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Now showing items 17101-17120 of 40729

CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis

Leguit, Roos J.; Raymakers, Reinier A.P.; Hebeda, Konnie M.; Goldschmeding, Roel (Springer Netherlands, 2021-03)

CCN2, formerly termed Connective Tissue Growth Factor, is a protein belonging to the Cellular Communication Network (CCN)-family of secreted extracellular matrix-associated proteins. As a matricellular protein it is mainly ...
Progression of Emphysema and Small Airways Disease in Cigarette Smokers

on behalf of the COPDGene investigators (COPD Foundation, 2021-04)

Background: Little is known about factors associated with emphysema progression in cigarette smokers. We evaluated factors associated with change in emphysema and forced expiratory volume in 1 second (FEV 1) in participants ...
Decisional conflict in breast cancer patients considering immediate breast reconstruction

ter Stege, Jacqueline A.; Oldenburg, Hester S.A.; Woerdeman, Leonie A.E.; Witkamp, Arjen J.; Kieffer, Jacobien M.; van Huizum, Martine A.; van Duijnhoven, Frederieke H.; Hahn, Daniela E.E.; Gerritsma, Miranda A.; Kuenen, Marianne A.; Kimmings, Nikola (A N.).; Ruhé, Quinten (P Q.).; Krabbe-Timmerman, Irene S.; Riet, Martijne van t.; Corten, Eveline M.L.; Sherman, Kerry A.; Bleiker, Eveline M.A. (Churchill Livingstone, 2021-02)

Background: Breast cancer (BC) patients who are treated with mastectomy are frequently offered immediate breast reconstruction. This study aimed to assess decisional conflict in patients considering immediate breast ...
The impact of an online patient decision aid for women with breast cancer considering immediate breast reconstruction: Study protocol of a multicenter randomized controlled trial

Ter Stege, Jacqueline A.; Woerdeman, Leonie A.E.; Hahn, Daniela E.E.; Van Huizum, Martine A.; Van Duijnhoven, Frederieke H.; Kieffer, Jacobien M.; Retèl, Valesca P.; Sherman, Kerry A.; Witkamp, Arjen J.; Oldenburg, Hester S.A.; Bleiker, Eveline M.A. (BioMed Central, 2019-08-19)

Background: Most breast cancer patients undergoing mastectomy are candidates for breast reconstruction. Deciding about breast reconstruction is complex and the preference-sensitive nature of this decision requires an ...
Characteristics and outcome of Pediatric Renal Cell Carcinoma patients registered in the International Society of Pediatric Oncology (SIOP) 93-01, 2001, and UK-IMPORT database: A report of the SIOP-Renal Tumor Study Group

van der Beek, Justine N; Hol, Janna A; Coulomb-l'Hermine, Aurore; Graf, Norbert; van Tinteren, Harm; Pritchard-Jones, Kathy; Houwing, Maite E; de Krijger, Ronald R; Vujanic, Gordan M; Dzhuma, Kristina; Schenk, Jens-Peter; Littooij, Annemieke S; Ramírez-Villar, Gema L; Murphy, Dermot; Ray, Satyajit; Al-Saadi, Reem; Gessler, Manfred; Godzinski, Jan; Ruebe, Christian; Collini, Paola; Verschuur, Arnaud C; Frisk, Tony; Vokuhl, Christian; Hulsbergen-van de Kaa, Christina A; de Camargo, Beatriz; Sandstedt, Bengt; Selle, Barbara; Tytgat, Godelieve A M; van den Heuvel-Eibrink, Marry M (John Wiley & Sons Inc., 2021-06-01)

In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric ...
Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial

Kerkmeijer, Linda G W; Groen, Veerle H; Pos, Floris J; Haustermans, Karin; Monninkhof, Evelyn M; Smeenk, Robert Jan; Kunze-Busch, Martina; de Boer, Johannes C J; van der Voort van Zijp, Jochem; van Vulpen, Marco; Draulans, Cédric; van den Bergh, Laura; Isebaert, Sofie; van der Heide, Uulke A (Lippincott Williams & Wilkins, 2021-03-01)

