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Now showing items 13641-13660 of 40729

Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study

Groot, Hilde E; van de Vegte, Yordi J; Verweij, Niek; Lipsic, Erik; Karper, Jacco C; van der Harst, Pim (Nature Publishing Group, 2020-09-08)

Small-scale studies have suggested a link between the human gut microbiome and highly prevalent diseases. However, the extent to which the human gut microbiome can be considered a determinant of disease and healthy aging ...
Safety and Tolerability of Sodium Thiosulfate in Patients with an Acute Coronary Syndrome Undergoing Coronary Angiography: A Dose-Escalation Safety Pilot Study (SAFE-ACS)

de Koning, Marie-Sophie L Y; Assa, Solmaz; Maagdenberg, Carlijn G; van Veldhuisen, Dirk J; Pasch, Andreas; van Goor, Harry; Lipsic, Erik; van der Harst, Pim (Wiley-Blackwell, 2020)

Background: In animal studies, hydrogen sulfide (H2S) has been shown to protect the heart from ischemia-reperfusion injury. This study evaluates the safety and tolerability of the H2S donor sodium thiosulfate (STS) in ...
Associations of Observational and Genetically Determined Caffeine Intake With Coronary Artery Disease and Diabetes Mellitus

Said, M Abdullah; van de Vegte, Yordi J; Verweij, Niek; van der Harst, Pim (Wiley-Blackwell, 2020-12-15)

BACKGROUND: Caffeine is the most widely consumed psychostimulant and is associated with lower risk of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). However, whether these associations are causal remains ...
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

CORtisol NETwork (CORNET) consortium (Springer Nature, 2021-06)

The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning ...
Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross-Sectional Results of the Population-Based ImaLife Study

Xia, Congying; Vonder, Marleen; Sidorenkov, Grigory; Ma, Runlei; Oudkerk, Matthijs; van der Harst, Pim; De Deyn, Peter Paul; Vliegenthart, Rozemarijn (Wiley-Blackwell, 2021-02-16)

Background The aim of this study was to investigate whether increased severity of coronary artery calcium (CAC), an imaging biomarker of subclinical coronary atherosclerosis, is associated with worse cognitive function ...
Effect of metabolic genetic variants on long-term disease comorbidity in patients with type 2 diabetes

Abedian, Shifteh; Abbasi, Ali; de Boer, Anthonius; Stricker, Bruno H; Bakker, Stephan J L; van der Harst, Pim; Sedaghat, Sanaz; Darvishian, Maryam; Ikram, M Arfan; Navis, Gerjan; Dehghan, Abbas; Pen, Ido; Stolk, Ronald P; Snieder, Harold; Klungel, Olaf H; Souverein, Patrick; Alizadeh, Behrooz Z (Nature Publishing Group, 2021-02-02)

Underlying genetic determinants contribute to developing type 2 diabetes (T2D) future diseases. The present study aimed to identify which genetic variants are associated with the incident of the major T2D co-morbid disease. ...
Heritability analyses of resting heart rate: Is it relevant?

Ahmadizar, Fariba; Kavousi, Maryam; van der Harst, Pim (Oxford University Press, 2021-11)
Genetically-determined body mass index and the risk of atrial fibrillation progression in men and women

Siland, J E; Nguyen, B O; de With, R R; Van Gelder, I C; van der Harst, P; Rienstra, M (Public Library of Science, 2021)

AIMS: Limited causal evidence is available on the relationship between body mass index (BMI) and atrial fibrillation (AF) progression. Sex differences have been noted and may be relevant for AF progression. We investigated ...
Translational insights from single-cell technologies across the cardiovascular disease continuum

van Blokland, Irene V; Groot, Hilde E; Franke, Lude H; van der Wijst, Monique G P; van der Harst, Pim (Elsevier, 2022-04)

Cardiovascular disease is the leading cause of death worldwide. The societal health burden it represents can be reduced by taking preventive measures and developing more effective therapies. Reaching these goals, however, ...
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein(a) Concentration: Protective Missense Variant on Lipoprotein(a) Concentration-Brief Report

Said, M Abdullah; Yeung, Ming Wai; van de Vegte, Yordi J; Benjamins, Jan Walter; Dullaart, Robin P F; Ruotsalainen, Sanni; Ripatti, Samuli; Natarajan, Pradeep; Juarez-Orozco, Luis Eduardo; Verweij, Niek; van der Harst, P (Lippincott Williams & Wilkins, 2021-05-05)

Objective: Lipoprotein(a) (Lp[a]) is associated with coronary artery disease (CAD) but also to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp(a) remains incompletely understood, as well as its ...
Improving patient identification for advanced cardiac imaging through machine learning-integration of clinical and coronary CT angiography data

Benjamins, Jan Walter; Yeung, Ming Wai; Maaniitty, Teemu; Saraste, Antti; Klén, Riku; van der Harst, Pim; Knuuti, Juhani; Juarez-Orozco, Luis Eduardo (Elsevier Ireland Ltd, 2021-07-15)

