Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 13881-13900 of 40729

The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis

Salmon, Kristiana; Kiernan, Matthew C; Kim, Seung H; Andersen, Peter M; Chio, Adriano; van den Berg, Leonard H; Van Damme, Philip; Al-Chalabi, Ammar; Lillo, Patricia; Andrews, Jinsy A; Genge, Angela (Oxford University Press, 2022-05-24)

Several genetically-targeted therapies are being developed for ALS. Research is increasingly supportive of a greater incidence of clinically actionable variants in sporadic ALS than previously reported. Salmon et al. outline ...
Safety profile of chloroquine and hydroxychloroquine: a disproportionality analysis of the FDA Adverse Event Reporting System database

Papazisis, G; Siafis, S; Cepatyte, D; Giannis, D; Stamoula, E; Tzachanis, D; Egberts, T (Verduci Editore s.r.l, 2021-10)

OBJECTIVE: The present study aims to identify potential safety signals of chloroquine (CQ) and hydroxychloroquine (HCQ), over the period preceding their repurpose as COVID-19 treatment options, through the analysis of ...
The effect of the anticholinergic burden on duration and severity of delirium in older hip-surgery patients with and without haloperidol prophylaxis: A post hoc analysis

Tillemans, Monique P H; Butterhoff-Terlingen, Madelon H; Stuffken, Rutger; Vreeswijk, Ralph; Egberts, Toine C G; Kalisvaart, Kees J (John Wiley & Sons Inc., 2021-12)

BACKGROUND: Anticholinergic acting drugs have been associated with delirium in older patients. OBJECTIVE: To examine the association between the anticholinergic burden (ACB) and the duration and severity of delirium in ...
Incidence of and Reasons and Determinants Associated with Retransitioning from Biosimilar Etanercept to Originator Etanercept

Meijboom, Rosanne W; Gardarsdottir, Helga; Becker, Matthijs L; Ten Wolde, Saskia; Egberts, Toine C G; Giezen, Thijs J (Adis, 2021-11)

BACKGROUND: Patients in clinical practice are transitioned from originator etanercept (OR-ETA) to biosimilar etanercept (BS-ETA), but some subsequently retransition. Insights into the incidence of and reasons for retransitioning ...
Patients Retransitioning from Biosimilar TNF alpha Inhibitor to the Corresponding Originator After Initial Transitioning to the Biosimilar: A Systematic Review: A Systematic Review

Meijboom, Rosanne W; Gardarsdottir, Helga; Egberts, Toine C G; Giezen, Thijs J (Adis, 2022-01)

BACKGROUND: Transitioning patients from an originator to a corresponding biosimilar has been extensively studied in both randomized controlled trials and observational studies. Although transitioning is considered ...
Key factors underlying the willingness of patients with cancer to participate in medication redispensing

Smale, E M; Egberts, T C G; Heerdink, E R; van den Bemt, B J F; Bekker, C L (Elsevier, 2022-08)

BACKGROUND: Redispensing medication unused by patients to other patients could reduce the environmental burden of medication waste. Simultaneously, associated financial loss could be reduced, particularly for expensive ...
The role of R-spondin proteins in cancer biology

Ter Steege, Eline J; Bakker, Elvira R M (Nature Publishing Group, 2021)

R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1-4) that have appeared as multipotent signaling ligands. The best-known molecular function of RSPOs lie within their capacity to agonize ...
MRI of the intraspinal nerve roots in patients with chronic inflammatory neuropathies: abnormalities correlate with clinical phenotypes

van Rosmalen, Marieke H.J.; Froeling, Martijn; Mandija, Stefano; Hendrikse, Jeroen; van der Pol, W. Ludo; Stephan Goedee, H. (Springer Science and Business Media Deutschland GmbH, 2022-06)

Objective: Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are caused by inflammatory changes of peripheral nerves. It is unknown if the intra-spinal roots are also affected. ...
Patients' and clinicians' perspectives on the primary care consultations for acute respiratory infections during the first wave of the COVID-19 pandemic: an eight-country qualitative study in Europe

Wanat, Marta; Hoste, Melanie Eugenie; Gobat, Nina Helene; Anastasaki, Marilena; Böhmer, Femke; Chlabicz, Slawomir; Colliers, Annelies; Farrell, Karen; Hollerbach, Sophie; Karkana, Maria-Nefeli; Kinsman, John; Lionis, Christos; Marcinowicz, Ludmila; Reinhardt, Katrin; Skoglund, Ingmarie; Sundvall, Pär-Daniel; Vellinga, Akke; Goossens, Herman; Butler, Christopher; van der Velden, Alike; Anthierens, Sibyl; Tonkin-Crine, Sarah (Royal College of General Practitioners, 2022-06)

BACKGROUND: The impact of the COVID-19 pandemic on patients' and clinicians' perceptions of healthcare-seeking behaviour and delivery of care is unclear. The pandemic accelerated the use of remote care, and understanding ...
Automated surveillance systems for healthcare-associated infections: results from a European survey and experiences from real-life utilization

Verberk, J. D.M.; Aghdassi, S. J.S.; Abbas, M.; Nauclér, P.; Gubbels, S.; Maldonado, N.; Palacios-Baena, Z. R.; Johansson, A. F.; Gastmeier, P.; Behnke, M.; van Rooden, S. M.; van Mourik, M. S.M. (W.B. Saunders Ltd, 2022-04)

