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Now showing items 13861-13880 of 40729

Stem cells, organoids, and organ-on-a-chip models for personalized in vitro drug testing

van Berlo, Damiën; Nguyen, Vivian V.T.; Gkouzioti, Vasiliki; Leineweber, Kirsten; Verhaar, Marianne C.; van Balkom, Bas W.M. (Elsevier, 2021-12)

Breakthroughs in stem cell biology and microfluidics technology have opened doors to in vitro screening platforms for personalized testing of safety (pharmaceuticals, nutrients, chemicals) and efficacy (pharmaceuticals, ...
Incidence and impact of postoperative pancreatic fistula after minimally invasive and open distal pancreatectomy

Dutch Pancreatic Cancer Group (Mosby Inc., 2022-06)

Background: Previous studies reported a higher rate of postoperative pancreatic fistula after minimally invasive distal pancreatectomy compared to open distal pancreatectomy. It is unknown whether the clinical impact of ...
Venous wedge and segment resection during pancreatoduodenectomy for pancreatic cancer: impact on short- and long-term outcomes in a nationwide cohort analysis

Dutch Pancreatic Cancer Group (John Wiley & Sons Inc., 2021-12-17)

BACKGROUND: Venous resection of the superior mesenteric or portal vein is increasingly performed in pancreatic cancer surgery, whereas results of studies on short- and long-term outcomes are contradictory. The aim of this ...
Aberrant patterns of PET response during treatment for DLBCL patients with MYC gene rearrangements

the HOVON imaging workgroup (Springer-Verlag, 2022-02)

Purpose: MYC gene rearrangements in diffuse large B-cell lymphoma (DLBCL) patients are associated with poor prognosis. Our aim was to compare patterns of 2[18F]fluoro-2-deoxy-D-glucose positron emission tomography computed ...
ASO Visual Abstract: Patient-Related Prognostic Factors for Anastomotic Leakage, Major Complications, and Short-Term Mortality Following Esophagectomy for Cancer: A Systematic Review and Meta-Analyses

van Kooten, Robert T.; Voeten, Daan M.; Steyerberg, Ewout W.; Hartgrink, Henk H.; van Berge Henegouwen, Mark I.; van Hillegersberg, Richard; Tollenaar, Rob A.E.M.; Wouters, Michel W.J.M. (Springer New York, 2021-12-01)
ASO Visual Abstract: The Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma-A Systematic Review and Retrospective Cohort Study

Jeremiasse, Bernadette; van der Steeg, Alida F.W.; Fiocco, Marta; Hobbelink, Monique G.G.; Merks, Johannes H.M.; Godzinski, Jan; Shulkin, Barry L.; Wijnen, Marc H.W.A.; van Scheltinga, Cecilia E.J.Terwisscha (Springer New York, 2021-12-01)
ASO Visual Abstract: Robotic Techniques in Esophagogastric Cancer Surgery: An Assessment of Short- and Long-Term Clinical Outcomes

Kamarajah, Sivesh K; Griffiths, Ewen A; Phillips, Alexander W; Ruurda, Jelle; van Hillegersberg, Richard; Hofstetter, Wayne L; Markar, Sheraz R (Springer New York, 2022-05-01)
GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence

Uceda-Castro, Rebeca; van Asperen, Jessy V.; Vennin, Claire; Sluijs, Jacqueline A.; van Bodegraven, Emma J.; Margarido, Andreia S.; Robe, Pierre A.J.; van Rheenen, Jacco; Hol, Elly M. (Nature Publishing Group, 2022-01-10)

Glioma is the most common form of malignant primary brain tumours in adults. Their highly invasive nature makes the disease incurable to date, emphasizing the importance of better understanding the mechanisms driving glioma ...
First-in-Human Study of the Biodistribution and Pharmacokinetics of Zr-89-CX-072, a Novel Immunopet Tracer Based on an Anti-PD-L1 Probody

Kist de Ruijter, Laura; Hooiveld-Noeken, Jahlisa S; Giesen, Danique; Lub-de Hooge, Marjolijn N; Kok, Iris C; Brouwers, Adrienne H; Elias, Sjoerd G; Nguyen, Margaret T L; Lu, Hong; Gietema, Jourik A; Jalving, Mathilde; de Groot, Derk J A; Vasiljeva, Olga; de Vries, Elisabeth G E (American Association for Cancer Research Inc., 2021-10-01)

Purpose: CX-072, a PD-L1–targeting Probody therapeutic, is engineered to be activated by tumor proteases that remove a masking peptide. To study effects on biodistribution and pharmacokinetics, we performed 89Zr-CX-072 ...
89Zr-pembrolizumab imaging as a non-invasive approach to assess clinical response to PD-1 blockade in cancer

Kok, I C; Hooiveld, J S; van de Donk, P P; Giesen, D; van der Veen, E L; Lub-de Hooge, M N; Brouwers, A H; Hiltermann, T J N; van der Wekken, A J; Hijmering-Kappelle, L B M; Timens, W; Elias, S G; Hospers, G A P; Groen, H J M; Uyterlinde, W; van der Hiel, B; Haanen, J B; de Groot, D J A; Jalving, M; de Vries, E G E (Oxford University Press, 2022-01)

