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Now showing items 16021-16040 of 40729

Associations between ghrelin and leptin and neural food cue reactivity in a fasted and sated state

Full4Health consortium (Academic Press Inc., 2021-10-15)

Food cue exposure can trigger eating. Food cue reactivity (FCR) is a conditioned response to food cues and includes physiological responses and activation of reward-related brain areas. FCR can be affected by hunger and ...
Een academische houding moet je leren

Muris, Jean; Damoiseaux, Roger (Bohn Stafleu van Loghum, 2021-07)

Academisering van de huisartsopleiding moet ervoor zorgen dat de opleiding kritisch denkende huisartsen aflevert die verdergaan dan het aanbieden van geprotocolleerde zorg. Om dat vorm te geven is het gewenst de kloof ...
Incidence, Clinical Characteristics and Outcomes of Early Hyperbilirubinemia in Critically ill Patients - Insights From The Mars Study

MARS Consortium (Lippincott Williams & Wilkins, 2022-02-01)

OBJECTIVE: To investigate the incidence, clinical characteristics and outcomes of early hyperbilirubinemia in critically ill patients. DESIGN AND SETTING: This is a post hoc analysis of a prospective multicenter cohort ...
Programmes to prepare siblings for future roles to support their brother or sister with a neurodisability: protocol of a scoping review

Nguyen, Linda; Bootsma, Jael; Di Rezze, Briano; Jack, Susan; Ketelaar, Marjolijn; Gorter, Jan Willem (BMJ Publishing Group, 2021-07-07)

INTRODUCTION: Siblings share a lifelong bond in their relationship, and they may choose to provide support to their brother or sister with a neurodisability. Previous reviews summarised programmes that only focused on the ...
Chronically Activated T-cells Retain Their Inflammatory Properties in Common Variable Immunodeficiency

Berbers, Roos-Marijn; van der Wal, M Marlot; van Montfrans, Joris M; Ellerbroek, Pauline M; Dalm, Virgil A S H; van Hagen, P Martin; Leavis, Helen L; van Wijk, Femke (Springer New York, 2021-10)

Purpose: Immune dysregulation complications cause significant morbidity and mortality in common variable immunodeficiency (CVID), but the underlying pathophysiology is poorly understood. While CVID is primarily considered ...
Unraveling heterogeneity in pediatric atopic dermatitis: identification of serum biomarker based patient clusters

Bakker, Daphne S; Graaf, Marlies de; Nierkens, Stefan; Delemarre, Eveline M; Knol, Edward; van Wijk, Femke; de Bruin-Weller, Marjolein S; Drylewicz, Julia; Thijs, Judith L (Mosby Inc., 2022-01)

BACKGROUND: Increasing evidence shows that pediatric atopic dermatitis (AD) differs from adult AD on a biologic level. Broad biomarker profiling across a wide range of ages of pediatric patients with AD is lacking. OBJECTIVE: ...
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer, Gerdien; Lutter, Lisanne; Mokry, Michal; van der Wal, Marlot; Scholman, Rianne; Fleskens, Veerle; Pandit, Aridaman; Tao, Weiyang; Wekking, Mark; Vervoort, Stephin; Roberts, Ceri; Petrelli, Alessandra; Peeters, Janneke G C; Knijff, Marthe; de Roock, Sytze; Vastert, Sebastiaan; Taams, Leonie S; van Loosdregt, Jorg; van Wijk, Femke (Nature Publishing Group, 2021-12)

Treg cells are critical regulators of immune homeostasis, and environment-driven Treg cell differentiation into effector (e)Treg cells is crucial for optimal functioning. However, human Treg cell programming in inflammation ...
Homeostatic function and inflammatory activation of ileal CD8+ tissue-resident T cells is dependent on mucosal location

Lutter, Lisanne; Roosenboom, Britt; Brand, Eelco C; Ter Linde, José J; Oldenburg, Bas; van Lochem, Ellen G; Horje Talabur Horjus, Carmen S; van Wijk, Femke (Elsevier, 2021-01-01)

Background & Aims: Tissue-resident memory T (Trm) cells, both of the CD4 and CD8 lineage, have been implicated in disease flares in inflammatory bowel disease. However, data are conflicting regarding the profile of human ...
Associations between dietary amino acid intakes and blood concentration levels

Iguacel, Isabel; Schmidt, Julie A.; Perez-Cornago, Aurora; Van Puyvelde, Heleen; Travis, Ruth; Stepien, Magdalena; Scalbert, Augustin; Casagrande, Corinne; Weiderpass, Elisabete; Riboli, Elio; Schulze, Matthias B.; Skeie, Guri; Bodén, Stina; Boeing, Heiner; Cross, Amanda J.; Harlid, Sophia; Jensen, Torill Enget; Huerta, José M.; Katzke, Verena; Kühn, Tilman; Lujan-Barroso, Leila; Masala, Giovanna; Rodriguez-Barranco, Miguel; Rostgaard-Hansen, Agnetha Linn; van der Schouw, Yvonne T.; Vermeulen, Roel; Tagliabue, Giovanna; Tjønneland, Anne; Trevisan, Morena; Ferrari, Pietro; Gunter, Marc J.; Huybrechts, Inge (Churchill Livingstone, 2021-06)

Background and aims: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects ...
Residential exposure to fast-food restaurants and its association with diet quality, overweight and obesity in the Netherlands: a cross-sectional analysis in the EPIC-NL cohort

Harbers, Marjolein C.; Beulens, Joline W.J.; Boer, Jolanda Ma; Karssenberg, Derek; Mackenbach, Joreintje D.; Rutters, Femke; Vaartjes, Ilonca; Verschuren, Wm Monique; van der Schouw, Yvonne T. (BioMed Central, 2021-06-16)

BACKGROUND: Unhealthy food environments may contribute to unhealthy diets and risk of overweight and obesity through increased consumption of fast-food. Therefore, we aimed to study the association of relative exposure to ...
Placental complement activation in fetal and neonatal alloimmune thrombocytopenia: An observational study

de Vos, Thijs W.; Winkelhorst, Dian; Baelde, Hans J.; Dijkstra, Kyra L.; van Bergen, Rianne D.M.; van der Meeren, Lotte E.; Nikkels, Peter G.J.; Porcelijn, Leendert; van der Schoot, C. Ellen; Vidarsson, Gestur; Eikmans, Michael; Kapur, Rick; van der Keur, Carin; Trouw, Leendert A.; Oepkes, Dick; Lopriore, Enrico; van der Hoorn, Marie Louise P.; Bos, Manon; de Haas, Masja (Multidisciplinary Digital Publishing Institute (MDPI), 2021-07-01)

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that causes thrombo-cytopenia and a risk of bleeding in the (unborn) child that result from maternal alloantibodies directed against fetal, paternally ...
Entrustable Professional Activities and Entrustment Decision Making: A Development and Research Agenda for the Next Decade

Ten Cate, Olle; Balmer, Dorene F.; Caretta-Weyer, Holly; Hatala, Rose; Hennus, Marije P.; West, Daniel C. (Wolters Kluwer, 2021-07-01)

To establish a research and development agenda for Entrustable Professional Activities (EPAs) for the coming decade, the authors, all active in this area of investigation, reviewed recent research papers, seeking recommendations ...
Venous creatinine as a biomarker for loss of fat-free mass and disease progression in patients with Amyotrophic Lateral Sclerosis

Holdom, Cory J; Janse van Mantgem, Mark R; van Eijk, Ruben P A; Howe, Stephanie L; van den Berg, Leonard H; McCombe, Pamela A; Henderson, Robert D; Ngo, Shyuan T; Steyn, Frederik J (Wiley-Blackwell, 2021-11)

BACKGROUND AND PURPOSE: To establish the utility of venous creatinine as a biomarker to monitor loss of fat-free mass in patients with amyotrophic lateral sclerosis (ALS). METHODS: In this multicenter natural history study, ...
ARHGDIB and AT1R autoantibodies are differentially related to the development and presence of chronic antibody-mediated rejection and fibrosis in kidney allografts

Betjes, Michiel G.H.; Sablik, Kasia A.; Litjens, Nicolle H.R.; Otten, Henny G.; de Weerd, Annelies E. (Elsevier, 2021-02)

