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UMC Repository: Recent submissions

  • Intra-assessor reliability and measurement error of ultrasound measures for foot muscle morphology in older adults using a tablet-based ultrasound machine 
    Willemse, Lydia; Wouters, Eveline J M; Pisters, Martijn F; Vanwanseele, Benedicte (BioMed Central, 2022-01-25)
    BACKGROUND: To gain insight into the role of plantar intrinsic foot muscles in fall-related gait parameters in older adults, it is fundamental to assess foot muscles separately. Ultrasonography is considered a promising ...
  • The effect of interventions anticipated to improve plantar intrinsic foot muscle strength on fall-related dynamic function in adults: a systematic review 
    Willemse, Lydia; Wouters, Eveline J.M.; Bronts, Henk M.; Pisters, Martijn F.; Vanwanseele, Benedicte (BioMed Central, 2022-01-20)
    Background: The plantar intrinsic foot muscles (PIFMs) have a role in dynamic functions, such as balance and propulsion, which are vital to walking. These muscles atrophy in older adults and therefore this population, which ...
  • A guide to immunotherapy for COVID-19 
    van de Veerdonk, Frank L.; Giamarellos-Bourboulis, Evangelos; Pickkers, Peter; Derde, Lennie; Leavis, Helen; van Crevel, Reinout; Engel, Job J.; Wiersinga, W. Joost; Vlaar, Alexander P.J.; Shankar-Hari, Manu; van der Poll, Tom; Bonten, Marc; Angus, Derek C.; van der Meer, Jos W.M.; Netea, Mihai G. (Nature Research, 2022-01)
    Immune dysregulation is an important component of the pathophysiology of COVID-19. A large body of literature has reported the effect of immune-based therapies in patients with COVID-19, with some remarkable successes such ...
  • Incidence of Childhood Meningoencephalitis in Children With a Suspected Meningoencephalitis in the Netherlands 
    de Blauw, D; Bruning, A H L; Wolthers, K C; van Wermeskerken, A M; Biezeveld, M H; Wildenbeest, J G; Pajkrt, D (Lippincott Williams & Wilkins, 2022-04-01)
    Supplemental Digital Content is available in the text.
  • The Applied Data Analytics in Medicine Program: Lessons Learned From Four Years' Experience With Personalizing Health Care in an Academic Teaching Hospital 
    Haitjema, Saskia; Prescott, Timothy R; van Solinge, Wouter W (JMIR Publications Inc., 2022-01-28)
    The University Medical Center (UMC) Utrecht piloted a hospital-wide innovation data analytics program over the past 4 years. The goal was, based on available data and innovative data analytics methodologies, to answer ...
  • Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation 
    Jung, Christian; Mamandipoor, Behrooz; Fjølner, Jesper; Bruno, Raphael; Wernly, Bernhard; Artigas, Antonio; Bollen Pinto, Bernardo; Schefold, Joerg C; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn H; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De Lange, Dylan W; Guidet, Bertrand; Flaatten, Hans; Osmani, Venet (JMIR Publications Inc., 2022-03-31)
    Background: The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ...
  • Ischemic signs on the post-resuscitation ECG in absence of STEMI is associated with lower survival. A COACT trial's sub-study 
    Spoormans, E.; Lemkes, J. S.; Janssens, G. N.; Van der Hoeven, N. W.; Soultana, O.; Jewbali, L. S. D.; Dubois, E. A.; Meuwissen, M.; Bosker, H. A.; Bleeker, G. B.; Vlachojannis, G. J.; Van der Harst, P.; Voskuil, M.; Van De Ven, P.; Van Royen, N. (Oxford University Press, 2021-10)
  • Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic 
    De Luca, Giuseppe; Nardin, Matteo; Algowhary, Magdy; Uguz, Berat; Oliveira, Dinaldo C; Ganyukov, Vladimir; Zimbakov, Zan; Cercek, Miha; Jensen, Lisette Okkels; Loh, Poay Huan; Calmac, Lucian; Roura Ferrer, Gerard; Quadros, Alexandre; Milewski, Marek; Scotto di Uccio, Fortunato; von Birgelen, Clemens; Versaci, Francesco; Ten Berg, Jurrien; Casella, Gianni; Lung, Aaron Wong Sung; Kala, Petr; Díez Gil, José Luis; Carrillo, Xavier; Dirksen, Maurits; Becerra-Munoz, Victor M; Lee, Michael Kang-Yin; Juzar, Dafsah Arifa; de Moura