Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Whole-Body MRI versus an FDG-PET/CT-Based Reference Standard for Early Response Assessment and Restaging of Paediatric Hodgkin's Lymphoma: A Prospective Multicentre Study 
    Spijkers, S.; Littooij, A.; Kwee, T.; Tolboom, N.; Beishuizen, A.; Bruin, M.; Enriquez, G.; Sabado, C.; Miller, E.; Granata, C.; De lange, C.; Verzegnassi, F.; Keizer, B.; Nievelstein, R. -J. (Wiley-Liss Inc., 2021-11)
    Background and Aims: To compare WB-MRI with an FDG-PET/CT-based reference for early response assessment and restaging in children with Hodgkin's lymphoma (HL). Methods: 51 children (ages 10-17) with HL were included in ...
  • Genomic insights in ascending aortic size and distensibility 
    Benjamins, Jan Walter; Yeung, Ming Wai; van de Vegte, Yordi J; Said, M Abdullah; van der Linden, Thijs; Ties, Daan; Juarez-Orozco, Luis E; Verweij, Niek; van der Harst, Pim (Elsevier, 2022-01)
    BACKGROUND: Alterations in the anatomic and biomechanical properties of the ascending aorta (AAo) can give rise to various vascular pathologies. The aim of the current study is to gain additional insights in the biology ...
  • Early detection of obstructive coronary artery disease in the asymptomatic high-risk population: objectives and study design of the EARLY-SYNERGY trial 
    Ties, Daan; van Dorp, Paulien; Pundziute, Gabija; van der Aalst, Carlijn M; Gratama, Jan Willem C; Braam, Richard L; Kuijpers, Dirkjan; Lubbers, Daniël D; van der Bilt, Ivo A C; Westenbrink, B Daan; Wolcherink, Martijn J Oude; Doggen, Carine J M; Išgum, Ivana; Nijveldt, Robin; de Koning, Harry J; Vliegenthart, Rozemarijn; Oudkerk, Matthijs; van der Harst, Pim (Mosby Inc., 2022-04)
    Background: Coronary artery disease (CAD) burden for society is expected to steeply increase over the next decade. Improved feasibility and efficiency of preventive strategies is necessary to flatten the curve. Acute ...
  • Respiratory Pathogen Detection in Children: Saliva as a Diagnostic Specimen 
    De Koff, Emma M.; Euser, Sjoerd M.; Badoux, Paul; Sluiter-Post, Judith; Eggink, Dirk; Sanders, Elisabeth A.M.; Van Houten, Marlies A. (Lippincott Williams & Wilkins, 2021-09)
    We compared pathogen detection between saliva, nasopharyngeal and oropharyngeal swabs in children with respiratory symptoms. The sensitivity in nasopharyngeal swabs was 93% (95% confidence interval [CI]: 78%-98%), in ...
  • Relation of Iron Status to Prognosis After Acute Coronary Syndrome 
    Gürgöze, Muhammed T; Kardys, Isabella; Akkerhuis, K Martijn; Oemrawsingh, Rohit M; Groot, Hilde E; van der Harst, Pim; Umans, Victor A; Kietselaer, Bas; Ronner, Eelko; Lenderink, Timo; Asselbergs, Folkert W; Manintveld, Olivier C; Boersma, Eric (Elsevier, 2022-04-01)
    Iron deficiency has been extensively researched and is associated with adverse outcomes in heart failure. However, to our knowledge, the temporal evolution of iron status has not been previously investigated in patients ...
  • Microbial community networks across body sites are associated with susceptibility to respiratory infections in infants 
    Reyman, Marta; Clerc, Melanie; van Houten, Marlies A.; Arp, Kayleigh; Chu, Mei Ling J.N.; Hasrat, Raiza; Sanders, Elisabeth A.M.; Bogaert, Debby (Springer Nature, 2021-10-28)
    Respiratory tract infections are a major cause of morbidity and mortality worldwide in young children. Concepts such as the gut-lung axis have highlighted the impact of microbial communities at distal sites in mediating ...
  • [F-18]metafluorobenzylguanidine (MFBG) PET-CT vs. [I-123]metaiodobenzylguanidine (MIBG) imaging in neuroblastoma patients 
    Samim, A.; Tytgat, G. A.; Blom, T.; Poot, A. J.; Tolboom, N.; Braat, A. J.; van Noesel, M. M.; Lam, M. G.; de Keizer, B. (Springer-Verlag, 2021-09)
    Aim/Introduction: [18F]metafuorobenzylguanidine (MFBG) is a new PET tracer for imaging of neuroblastoma. Compared to standard [123I]metaiodobenzylguanidine (MIBG) imaging, MFBG PET-CT ofers the advantages of faster ...
  • Association of Lipoprotein(a) With Atherosclerotic Plaque Progression 
    Kaiser, Yannick; Daghem, Marwa; Tzolos, Evangelos; Meah, Mohammed N; Doris, Mhairi K; Moss, Alistair J; Kwiecinski, Jacek; Kroon, Jeffrey; Nurmohamed, Nick S; van der Harst, Pim; Adamson, Philip D; Williams, Michelle C; Dey, Damini; Newby, David E; Stroes, Erik S G; Zheng, Kang H; Dweck, Marc R (Elsevier, 2022-01-25)
    BACKGROUND: Lipoprotein(a) [Lp(a)] is associated with increased risk of myocardial infarction, although the mechanism for this observation remains uncertain. OBJECTIVES: This study aims to investigate whether Lp(a) is ...
