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UMC Repository: Recent submissions

  • Correction to: DIALysis or not: Outcomes in older kidney patients with GerIatriC Assessment (DIALOGICA): rationale and design 
    on behalf of the DIALOGICA study group (BioMed Central, 2021-03-29)
    Following publication of the original article [1], the authors informed us that would like to update the Acknowledgements section by giving credit to someone who played a key role in the initial design of the study as ...
  • Histology and computed tomography of incidental calcifications in the human basal ganglia 
    de Brouwer, Esther J.M.; de Jong, Pim A.; De Jonghe, Annemarieke; Emmelot-Vonk, Marielle H.; Koek, Huiberdina L.; Dankbaar, Jan Willem; Mohamed Hoesein, Firdaus A.A.; Van Hecke, Wim (Springer-Verlag, 2021-07)
    Incidental basal ganglia calcifications are a common finding on computed tomography (CT). We investigated the histological characteristics of these calcifications and their association with CT findings, using post-mortem ...
  • Study objectives in clinical trials in older patients with solid malignancies: do we measure what matters? 
    Scheepers, E. R.M.; van Huis-Tanja, L. H.; Emmelot-Vonk, M. H.; Hamaker, M. E. (Springer Netherlands, 2021-07)
    Purpose: We set out to determine study objectives of clinical trials which included older patients with the four most common malignancies, to assess the extent to which the inclusion of patient-related outcomes (PROs) has ...
  • Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study 
    Blomaard, Laura C.; van der Linden, Carolien M.J.; van der Bol, Jessica M.; Jansen, Steffy W.M.; Polinder-Bos, Harmke A.; Willems, Hanna C.; Festen, Jan; Barten, Dennis G.; Borgers, Anke J.; Bos, Jeannet C.; van den Bos, Frederiek; de Brouwer, Esther J.M.; van Deudekom, Floor J.A.; van Dijk, Suzanne C.; Emmelot-Vonk, Mariëlle H.; Geels, Raya E.S.; van de Glind, Esther M.M.; de Groot, Bas; Hempenius, Liesbeth; Kamper, Ad M.; Kampschreur, Linda M.; de Koning, Marre M.M.; Labots, Geert; Looman, Roy; Lucke, Jacinta A.; Maas, Huub A.A.M.; Mattace-Raso, Francesco U.S.; El Moussaoui, Rachida; van Munster, Barbara C.; van Nieuwkoop, Cees; Oosterwijk, Leanne B.L.E.; Regtuijt, Marlies E.M.; Robben, Sarah H.M.; Ruiter, Rikje; Salarbaks, Aisha M.; Schouten, Henrike J.; Smit, Orla M.; Smits, Rosalinde A.L.; Spies, Petra E.; Vreeswijk, Ralph; de Vries, Oscar J.; Wijngaarden, Marjolein A.; Wyers, Caroline E.; Mooijaart, Simon P. (Oxford University Press, 2021-05-05)
    BACKGROUND: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been ...
  • Validity and reliability of the Dutch STarT MSK tool in patients with musculoskeletal pain in primary care physiotherapy 
    van den Broek, Anke G.; Kloek, Corelien J.J.; Pisters, Martijn F.; Veenhof, Cindy (Public Library of Science, 2021-03-18)
    Objective To evaluate the validity and reliability of the Dutch STarT MSK tool in patients with musculoskeletal pain in primary care physiotherapy. Methods Physiotherapists included patients with musculoskeletal pain, aged ...
  • Decision-Making on Referral to Primary Care Physiotherapy After Inpatient Stroke Rehabilitation 
    Geerars, Marieke; Wondergem, Roderick; Pisters, Martijn F. (W.B. Saunders, 2021-05)
    Objective: This study aimed to acquire insight into the decision-making processes of healthcare professionals concerning referral to primary care physiotherapy at the time of discharge from inpatient stroke rehabilitation. ...
  • Digital Tools for the Self-Assessment of Visual Acuity: A Systematic Review 
    Claessens, Janneau L.J.; Geuvers, Judith R.; Imhof, Saskia M.; Wisse, Robert P.L. (Springer London, 2021-12)
    Introduction: Numerous digital tools to self-assess visual acuity have been introduced. The recent COVID-19 pandemic underlined the need for high-quality remote care. This review gives a current overview of digital tools ...
  • Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise 
    Mul, Joeri; Melchior, Patrick; Seravalli, Enrica; Saunders, Daniel; Bolle, Stephanie; Cameron, Alison L.; Gurtner, Kristin; Harrabi, Semi; Lassen-Ramshad, Yasmin; Lavan, Naomi; Magelssen, Henriette; Mandeville, Henry; Boterberg, Tom; Kroon, Petra S.; Kotte, Alexis N.T.J.; Hoeben, Bianca A.W.; van Rossum, Peter S.N.; van Grotel, Martine; Graf, Norbert; van den Heuvel-Eibrink, Marry M.; Rübe, Christian; Janssens, Geert O. (Elsevier Ireland Ltd, 2021-05)
    Background and purpose: Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation ...
