Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
Bär, Christian; Chatterjee, Shambhabi; Falcão Pires, Inês; Rodrigues, Patrícia; Sluijter, Joost P G; Boon, Reinier A; Nevado, Rosa M; Andrés, Vicente; Sansonetti, Marida; de Windt, Leon; Ciccarelli, Michele; Hamdani, Nazha; Heymans, Stephane; Figuinha Videira, Raquel; Tocchetti, Carlo G; Giacca, Mauro; Zacchigna, Serena; Engelhardt, Stefan; Dimmeler, Stefanie; Madonna, Rosalinda; Thum, Thomas
(2020) Cardiovascular Research, volume 116, issue 11, pp. 1805 - 1819
(Article)
Abstract
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes
... read more
including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: Aging, Cardiovascular disease, MicroRNA, Non-coding RNA, Noncoding RNA therapy, Regeneration, Remodelling, Cardiology and Cardiovascular Medicine, Physiology (medical), Physiology, Journal Article
ISSN: 0008-6363
Publisher: Oxford University Press
Note: Funding Information: T.T. and C.B. were supported by Deutsche Forschungsgemeinschaft, DFG (TRR267) and the ERANet CVD (JTC2016 project EXPERT to T.T. and JTC2018 project INNOVATION to C.B.). C.G.T. was supported by a 'Federico II University/Ricerca di Ateneo' grant. I.F.P. is supported by Fundo Europeu de Desenvolvimento Regional (FEDER) through Compete 2020-Programa Operacional Competitividade E Internacionalização (POCI), the project NETDIAMOND (POCI-01-0145-FEDER-016385), supported by European Structural and Investment Funds, Lisbon's regional operational programme 2020. P.R. is funded by FCT (SFRH/BD/96026/2013). R.M. was supported by a Cardio-Oncology grants from Incyte s.r.l. and funds from Ministero dell'Istruzione, Università e Ricerca Scientifica (549901_ 2020_Madonna: Ateneo). N.H. was supported by Deutsche Forschungsgemeinschaft, DFG (HA7512/2-1). J.P.G.S. was supported by the Project EVICARE (No. 725229) of the European Research Council (ERC). V.A.'s laboratory received support from the Instituto de Salud Carlos III (ISCIII) (grant AC16/00091, as member of the ERA-CVD JCT2016 EXPERT Network, European Union's Horizon 2020 Framework Programme), with co-funding from the European Regional Development Fund (ERDF/FEDER, 'Una manera de hacer Europa'). R.M.N. is supported by the Ministerio de Educación, Cultura y Deporte (predoctoral contract FPU16/05027). The CNIC is supported by the Spanish Ministerio de Ciencia e Innovación (MCI), the ISCIII, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Publisher Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020.
(Peer reviewed)