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Now showing items 13601-13620 of 40729

Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress

Katrinli, Seyma; Maihofer, Adam X; Wani, Agaz H; Pfeiffer, John R; Ketema, Elizabeth; Ratanatharathorn, Andrew; Baker, Dewleen G; Boks, Marco P; Geuze, Elbert; Kessler, Ronald C; Risbrough, Victoria B; Rutten, Bart P F; Stein, Murray B; Ursano, Robert J; Vermetten, Eric; Logue, Mark W; Nievergelt, Caroline M; Smith, Alicia K; Uddin, Monica (Springer Nature, 2022-03)

Epigenetic factors modify the effects of environmental factors on biological outcomes. Identification of epigenetic changes that associate with PTSD is therefore a crucial step in deciphering mechanisms of risk and resilience. ...
Long-term risk for mental health symptoms in Dutch ISAF veterans: the role of perceived social support

van der Wal, Sija J; Geuze, Elbert; Vermetten, Eric (Cambridge University Press, 2023-06)

BACKGROUND: Military personnel deployed to combat and peacekeeping missions are exposed to high rates of traumatic events. Accumulating evidence suggests an important association between deployment and the development of ...
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume

Zheng, Yuanchao; Garrett, Melanie E; Sun, Delin; Clarke-Rubright, Emily K; Haswell, Courtney C; Maihofer, Adam X; Elman, Jeremy A; Franz, Carol E; Lyons, Michael J; Kremen, William S; Peverill, Matthew; Sambrook, Kelly; McLaughlin, Katie A; Davenport, Nicholas D; Disner, Seth; Sponheim, Scott R; Andrew, Elpiniki; Korgaonkar, Mayuresh; Bryant, Richard; Varkevisser, Tim; Geuze, Elbert; Coleman, Jonathan; Beckham, Jean C; Kimbrel, Nathan A; Sullivan, Danielle; Miller, Mark; Hayes, Jasmeet; Verfaellie, Mieke; Wolf, Erika; Salat, David; Spielberg, Jeffrey M; Milberg, William; McGlinchey, Regina; Dennis, Emily L; Thompson, Paul M; Medland, Sarah; Jahanshad, Neda; Nievergelt, Caroline M; Ashley-Koch, Allison E; Logue, Mark W; Morey, Rajendra A (Nature Publishing Group, 2021-12-16)

The volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, environmental effects such as trauma, and disease effects such as posttraumatic stress disorder ...
Cardiometabolic Profiles in Women with a History of Hypertensive and Normotensive Fetal Growth Restriction

Bijl, Rianne C; Cornette, Jérôme M J; Vasak, Blanka; Franx, Arie; Lely, A Titia; Bots, Michiel L; van Rijn, Bas B; Koster, Maria P H (Mary Ann Liebert Inc., 2022-01-12)

Background: The majority of evidence on associations between pregnancy complications and future maternal disease focuses on hypertensive (Ht) complications. We hypothesize that impaired cardiometabolic health after pregnancies ...
EXPloring attitudes and factors influencing reproductive Choices in kidney Transplant patients (The EXPECT-study)

van Buren, Marleen C; Beck, Denise K; Lely, A Titia; van de Wetering, Jacqueline; Massey, Emma K (Wiley-Blackwell, 2021-12)

Pregnancy can have risks after kidney transplantation (KT). This mixed-methods study aimed to identify the percentage of women getting pregnant after KT and explore motives for and against pregnancy together with psychosocial ...
Maternal sildenafil vs placebo in pregnant women with severe early-onset fetal growth restriction: A randomized clinical trial

Pels, Anouk; Derks, Jan; Elvan-Taspinar, Ayten; Van Drongelen, Joris; De Boer, Marjon; Duvekot, Hans; Van Laar, Judith; Van Eyck, Jim; Al-Nasiry, Salwan; Sueters, Marieke; Post, Marinka; Onland, Wes; Van Wassenaer-Leemhuis, Aleid; Naaktgeboren, Christiana; Jakobsen, Janus C.; Gluud, Christian; Duijnhoven, Ruben G.; Lely, Titia; Gordijn, Sanne; Ganzevoort, Wessel (American Medical Association, 2020-06-01)

