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Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy

Feyen, Dries A.M.; Perea-Gil, Isaac; Maas, Renee G.C.; Harakalova, Magdalena; Gavidia, Alexandra A.; Arthur Ataam, Jennifer; Wu, Ting Hsuan; Vink, Aryan; Pei, Jiayi; Vadgama, Nirmal; Suurmeijer, Albert J.; Te Rijdt, Wouter P.; Vu, Michelle; Amatya, Prashila L.; Prado, Maricela; Zhang, Yuan; Dunkenberger, Logan; Sluijter, Joost P.G.; Sallam, Karim; Asselbergs, Folkert W.; Mercola, Mark; Karakikes, Ioannis (Lippincott Williams & Wilkins, 2021-08-03)

Background: Phospholamban (PLN) is a critical regulator of calcium cycling and contractility in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated cardiomyopathy with a high prevalence ...
Correction to: Cardiac hypertrophy at autopsy

Association for European Cardiovascular Pathology (Springer-Verlag, 2021-07)

Correction to: Virchows Archiv https://doi.org/10.1007/s00428-021-03038-0 In the original published version of this article, the publisher regrets that the uploaded Supplementary Material Table 1 was incorrect. The correct ...
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

Cuello, Friederike; Knaust, Anika E; Saleem, Umber; Loos, Malte; Raabe, Janice; Mosqueira, Diogo; Laufer, Sandra; Schweizer, Michaela; van der Kraak, Petra; Flenner, Frederik; Ulmer, Bärbel M; Braren, Ingke; Yin, Xiaoke; Theofilatos, Konstantinos; Ruiz-Orera, Jorge; Patone, Giannino; Klampe, Birgit; Schulze, Thomas; Piasecki, Angelika; Pinto, Yigal; Vink, Aryan; Hübner, Norbert; Harding, Sian; Mayr, Manuel; Denning, Chris; Eschenhagen, Thomas; Hansen, Arne (Springer Science and Business Media Deutschland GmbH, 2021-06-07)

The phospholamban (PLN) p.Arg14del mutation causes dilated cardiomyopathy, with the molecular disease mechanisms incompletely understood. Patient dermal fibroblasts were reprogrammed to hiPSC, isogenic controls were ...
Can automatic image analysis replace the pathologist in cardiac allograft rejection diagnosis?

Veta, Mitko; van Diest, Paul J; Vink, Aryan (Oxford University Press, 2021-06-21)

Hypothetical workflow of cardiac allograft rejection diagnostics after implementation of recent developments. New noninvasive screening methods for rejection diagnostics are being developed, such as detection of donor-specific ...
Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications

Margaritis, Marios; Saini, Francesca; Baranowska-Clarke, Ania A; Parsons, Sarah; Vink, Aryan; Budgeon, Charley; Alcock, Natalie; Wagner, Bart E; Samani, Nilesh J; von der Thüsen, Jan; Robertus, Jan Lukas; Sheppard, Mary N; Adlam, David (Oxford University Press, 2022-06-22)

Aims: Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndromes and in rare cases sudden cardiac death (SCD). Connective tissue abnormalities, coronary inflammation, increased coronary vasa vasorum ...
Echocardiography protocol for early detection of cardiac dysfunction in childhood cancer survivors in the multicenter DCCSS LATER 2 CARD study: Design, feasibility, and reproducibility

The Dutch LATER Study Group (Wiley-Blackwell, 2021-06)

Background: Cardiotoxicity is a well-known side effect after anthracyclines and chest radiotherapy in childhood cancer survivors (CCS). The DCCSS LATER 2 CARD (cardiology) study includes evaluation of echocardiographic ...
Vitamin D supplementation for children with cancer: A systematic review and consensus recommendations

van Atteveld, Jenneke E.; Verhagen, Iris E.; van den Heuvel-Eibrink, Marry M.; van Santen, Hanneke M.; van der Sluis, Inge M.; Di Iorgi, Natascia; Simmons, Jill H.; Ward, Leanne M.; Neggers, Sebastian J.C.M.M. (John Wiley & Sons Inc., 2021-07)

Background: Prevalent vitamin D deficiency (VDD) and low bone mineral density (BMD) have led to vitamin D supplementation for children with cancer, regardless vitamin D status. However, it remains unsettled whether this ...
Preface Special Issue (Sung Wan Kim memorial, Journal of Controlled Release)

Grainger, David W; Hennink, Wim; Schiffelers, Raymond; Bae, You Han (Elsevier, 2021-04-10)
Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

Kooijmans, Sander A A; de Jong, Olivier G; Schiffelers, Raymond M (Elsevier, 2021-06)

Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins, nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another to modulate physiological and pathological ...
Beyond nephronophthisis: Retinal dystrophy in the absence of kidney dysfunction in childhood expands the clinical spectrum of CEP83 deficiency

