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UMC Repository: Recent submissions

  • Childhood-onset of primary Sjögren's syndrome: phenotypic characterization at diagnosis of 158 children 
    Sjogren Big Data Consortium (Oxford University Press, 2021-10)
    Objectives: To characterize the phenotypic presentation at diagnosis of childhood-onset primary SS. Methods: The Big Data Sjögren Project Consortium is an international, multicentre registry using worldwide data-sharing ...
  • Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero 
    Widowski, Helene; Ophelders, Daan R M G; van Leeuwen, Anaïs J C N; Nikkels, Peter G J; Severens-Rijvers, Carmen A H; LaPointe, Vanessa L S; Cleutjens, Jack P M; Hütten, Matthias C; Kemp, Matthew W; Payne, Matthew S; Saito, Masatoshi; Usuda, Haruo; Newnham, John P; Jobe, Alan H; Kramer, Boris W; Delhaas, Tammo; Wolfs, Tim G A M; Reynaert, Niki L (Lippincott Williams & Wilkins, 2021-09)
    BACKGROUND: Chorioamnionitis, an intrauterine infection of the placenta and fetal membranes, is a common risk factor for adverse pulmonary outcomes in premature infants including BPD, which is characterized by an arrest ...
  • Placenta Pathology From Term Born Neonates With Normal or Adverse Outcome 
    Nikkels, Peter Gj; Evers, Annemieke Cc; Schuit, Ewoud; Brouwers, Hens Aa; Bruinse, Hein W; Bont, Louis; Houben, Michiel L; Kwee, Anneke (SAGE Publications Inc., 2021-04-01)
    BACKGROUND: The incidence of umbilical cord or placental parenchyma abnormalities associated with mortality or morbidity of term infants is lacking. METHODS: Placentas of 55 antepartum stillbirths (APD), 21 intrapartum ...
  • Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: a case series 
    van den Broek, Medard F M; Rijks, Ester B G; Nikkels, Peter G J; Wolters, Victorien M; van Es, Robert J J; van Santen, Hanneke M; van Nesselrooij, Bernadette P M; Vriens, Menno R; van Leeuwaarde, Rachel S; Valk, Gerlof D; Verrijn Stuart, Annemarie A (Humana Press, 2021-06)
    BACKGROUND: Medullary thyroid carcinoma (MTC) in childhood is rare and has an unfavorable prognosis. To improve outcome, early diagnosis is essential. In patients with multiple endocrine neoplasia type 2B (MEN2B), MTC can ...
  • Detailed somatotopy of tongue movement in the human sensorimotor cortex: A case study 
    Schippers, Anouck; Vansteensel, Mariska J; Freudenburg, Zachary V; Leijten, Frans S S; Ramsey, Nick F (Elsevier, 2021-03)
  • Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals 
    Arredondo-Alonso, Sergio; Top, Janetta; Corander, Jukka; Willems, Rob J L; Schürch, Anita C (BioMed Central, 2021-01-20)
    BACKGROUND: Enterococcus faecium is a commensal of the gastrointestinal tract of animals and humans but also a causative agent of hospital-acquired infections. Resistance against glycopeptides and to vancomycin has motivated ...
  • Developing a regional transmural care database: A roadmap 
    Vermond, Debbie; Helsper, Charles W; Kortekaas, Marlous F; Boekema, Nicole; de Groot, Esther; de Wit, Niek J; Zwart, Dorien L M (Elsevier Ireland Ltd, 2021-04)
    INTRODUCTION: In primary care health care systems, primary care physicians (PCPs) provide most basic care services, and if necessary, refer to secondary care for specialized work-up and treatment. If hospital care is ...
