Human Immunodeficiency Virus-2 (HIV-2): A Summary of the Present Standard of Care and Treatment Options for Individuals Living with HIV-2 in Western Europe
Berzow, Dirk; Descamps, Diane; Obermeier, Martin; Charpentier, Charlotte; Kaiser, Rolf; Guertler, Lutz; Eberle, Josef; Wensing, Annemarie; Sierra, Saleta; Ruelle, Jean; Gomes, Perpetua; Mansinho, Kamal; Taylor, Ninon; Jensen, Björn; Döring, Matthias; Stürmer, Martin; Rockstroh, Jürgen; Camacho, Ricardo
(2021) Clinical Infectious Diseases, volume 72, issue 3, pp. 503 - 509
(Article)
Abstract
Human immunodeficiency virus-2 (HIV-2) is endemic in some countries in West Africa. Due to the lower prevalence in industrialized countries, there is limited experience and knowledge on the management of individuals living with HIV-2 in Europe. Compared to HIV-1, there are differential characteristics of HIV-2 regarding diagnostic procedures, the clinical
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course, and, most importantly, antiretroviral therapy. We integrated the published literature on HIV-2 (studies and reports on epidemiology, diagnostics, the clinical course, and treatment), as well as expert experience in diagnosing and clinical care, to provide recommendations for a present standard of medical care of those living with HIV-2 in Western European countries, including an overview of strategies for diagnosis, monitoring, and treatment, with suggestions for effective drug combinations for first- and second-line treatments, post-exposure prophylaxis, and the prevention of mother-to-child transmission, as well as listings of mutations related to HIV-2 drug resistance and C-C motif chemokine receptor type 5 and C-X-C motif chemokine receptor type 4 coreceptor tropism.
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Keywords: antiretroviral therapy, care, diagnosis, HIV-2, resistance, Standard of Care, Europe, Humans, Anti-HIV Agents/therapeutic use, Infectious Disease Transmission, Vertical, HIV Infections/diagnosis, Female, Child, Africa, Western, HIV-2/genetics, Microbiology (medical), Infectious Diseases, Research Support, Non-U.S. Gov't, Journal Article
ISSN: 1058-4838
Publisher: Oxford University Press
Note: Publisher Copyright: © 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
(Peer reviewed)