Joaquim, Rodrigo; Paladino, Roberto; Milicic, Davor; Davlouros, Periklis; Bakraceski, Nikola; Zilio, Filippo; Donazzan, Luca; Kraaijeveld, Adriaan; Galasso, Gennaro; Lux, Arpad; Marinucci, Lucia; Guiducci, Vincenzo; Menichelli, Maurizio; Scoccia, Alessandra; Yamac, Aylin Hatice; Mert, Kadir Ugur; Flores Rios, Xacobe; Kovarnik, Tomas; Kidawa, Michal; Moreu, Josè; Flavien, Vincent; Fabris, Enrico; Martínez-Luengas, Iñigo Lozano; Boccalatte, Marco; Bosa Ojeda, Francisco; Arellano-Serrano, Carlos; Caiazzo, Gianluca; Cirrincione, Giuseppe; Kao, Hsien-Li; Sanchis Forés, Juan; Vignali, Luigi; Pereira, Helder; Manzo, Stephane; Ordoñez, Santiago; Arat Özkan, Alev; Scheller, Bruno; Lehtola, Heidi; Teles, Rui; Mantis, Christos; Antti, Ylitalo; Brum Silveira, João António; Zoni, Rodrigo; Bessonov, Ivan; Savonitto, Stefano; Kochiadakis, George; Alexopulos, Dimitrios; Uribe, Carlos E; Kanakakis, John; Faurie, Benjamin; Gabrielli, Gabriele; Gutierrez Barrios, Alejandro; Bachini, Juan Pablo; Rocha, Alex; Tam, Frankie Chor-Cheung; Rodriguez, Alfredo; Lukito, Antonia Anna; Saint-Joy, Veauthyelau; Pessah, Gustavo; Tuccillo, Andrea; Cortese, Giuliana; Parodi, Guido; Bouraghda, Mohammed Abed; Kedhi, Elvin; Lamelas, Pablo; Suryapranata, Harry; Verdoia, Monica (Elsevier, 2022-01-25)
    Background: During the coronavirus disease 2019 (COVID-19) pandemic, concerns have been arisen on the use of renin-angiotensin system inhibitors (RASI) due to the potentially increased expression of Angiotensin-converting-enzyme ...
  • The incidence and characteristics of venous thromboembolisms in paediatric-onset inflammatory bowel disease; a prospective international cohort study based on the PIBD-SETQuality Safety Registry 
    Aardoom, Martine A; Klomberg, Renz C W; Kemos, Polychronis; Ruemmele, Frank M; van Ommen, Heleen; de Ridder, Lissy; Croft, Nicholas M; PIBD-VTE Group; PIBD-SETQuality Consortium (Elsevier, 2022-05-01)
    Background and Aims: Guidelines regarding thromboprophylaxis for venous thromboembolisms [VTEs] in children with inflammatory bowel disease [IBD] are based on limited paediatric evidence. We aimed to prospectively assess ...
  • Improved Gene Fusion Detection in Childhood Cancer Diagnostics Using RNA Sequencing 
    Hehir-Kwa, Jayne Y; Koudijs, Marco J; Verwiel, Eugene T P; Kester, Lennart A; van Tuil, Marc; Strengman, Eric; Buijs, Arjan; Kranendonk, Mariëtte E G; Hiemcke-Jiwa, Laura S; de Haas, Valerie; van de Geer, Ellen; de Leng, Wendy; van der Lugt, Jasper; Lijnzaad, Philip; Holstege, Frank C P; Kemmeren, Patrick; Tops, Bastiaan B J (Lippincott Williams & Wilkins, 2022-01)
    PURPOSE: Gene fusions play a significant role in cancer etiology, making their detection crucial for accurate diagnosis, prognosis, and determining therapeutic targets. Current diagnostic methods largely focus on either ...
  • Juvenile polyposis diagnosed with an integrated histological, immunohistochemical and molecular approach identifying new SMAD4 pathogenic variants 
    Mafficini, Andrea; Brosens, Lodewijk A A; Piredda, Maria L; Conti, Cristian; Mattiolo, Paola; Turri, Giulia; Mastrosimini, Maria G; Cingarlini, Sara; Crinò, Stefano F; Fassan, Matteo; Piccoli, Paola; Simbolo, Michele; Nottegar, Alessia; Lawlor, Rita T; Guglielmi, Alfredo; Scarpa, Aldo; Pedrazzani, Corrado; Luchini, Claudio (Springer Netherlands, 2022-10)
    Juvenile polyposis (JP) is a rare familial syndrome characterized by the development of numerous hamartomatous polyps of the gastrointestinal tract and by an increased risk of developing gastrointestinal cancers. It follows ...
  • Risk Factors for Late-Onset Sepsis in Preterm Infants: A Multicenter Case-Control Study 
    El Manouni El Hassani, Sofia; Berkhout, Daniel J C; Niemarkt, Hendrik J; Mann, Sarah; de Boode, Willem P; Cossey, Veerle; Hulzebos, Christian V; van Kaam, Anton H; Kramer, Boris W; van Lingen, Richard A; van Goudoever, Johannes B; Vijlbrief, Daniel C; van Weissenbruch, Mirjam M; Benninga, Marc A; de Boer, Nanne K H; de Meij, Tim G J (S. Karger AG, 2019-07-01)
    BACKGROUND: Late-onset sepsis (LOS) in preterm infants is a leading cause of mortality and morbidity. Timely recognition and initiation of antibiotics are important factors for improved outcomes. Identification of risk ...
  • Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia 
    Zielen, Stefan; Duecker, Ruth Pia; Woelke, Sandra; Donath, Helena; Bakhtiar, Sharhzad; Buecker, Aileen; Kreyenberg, Hermann; Huenecke, Sabine; Bader, Peter; Mahlaoui, Nizar; Ehl, Stephan; El-Helou, Sabine M.; Pietrucha, Barbara; Plebani, Alessandro; van der Flier, Michiel; van Aerde, Koen; Kilic, Sara S.; Reda, Shereen M.; Kostyuchenko, Larysa; McDermott, Elizabeth; Galal, Nermeen; Pignata, Claudio; Pérez, Juan Luis Santos; Laws, Hans Juergen; Niehues, Tim; Kutukculer, Necil; Seidel, Markus G.; Marques, Laura; Ciznar, Peter; Edgar, John David M.; Soler-Palacín, Pere; von Bernuth, Horst; Krueger, Renate; Meyts, Isabelle; Baumann, Ulrich; Kanariou, Maria; Grimbacher, Bodo; Hauck, Fabian; Graf, Dagmar; Granado, Luis Ignacio Gonzalez; Prader, Seraina; Reisli, Ismail; Slatter, Mary; Rodríguez-Gallego, Carlos; Arkwright, Peter D.; Bethune, Claire; Deripapa, Elena; Sharapova, Svetlana O.; Lehmberg, Kai; Davies, E. Graham (Springer New York, 2021-11)
    Patients with ataxia-telangiectasia (A-T) suffer from progressive cerebellar ataxia, immunodeficiency, respiratory failure, and cancer susceptibility. From a clinical point of view, A-T patients with IgA deficiency show ...
  • Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing 
    Langereis, Jeroen D.; van der Molen, Renate G.; de Kat Angelino, Corrie; Henriet, Stefanie S.; de Jonge, Marien I.; Joosten, Irma; Simons, Annet; Schuurs-Hoeijmakers, Janneke H.M.; van Deuren, Marcel; van Aerde, Koen; van der Flier, Michiel (Nature Publishing Group, 2021)
    Objectives: Complete deficiency of alternative pathway (AP) complement factors, explained by homozygous mutations, is a well-known risk factor for invasive bacterial infections; however, this is less obvious for heterozygous ...
  • Grading of invasive breast carcinoma: the way forward 
    van Dooijeweert, C; van Diest, P J; Ellis, I O (Springer-Verlag, 2022-01)
    Histologic grading has been a simple and inexpensive method to assess tumor behavior and prognosis of invasive breast cancer grading, thereby identifying patients at risk for adverse outcomes, who may be eligible for ...
  • Quality of Life After Stereotactic Body Radiation Therapy Versus Conventional Radiation Therapy in Patients With Bone Metastases 
    Pielkenrood, Bart J; Gal, Roxanne; Kasperts, Nicolien; Verhoeff, Joost Jc; Bartels, Marcia Mtj; Seravalli, Enrica; van der Linden, Yvette M; Monninkhof, Evelyn M; Verlaan, Jorrit-Jan; van der Velden, Joanne M; Verkooijen, Helena M (Elsevier, 2022-04-01)
    Purpose: Painful bone metastases hamper quality of life (QoL). The aim of this prespecified secondary analysis of the PRESENT trial was to compare change in global QoL, physical functioning, emotional functioning, functional ...
  • Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles 
    Evers, Martijn J W; Du, Wenjuan; Yang, Qiangbing; Kooijmans, Sander A A; Vink, Arjan; van Steenbergen, Mies; Vader, Pieter; de Jager, Saskia C A; Fuchs, Sabine A; Mastrobattista, Enrico; Sluijter, Joost P G; Lei, Zhiyong; Schiffelers, Raymond (Elsevier, 2022-03)
    Lipid Nanoparticles (LNPs) are a promising drug delivery vehicle for clinical siRNA delivery. Modified mRNA (modRNA) has recently gained great attention as a therapeutic molecule in cardiac regeneration. However, for mRNA ...
  • KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern 
    LifeLines Cohort Study (American Society for Clinical Investigation, 2019-12-05)
    BACKGROUND: The presence of an early repolarization pattern (ERP) on the surface ECG is associated with risk of ventricular fibrillation and sudden cardiac death. Family studies have shown that ERP is a highly heritable ...
  • Genetically Determined High Levels of Iron Parameters Are Protective for Coronary Artery Disease 
    Grote Beverborg, Niels; Said, M Abdullah; van der Wal, Haye H; Verweij, Niek; van der Meer, Peter; van der Harst, Pim (Lippincott Williams & Wilkins, 2020-02)
  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci 
    LifeLines Cohort Study (Springer Nature, 2021-06)
    Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses ...