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Now showing items 16261-16280 of 40729

Comparability of different Z-score equations for aortic root dimensions in children with Marfan syndrome

Rutten, Dominiek W E; Aarts-Janssen, Ilse J H; Kempers, Marlies J E; Reimer, Annette G; Udink Ten Cate, Floris E A; Loeys, Bart L; Slieker, Martijn G (Cambridge University Press, 2021-12)

Background: Aortic root dilation is a major complication of Marfan syndrome and is one of the most important criteria in establishing the diagnosis. Currently, different echocardiographic nomograms are used to calculate ...
Magnetic Resonance Guided Radiation Therapy for Pancreatic Adenocarcinoma, Advantages, Challenges, Current Approaches, and Future Directions

Hall, William A; Small, Christina; Paulson, Eric; Koay, Eugene J; Crane, Christopher; Intven, Martijn; Daamen, Lois A; Meijer, Gert J; Heerkens, Hanne D; Bassetti, Michael; Rosenberg, Stephen A; Aitken, Katharine; Myrehaug, Sten; Dawson, Laura A; Lee, Percy; Gani, Cihan; Chuong, Michael David; Parikh, Parag J; Erickson, Beth A (Frontiers Media S. A., 2021-05-11)

Introduction: Pancreatic adenocarcinoma (PAC) has some of the worst treatment outcomes for any solid tumor. PAC creates substantial difficulty for effective treatment with traditional RT delivery strategies primarily ...
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

Patel, Yash; Parker, Nadine; Shin, Jean; Howard, Derek; French, Leon; Thomopoulos, Sophia I.; Pozzi, Elena; Abe, Yoshinari; Abé, Christoph; Anticevic, Alan; Alda, Martin; Aleman, Andre; Alloza, Clara; Alonso-Lana, Silvia; Ameis, Stephanie H.; Anagnostou, Evdokia; McIntosh, Andrew A.; Arango, Celso; Arnold, Paul D.; Asherson, Philip; Assogna, Francesca; Auzias, Guillaume; Ayesa-Arriola, Rosa; Bakker, Geor; Banaj, Nerisa; Banaschewski, Tobias; Bandeira, Cibele E.; Baranov, Alexandr; Bargalló, Núria; Bau, Claiton H.D.; Baumeister, Sarah; Baune, Bernhard T.; Bellgrove, Mark A.; Benedetti, Francesco; Bertolino, Alessandro; Boedhoe, Premika S.W.; Boks, Marco; Bollettini, Irene; Del Mar Bonnin, Caterina; Borgers, Tiana; Borgwardt, Stefan; Brandeis, Daniel; Brennan, Brian P.; Bruggemann, Jason M.; Janssen, Joost; Murphy, Declan; Ophoff, Roel A.; Oranje, Bob; Shook, Devon; Van Haren, Neeltje E.M. (American Medical Association, 2021-01)

Importance: Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. Objective: ...
A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

Oblak, Lara; van der Zaag, Jeroen; Higgins-Chen, Albert T.; Levine, Morgan E.; Boks, Marco P. (Elsevier Ireland Ltd, 2021-08)

Aging involves a diverse set of biological changes accumulating over time that leads to increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify biological aging, in order to investigate ...
Questioning medical competence: Should the Covid-19 crisis affect the goals of medical education?

Ten Cate, Olle; Schultz, Karen; Frank, Jason R; Hennus, Marije P; Ross, Shelley; Schumacher, Daniel J; Snell, Linda S; Whelan, Alison J; Young, John Q (Informa Healthcare, 2021-07)

The COVID-19 pandemic has disrupted many societal institutions, including health care and education. Although the pandemic's impact was initially assumed to be temporary, there is growing conviction that medical education ...
Worldwide Practice in Gastric Cancer Surgery: A 6-Year Update

Gertsen, Emma C; Brenkman, Hylke J F; Haverkamp, Leonie; Read, Matthew; Ruurda, Jelle P; van Hillegersberg, Richard (S. Karger AG, 2021)

OBJECTIVES: The aim of the study was to evaluate the current status of gastric cancer surgery worldwide and update the changes compared to a previous survey in 2014. METHODS: A cross-sectional survey was sent to surgical ...
Whole-body MRI versus an [18F]FDG-PET/CT-based reference standard for early response assessment and restaging of paediatric Hodgkin's lymphoma: a prospective multicentre study

