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Pulmonary Vascular Complications in Hereditary Hemorrhagic Telangiectasia and the Underlying Pathophysiology

Bofarid, Sala; Hosman, Anna E; Mager, Johannes J; Snijder, Repke J; Post, Marco C (Multidisciplinary Digital Publishing Institute (MDPI), 2021-03-27)

In this review, we discuss the role of transforming growth factor-beta (TGF-β) in the development of pulmonary vascular disease (PVD), both pulmonary arteriovenous malformations (AVM) and pulmonary hypertension (PH), in ...
Evolution of patients with chronic thromboembolic pulmonary hypertension treated by balloon pulmonary angioplasty, according to their anticoagulant regimes

van de Groep, Liza D; van Thor, Mitch C J; Mager, Johannes J; Post, Marco C (Springer, 2021-10)
Clinical Phenotypes of Sarcoidosis-Associated Pulmonary Hypertension

Mathijssen, Harold; Huitema, Marloes P; Bakker, Annelies L M; Smits, Fokko; Mager, Johannes J; Snijder, Repke J; Grutters, Jan C; Post, Marco C (Elsevier, 2021-10)

Background and objective: Pulmonary hypertension (PH) is a known complication of pulmonary sarcoidosis and its aetiology is unclear. Different pathophysiological mechanisms in sarcoidosis-associated pulmonary hypertension ...
The longitudinal use of EmPHasis-10 and CAMPHOR questionnaire health-related quality of life scores in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Hendriks, Paul M; van Thor, Mitch C J; Wapenaar, Monique; Chandoesing, Prewesh; van den Toorn, Leon M; van den Bosch, Annemien E; Post, Marco C; Boomars, Karin A (W.B. Saunders Ltd, 2021-09)

BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with pulmonary hypertension (PH). The EmPHasis-10 and CAMPHOR questionnaires are developed to evaluate HRQoL specifically in patients with PH. Data ...
Effectiveness and safety of infliximab in cardiac Sarcoidosis

Bakker, A. L.M.; Mathijssen, H.; Azzahhafi, J.; Swaans, M. J.; Veltkamp, M.; Keijsers, R. G.M.; Akdim, F.; Post, M. C.; Grutters, J. C. (Elsevier Ireland Ltd, 2021-05-01)

Background: Immunosuppressive therapy in active cardiac sarcoidosis (CS) might prevent potential life-threatening complications. Infliximab (IFX) is a tumor necrosis factor alpha monoclonal antibody proven to be effective ...
Idiopathic and hereditary haemorrhagic telangiectasia associated pulmonary arteriovenous malformations: comparison of clinical and radiographic characteristics

Kroon, S.; van den Heuvel, D. A.F.; Vos, J. A.; van Leersum, M.; van Strijen, M. J.L.; Post, M. C.; Mager, J. J.; Snijder, R. J. (W.B. Saunders Ltd, 2021-05)

AIM: To determine whether there are differences between idiopathic and hereditary haemorrhagic telangiectasia (HHT) associated pulmonary arteriovenous malformations (PAVMs) (HHT-PAVM) regarding clinical and radiographic ...
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

REMAP-CAP Investigators (Springer-Verlag, 2021-08-01)

Purpose: To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). Methods: Critically ill adults with COVID-19 were randomized to receive ...
Exploring key elements of approaches that support childrens' preferences during painful and stressful medical procedures: A scoping review

Segers, Elisatbeth W; Ketelaar, Marjolijn; Taddio, Anna; de Man, Marjorie A C P; Schoonhoven, Lisette; van de Putte, Elise M; van den Hoogen, Agnes (W.B. Saunders, 2022-01-01)

PROBLEM: Children undergoing medical procedures can experience pain and distress. While numerous interventions exist to mitigate pain and distress, the ability to individualize the intervention to suit the needs and ...
Prediction rules for ruling out endocarditis in patients with Staphylococcus aureus bacteremia

van der Vaart, Thomas W; Prins, Jan M; Soetekouw, Robin; van Twillert, Gitte; Veenstra, Jan; Herpers, Bjorn L; Rozemeijer, Wouter; Jansen, Rogier R; Bonten, Marc J M; van der Meer, Jan T M (Oxford University Press, 2022-04-15)

BACKGROUND: Staphylococcus aureus bacteremia (SAB) is in 10% to 20% of cases complicated by infective endocarditis. Clinical prediction scores may select patients with SAB at highest risk for endocarditis, improving the ...
Reliability and Agreement of 2D and 3D Measurements on MRAs for Growth Assessment of Unruptured Intracranial Aneurysms

Timmins, Kimberley; Kuijf, Hugo; Vergouwen, Mervyn; Otten, Maarten; Ruigrok, Ynte; Velthuis, BK; van der Schaaf, Irene (American Society of Neuroradiology, 2021-09-01)

BACKGROUND AND PURPOSE: Reliable and reproducible measurement of unruptured intracranial aneurysm growth is important for unruptured intracranial aneurysm rupture risk assessment. This study aimed to compare the reliability ...
Developing a reporting guideline for artificial intelligence-centred diagnostic test accuracy studies: the STARD-AI protocol

STARD-AI Steering Committee (BMJ Publishing Group, 2021-06-28)

INTRODUCTION: Standards for Reporting of Diagnostic Accuracy Study (STARD) was developed to improve the completeness and transparency of reporting in studies investigating diagnostic test accuracy. However, its current ...
Protocol for development of a reporting guideline (TRIPOD-AI) and risk of bias tool (PROBAST-AI) for diagnostic and prognostic prediction model studies based on artificial intelligence