  • Mildly Increased Renin Expression in the Absence of Kidney Injury in the Murine Transverse Aortic Constriction Model 
    Wesseling, Marian; Mulder, Eva; Brans, Maike A D; Kapteijn, Daniek M C; Bulthuis, Marian; Pasterkamp, Gerard; Verhaar, Marianne C; Danser, A H Jan; van Goor, Harry; Joles, Jaap A; de Jager, Saskia C A (Frontiers Media S. A., 2021-06-15)
    Cardiorenal syndrome type 2 is characterized by kidney failure as a consequence of heart failure that affects >50% of heart failure patients. Murine transverse aortic constriction (TAC) is a heart failure model, where ...
  • A systematic review and meta-analysis of COVID-19 in kidney transplant recipients: Lessons to be learned 
    Kremer, Daan; Pieters, Tobias T.; Verhaar, Marianne C.; Berger, Stefan P.; Bakker, Stephan J.L.; van Zuilen, Arjan D.; Joles, Jaap A.; Vernooij, Robin W.M.; van Balkom, Bas W.M. (Elsevier, 2021-12)
    Kidney transplant recipients (KTR) may be at increased risk of adverse COVID-19 outcomes, due to prevalent comorbidities and immunosuppressed status. Given the global differences in COVID-19 policies and treatments, a ...
  • Ultra-central lung tumors: safety and efficacy of protracted stereotactic body radiotherapy 
    Lodeweges, Joyce E; van Rossum, Peter S N; Bartels, Marcia M T J; van Lindert, Anne S R; Pomp, Jacqueline; Peters, Max; Verhoeff, Joost J C (Informa Healthcare, 2021-08-03)
    Background: For patients with early stage or medically inoperable lung cancer, stereotactic body radiotherapy (SBRT) is a general accepted and effective treatment option. The role of SBRT in ultra-central tumors remains ...
  • Controlling the pandemic during the SARS-CoV-2 vaccination rollout 
    Viana, João; van Dorp, Christiaan H.; Nunes, Ana; Gomes, Manuel C.; van Boven, Michiel; Kretzschmar, Mirjam E.; Veldhoen, Marc; Rozhnova, Ganna (Nature Publishing Group, 2021-06-16)
    There is a consensus that mass vaccination against SARS-CoV-2 will ultimately end the COVID-19 pandemic. However, it is not clear when and which control measures can be relaxed during the rollout of vaccination programmes. ...
  • CSNK2B: A broad spectrum of neurodevelopmental disability and epilepsy severity 
    Ernst, Michelle E; Baugh, Evan H; Thomas, Amanda; Bier, Louise; Lippa, Natalie; Stong, Nicholas; Mulhern, Maureen S; Kushary, Sulagna; Akman, Cigdem I; Heinzen, Erin L; Yeh, Raymond; Bi, Weimin; Hanchard, Neil A; Burrage, Lindsay C; Leduc, Magalie S; Chong, Josephine S C; Bend, Renee; Lyons, Michael J; Lee, Jennifer A; Suwannarat, Pim; Brilstra, Eva; Simon, Marleen; Koopmans, Marije; van Binsbergen, Ellen; Groepper, Daniel; Fleischer, Julie; Nava, Caroline; Keren, Boris; Mignot, Cyril; Mathieu, Sophie; Mancini, Grazia M S; Madan-Khetarpal, Suneeta; Infante, Elena M; Bluvstein, Judith; Seeley, Andrea; Bachman, Kristine; Klee, Eric W; Schultz-Rogers, Laura E; Hasadsri, Linda; Barnett, Sarah; Ellingson, Marissa S; Ferber, Matthew J; Narayanan, Vinodh; Ramsey, Keri; Rauch, Anita; Joset, Pascal; Steindl, Katharina; Sheehan, Theodore; Poduri, Annapurna; Vasquez, Alejandra; Ruivenkamp, Claudia; White, Susan M; Pais, Lynn; Monaghan, Kristin G; Goldstein, David B; Sands, Tristan T; Aggarwal, Vimla (Wiley-Blackwell, 2021-07)
    CSNK2B has recently been implicated as a disease gene for neurodevelopmental disability (NDD) and epilepsy. Information about developmental outcomes has been limited by the young age and short follow-up for many of the ...
  • Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer: Systematic Review and Still-Open Questions 
    Lawlor, Rita T; Mattiolo, Paola; Mafficini, Andrea; Hong, Seung-Mo; Piredda, Maria L; Taormina, Sergio V; Malleo, Giuseppe; Marchegiani, Giovanni; Pea, Antonio; Salvia, Roberto; Kryklyva, Valentyna; Shin, Jae Il; Brosens, Lodewijk A; Milella, Michele; Scarpa, Aldo; Luchini, Claudio (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-22)
    Tumor mutational burden (TMB) is a numeric index that expresses the number of mutations per megabase (muts/Mb) harbored by tumor cells in a neoplasm. TMB can be determined using different approaches based on next-generation ...
  • Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies 
    Gruber, Victoria-Elisabeth; Lang, Judith; Endmayr, Verena; Diehm, Robert; Pimpel, Birgit; Glatter, Sarah; Anink, Jasper J; Bongaarts, Anika; Luinenburg, Mark J; Reinten, J A; van der Wel, Nicole; Larsen, Per; Hainfellner, Johannes A; Rössler, Karl; Aronica, Eleonora; Scholl, Theresa; Mühlebner, Angelika; Feucht, Martha (Wiley-Blackwell, 2021-10)
    AIMS: We aim to evaluate if the myelin pathology observed in epilepsy-associated focal cortical dysplasia type 2B (FCD2B) and-histologically indistinguishable-cortical tubers of tuberous sclerosis complex (TSC) is primarily ...
  • NANS-CDG: Delineation of the Genetic, Biochemical, and Clinical Spectrum 
    den Hollander, Bibiche; Rasing, Anne; Post, Merel A; Klein, Willemijn M; Oud, Machteld M; Brands, Marion M; de Boer, Lonneke; Engelke, Udo F H; van Essen, Peter; Fuchs, Sabine A; Haaxma, Charlotte A; Jensson, Brynjar O; Kluijtmans, Leo A J; Lengyel, Anna; Lichtenbelt, Klaske D; Østergaard, Elsebet; Peters, Gera; Salvarinova, Ramona; Simon, Marleen E H; Stefansson, Kari; Thorarensen, Ólafur; Ulmen, Ulrike; Coene, Karlien L M; Willemsen, Michèl A; Lefeber, Dirk J; van Karnebeek, Clara D M (Frontiers Media S. A., 2021-06)
    Background: NANS-CDG is a recently described congenital disorder of glycosylation caused by biallelic genetic variants in NANS, encoding an essential enzyme in de novo sialic acid synthesis. Sialic acid at the end of ...
  • IL4-10 Fusion Protein Shows DMOAD Activity in a Rat Osteoarthritis Model 
    van Helvoort, E. M.; de Visser, H. M.; Lafeber, F. P.J.G.; Coeleveld, K.; Versteeg, S.; Weinans, H. H.; Popov-Celeketic, J.; Eijkelkamp, N.; Mastbergen, S. C. (SAGE Publications Inc., 2021-12)
    OBJECTIVE: Ideally, disease-modifying osteoarthritis (OA) drugs (DMOAD) should combine chondroprotective, anti-inflammatory, and analgesic effects in a single molecule. A fusion protein of interleukin-4 (IL-4) and IL-10 ...
  • The Role of Physiotherapy in the New Treatment Landscape for Haemophilia 
    Lobet, Sébastien; Timmer, Merel; Königs, Christoph; Stephensen, David; McLaughlin, Paul; Duport, Gaetan; Hermans, Cédric; Mancuso, Maria Elisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-26)
    The physiotherapist plays an essential role for people with haemophilia, an inherited bleeding disease responsible for musculoskeletal complications. Yet, with the advent of new and advanced therapies, the medical landscape ...
  • The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm 
    Koopman, Charlotte D.; de Angelis, Jessica; Iyer, Swati P.; Verkerk, Arie O.; Silva, Jason Da; Berecki, Geza; Jeanes, Angela; Baillie, Gregory J.; Paterson, Scott; Uribe, Veronica; Ehrlich, Ophelia V.; Robinson, Samuel D.; Garric, Laurence; Petrou, Steven; Simons, Cas; Vetter, Irina; Hogan, Benjamin M.; de Boer, Teun P.; Bakkers, Jeroen; Smith, Kelly A. (National Academy of Sciences, 2021-03-02)
    The establishment of cardiac function in the developing embryo is essential to ensure blood flow and, therefore, growth and survival of the animal. The molecular mechanisms controlling normal cardiac rhythm remain to be ...
  • Sensations Reported During Urodynamic Bladder Filling in Spinal Cord Injury Patients Give Additional Important Information 
    Wyndaele, Jean Jacques; Wyndaele, Michel; Rosier, Peter F.W.M. (Korean Association of Medical Journal Edirors, 2022-02)
    Purpose: This study investigated the sensations reported during filling cystometry in patients with spinal cord lesions (SCLs) of different levels and completeness. Methods: In this retrospective cohort study, information ...