Spijkers, Suzanne; Littooij, Annemieke S; Kwee, Thomas C; Tolboom, Nelleke; Beishuizen, Auke; Bruin, Marrie C A; Enríquez, Goya; Sábado, Constantino; Miller, Elka; Granata, Claudio; de Lange, Charlotte; Verzegnassi, Federico; de Keizer, Bart; Nievelstein, Rutger A J (Springer-Verlag, 2021-12)

OBJECTIVES: To compare WB-MRI with an [18F]FDG-PET/CT-based reference for early response assessment and restaging in children with Hodgkin's lymphoma (HL). METHODS: Fifty-one children (ages 10-17) with HL were included in ...
CFTR Modulators: Does One Dose Fit All?

van der Meer, Renske; Wilms, Erik B; Heijerman, Harry G M (MDPI Multidisciplinary Digital Publishing Institute, 2021-06)

For many people with cystic fibrosis (pwCF), CFTR modulators will be the cornerstone of their treatment. These modulators show robust treatment effects at group level in pwCF with specific mutations. The individual effect ...
Epigenetic-age acceleration in the emerging burden of cardiometabolic diseases among migrant and non-migrant African populations: a population-based cross-sectional RODAM substudy

Chilunga, Felix P; Henneman, Peter; Elliott, Hannah R; Cronjé, H Toinét; Walia, Gagandeep K; Meeks, Karlijn A C; Requena-Mendez, Ana; Venema, Andrea; Bahendeka, Silver; Danquah, Ina; Adeyemo, Adebowale; Klipstein-Grobusch, Kerstin; Pieters, Marlien; Mannens, Marcels M A M; Agyemang, Charles (Elsevier, 2021-06)

Background African populations are going through health transitions due to rapid urbanisation and international migration. However, the role of biological ageing in the emerging burden of cardiometabolic diseases among ...
Identification of Risk of Cardiovascular Disease by Automatic Quantification of Coronary Artery Calcifications on Radiotherapy Planning CT Scans in Patients with Breast Cancer

Gal, Roxanne; Van Velzen, Sanne G.M.; Hooning, Maartje J.; Emaus, Marleen J.; Van Der Leij, Femke; Gregorowitsch, Madelijn L.; Blezer, Erwin L.A.; Gernaat, Sofie A.M.; Lessmann, Nikolas; Sattler, Margriet G.A.; Leiner, Tim; De Jong, Pim A.; Teske, Arco J.; Verloop, Janneke; Penninkhof, Joan J.; Vaartjes, Ilonca; Meijer, Hanneke; Van Tol-Geerdink, Julia J.; Pignol, Jean Philippe; Van Den Bongard, Desirée H.J.G.; Išgum, Ivana; Verkooijen, Helena M. (American Medical Association, 2021-07-01)

Importance: Cardiovascular disease (CVD) is common in patients treated for breast cancer, especially in patients treated with systemic treatment and radiotherapy and in those with preexisting CVD risk factors. Coronary ...
ADVANCE system testing: Estimating the incidence of adverse events following pertussis vaccination in healthcare databases with incomplete exposure data

Dodd, Caitlin; de Ridder, Maria; Weibel, Daniel; Mahaux, Olivia; Haguinet, Francois; de Smedt, Tom; de Lusignan, Simon; McGee, Chris; Duarte-Salles, Talita; Emborg, Hanne-Dorthe; Huerta-Alvarez, Consuelo; Martín-Merino, Elisa; Picelli, Gino; Berencsi, Klara; Danieli, Giorgia; Sturkenboom, Miriam (Elsevier, 2020-12-22)

The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test a system for rapid vaccine benefit-risk monitoring using existing European ...
The Certainty Framework for Assessing Real-World Data in Studies of Medical Product Safety and Effectiveness

Cocoros, Noelle M; Arlett, Peter; Dreyer, Nancy A; Ishiguro, Chieko; Iyasu, Solomon; Sturkenboom, Miriam; Zhou, Wei; Toh, Sengwee (Wiley-Blackwell, 2021-05)

A fundamental question in using real-world data for clinical and regulatory decision making is: How certain must we be that the algorithm used to capture an exposure, outcome, cohort-defining characteristic, or confounder ...
Methodological frontiers in vaccine safety: qualifying available evidence for rare events, use of distributed data networks to monitor vaccine safety issues, and monitoring the safety of pregnancy interventions