BACKGROUND: Programmed cell death protein 1 (PD-1) antibody treatment is standard of care for melanoma and non-small-cell lung cancer (NSCLC). Accurately predicting which patients will benefit is currently not possible. ...
De behandeling van oudere vrouwen met borstkanker

Scholten, Astrid N; Schröder, Carolien P; Elias, Sjoerd G; Liefers, Gerrit Jan (Bohn Stafleu van Loghum, 2021-10-14)

The prognosis of breast cancer patients has greatly improved in recent decades. Innovations in imaging techniques, pathological assessment, optimized surgical and radiotherapy techniques have contributed to this. Much of ...
Full-Thickness Scar Resection after R1/Rx Excised T1 Colorectal Cancers as an Alternative to Completion Surgery

Dutch T1 CRC Working Group (Wolters Kluwer Health, 2022-04-01)

INTRODUCTION: Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), ...
Multi-parametric quantitative magnetic resonance imaging of the upper arm muscles of patients with spinal muscular atrophy

Hooijmans, Melissa T.; Habets, Laura E.; van den Berg-Faay, Sandra A.M.; Froeling, Martijn; Asselman, Fay Lynn; Strijkers, Gustav J.; Jeneson, Jeroen A.L.; Bartels, Bart; Nederveen, Aart J.; van der Pol, W. Ludo (John Wiley & Sons Inc., 2022-07)

Quantitative magnetic resonance imaging (qMRI) is frequently used to map the disease state and disease progression in the lower extremity muscles of patients with spinal muscular atrophy (SMA). This is in stark contrast ...
People with Stroke Are Most Sedentary in the Afternoon and Evening

English, Coralie; Wondergem, Roderick; Hendrickx, Wendy; Pisters, Martijn F (S. Karger AG, 2022)

QUESTIONS: What are the daily temporal patterns of movement behaviours (sedentary time, light-intensity physical activity, and moderate-vigorous physical activity) in people with stroke? Do daily temporal patterns of ...
Multiple Myeloma Relapse Is Associated with Increased NFκB Pathway Activity and Upregulation of the Pro-Survival BCL-2 Protein BFL-1

Spaan, Ingrid; van de Stolpe, Anja; Raymakers, Reinier A; Peperzak, Victor (Multidisciplinary Digital Publishing Institute (MDPI), 2021-09-17)

Multiple myeloma (MM) is a hematological malignancy that is still considered incurable due to the development of therapy resistance and subsequent relapse of disease. MM plasma cells (PC) use NFκB signaling to stimulate ...
Inhibitory pattern recognition receptors

Rumpret, Matevž; von Richthofen, Helen J; Peperzak, Victor; Meyaard, Linde (Rockefeller University Press, 2021-12-14)

Pathogen- and damage-associated molecular patterns are sensed by the immune system's pattern recognition receptors (PRRs) upon contact with a microbe or damaged tissue. In situations such as contact with commensals or ...
Advances and Perspectives in the Treatment of B-Cell Malignancies

Peperzak, Victor; Cuenca Lopera, Marta (Multidisciplinary Digital Publishing Institute (MDPI), 2021-05-08)
A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS

Katz, Jonathan S; Rothstein, Jeffrey D; Cudkowicz, Merit E; Genge, Angela; Oskarsson, Björn; Hains, Avis B; Chen, Chen; Galanter, Joshua; Burgess, Braydon L; Cho, William; Kerchner, Geoffrey A; Yeh, Felix L; Ghosh, Arundhati Sengupta; Cheeti, Sravanthi; Brooks, Logan; Honigberg, Lee; Couch, Jessica A; Rothenberg, Michael E; Brunstein, Flavia; Sharma, Khema R; van den Berg, Leonard; Berry, James D; Glass, Jonathan D (John Wiley & Sons Inc., 2022-01)

OBJECTIVE: Dual leucine zipper kinase (DLK), which regulates the c-Jun N-terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral ...
Immunoglobulin for multifocal motor neuropathy

Keddie, Stephen; Eftimov, Filip; van den Berg, Leonard H; Brassington, Ruth; de Haan, Rob J; van Schaik, Ivo N (John Wiley & Sons Inc., 2022-01-11)

BACKGROUND: Multifocal motor neuropathy (MMN) is a rare, probably immune-mediated disorder characterised by slowly progressive, asymmetric, distal weakness of one or more limbs with no objective loss of sensation. It may ...
Identifying adverse drug reactions from free-text electronic hospital health record notes

Wasylewicz, Arthur; van de Burgt, Britt; Weterings, Aniek; Jessurun, Naomi; Korsten, Erik; Egberts, Toine; Bouwman, Arthur; Kerskes, Marieke; Grouls, René; van der Linden, Carolien (Wiley-Blackwell, 2022-03)

BACKGROUND: Adverse drug reactions (ADRs) are estimated to be the fifth cause of hospital death. Up to 50% are potentially preventable and a significant number are recurrent (reADRs). Clinical decision support systems have ...

Now showing items 13861-13880 of 40729