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UMC Repository: Recent submissions

  • Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids 
    Dekkers, Johanna F.; van Vliet, Esmée J.; Sachs, Norman; Rosenbluth, Jennifer M.; Kopper, Oded; Rebel, Heggert G.; Wehrens, Ellen J.; Piani, Carol; Visvader, Jane E.; Verissimo, Carla S.; Boj, Sylvia F.; Brugge, Joan S.; Clevers, Hans; Rios, Anne C. (Springer Nature, 2021-04)
    Organoid technology has revolutionized the study of human organ development, disease and therapy response tailored to the individual. Although detailed protocols are available for the generation and long-term propagation ...
  • LGR6 marks nephron progenitor cells 
    van Ineveld, Ravian L.; Margaritis, Thanasis; Kooiman, Berend A.P.; Groenveld, Femke; Ariese, Hendrikus C.R.; Lijnzaad, Philip; Johnson, Hannah R.; Korving, Jeroen; Wehrens, Ellen J.; Holstege, Frank; van Rheenen, Jacco; Drost, Jarno; Rios, Anne C.; Bos, Frank L. (Wiley-Liss Inc., 2021-11)
    Background: Nephron progenitor cells (NPCs) undergo a stepwise process to generate all mature nephron structures. Mesenchymal to epithelial transition (MET) is considered a multistep process of NPC differentiation to ensure ...
  • De invloed van CYP2D6 op veelgebruikte psychofarmaca 
    Ebbelaar, Chiel F; Sallevelt, Bastiaan (2021-04-26)
    ‘Zou farmacogenetisch onderzoek voor deze patiënt zinvol zijn?’ is een vraag vanuit de psychiatrische praktijk die steeds vaker haar weg naar de apotheker vindt. Het doel van farmacogenetisch onderzoek is om de keuze en ...
  • The Implementation of Entrustable Professional Activities in Postgraduate Medical Education in the Netherlands: Rationale, Process, and Current Status 
    de Graaf, Jacqueline; Bolk, Marieke; Dijkstra, Auk; van der Horst, Marieke; Hoff, Reinier G; Ten Cate, Olle (Wolters Kluwer, 2021-07-01)
    Postgraduate medical education in the Netherlands has adopted competency-based education since the turn of the century. In 2006, the CanMEDS competency framework was introduced. A 2013 government plan to reduce the length ...
  • Reporting of prognostic clinical prediction models based on machine learning methods in oncology needs to be improved 
    Dhiman, Paula; Ma, Jie; Navarro, Constanza Andaur; Speich, Benjamin; Bullock, Garrett; Damen, Johanna Aa; Kirtley, Shona; Hooft, Lotty; Riley, Richard D; Van Calster, Ben; Moons, Karel G M; Collins, Gary S (Elsevier, 2021-10)
    OBJECTIVE: Evaluate the completeness of reporting of prognostic prediction models developed using machine learning methods in the field of oncology. STUDY DESIGN AND SETTING: We conducted a systematic review, searching the ...
  • Effectiveness of contact tracing apps for SARS-CoV-2: a rapid systematic review 
    Jenniskens, Kevin; Bootsma, Martin C J; Damen, Johanna A A G; Oerbekke, Michiel S; Vernooij, Robin W M; Spijker, René; Moons, Karel G M; Kretzschmar, Mirjam E E; Hooft, Lotty (BMJ Publishing Group, 2021-07-12)
    OBJECTIVE: To systematically review evidence on effectiveness of contact tracing apps (CTAs) for SARS-CoV-2 on epidemiological and clinical outcomes. DESIGN: Rapid systematic review. DATA SOURCES: EMBASE (OVID), MEDLINE ...