Veldman, Bram C.F.; Kuper, Willemijn F.E.; Lilien, Marc; Schuurs-Hoeijmakers, Janneke H.M.; Marcelis, Carlo; Phan, Milan; Hettinga, Ymkje; Talsma, Herman E.; van Hasselt, Peter M.; Haijes, Hanneke A. (John Wiley & Sons Inc., 2021-07)

The CEP83 protein is an essential part in the first steps of ciliogenesis, causing a ciliopathy if deficient. As a core component of the distal appendages of the centriole, CEP83 is located in almost all cell types and is ...
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

Escudé Martinez de Castilla, Pol; Tong, Lingjun; Huang, Chenyuan; Sofias, Alexandros Marios; Pastorin, Giorgia; Chen, Xiaoyuan; Storm, Gert; Schiffelers, Raymond M; Wang, Jiong-Wei (Elsevier, 2021-08)

During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug delivery system. Here, we assess their pre-clinical applications, in the form of a systematic review. For each study published in the ...
Preventive screening for intracranial aneurysms

Rinkel, Gabriel J.E.; Ruigrok, Ynte M. (SAGE Publications Ltd, 2022-01)

Background: Subarachnoid hemorrhage from rupture of an intracranial aneurysm (aneurysmal subarachnoid hemorrhage) is a devastating subset of stroke. Since brain damage from the initial hemorrhage is a major cause for the ...
Is there a role for doravirine in African HIV treatment programmes? A large observational resistance study in South Africa

Steegen, Kim; Moorhouse, Michelle; Wensing, Annemarie M.J.; Venter, Willem D.F.; Hans, Lucia (International AIDS Society, 2021-05)

Introduction: Dolutegravir has replaced efavirenz in most low- and middle-income countries, due to better tolerability and formidable resistance profile, but dolutegravir side effects suggest alternatives are needed. We ...
Human Immunodeficiency Virus-2 (HIV-2): A Summary of the Present Standard of Care and Treatment Options for Individuals Living with HIV-2 in Western Europe

Berzow, Dirk; Descamps, Diane; Obermeier, Martin; Charpentier, Charlotte; Kaiser, Rolf; Guertler, Lutz; Eberle, Josef; Wensing, Annemarie; Sierra, Saleta; Ruelle, Jean; Gomes, Perpetua; Mansinho, Kamal; Taylor, Ninon; Jensen, Björn; Döring, Matthias; Stürmer, Martin; Rockstroh, Jürgen; Camacho, Ricardo (Oxford University Press, 2021-02-01)

Human immunodeficiency virus-2 (HIV-2) is endemic in some countries in West Africa. Due to the lower prevalence in industrialized countries, there is limited experience and knowledge on the management of individuals living ...
Incidence of atrial fibrillation, ischaemic heart disease and heart failure in patients with diabetes

Groenewegen, Amy; Zwartkruis, Victor W.; Cekic, Betül; de Boer, Rudolf A.; Rienstra, Michiel; Hoes, Arno W.; Rutten, Frans H.; Hollander, Monika (BioMed Central, 2021-06-16)

Background: Diabetes has strongly been linked to atrial fibrillation, ischaemic heart disease and heart failure. The epidemiology of these cardiovascular diseases is changing, however, due to changes in prevalence of ...
Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials

for the GRIT Study Group; the TRUFFLE Study Group (John Wiley & Sons Inc., 2020-01)

OBJECTIVE: To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR). METHODS: This was a cohort analysis of individual participant data from two ...
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial

COVID-RED Consortium (BioMed Central, 2021-06-22)

OBJECTIVES: It is currently thought that most-but not all-individuals infected with SARS-CoV-2 develop symptoms, but that the infectious period starts on average two days before the first overt symptoms appear. It is ...
Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study

Goodfellow, Laura; Verwijs, Marijn C; Care, Angharad; Sharp, Andrew; Ivandic, Jelena; Poljak, Borna; Roberts, Devender; Bronowski, Christina; Gill, A Christina; Darby, Alistair C; Alfirevic, Ana; Muller-Myhsok, Bertram; Alfirevic, Zarko; van de Wijgert, Janneke H H M (Wiley-Blackwell, 2021-12)

Objective: To assess the association between vaginal microbiome (VMB) composition and recurrent early spontaneous preterm birth (sPTB)/preterm prelabour rupture of membranes (PPROM). Design: Nested case–control study. ...
Neuroimaging of the Preterm Brain - Review and Recommendations

Inder, Terrie E; de Vries, Linda S; Ferriero, Donna M; Grant, P Ellen; Ment, Laura R; Miller, Steven P; Volpe, Joseph J (Mosby Inc., 2021-10)
Comparative analysis identifies similarities between the human and murine microglial sensomes

Abels, Erik R.; Nieland, Lisa; Hickman, Suzanne; Broekman, Marike L.D.; Khoury, Joseph El; Maas, Sybren L.N. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-01)

One of the essential functions of microglia is to continuously sense changes in their environment and adapt to those changes. For this purpose, they use a set of genes termed the sensome. This sensome is comprised of the ...

Now showing items 16121-16140 of 40729