Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Deuterium Metabolic Imaging of the Healthy and Diseased Brain 
    Straathof, Milou; Meerwaldt, Anu E.; De Feyter, Henk M.; de Graaf, Robin A.; Dijkhuizen, Rick M. (Elsevier Limited, 2021-10-15)
    Altered brain metabolism contributes to pathophysiology in cerebrovascular and neurodegenerative diseases such as stroke and Alzheimer's disease. Current clinical tools to study brain metabolism rely on positron emission ...
  • New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases 
    Boltze, Johannes; Aronowski, Jaroslaw A.; Badaut, Jerome; Buckwalter, Marion S.; Caleo, Mateo; Chopp, Michael; Dave, Kunjan R.; Didwischus, Nadine; Dijkhuizen, Rick M.; Doeppner, Thorsten R.; Dreier, Jens P.; Fouad, Karim; Gelderblom, Mathias; Gertz, Karen; Golubczyk, Dominika; Gregson, Barbara A.; Hamel, Edith; Hanley, Daniel F.; Härtig, Wolfgang; Hummel, Friedhelm C.; Ikhsan, Maulana; Janowski, Miroslaw; Jolkkonen, Jukka; Karuppagounder, Saravanan S.; Keep, Richard F.; Koerte, Inga K.; Kokaia, Zaal; Li, Peiying; Liu, Fudong; Lizasoain, Ignacio; Ludewig, Peter; Metz, Gerlinde A.S.; Montagne, Axel; Obenaus, Andre; Palumbo, Alex; Pearl, Monica; Perez-Pinzon, Miguel; Planas, Anna M.; Plesnila, Nikolaus; Raval, Ami P.; Rueger, Maria A.; Sansing, Lauren H.; Sohrabji, Farida; Stagg, Charlotte J.; Stetler, R. Anne; Stowe, Ann M.; Sun, Dandan; Taguchi, Akihiko; Tanter, Mickael; Vay, Sabine U.; Vemuganti, Raghu; Vivien, Denis; Walczak, Piotr; Wang, Jian; Xiong, Ye; Zille, Marietta (Frontiers Research Foundation, 2021-01-28)
    The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number ...
  • Translational Value of Skilled Reaching Assessment in Clinical and Preclinical Studies on Motor Recovery After Stroke 
    van Lieshout, Eline C.C.; Boonzaier, Julia; Pel, Adam J.; van Heijningen, Caroline L.; Vink, Jord J.; Visser-Meily, Johanna M.A.; van Tilborg, Geralda A.F.; Dijkhuizen, Rick M. (SAGE Publications Inc., 2021-05)
    BACKGROUND: Assessment of skilled reaching enables extensive analysis of upper limb function in clinical and preclinical studies on poststroke outcome. However, translational research if often limited by lack of correspondence ...
  • Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury 
    Ustaoglu, Sebnem Garip; Ali, Mohamed H.M.; Rakib, Fazle; Blezer, Erwin L.A.; Van Heijningen, Caroline L.; Dijkhuizen, Rick M.; Severcan, Feride (Nature Publishing Group, 2021-06-14)
    Traumatic brain injury (TBI) is the main cause of disability and mortality in individuals under the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue due to TBI is crucial to understand ...
  • Morphological variants to predict outcome of avascular necrosis in developmental dysplasia of the hip 
    Pollet, Virginie; Bonsel, Joshua; Ganzeboom, Britt; Sakkers, Ralph; Waarsing, Erwin (British Editorial Society of Bone and Joint Surgery, 2021-05-01)
    Aims the most important complication of treatment of developmental dysplasia of the hip (ddh) is avascular necrosis (aVn) of the femoral head, which can result in proximal femoral growth disturbances leading to pain, ...
  • A roadmap to surgery in osteogenesis imperfecta: results of an international collaboration of patient organizations and interdisciplinary care teams 
    Sakkers, Ralph J; Montpetit, Kathleen; Tsimicalis, Argerie; Wirth, Thomas; Verhoef, Marjolein; Hamdy, Reginald; Ouellet, Jean A; Castelein, Rene M; Damas, Chantal; Janus, Guus J; Nijhuis, Wouter H; Panzeri, Leonardo; Paveri, Simona; Mekking, Dagmar; Thorstad, Kelly; Kruse, Richard W (Informa Healthcare, 2021-10-08)
    Background and purpose - Involvement of patient organizations is steadily increasing in guidelines for treatment of various diseases and conditions for better care from the patient's viewpoint and better comparability of ...