  • Safety Of Electro-Oxidation For Urea Removal In A Wearable Artificial Kidney Is Compromised By Formation Of Glucose Degradation Products 
    van Gelder, Maaike K; Vollenbroek, Jeroen C; Lentferink, Babette H; Hazenbrink, Diënty H M; Besseling, Paul J; Simonis, Frank; Giovanella, Silvia; Ligabue, Giulia; Bajo Rubio, Maria A; Cappelli, Gianni; Joles, Jaap A; Verhaar, Marianne C; Gerritsen, Karin G F (Wiley-Blackwell, 2021-11)
    A major challenge for the development of a wearable artificial kidney (WAK) is the removal of urea from the spent dialysate, as urea is the waste solute with the highest daily molar production and is difficult to adsorb. ...
  • Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): Cluster randomised controlled trial 
    Blum, Manuel R.; Sallevelt, Bastiaan T.G.M.; Spinewine, Anne; O'Mahony, Denis; Moutzouri, Elisavet; Feller, Martin; Baumgartner, Christine; Roumet, Marie; Jungo, Katharina Tabea; Schwab, Nathalie; Bretagne, Lisa; Beglinger, Shanthi; Aubert, Carole E.; Wilting, Ingeborg; Thevelin, Stefanie; Murphy, Kevin; Huibers, Corlina J.A.; Clara Drenth-Van Maanen, A.; Boland, Benoit; Crowley, Erin; Eichenberger, Anne; Meulendijk, Michiel; Jennings, Emma; Adam, Luise; Roos, Marvin J.; Gleeson, Laura; Shen, Zhengru; Marien, Sophie; Meinders, Arend Jan; Baretella, Oliver; Netzer, Seraina; De Montmollin, Maria; Fournier, Anne; Mouzon, Ariane; O'Mahony, Cian; Aujesky, Drahomir; Mavridis, Dimitris; Byrne, Stephen; Jansen, Paul A.F.; Schwenkglenks, Matthias; Spruit, Marco; Dalleur, Olivia; Knol, Wilma; Trelle, Sven; Rodondi, Nicolas (BMJ Publishing Group, 2021-07-13)
    Objective To examine the effect of optimising drug treatment on drug related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting ...
  • Classification of Uremic Toxins and Their Role in Kidney Failure 
    Rosner, Mitchell; Reis, Thiago; Husain-Syed, Faeq; Vanholder, Raymond; Hutchison, Colin; Stenvinkel, Peter; Blankestijn, Peter; Cozzolino, Mario; Juillard, Laurent; Kashani, Kianoush; Kaushik, Manish; Kawanishi, Hideki; Massy, Ziad; Sirich, Tammy; Zuo, Li; Ronco, Claudio (Lippincott Williams & Wilkins, 2021-12)
    Advances in our understanding of uremic retention solutes, and improvements in hemodialysis membranes and other techniques designed to remove uremic retention solutes, offer opportunities to readdress the definition and ...
  • Rescue therapy for vasospasm following aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis with machine learning 
    SAHIT collaboration (American Association of Neurological Surgeons, 2022-01-01)
    OBJECTIVE: Rescue therapies have been recommended for patients with angiographic vasospasm (aVSP) and delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH). However, there is little evidence from randomized ...
  • Quality of life in patients with IBD during the COVID-19 pandemic in the Netherlands 
    De Bock, Ellen; Filipe, Mando D.; Meij, Vincent; Oldenburg, Bas; Van Schaik, Fiona D.M.; Bastian, Okan W.; Fidder, Herma F.; Vriens, Menno R.; Richir, Milan C. (BMJ Publishing Group, 2021-07-02)
    Objective COVID-19 has put a strain on regular healthcare worldwide. For inflammatory bowel disease (IBD), gastrointestinal surgeries were postponed and changes in treatment and diagnostic procedures were made. As abrupt ...
  • Obesity is associated with increased risk of Crohn's disease, but not ulcerative colitis: A pooled analysis of five prospective cohort studies 
    DEFINe-IBD Investigators (W.B. Saunders, 2022-05)
    Background and Aims: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity ...
  • Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis 
    Verweij, Paul E; Brüggemann, Roger J M; Azoulay, Elie; Bassetti, Matteo; Blot, Stijn; Buil, Jochem B; Calandra, Thierry; Chiller, Tom; Clancy, Cornelius J; Cornely, Oliver A; Depuydt, Pieter; Koehler, Philipp; Lagrou, Katrien; de Lange, Dylan; Lass-Flörl, Cornelia; Lewis, Russell E; Lortholary, Olivier; Liu, Peter-Wei Lun; Maertens, Johan; Nguyen, M Hong; Patterson, Thomas F; Rijnders, Bart J A; Rodriguez, Alejandro; Rogers, Thomas R; Schouten, Jeroen A; Wauters, Joost; van de Veerdonk, Frank L; Martin-Loeches, Ignacio (Springer-Verlag, 2021-08)
    PURPOSE: Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 associated ...
  • Steroid use in elderly critically ill COVID-19 patients 
    COVIP study group (see appendix 1 covip@med.uni-duesseldorf.de) (European Respiratory Society, 2021-10-01)
  • Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study 
    VIP1 (Springer Science + Business Media, 2021-07-01)
    Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ...
  • Publisher Correction: Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 
    Wernly, Bernhard; Bruno, Raphael Romano; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Muessig, Johanna M; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agvald; Pinto, Bernado Bollen; Soliman, Ivo W; Szczeklik, Wojciech; Niederseer, David; Valentin, Andreas; Watson, Ximena; Leaver, Susannah; Boulanger, Carole; Walther, Sten; Schefold, Joerg C; Joannidis, Michael; Nalapko, Yuriy; Elhadi, Muhammed; Fjølner, Jesper; Zafeiridis, Tilemachos; De Lange, Dylan W; Guidet, Bertrand; Flaatten, Hans; Jung, Christian (Nature Publishing Group, 2021-12)
    Correction to: Scientifc Reports https://doi.org/10.1038/s41598-020-74910-3, published online 29 October 2020 In the original version of this Article, the VIP2 Study Group was incorrectly listed as an author in the author ...
  • Gender-stratified analyses of symptoms associated with acute coronary syndrome in telephone triage: A cross-sectional study 
    Wouters, Loes T.C.M.; Zwart, Dorien L.M.; Erkelens, Daphne C.A.; De Groot, Esther; Van Smeden, Maarten; Hoes, Arno W.; Damoiseaux, Roger A.M.J.; Rutten, Frans H. (BMJ Publishing Group, 2021-06-25)
    OBJECTIVES: To identify clinical variables that are associated with the diagnosis acute coronary syndrome (ACS) in women and men with chest discomfort who contact out-of-hours primary care (OHS-PC) by telephone, and to ...
  • EBM-onderwijs en leren van elkaar in de huisartsenpraktijk 
    Bartelink, Marie Louise; Welink, Lisanne; Beurskens, Niels; van Peet, Petra; Damoiseaux, Roger (Bohn Stafleu van Loghum, 2021-07)
    Evidence-based medicine (EBM) werd geïntroduceerd als hulp bij een leven lang leren. Huisartsen hebben tegenwoordig allemaal een computer op zak en kunnen altijd en overal bij evidence. Toch blijkt integratie van deze ...
  • De huisartsopleiding in een Europees perspectief 
    Damoiseaux, Roger; Michels, Nele; Scherpbier, Nynke (Bohn Stafleu van Loghum, 2021-07)
    Volgens de Europese regelgeving gelden huisartsendiploma’s in de hele Europese Unie. Maar beschikken Europese huisartsen wel over dezelfde kennis en vaardigheden? En worden ze op een vergelijkbare wijze opgeleid? Wanneer ...
  • Onderzoek van medisch onderwijs onmisbaar voor goede opleiding 
    Damoiseaux, Roger; Kramer, Anneke; Scherpbier, Nynke (Bohn Stafleu van Loghum, 2021-07)
    Het opleiden van huisartsen is net zoals dokteren een vak met een wetenschappelijke basis. Daarom wordt er onderzoek naar medisch onderwijs gedaan, dat bijvoorbeeld gericht is op interprofessioneel leren, docentprofessionalisering ...