  • Eight years of experience with vismodegib for advanced and multiple basal cell carcinoma patients in the Netherlands: a retrospective cohort study 
    Verkouteren, Babette J A; Wakkee, Marlies; Reyners, An K L; Nelemans, Patty; Aarts, Maureen J B; Rácz, Emőke; Terra, Jorrit B; Devriese, Lot A; Alers, Robert-Jan; Kapiteijn, Ellen; van Doorn, Remco; Bekkenk, Marcel W; Reinders, Marie G H C; Mosterd, Klara (Springer Nature, 2021-03-30)
    BACKGROUND: Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates ...
  • Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients 
    Märtson, Anne-Grete; van der Elst, Kim C M; Veringa, Anette; Zijlstra, Jan G; Beishuizen, Albertus; van der Werf, Tjip S; Kosterink, Jos G W; Neely, Michael; Alffenaar, Jan-Willem (American Society for Microbiology, 2020-08-20)
    The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients ...
  • Clinical impact of COVID-19 on patients with cancer treated with immune checkpoint inhibition 
    Rogiers, Aljosja; Pires da Silva, Ines; Tentori, Chiara; Tondini, Carlo Alberto; Grimes, Joseph M; Trager, Megan H; Nahm, Sharon; Zubiri, Leyre; Manos, Michael; Bowling, Peter; Elkrief, Arielle; Papneja, Neha; Vitale, Maria Grazia; Rose, April A N; Borgers, Jessica S W; Roy, Severine; Mangana, Joanna; Pimentel Muniz, Thiago; Cooksley, Tim; Lupu, Jeremy; Vaisman, Alon; Saibil, Samuel D; Butler, Marcus O; Menzies, Alexander M; Carlino, Matteo S; Erdmann, Michael; Berking, Carola; Zimmer, Lisa; Schadendorf, Dirk; Pala, Laura; Queirolo, Paola; Posch, Christian; Hauschild, Axel; Dummer, Reinhard; Haanen, John; Blank, Christian U; Robert, Caroline; Sullivan, Ryan J; Ascierto, Paolo Antonio; Miller, Wilson H; Stephen Hodi, F; Suijkerbuijk, Karijn P M; Reynolds, Kerry L; Rahma, Osama E; Lorigan, Paul C; Carvajal, Richard D; Lo, Serigne; Mandala, Mario; Long, Georgina V (BioMed Central Ltd., 2021-01-19)
    BACKGROUND: Patients with cancer who are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to develop severe illness and die compared with those without cancer. The impact of immune ...
  • The Impact of a Standardized Pre-visit Laboratory Testing Panel in the Internal Medicine Outpatient Clinic: a Controlled "On-Off" Trial 
    Vrijsen, B E L; Ten Berg, M J; Naaktgeboren, C A; Vis, J Y; Dijstelbloem, H M; Westerink, J; Dekker, D; Hoefer, I E; Haitjema, S; Hulsbergen-Veelken, C A R; van Solinge, W W; Kaasjager, H A H (Springer New York, 2021-07)
    Background: In several settings, a shorter time to diagnosis has been shown to lead to improved clinical outcomes. The implementation of a rapid laboratory testing allows for a pre-visit testing in the outpatient clinic, ...
  • αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies 
    De Witte, Moniek A.; Janssen, Anke; Nijssen, Klaartje; Karaiskaki, Froso; Swanenberg, Luuk; van Rhenen, Anna; Admiraal, Rick; van der Wagen, Lotte; Minnema, Monique C.; Petersen, Eefke; Raymakers, Reinier A.P.; Westinga, Kasper; Straetemans, Trudy; Halkes, Constantijn J.M.; Boelens, Jaap Jan; Kuball, Jurgen (The American Society of Hematology, 2021-01-12)
    We conducted a multicenter prospective single-arm phase 1/2 study that assesses the outcome of αβ T-cell depleted allogeneic hematopoietic stem cell transplantation (allo-HSCT) of peripheral blood derived stem cells from ...