  • Patient-specific 3D-printed shelf implant for the treatment of hip dysplasia: Anatomical and biomechanical outcomes in a canine model 
    Willemsen, Koen; Dvm, Marianna Tryfonidou; Sakkers, Ralph; Castelein, René M; Zadpoor, Amir A; Seevinck, Peter; Weinans, Harrie; Dvm, Björn Meij; van der Wal, Bart C H (John Wiley & Sons Inc., 2022-05)
    A solution for challenging hip dysplasia surgery could be a patient-specific 3D-printed shelf implant that is positioned extra-articular and restores the dysplastic acetabular rim to normal anatomical dimensions. The ...
  • Pharmacokinetic interactions between ivacaftor and cytochrome P450 3A4 inhibitors in people with cystic fibrosis and healthy controls 
    van der Meer, Renske; Wilms, Erik B; Sturm, Richart; Heijerman, Harry G M (Elsevier, 2021-09)
    BACKGROUND: Ivacaftor is currently the only CFTR potentiator approved and is increasingly used since the development of CFTR correctors. Ivacaftor is metabolized by CYP3A4 and therefore dose reduction is required when ...
  • Targeted exhaled breath analysis for detection of Pseudomonas aeruginosa in cystic fibrosis patients 
    Amsterdam Mucociliary Clearance Disease (AMCD) Research Group and the Amsterdam UMC Breath Research Group (Elsevier, 2022-01)
    Background: Pseudomonas aeruginosa (PA) is an important respiratory pathogen for cystic fibrosis (CF) patients. Routine microbiology surveillance is time-consuming, and is best performed on expectorated sputum. As alternative, ...
  • Breast development in a 7 year old girl with CF treated with ivacaftor: An indication for personalized dosing? 
    Jeyaratnam, Joshena; van der Meer, Renske; Berkers, Gitte; Heijerman, Harry Gm; Beekman, Jeffrey M; van der Ent, Cornelis K (Elsevier, 2021-09)
    Substantial progress has been made in the treatment of Cystic fibrosis due to introduction of CFTR modulators. However, little is known about the long term side effects of treatment with these drugs. We here present a 7 ...
  • Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders 
    Erezuma, Itsasne; Eufrasio-da-Silva, Tatiane; Golafshan, Nasim; Deo, Kaivalya; Mishra, Yogendra Kumar; Castilho, Miguel; Gaharwar, Akhilesh K; Leeuwenburgh, Sander; Dolatshahi-Pirouz, Alireza; Orive, Gorka (John Wiley & Sons Inc., 2021-08-18)
    Nanoclay-reinforced biomaterials have sparked a new avenue in advanced healthcare materials that can potentially revolutionize treatment of musculoskeletal defects. Native tissues display many important chemical, mechanical, ...
  • Shaping Collagen for Engineering Hard Tissues: Towards a Printomics Approach 
    Maher, Malachy; Castilho, Miguel; Yue, Zhilian; Glattauer, Veronica; Hughes, Timothy C; Ramshaw, John A M; Wallace, Gordon G (Elsevier, 2021-09-01)
    Hard tissue engineering has evolved over the past decades, with multiple approaches being explored and developed. Despite the rapid development and success of advanced 3D cell culture, 3D printing technologies and material ...
  • Transcatheter Aortic Valve Replacement for Degenerated Transcatheter Aortic Valves: The TRANSIT International Project 
    Testa, Luca; Agnifili, Mauro; Van Mieghem, Nicolas M; Tchétché, Didier; Asgar, Anita W; De Backer, Ole; Latib, Azeem; Reimers, Bernhard; Stefanini, Giulio; Trani, Carlo; Colombo, Antonio; Giannini, Francesco; Bartorelli, Antonio; Wojakowski, Wojtek; Dabrowski, Maciej; Jagielak, Dariusz; Banning, Adrian P; Kharbanda, Rajesh; Moreno, Raul; Schofer, Joachim; van Royen, Niels; Pinto, Duane; Serra, Antoni; Segev, Amit; Giordano, Arturo; Brambilla, Nedy; Popolo Rubbio, Antonio; Casenghi, Matteo; Oreglia, Jacopo; De Marco, Federico; Tanja, Rudolph; McCabe, James M; Abizaid, Alexander; Voskuil, Michiel; Teles, Rui; Biondi Zoccai, Giuseppe; Bianchi, Giovanni; Sondergaard, Lars; Bedogni, Francesco (Lippincott Williams & Wilkins, 2021-06)
    Background: Transcatheter aortic valve replacement (TAVR) has determined a paradigm shift in the treatment of patients with severe aortic stenosis. However, the durability of bioprostheses is still a matter of concern, and ...