  • More than 10 years after introduction of an acellular pertussis vaccine in infancy: a cross-sectional serosurvey of pertussis in the Netherlands 
    Versteegen, Pauline; Berbers, Guy A.M.; Smits, Gaby; Sanders, Elisabeth A.M.; van der Klis, Fiona R.M.; de Melker, Hester E.; van der Maas, Nicoline A.T. (Elsevier, 2021-11)
    Background: Pertussis is a respiratory disease and still endemic despite high vaccination coverage. In the Dutch national immunisation programme (NIP) whole cell pertussis (wP) priming vaccines for infants were replaced ...
  • Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events 
    BIOMArCS Investigators (Informa Healthcare, 2022-05)
    Purpose Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time in post-ACS patients prior to a recurrent ACS ...
  • Der diagnostische und prognostischeWert der Koronarkalkmessung bei Patienten mit anhaltenden Brustschmerzen: Ein narrativer Uberblick 
    Koopman, Moniek Y; Willemsen, Robert T A; van der Harst, Pim; van Bruggen, Rykel; Gratama, Jan Willem C; Braam, Richard; van Ooijen, Peter M A; Doggen, Carine J M; Dinant, Geert-Jan; Kietselaer, Bas; Vliegenthart, Rozemarijn (Georg Thieme Verlag, 2022-03-01)
    Background Non-contrast computed tomography (CT) scanning allows for reliable coronary calcium score (CCS) calculation at a low radiation dose and has been well established as marker to assess the future risk of coronary ...
  • Urethral and bladder dose-effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial 
    Groen, Veerle H; van Schie, Marcel; Zuithoff, Nicolaas P A; Monninkhof, Evelyn M; Kunze-Busch, Martina; de Boer, Johannes C J; van der Voort van Zijp, Jochem; Pos, Floris J; Smeenk, Robert Jan; Haustermans, Karin; Isebaert, Sofie; Draulans, Cédric; Depuydt, Tom; Verkooijen, Helena M; van der Heide, Uulke A; Kerkmeijer, Linda G W (Elsevier Ireland Ltd, 2022-02)
    Purpose or objectives: The FLAME trial (NCT01168479) showed that by adding a focal boost to conventional fractionated EBRT in the treatment of localized prostate cancer, the five-year biochemical disease-free survival ...
  • Reply to I. R. Vogelius et al: [Radiation Dose Escalation for Early Prostate Cancer: Reigniting the FLAME?] 
    Kerkmeijer, Linda G. W.; Pos, Floris J.; Haustermans, Karin; van der Heide, Uulke A. (Lippincott Williams & Wilkins, 2021-09-20)
  • Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds 
    Van Eijk, Martin; Boerefijn, Stephanie; Cen, Lida; Rosa, Marisela; Morren, Marnix J.H.; Van Der Ent, Cornelis K.; Kraak, Bart; Dijksterhuis, Jan; Valdes, Ivan D.; Haagsman, Henk P.; De Cock, Hans (Informa Healthcare, 2020-11-01)
    Fungal infections in humans are increasing worldwide and are currently mostly treated with a relative limited set of antifungals. Resistance to antifungals is increasing, for example, in Aspergillus fumigatus and Candida ...
  • PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections 
    van Eijk, Martin; van Dijk, Albert; van der Ent, Cornelis K.; Arets, Hubertus G.M.; Breukink, Eefjan; van Os, Nico; Adrichem, Roy; van der Water, Sven; Lino Gómez, Rita; Kristensen, Maartje; Hessing, Martin; Jekhmane, Shehrazade; Weingarth, Markus; Veldhuizen, Ruud A.W.; Veldhuizen, Edwin J.A.; Haagsman, Henk P. (Elsevier, 2021-09)
    Background: Antimicrobial peptides are considered potential alternatives to antibiotics. Here we describe the antibacterial properties of a family of novel cathelicidin-related (CR-) peptides, which we named PepBiotics, ...
  • A new direction for simulation in healthcare education: Improving learners’ insight into the perspectives of patients through lived experience 
    van Geelen, Stefan; Dekker, Merel; van der Ent, Kors (Informa Healthcare, 2022-02-01)
  • A new era for people with cystic fibrosis 
    Bierlaagh, Marlou C.; Muilwijk, Danya; Beekman, Jeffrey M.; van der Ent, Cornelis K. (Springer-Verlag, 2021-09)
    Cystic fibrosis is the most prevalent inherited disease caused by a defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The impaired electrolyte homeostasis caused by the mutated or absent protein ...
  • Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids 
    Geurts, Maarten H.; de Poel, Eyleen; Pleguezuelos-Manzano, Cayetano; Oka, Rurika; Carrillo, Léo; Andersson-Rolf, Amanda; Boretto, Matteo; Brunsveld, Jesse E.; van Boxtel, Ruben; Beekman, Jeffrey M.; Clevers, Hans (Life Science Alliance, LLC, 2021-10)
    Prime editing is a recently reported genome editing tool using a nickase-cas9 fused to a reverse transcriptase that directly synthesizes the desired edit at the target site. Here, we explore the use of prime editing in ...
  • CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy 
    de Poel, Eyleen; Spelier, Sacha; Korporaal, Ricardo; Lai, Ka Wai; Boj, Sylvia F.; Conrath, Katja; van der Ent, Cornelis K.; Beekman, Jeffrey M. (Frontiers Media S. A., 2021-09-15)
    Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have transformed the treatment of cystic fibrosis (CF) by targeting the basis of the disease. In particular, treatment regimen consisting of multiple ...
  • Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids 
    de Poel, E.; Spelier, S.; Suen, S. W.F.; Kruisselbrink, E.; Graeber, S. Y.; Mall, M. A.; Weersink, E. J.M.; van der Eerden, M. M.; Koppelman, G. H.; van der Ent, C. K.; Beekman, J. M. (Elsevier, 2022-03)
    Background: Pharmacotherapies for people with cystic fibrosis (pwCF) who have premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are under development. Thus far, ...