yike; Neijts, Roel; de Laat, Wouter (Elsevier, 2020-11)
    The 3D organization of our genome is an important determinant for the transcriptional output of a gene in (patho)physiological contexts. The spatial organization of linear chromosomes within nucleus is dominantly inferred ...