  • Response to the Comment on "Meta-analysis of Effect of Volume (Hospital and Operator) on Carotid Revascularization Outcomes" 
    Poorthuis, Michiel H.F.; Brand, Eelco C.; Halliday, Alison; Bulbulia, Richard; Bots, Michiel L.; de Borst, Gert J. (Lippincott Williams & Wilkins, 2021-07-01)
  • Extracellular Granzyme K Modulates Angiogenesis by Regulating Soluble VEGFR1 Release From Endothelial Cells 
    Li, Shuang; van Dijk, Christian G.M.; Meeldijk, Jan; Kok, Helena M.; Blommestein, Isabelle; Verbakel, Annick L.F.; Kotte, Marit; Broekhuizen, Roel; Laclé, Miangela M.; Goldschmeding, Roel; Cheng, Caroline; Bovenschen, Niels (Frontiers Media S. A., 2021-06-09)
    Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer. Granzymes are serine proteases stored in the granules ...
  • Intracellular expression of granzymes A, B, K and M in blood lymphocyte subsets of critically ill patients with or without sepsis 
    García-Laorden, M. Isabel; Hoogendijk, Arie J.; Wiewel, Maryse A.; van Vught, Lonneke A.; Schultz, Marcus J.; Bovenschen, Niels; de Vos, Alex F.; van der Poll, Tom (Wiley-Blackwell, 2021-08)
    Sepsis is a complex syndrome related to an infection-induced exaggerated inflammatory response, which is associated with a high mortality. Granzymes (Gzm) are proteases mainly found in cytotoxic lymphocytes that not only ...
  • Investigating morphological changes in the brain in relation to etiology and duration of olfactory dysfunction with voxel-based morphometry 
    Postma, E. M.; Smeets, P. A.M.; Boek, W. M.; Boesveldt, S. (Nature Publishing Group, 2021-06-16)
    Olfactory loss (OL) affects up to 20% of the general population and is related to changes in olfaction-related brain regions. This study investigated the effect of etiology and duration of OL on gray matter volume (GMV) ...
  • Exploring a Safety Signal of Antipsychotic-Associated Pneumonia: A Pharmacovigilance-Pharmacodynamic Study 
    Cepaityte, Dainora; Siafis, Spyridon; Egberts, Toine; Leucht, Stefan; Kouvelas, Dimitrios; Papazisis, Georgios (Oxford University Press, 2021-04-29)
    An association between antipsychotic drugs and pneumonia has been demonstrated in several studies; however, the risk for pneumonia caused by specific antipsychotics has not been extensively studied. The underlying mechanism ...
  • A compact and mobile hybrid C-arm scanner for simultaneous nuclear and fluoroscopic image guidance 
    Dietze, Martijn M.A.; Kunnen, Britt; Brontsema, Frank; Ramaekers, Pascal; Beijst, Casper; Afifah, Maryam; Braat, Arthur J.A.T.; Lam, Marnix G.E.H.; de Jong, Hugo W.A.M. (Springer-Verlag, 2022-01)
    Purpose: This study evaluates the performance of a mobile and compact hybrid C-arm scanner (referred to as IXSI) that is capable of simultaneous acquisition of 2D fluoroscopic and nuclear projections and 3D image reconstruction ...
  • Regulatory Safety Learning Driven by the Mechanism of Action: The Case of TNF-alpha Inhibitors: The Case of TNF-α Inhibitors 
    Minnema, Lotte A.; Giezen, Thijs J.; Hoekman, Jarno; Egberts, Toine C.G.; Leufkens, Hubert G.M.; Gardarsdottir, Helga (Wiley-Blackwell, 2021-07)
    The summary of product characteristics (SmPCs) is an important information source that includes the adverse drug reactions (ADRs) associated with the drug. Drugs with the same mechanism of action are expected to have a ...