Dodd, Caitlin; Andrews, Nick; Petousis-Harris, Helen; Sturkenboom, Miriam; Omer, Saad B; Black, Steven (BMJ Publishing Group, 2021-05)

While vaccines are rigorously tested for safety and efficacy in clinical trials, these trials do not include enough subjects to detect rare adverse events, and they generally exclude special populations such as pregnant ...
Systematic review of statistical methods for safety data in malaria chemoprevention in pregnancy trials

Patson, Noel; Mukaka, Mavuto; Otwombe, Kennedy N; Kazembe, Lawrence; Mathanga, Don P; Mwapasa, Victor; Kabaghe, Alinune N; Eijkemans, Marinus J C; Laufer, Miriam K; Chirwa, Tobias (BioMed Central, 2020-03-20)

BACKGROUND: Drug safety assessments in clinical trials present unique analytical challenges. Some of these include adjusting for individual follow-up time, repeated measurements of multiple outcomes and missing data among ...
Effect of disease related biases on the subjective assessment of social functioning in Alzheimer's disease and schizophrenia patients

Jongs, Niels; Penninx, Brenda; Arango, Celso; Ayuso-Mateos, Jose Luis; van der Wee, Nic; Rossum, Inge Winter-van; Saris, Ilja M J; van Echteld, Amber; Koops, Sanne; Bilderbeck, Amy C; Raslescu, Andreea; Dawson, Gerard R; Sommer, Bernd; Marston, Hugh; Vorstman, Jacob A; Eijkemans, Marinus Jc; Kas, Martien J (Elsevier Limited, 2022-01)

Background: Questionnaires are the current hallmark for quantifying social functioning in human clinical research. In this study, we compared self- and proxy-rated (caregiver and researcher) assessments of social functioning ...
Does the effectiveness of IUI in couples with unexplained subfertility depend on their prognosis of natural conception?: A replication of the H2Oil study

van Eekelen, R; Rosielle, K; van Welie, N; Dreyer, K; van Wely, M; Mol, B W; Eijkemans, M J; Mijatovic, V; van Geloven, N (2020)

STUDY QUESTION: Can we replicate the finding that the benefit of IUI-ovarian stimulation (IUI-OS) compared to expectant management for couples with unexplained subfertility depends on the prognosis of natural conception? ...
The Importance of Radiation Dose to the Atherosclerotic Plaque in the Left Anterior Descending Coronary Artery for Radiation-Induced Cardiac Toxicity of Breast Cancer Patients?

van den Bogaard, Veerle A B; Spoor, Daan S; van der Schaaf, Arjen; van Dijk, Lisanne V; Schuit, Ewoud; Sijtsema, Nanna M; Langendijk, Johannes A; Maduro, John H; Crijns, Anne P G (Elsevier, 2021-08-01)

PURPOSE: Radiation-induced acute coronary events (ACEs) may occur as a treatment-related late adverse effect of breast cancer (BC) radiation. However, the underlying mechanisms behind this radiation-induced cardiac disease ...
Timing of recurrence after surgery in pelvic organ prolapse

Roos, Eveline J; Schuit, Ewoud (Springer Nature, 2021-08)

OBJECTIVES: The aim of this study was to determine when women are at risk for recurrent pelvic organ prolapse (POP). METHODS: From 2010 to 2018, all women with symptomatic prolapse, Pelvic Organ Prolapse Quantification ...
Change in cervical length after arrested preterm labor and risk of preterm birth

Rennert, K N; Breuking, S; Schuit, E; Bekker, M N; Woiski, M; de Boer, M A; Sueters, M; Scheepers, H C J; Franssen, M T M; Pajkrt, E; Mol, B W J; Kok, M; Hermans, F J R (John Wiley & Sons Inc., 2021-11)

Objective: To assess the association between preterm birth and cervical length after arrested preterm labor in high-risk pregnant women. Methods: In this post-hoc analysis of a randomized clinical trial, transvaginal ...
Prognostic Models Predicting Mortality in Preterm Infants: Systematic Review and Meta-analysis

van Beek, Pauline E; Andriessen, Peter; Onland, Wes; Schuit, Ewoud (American Academy of Pediatrics, 2021-05-01)

CONTEXT: Prediction models can be a valuable tool in performing risk assessment of mortality in preterm infants. OBJECTIVE: Summarizing prognostic models for predicting mortality in very preterm infants and assessing their ...

Now showing items 16261-16280 of 40729