  • Post-exercise intramuscular O2 supply is tightly coupled with a higher proximal-to-distal ATP synthesis rate in human tibialis anterior 
    Heskamp, Linda; Lebbink, Franciska; van Uden, Mark J.; Maas, Marnix C.; Claassen, Jurgen A.H.R.; Froeling, Martijn; Kemp, Graham J.; Boss, Andreas; Heerschap, Arend (Wiley-Blackwell, 2021-03)
    KEY POINTS: The post-exercise recovery of phosphocreatine, a measure of the oxidative capacity of muscles, as assessed by 31 P MR spectroscopy, shows a striking increase from distal to proximal along the human tibialis ...
  • How does image quality affect radiologists' perceived ability for image interpretation and lesion detection in digital mammography? 
    VISUAL group (Springer-Verlag, 2021-07)
    OBJECTIVES: To study how radiologists' perceived ability to interpret digital mammography (DM) images is affected by decreases in image quality. METHODS: One view from 45 DM cases (including 30 cancers) was degraded to six ...
  • The effect of cisatracurium infusion on the energy expenditure of critically ill patients: An observational cohort study 
    Koekkoek, W. A.C.; Menger, Y. A.; Van Zanten, F. J.L.; Van Dijk, D.; Van Zanten, A. R.H. (Springer Science + Business Media, 2020-02-03)
    Background: Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. ...
  • A Randomized Trial of Initiation of Chronic Noninvasive Mechanical Ventilation at Home vs In-Hospital in Patients With Neuromuscular Disease and Thoracic Cage Disorder: The Dutch Homerun Trial 
    van den Biggelaar, Ries J.M.; Hazenberg, Anda; Cobben, Nicolle A.M.; Gaytant, Michael A.; Vermeulen, Karin M.; Wijkstra, Peter J. (Elsevier, 2020-12)
    Background: There is an increasing demand for home mechanical ventilation (HMV) in patients with chronic respiratory insufficiency. At present, noninvasive ventilation is exclusively initiated in a clinical setting at all ...
  • Monocyte derived macrophages from lung transplantation patients have an increased M2 profile 
    Schreurs, I.; Meek, B.; van Moorsel, C. H.M.; van Kessel, D. A.; Luijk, H. D.; Grutters, J. C. (Elsevier, 2020-03)
    Introduction: Lung transplantation (LTx) is a last treatment option for patients with an end-stage pulmonary disease. Although the monocyte-macrophage lineage is accepted to be clinically important only little is known ...
  • Thyroid dysfunction during treatment with systemic antineoplastic therapy for childhood cancer (Protocol) 
    Lebbink, Chantal; Lentjes, Eef; Tissing, Wim; van den Heuvel-Eibrink, M.M.; van Santen, HM; van Dalen, Elvira C (John Wiley & Sons Inc., 2020-12)
    Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To gain insight into the occurrence of and risk factors for aberrant thyroid function parameters (i.e. TSH, free thyroxine ...
  • Lung Transplantation Has a Strong Impact on the Distribution and Phenotype of Monocyte Subsets 
    Schreurs, I.; Meek, B.; Hijdra, D.; van Moorsel, C. H.M.; Luijk, H. D.; Kwakkel-van Erp, J. M.; Oudijk, E.; van Kessel, D. A.; Grutters, J. C. (Elsevier, 2020-04)
    Background: Lung transplantation (LTx) is a last treatment option for patients with an end-stage pulmonary disease. Chronic lung allograft dysfunction, which generally manifests as bronchiolitis obliterans syndrome (BOS), ...
  • Lung transplant patients show a dissimilar peripheral b-cell subset ratio compared with healthy controls 
    Schreurs, Inge; Meek, Bob; Hijdra, Daniëlle; Gomez, Maria Rodriguez; van Moorsel, Coline H.M.; Luijk, H. D.; Kwakkel-Van Erp, Johanna M.; Oudijk, Erik Jan; van Kessel, Diana A.; Grutters, Jan C. (Baskent University, 2020)
    Objectives: Lung transplant is a last treatment option for patients with end-stage pulmonary disease. Chronic lung allograft dysfunction, which generally manifests as bronchiolitis obliterans syndrome, is a major long-term ...