PURPOSE: This study investigates whether focal boosting of the macroscopic visible tumor with external beam radiotherapy increases biochemical disease-free survival (bDFS) in patients with localized prostate cancer. PATIENTS ...
Brain tumors: Medulloblastoma, ATRT, ependymoma

Baliga, Sujith; Gandola, Lorenza; Timmermann, Beate; Gail, Horan; Padovani, Laetitia; Janssens, Geert O.; Yock, Torunn I. (Wiley-Liss Inc., 2021-05)

Children with medulloblastoma, atypical teratoid rhabdoid tumor (ATRT), and ependymoma are treated with a multidisciplinary approach including surgery, radiotherapy, and chemotherapy. Lower doses of craniospinal irradiation ...
Failure to Cure in Patients Undergoing Surgery for Gastric Cancer: A Nationwide Cohort Study

Dutch Upper Gastrointestinal Cancer Audit group (Springer New York, 2021-08)

BACKGROUND: This study aimed to describe the incidence of failure to cure (a composite outcome measure defined as surgery not meeting its initial aim), and the impact of hospital variation in the administration of neoadjuvant ...
Anti-β2-glycoprotein I and anti-prothrombin antibodies cause lupus anticoagulant through different mechanisms of action

Noordermeer, Tessa; Molhoek, Jessica E; Schutgens, Roger E G; Sebastian, Silvie A E; Drost-Verhoef, Sandra; van Wesel, Annet C W; de Groot, Philip G; Meijers, Joost C M; Urbanus, Rolf T (Wiley-Blackwell, 2021-04)

Background: The presence of lupus anticoagulant (LA) is an independent risk factor for thrombosis. This laboratory phenomenon is detected as a phospholipid-dependent prolongation of the clotting time and is caused by ...
DOAC in COVID-19: Yes or No?

Schutgens, Roger E (Wolters Kluwer Health, 2021-01)
First do no harm

van Dijk, D. (Netherlands Society of Intensive Care, 2020-01)
Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)

Terra, Lara; Hooning, Maartje J; Heemskerk-Gerritsen, Bernadette A M; van Beurden, Marc; Roeters van Lennep, Jeanine E; van Doorn, Helena C; de Hullu, Joanne A; Mom, Constantijne; van Dorst, Eleonora B L; Mourits, Marian J E; Slangen, Brigitte F M; Gaarenstroom, Katja N; Zillikens, M Carola; Leiner, Tim; van der Kolk, Lizet; Collee, Margriet; Wevers, Marijke; Ausems, Margreet G E M; van Engelen, Klaartje; Berger, Lieke Pv; van Asperen, Christi J; Gomez-Garcia, Encarna B; van de Beek, Irma; Rookus, Matti A; Hauptmann, Michael; Bleiker, Eveline M; Schagen, Sanne B; Aaronson, Neil K; Maas, Angela H E M; van Leeuwen, Flora E (JMIR Publications Inc., 2021-01-22)

Background: BRCA1/2 mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) at 35 to 45 years of age. RRSO substantially decreases ovarian cancer risk, but at the cost of immediate menopause. ...
An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients

Spijkerman, Roy; Jorritsma, Nikita Kn; Bongers, Suzanne H; Bindels, Bas Jj; Jukema, Bernard N; Hesselink, Lillian; Hietbrink, Falco; Leenen, Luke Ph; van Goor, Harriët Mr; Vrisekoop, N; Kaasjager, Karin Ah; Koenderman, Leo; COVPACH study group (Wiley-Blackwell, 2021-06)

OBJECTIVES: A high incidence of pulmonary embolism (PE) is reported in patients with critical Corona Virus Disease 2019 (COVID-19). Neutrophils may contribute to this through a process referred to as immunothrombosis. The ...
Toward improved endoscopic surveillance with multidiameter single fiber reflectance spectroscopy in patients with Barrett's esophagus

Post, Anouk L; de Groof, Albert J; Zhang, Xu U; Swager, Anne-Fré; Fockens, Kiki N; Pouw, Roos E; Weusten, Bas L A M; Faber, Dirk J; de Bruin, Daniel M; Bergman, Jacques J G H M; van Leeuwen, Ton G; Sterenborg, Henricus J C M; Curvers, Wouter L (Wiley-VCH Verlag, 2021-04)

