Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders
Erezuma, Itsasne; Eufrasio-da-Silva, Tatiane; Golafshan, Nasim; Deo, Kaivalya; Mishra, Yogendra Kumar; Castilho, Miguel; Gaharwar, Akhilesh K; Leeuwenburgh, Sander; Dolatshahi-Pirouz, Alireza; Orive, Gorka
(2021) Advanced Healthcare Materials, volume 10, issue 16, pp. 1 - 20
(Article)
Abstract
Nanoclay-reinforced biomaterials have sparked a new avenue in advanced healthcare materials that can potentially revolutionize treatment of musculoskeletal defects. Native tissues display many important chemical, mechanical, biological, and physical properties that engineered biomaterials need to mimic for optimal tissue integration and regeneration. However, it is time-consuming and difficult to endow
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such combinatorial properties on materials via feasible and nontoxic procedures. Fortunately, a number of nanomaterials such as graphene, carbon nanotubes, MXenes, and nanoclays already display a plethora of material properties that can be transferred to biomaterials through a simple incorporation procedure. In this direction, the members of the nanoclay family are easy to functionalize chemically, they can significantly reinforce the mechanical performance of biomaterials, and can provide bioactive properties by ionic dissolution products to upregulate cartilage and bone tissue formation. For this reason, nanoclays can become a key component for future orthopedic biomaterials. In this review, we specifically focus on the rapidly decreasing gap between clinic and laboratory by highlighting their application in a number of promising in vivo studies.
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Keywords: halloysite nanotubes, hydrogels, nanoclay, nanomaterials, nanosilicate, tissue engineering, Biomedical Engineering, Biomaterials, Pharmaceutical Science, Review, Journal Article
ISSN: 2192-2640
Publisher: John Wiley and Sons Ltd
Note: Funding Information: A.D.P. would like to acknowledge the Danish Council for Independent Research (Technology and Production Sciences, 8105‐00003B) and the VIDI research program with project number R0004387, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). G.O. wishes to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016‐76150‐R and BFU2017‐82421‐P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. The authors also appreciate the support from the Basque Country Government (Grupos Consolidados, No ref: IT907‐16). I.E. thanks the Basque Government for the Ph.D. grant (PRE_2020_2_0042) and M.C. the gravitation program “Materials Driven Regeneration” by the Netherlands Organization for Scientific Research (024.003.013). A.K.G. would like to acknowledge financial support from the National Institute of Health (NIH) (DP2 EB026265) and the National Science Foundation (CBET 1705852). Y.K.M. acknowledges funding by Interreg Deutschland‐Denmark with money from the European Regional Development Fund, project number 096‐1.1‐18. Funding Information: A.D.P. would like to acknowledge the Danish Council for Independent Research (Technology and Production Sciences, 8105-00003B) and the VIDI research program with project number R0004387, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). G.O. wishes to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016-76150-R and BFU2017-82421-P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. The authors also appreciate the support from the Basque Country Government (Grupos Consolidados, No ref: IT907-16). I.E. thanks the Basque Government for the Ph.D. grant (PRE_2020_2_0042) and M.C. the gravitation program ?Materials Driven Regeneration? by the Netherlands Organization for Scientific Research (024.003.013). A.K.G. would like to acknowledge financial support from the National Institute of Health (NIH) (DP2 EB026265) and the National Science Foundation (CBET 1705852). Y.K.M. acknowledges funding by Interreg Deutschland-Denmark with money from the European Regional Development Fund, project number 096-1.1-18. Publisher Copyright: © 2021 Wiley-VCH GmbH
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