Collins, Gary S; Dhiman, Paula; Andaur Navarro, Constanza L; Ma, Jie; Hooft, Lotty; Reitsma, Johannes B; Logullo, Patricia; Beam, Andrew L; Peng, Lily; Van Calster, Ben; van Smeden, Maarten; Riley, Richard D; Moons, Karel Gm (BMJ Publishing Group, 2021-07-09)

The Transparent Reporting of a multivariable prediction model of Individual Prognosis Or Diagnosis (TRIPOD) statement and the Prediction model Risk Of Bias ASsessment Tool (PROBAST) were both published to improve the ...
Cancer immunotherapy by nc410, a lair-2 fc protein blocking human lair-collagen interaction

Ramos, M. Ines Pascoal; Tian, Linjie; de Ruiter, Emma J.; Song, Chang; Paucarmayta, Ana; Singh, Akashdip; Elshof, Eline; Vijver, Saskia V.; Shaik, Jahangheer; Bosiacki, Jason; Cusumano, Zachary; Jensen, Christina; Willumsen, Nicholas; Karsdal, Morten A.; Liu, Linda; Langermann, Sol; Willems, Stefan; Flies, Dallas; Meyaard, Linde (eLife Sciences Publications, 2021-06-14)

Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte-associated immunoglobulin-like receptor (LAIR)-1. LAIR-2 is a secreted protein that can ...
Topographic features of nano-pores within the osteochondral interface and their effects on transport properties –a 3D imaging and modeling study

Pouran, Behdad; Raoof, Amir; de Winter, D. A.Matthijs; Arbabi, Vahid; Bleys, Ronald L.A.W.; Beekman, Frederik J.; Zadpoor, Amir A.; Malda, Jos; Weinans, Harrie (Elsevier Limited, 2021-06-23)

Recent insights suggest that the osteochondral interface plays a central role in maintaining healthy articulating joints. Uncovering the underlying transport mechanisms is key to the understanding of the cross-talk between ...
Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Costa, Joana; Villa, Caterina; Verhoeckx, Kitty; Cirkovic-Velickovic, Tanja; Schrama, Denise; Roncada, Paola; Rodrigues, Pedro M.; Piras, Cristian; Martín-Pedraza, Laura; Monaci, Linda; Molina, Elena; Mazzucchelli, Gabriel; Mafra, Isabel; Lupi, Roberta; Lozano-Ojalvo, Daniel; Larré, Colette; Klueber, Julia; Gelencser, Eva; Bueno-Diaz, Cristina; Diaz-Perales, Araceli; Benedé, Sara; Bavaro, Simona Lucia; Kuehn, Annette; Hoffmann-Sommergruber, Karin; Holzhauser, Thomas (Humana Press, 2022-02)

Key determinants for the development of an allergic response to an otherwise ‘harmless’ food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the ...
Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Smits, Mark; Meijerink, Marjolein; Le, Thuy My; Knulst, André; de Jong, Aard; Caspers, Martinus Petrus Maria; Lima, Everton Souto; Babé, Lilia; Ladics, Gregory; McClain, Scott; Houben, Geert; Verhoeckx, Kitty (BioMed Central, 2021-04-13)

Background: Food proteins differ in their allergenic potential. Currently, there is no predictive and validated bio-assay to evaluate the allergenicity of novel food proteins. The objective of this study was to investigate ...
Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study

Michels, Charlotte T.J.; Wijburg, Carl J.; Hannink, Gerjon; Witjes, J. Alfred; Rovers, Maroeska M.; Grutters, Janneke P.C.; Helder, Sip; Venderbosch, Guus; Calsbeek, Hilly; Onna, Ilze E.W.van; Barten, Evert J.; Koldewijn, Evert L.; Boormans, Joost L.; Wijsman, Bart P.; Nooter, Ronald I.; Zwaan, Peter J.; Slaa, Ed te; Meer, Saskia van der; Klaver, Sjoerd O.; Fossion, Laurent M.C.L.; Bos, Siebe D.; Melick, Harm H.E.van; Leliveld, Anna M.; Meijer, Richard P.; Vis, André N.; Molijn, Gerard J.; Berendsen, Chris L.; Oddens, Jorg R. (Elsevier, 2022-05)

Background: Open radical cystectomy (ORC) is regarded as the standard treatment for muscle-invasive bladder cancer, but robot-assisted radical cystectomy (RARC) is increasingly used in practice. A recent study showed that ...
Generative lesion pattern decomposition of cognitive impairment after stroke

Bonkhoff, Anna K; Lim, Jae-Sung; Bae, Hee-Joon; Weaver, Nick A; Kuijf, Hugo J; Biesbroek, J Matthijs; Rost, Natalia S; Bzdok, Danilo (Oxford University Press, 2021)

Cognitive impairment is a frequent and disabling sequela of stroke. There is however incomplete understanding of how lesion topographies in the left and right cerebral hemisphere brain interact to cause distinct cognitive ...
Managing mother’s own milk for very preterm infants in neonatal units in 11 European countries

the EPICE Research Group (Wiley-Blackwell, 2021-01)
Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age

the EPICE Research Group (BioMed Central, 2021-06-06)

BACKGROUND: Loss to follow-up is a major challenge for very preterm (VPT) cohorts; attrition is associated with social disadvantage and parents with impaired children may participate less in research. We investigated the ...

Now showing items 15981-16000 of 40729