Patients with Barrett's esophagus are at an increased risk to develop esophageal cancer and, therefore, undergo regular endoscopic surveillance. Early detection of neoplasia enables endoscopic treatment, which improves ...
Meta-analysis and cost-effectiveness of ductoscopy, duct excision surgery and MRI for the diagnosis and treatment of patients with pathological nipple discharge

Filipe, M D; Patuleia, S I S; Vriens, M R; van Diest, P J; Witkamp, A J (Springer New York, 2021-04)

INTRODUCTION: Pathological nipple discharge (PND) is a common breast-related complaint for referral to a surgical breast clinic because of its association with breast cancer. The aim of this meta-analysis was to compare ...
Radical radiotherapy for paediatric solid tumour metastases: An overview of current European protocols and outcomes of a SIOPE multicenter survey

Huijskens, Sophie C; Kroon, Petra S; Gaze, Mark N; Gandola, Lorenza; Bolle, Stephanie; Supiot, Stephane; Abakay, Candan D; Alexopoulou, Aikaterini; Bokun, Jelena; Chojnacka, Marzanna; Escande, Alexandre; Giralt, Jordi; Harrabi, Semi; Maduro, John H; Mandeville, Henry; Mussano, Anna; Napieralska, Aleksandra; Padovani, Laetitia; Scarzello, Giovanni; Timmermann, Beate; Claude, Line; Seravalli, Enrica; Janssens, Geert O (Elsevier Limited, 2021-03)

PURPOSE/OBJECTIVE: About 20% of children with solid tumours (ST) present with distant metastases (DM). Evidence regarding the use of radical radiotherapy of these DM is sparse and open for personal interpretation. The aim ...
Longitudinal effects of adjuvant chemotherapy and related neuropathy on HU in stage II and III colon cancer patients: A prospective cohort study

Jongeneel, Gabrielle; Greuter, Marjolein J E; van Erning, Felice N; Twisk, Jos W R; Koopman, Miriam; Punt, Cornelis J A; Vink, Geraldine R; Coupé, Veerle M H (John Wiley & Sons Inc., 2021-06-01)

Patient's quality of life should be included in clinical decision making regarding the administration of adjuvant chemotherapy (ACT) in stage II/III colon cancer. Therefore, quality of life, summarized as health utility ...
A self-matched leaky-wave antenna for ultrahigh-field magnetic resonance imaging with low specific absorption rate

Solomakha, G; Svejda, J T; van Leeuwen, C; Rennings, A; Raaijmakers, A J; Glybovski, S; Erni, D (Nature Publishing Group, 2021-12)

The technology of magnetic resonance imaging is developing towards higher magnetic fields to improve resolution and contrast. However, whole-body imaging at 7 T or even higher flux densities remains challenging due to wave ...
Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients

Brand, Eelco C; Klaassen, Marjolein A Y; Gacesa, Ranko; Vila, Arnau Vich; Ghosh, Hiren; de Zoete, Marcel R; Boomsma, Dorret I; Hoentjen, Frank; Horjus Talabur Horje, Carmen S; van de Meeberg, Paul C; Willemsen, Gonneke; Fu, Jingyuan; Wijmenga, Cisca; van Wijk, Femke; Zhernakova, Alexandra; Oldenburg, Bas; Weersma, Rinse K; Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis (W.B. Saunders, 2021-05)

Background & aims: It is currently unclear whether reported changes in the gut microbiome are cause or consequence of inflammatory bowel disease (IBD). Therefore, we studied the gut microbiome of IBD-discordant and -concordant ...
Treatment decision-making and the added value of the general practitioner: A qualitative exploration of cancer patients' perspectives

Noteboom, Eveline A; Vervoort, Sigrid C J M; May, Anne M; van Dorst, Eleonora B L; van Lindert, Anne S R; van Elst, Maarten W; Bijlsma, Rhodé M; van der Wall, Elsken; de Wit, Niek J; Helsper, Charles W (Wiley-Blackwell, 2021-05)

OBJECTIVE: Cancer patients are increasingly involved in decision-making for cancer treatment. General practitioners' (GPs) support in this process is advocated. Therefore, GPs need to be aware of patients' treatment ...

Now showing items 17101-17120 of 40729