Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies
Escudé Martinez de Castilla, Pol; Tong, Lingjun; Huang, Chenyuan; Sofias, Alexandros Marios; Pastorin, Giorgia; Chen, Xiaoyuan; Storm, Gert; Schiffelers, Raymond M; Wang, Jiong-Wei
(2021) Advanced Drug Delivery Reviews, volume 175, pp. 1 - 39
(Article)
Abstract
During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug delivery system. Here, we assess their pre-clinical applications, in the form of a systematic review. For each study published in the past decade, disease models, animal species, EV donor cell types, active pharmaceutical ingredients (APIs), EV surface
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modifications, API loading methods, EV size and charge, estimation of EV purity, presence of biodistribution studies and administration routes were quantitatively analyzed in a defined and reproducible way. We have interpreted the trends we observe over the past decade, to define the niches where to apply EVs for drug delivery in the future and to provide a basis for regulatory guidelines.
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Keywords: Clinical trial, Drug delivery, Extracellular vesicles, Liposomes, Preclinical animal models, Systematic review, Pharmaceutical Science, Review, Journal Article
ISSN: 0169-409X
Publisher: Elsevier
Note: Funding Information: The authors would like to thank the funding support from the Singapore Ministry of Health’s National Medical Research Council (NMRC/OFYIRG/0081/2018 to J.W.W., G.P. and G.S.), NUHS (NUHSRO/2018/095/RO5 + 5/Seed-Nov/05 to J.W.W.; NUHSRO/2021/034/TRP/09/Nanomedicine to X.C., G.S., and J.W.W.), NUS ODPRT Cross-Faculty Research Fund (CFGFY20P14 to J.W.W.), the National University of Singapore NanoNASH Program (NUHSRO/2020/002/NanoNash/LOA to G.S., G.P., and J.W.W.), the National University of Singapore start-up fund (NUHSRO/2020/133/Startup/08 to X.C.; NUHSRO/2019/077/STARTUP/03-ODPRT and NUHSRO/2019/077/STARTUP/03-NUSMed to G.S.), the National University of Singapore (R-148-000-296-114 and R-148-000-284-114 to G.P.) and the RIE2020 Advanced Manufacturing and Engineering (AME) Industry Alignment Fund – Pre Positioning (IAF-PP) grant (A20G1a0046 and R-148-000-307-305 to G.P.), and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement (proEVLifeCycle, grant No 860303; and the B-SMART project, grant No 721058; to R.M.S). Figs. 1, 2, 14–16 were created with BioRender.com. Funding Information: The authors would like to thank the funding support from the Singapore Ministry of Health's National Medical Research Council (NMRC/OFYIRG/0081/2018 to J.W.W. G.P. and G.S.), NUHS (NUHSRO/2018/095/RO5?+?5/Seed-Nov/05 to J.W.W.; NUHSRO/2021/034/TRP/09/Nanomedicine to X.C. G.S. and J.W.W.), NUS ODPRT Cross-Faculty Research Fund (CFGFY20P14 to J.W.W.), the National University of Singapore NanoNASH Program (NUHSRO/2020/002/NanoNash/LOA to G.S. G.P. and J.W.W.), the National University of Singapore start-up fund (NUHSRO/2020/133/Startup/08 to X.C.; NUHSRO/2019/077/STARTUP/03-ODPRT and NUHSRO/2019/077/STARTUP/03-NUSMed to G.S.), the National University of Singapore (R-148-000-296-114 and R-148-000-284-114 to G.P.) and the RIE2020 Advanced Manufacturing and Engineering (AME) Industry Alignment Fund ? Pre Positioning (IAF-PP) grant (A20G1a0046 and R-148-000-307-305 to G.P.), and the European Union's Horizon 2020 research and innovation programme under the Marie Sk?odowska-Curie grant agreement (proEVLifeCycle, grant No 860303; and the B-SMART project, grant No 721058; to R.M.S). Figs. 1, 2, 14?16 were created with BioRender.com. Publisher Copyright: © 2021 Elsevier B.V.
(Peer reviewed)