BACKGROUND: Standard computed tomography angiography (CTA) outputs a myriad of interrelated variables in the evaluation of suspected coronary artery disease (CAD). But an important proportion of obstructive lesions does ...
Atrial fibrillation and left atrial size and function: a Mendelian randomization study

van de Vegte, Yordi J; Siland, Joylene E; Rienstra, Michiel; van der Harst, Pim (Nature Publishing Group, 2021-04-19)

Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested enlarged atria as both cause and consequence of AF. The aim of this study is to investigate the causal association between AF and ...
Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics

Arbustini, Eloisa; Behr, Elijah R; Carrier, Lucie; van Duijn, Cornelia; Evans, Paul; Favalli, Valentina; van der Harst, Pim; Haugaa, Kristina Hermann; Jondeau, Guillaume; Kääb, Stefan; Kaski, Juan Pablo; Kavousi, Maryam; Loeys, Bart; Pantazis, Antonis; Pinto, Yigal; Schunkert, Heribert; Di Toro, Alessandro; Thum, Thomas; Urtis, Mario; Waltenberger, Johannes; Elliott, Perry (Oxford University Press, 2022-05-21)

This document describes the contribution of clinical criteria to the interpretation of genetic variants using heritable Mendelian cardiomyopathies as an example. The aim is to assist cardiologists in defining the clinical ...
Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years

van Zeventer, Isabelle A; Salzbrunn, Jonas B; de Graaf, Aniek O; van der Reijden, Bert A; Boezen, H Marike; Vonk, Judith M; van der Harst, Pim; Schuringa, Jan Jacob; Jansen, Joop H; Huls, Gerwin (The American Society of Hematology, 2021-04-27)

Clonal hematopoiesis (CH), characterized by a fraction of peripheral blood cells carrying an acquired genetic variant, emerges with age. Although in general CH is associated with increased mortality and morbidity, no higher ...
Image-based analysis of skeletal muscle mass predicts cisplatin dose-limiting toxicity in patients with locally advanced head and neck cancer

Chargi, Najiba; Bashiri, Fereshta; Wendrich, Anne W.; Smid, Ernst J.; de Jong, Pim A.; Huitema, Alwin D.R.; Devriese, Lot A.; de Bree, Remco (Springer-Verlag, 2022-07)

Purpose: Evidence suggests that patients’ skeletal muscle mass (SMM) can predict the patients at risk for cisplatin dose-limiting toxicities (DLT). Cisplatin is currently dosed on body surface area (BSA). The predictive ...
Reply to the Letter to the Editor: "It is urgent to evaluate the efficacy and safety of genotype guided antiplatelet therapy in patients after percutaneous coronary intervention in East Asian"

Al-Rubaish, Abdullah M; Al-Muhanna, Fahad A; Alshehri, Abdullah M; Al-Mansori, Mohammed A; Alali, Rudaynah A; Khalil, Rania M; Al-Faraidy, Khalid A; Cyrus, Cyril; Sulieman, Mohammed M; Vatte, Chittibabu; Loza, Bao-Li; Claassens, Daniel M F; Asselbergs, Folkert W; Al-Ali, Amein K (Elsevier Ireland Ltd, 2022-02-01)
Comprehensive trends in incidence, treatment, survival and mortality of first primary invasive breast cancer stratified by age, stage and receptor subtype in the Netherlands between 1989 and 2017

van der Meer, Daniël J.; Kramer, Iris; van Maaren, Marissa C.; van Diest, Paul J.; C. Linn, Sabine; Maduro, John H.; J.A. Strobbe, Luc; Siesling, Sabine; Schmidt, Marjanka K.; Voogd, Adri C. (John Wiley & Sons Inc., 2021-05-01)

Our study aimed to provide a comprehensive overview of trends in incidence, survival, mortality and treatment of first primary invasive breast cancer (BC), according to age, stage and receptor subtype in the Netherlands ...
No Influence of Previous Coxiella burnetii Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2

Weehuizen, Jesper M.; Spronsen, Rik van; Hoepelman, Andy I.M.; Bleeker-Rovers, Chantal P.; Oosterheert, Jan Jelrik; Wever, Peter C. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-20)

Background: the geographical similarities of the Dutch 2007–2010 Q fever outbreak and the start of the 2020 coronavirus disease 19 (COVID-19) outbreak in the Netherlands raised questions and provided a unique opportunity ...
Lack of association between CDKN2A germline mutations and survival in patients with melanoma: A retrospective cohort study

Netherlands Foundation for Detection of Hereditary Tumors collaborative investigators (Mosby Inc., 2022-08)
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

The International Immuno-Oncology Biomarker Working Group (Elsevier, 2021-12)

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes ...

Now showing items 13641-13660 of 40729