The role of non-HLA autoantibodies in chronic-active antibody-mediated rejection (c-aABMR) of kidney transplants is largely unknown. In this study, the presence and clinical relevance of non-HLA autoantibodies using a ...
High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy

Bos, Jeroen W.; Otten, Henny G.; Herraets, Ingrid J.T.; Goedee, H. Stephan; Cats, E. A.; de Hoop, Talitha; Verduijn, Willem; van der Pol, W. Ludo; van den Berg, Leonard H. (Elsevier, 2021-05)

Objective: To gain further insight in the immunopathology underlying multifocal motor neuropathy (MMN) by exploring the association between MMN and the human leukocyte antigen (HLA) class II DRB1, DQB1, and DQA loci in ...
Fructo-Oligosaccharides Modify Human DC Maturation and Peanut-Induced Autologous T-Cell Response of Allergic Patients In Vitro

Hayen, Simone M.; Knulst, André C.; Garssen, Johan; Otten, Henny G.; Willemsen, Linette E.M. (Frontiers Media S. A., 2021-02-15)

Background: Dendritic cells (DCs) play an important role in antigen presentation, and are an interesting target for immune-modulation in allergies. Short- and long-chain fructo-oligosaccharides (scFOS/lcFOS, FF) have ...
Predictors of blood pressure response to ultrasound renal denervation in the RADIANCE-HTN SOLO study

Saxena, Manish; Schmieder, Roland E.; Kirtane, Ajay J.; Mahfoud, Felix; Daemen, Joost; Basile, Jan; Lurz, Philipp; Gosse, Philippe; Sanghvi, Kintur; Fisher, Naomi D.L.; Rump, Lars C.; Pathak, Atul; Blankestijn, Peter J.; Mathur, Anthony; Wang, Yale; Weber, Michael A.; Sharp, Andrew S.P.; Bloch, Michael J.; Barman, Neil C.; Claude, Lisa; Song, Yang; Azizi, Michel; Lobo, Melvin D. (Springer Nature, 2022-07)

The blood pressure (BP) lowering response to renal denervation (RDN) remains variable with about one-third of patients not responding to ultrasound or radiofrequency RDN. Identification of predictors of the BP response to ...
Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing

Aengevaeren, Vincent L; van Kimmenade, Roland R J; Ordóñez-Llanos, Jordi; García-Osuna, Álvaro; Kaier, Thomas E; Marber, Michael; Froeling, Martijn; van den Berg-Faay, Sandra; Hooijmans, Melissa T; Monte, Jithsa R; Hopman, Maria T E; Strijkers, Gustav J; Nederveen, Aart J; Bakermans, Adrianus J; Eijsvogels, Thijs M H (Wiley-Blackwell, 2021-07-06)
The diagnostic value of skin biopsies in Sneddon syndrome

Starmans, N. L.P.; Zoetemeyer, S.; van Dijk, M. R.; Kappelle, L. J.; Frijns, C. J.M. (Public Library of Science, 2021-06-28)

Background Sneddon syndrome (SS) is defined by widespread livedo reticularis (LR) and stroke. There is no single diagnostic test for SS and diagnosis can be solely based on clinical features. This cross-sectional case-control ...
Impact of extra-corporeal life support (ECLS) cannulation strategy on outcome after durable mechanical circulation support system implantation on behalf of durable MCS after ECLS Study Group

Saeed, Diyar; Potapov, Evgenij; Loforte, Antonio; Morshuis, Michiel; Schibilsky, David; Zimpfer, Daniel; Riebandt, Julia; Pappalardo, Federico; Attisani, Matteo; Rinaldi, Mauro; Pacini, Davide; Haneya, Assad; Ramjankhan, Faiz; Donker, Dirk W.; Jorde, Ulrich P.; Otto, Wolfgang; Stein, Julia; Tsyganenko, Dmytro; Al-Naamani, Ameen; Wieloch, Radi; Ayala, Rafael; Cremer, Jochen; Borger, Michael; Lichtenberg, Artur; Gummert, Jan (AME Publishing Company, 2021-05)

Background: The literature on outcomes of patients requiring durable mechanical circulatory support (MCS) after extra-corporeal life support (ECLS) is limited. The aim of this study was to investigate the impact of ...

Now showing items 16021-16040 of 40729