Importance: Severe early onset fetal growth restriction caused by placental dysfunction leads to high rates of perinatal mortality and neonatal morbidity. The phosphodiesterase 5 inhibitor, sildenafil, inhibits cyclic ...
Long-term graft survival and graft function following pregnancy in kidney transplant recipients: A systematic review and meta-analysis

Van Buren, Marleen C.; Schellekens, Anouk; Groenhof, T. Katrien J.; Van Reekum, Franka; Van De Wetering, Jacqueline; Paauw, Nina D.; Lely, A. Titia (Lippincott Williams & Wilkins, 2020-08-01)

Background. The incidence of pregnancy in kidney transplantation (KT) recipients is increasing. Studies report that the incidence of graft loss (GL) during pregnancy is low, but less data are available on long-term effects ...
On the use of intravenous immunoglobulins for the treatment of the antiphospholipid syndrome – A systematic review and meta-analysis

Lalmahomed, Tariq Anwar; Walter, Isabel Johanna; Lely, Anne Titia; Bloemenkamp, Katharina Wilhelmina Maria; Kooiman, Judith; Limper, Maarten (Elsevier, 2021-06)
Systematic Reviews and Meta-Analyses across Species Are Critical to Improve Clinical Translation of Therapeutic Agents for Placental Insufficiency Syndromes

Terstappen, Fieke; Ganzevoort, Wessel; Lely, A. Titia (Lippincott Williams & Wilkins, 2021-02)
Pregnancy outcome predictors in antiphospholipid syndrome: A systematic review and meta-analysis

Walter, Isabel Johanna; Klein Haneveld, Mirthe Jasmijn; Lely, Anne Titia; Bloemenkamp, Katharina Wilhelmina Maria; Limper, Maarten; Kooiman, Judith (Elsevier, 2021-10)

Objective: To identify and assess the magnitude of effect of pregnancy outcome predictors in women with antiphospholipid syndrome (APS) by means of systematic review and meta-analysis. Methods: PubMed and Embase were ...
Effect of Pregnancy on EGFR After Kidney Transplantation: a National Cohort Study

van Buren, Marleen C; Gosselink, Margriet; Groen, Henk; van Hamersvelt, Henk; de Jong, Margriet; de Borst, Martin H; Zietse, Robert; van de Wetering, Jacqueline; Lely, A Titia; PARTOUT working group (Lippincott Williams & Wilkins, 2022-06-01)

BACKGROUND: The effect of pregnancy on the course of estimated glomerular filtration rate (eGFR) is unknown in kidney transplant recipients (KTRs). METHODS: We conducted a nationwide multicenter cohort study in KTRs with ...
Comparison of pregnancy outcomes in Dutch kidney recipients with and without calcineurin inhibitor exposure: a retrospective study

Members of the PARTOUT network* (Wiley-Blackwell, 2021-12)

Within pregnancies occurring between 1986 and 2017 in Dutch kidney transplant recipients (KTR), we retrospectively compared short-term maternal and foetal outcomes between patients on calcineurin inhibitor (CNI) based ...
Maternal, Decidual, and Neonatal Lymphocyte Composition Is Affected in Pregnant Kidney Transplant Recipients

Feyaerts, Dorien; Gillard, Joshua; van Cranenbroek, Bram; Rigodanzo Marins, Lina; Baghdady, Mariam M S; Comitini, Gaia; Lely, A Titia; van Hamersvelt, Henk W; van der Heijden, Olivier W H; Joosten, Irma; van der Molen, Renate G (Frontiers Media S. A., 2021)

Pregnancy after renal transplantation is associated with an increased risk of complications. While a delicately balanced uterine immune system is essential for a successful pregnancy, little is known about the uterine ...
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression

Muilwijk, Danya; de Poel, Eyleen; van Mourik, Peter; Suen, Sylvia W F; Vonk, Annelotte M; Brunsveld, Jesse E; Kruisselbrink, Evelien; Oppelaar, Hugo; Hagemeijer, Marne C; Berkers, Gitte; de Winter-de Groot, Karin M; Heida-Michel, Sabine; Jans, Stephan R; van Panhuis, Hannah; van der Eerden, Menno M; van der Meer, Renske; Roukema, Jolt; Dompeling, Edward; Weersink, Els J M; Koppelman, Gerard H; Vries, Robert; Zomer-van Ommen, Domenique D; Eijkemans, Marinus J C; van der Ent, Cornelis K; Beekman, Jeffrey M (European Respiratory Society, 2022-08-01)

Rationale Cystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here we assessed the association of forskolin-induced ...
Twenty Years On: RECIST as a Biomarker of Response in Solid Tumours an EORTC Imaging Group - ESOI Joint Paper

Fournier, Laure; de Geus-Oei, Lioe-Fee; Regge, Daniele; Oprea-Lager, Daniela-Elena; D'Anastasi, Melvin; Bidaut, Luc; Bäuerle, Tobias; Lopci, Egesta; Cappello, Giovanni; Lecouvet, Frederic; Mayerhoefer, Marius; Kunz, Wolfgang G; Verhoeff, Joost J C; Caruso, Damiano; Smits, Marion; Hoffmann, Ralf-Thorsten; Gourtsoyianni, Sofia; Beets-Tan, Regina; Neri, Emanuele; deSouza, Nandita M; Deroose, Christophe M; Caramella, Caroline (Frontiers Media S. A., 2021)

Response evaluation criteria in solid tumours (RECIST) v1.1 are currently the reference standard for evaluating efficacy of therapies in patients with solid tumours who are included in clinical trials, and they are widely ...
Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Bollen, Yannik; Hageman, Joris H; van Leenen, Petra; Derks, Lucca L M; Ponsioen, Bas; Buissant des Amorie, Julian R; Verlaan-Klink, Ingrid; van den Bos, Myrna; Terstappen, Leon W M M; van Boxtel, Ruben; Snippert, Hugo J G (Public Library of Science, 2022-01-28)

AU CRISPR-associated: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly nucleases are powerful tools for precise : genome editing of model systems, including human organoids. Current methods describing fluorescent ...
Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study

VX14-661-110 study group (Elsevier Limited, 2021-07)

Background: Tezacaftor–ivacaftor is an approved cystic fibrosis transmembrane conductance regulator (CFTR) modulator shown to be efficacious and generally safe and well tolerated over 8–24 weeks in phase 3 clinical studies ...
Official ERS technical standard: Global lung function initiative reference values for static lung volumes in individuals of european ancestry

Hall, Graham L.; Filipow, Nicole; Ruppel, Gregg; Okitika, Tolu; Thompson, Bruce; Kirkby, Jane; Steenbruggen, Irene; Cooper, Brendan G.; Stanojevic, Sanja; GLI Network members (European Respiratory Society, 2021)

Background: Measurement of lung volumes across the life course is critical to the diagnosis and management of lung disease. The aim of the study was to use the Global Lung Function Initiative methodology to develop all-age ...
Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study

Gerritsen, Lotte; Sigurdsson, Sigurdur; Jonsson, Palmi V; Gudnason, Vilmundur; Launer, Lenore J; Geerlings, Mirjam I (Elsevier, 2022-03)

Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD. In 4354 participants (76 ± 5 years; 58% female) from the Age, Gene/Environment ...
Depression and Dementia: The Role of Cortisol and Vascular Brain Lesions. AGES-Reykjavik Study

Gerritsen, Lotte; Twait, Emma L; Jonsson, Palmi V; Gudnason, Vilmundur; Launer, Lenore J; Geerlings, Mirjam I (IOS Press, 2022)

BACKGROUND: Late-life depression (LLD) is related to an increased risk of developing dementia; however, the biological mechanisms explaining this relationship remain unclear. OBJECTIVE: To determine whether the relationship ...

Now showing items 13601-13620 of 40729