Background: As most automated surveillance (AS) methods to detect healthcare-associated infections (HAIs) have been developed and implemented in research settings, information about the feasibility of large-scale implementation ...
Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

de Vor, Lisanne; van Dijk, Bruce; van Kessel, Kok; Kavanaugh, Jeffrey S.; de Haas, Carla; Aerts, Piet C.; Viveen, Marco C.; Boel, Edwin C.; Fluit, Ad C.; Kwiecinski, Jakub M.; Krijger, Gerard C.; Ramakers, Ruud M.; Beekman, Freek J.; Dadachova, Ekaterina; Lam, Marnix G. E. H.; Vogely, H. Charles; van der Wal, Bart C. H.; van Strijp, Jos A. G.; Horswill, Alexander R.; Weinans, Harrie; Rooijakkers, Suzan H. M. (eLife Sciences Publications, 2022-01-06)

Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could ...
Home mechanical ventilation: the Dutch approach

van den Biggelaar, R J M; Hazenberg, A; Cobben, N A M; Gommers, D A M P J; Gaytant, M A; Wijkstra, P J (Taylor and Francis Ltd., 2022-03)

In the Netherlands we have an unique organisation of only 4 centres being responsible for all patients who need Home Mechanical ventilation(HMV). Nationwide criteria for referral and initiation of HMV are stated in our ...
Impact of time to antibiotic therapy on clinical outcome in patients with bacterial infections in the emergency department: implications for antimicrobial stewardship

Nauclér, P.; Huttner, A.; van Werkhoven, C. H.; Singer, M.; Tattevin, P.; Einav, S.; Tängdén, T. (Elsevier, 2021-02)

Background: Rapid initiation of antibiotic treatment is considered crucial in patients with severe infections such as septic shock and bacterial meningitis, but may not be as important for other infectious syndromes. A ...
Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics

the ANTICIPATE study group (Nature Publishing Group, 2021-04-14)

Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in ...
Five versus seven days of nitrofurantoin for urinary tract infections in women with diabetes: a retrospective cohort study

Hendriks-Spoor, Kelly D.; Wille, Floor L.; Doesschate, Thijs ten; Dorigo-Zetsma, Julia W.; Verheij, Theo J.M.; van Werkhoven, Cornelis H. (Elsevier, 2022-03)

Objective: To compare the effectiveness of 5 versus 7 days of nitrofurantoin treatment for urinary tract infection (UTI) in women with diabetes. Methods: Data were collected retrospectively from Dutch general practitioners ...
Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Korotkov, Anatoly; Luinenburg, Mark J; Romagnolo, Alessia; Zimmer, Till S; van Scheppingen, Jackelien; Bongaarts, Anika; Broekaart, Diede W M; Anink, Jasper J; Mijnsbergen, Caroline; Jansen, Floor E; van Hecke, Wim; Spliet, Wim G; van Rijen, Peter C; Feucht, Martha; Hainfellner, Johannes A; Krsek, Pavel; Zamecnik, Josef; Crino, Peter B; Kotulska, Katarzyna; Lagae, Lieven; Jansen, Anna C; Kwiatkowski, David J; Jozwiak, Sergiusz; Curatolo, Paolo; Mühlebner, Angelika; van Vliet, Erwin A; Mills, James D; Aronica, Eleonora (Springer New York, 2022-01-15)

Background: The genetic disorder tuberous sclerosis complex (TSC) is frequently accompanied by the development of neuropsychiatric disorders, including autism spectrum disorder and intellectual disability, with varying ...
Acute kidney injury in renal transplant recipients undergoing cardiac surgery

Hundemer, Gregory L; Srivastava, Anand; Jacob, Kirolos A; Krishnasamudram, Neeraja; Ahmed, Salman; Boerger, Emily; Sharma, Shreyak; Pokharel, Kapil K; Hirji, Sameer A; Pelletier, Marc; Safa, Kassem; Kulvichit, Win; Kellum, John A; Riella, Leonardo V; Leaf, David E (Oxford University Press, 2021-01-01)

BACKGROUND: Acute kidney injury (AKI) is a key risk factor for chronic kidney disease in the general population, but has not been investigated in detail among renal transplant recipients (RTRs). We investigated the incidence, ...
Checklist Individual Strength to measure severe fatigue in immune thrombocytopenia

van Dijk, Wobke E.M.; Penson, Adriaan; Kuijlaars, Isolde A.R.; Suijker, Monique; van Galen, Karin P.M.; Knoop, Hans; Schutgens, Roger E.G. (Wiley-Blackwell, 2022-05)
Association of adalimumab trough concentrations and treatment response in patients with juvenile idiopathic arthritis

Doeleman, Martijn J H; de Roock, Sytze; El Amrani, Mohsin; van Maarseveen, Erik M; Wulffraat, Nico M; Swart, Joost F (Oxford University Press, 2021-12-24)

OBJECTIVE: The objective of this study was to assess the relationship between adalimumab trough concentrations and treatment response in paediatric patients with JIA. METHODS: This was a monocentric cohort study of JIA ...
Portable fixed dynamometry: towards remote muscle strength measurements in patients with motor neuron disease

Bakers, Jaap N E; van den Berg, Leonard H; Ajeks, Toju G; Holleman, Maxine J; Verhoeven, Jill; Beelen, Anita; Visser-Meily, Johanna M A; van Eijk, Ruben P A (Springer Science and Business Media Deutschland GmbH, 2021-05)

BACKGROUND: We aimed to determine (1) the test-retest reliability of a newly developed portable fixed dynamometer (PFD) as compared to the hand-held dynamometer (HHD) in patients with motor neuron disease (MND) and (2) the ...

Now showing items 13881-13900 of 40729