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UMC Repository: Recent submissions

  • Congenital tracheobronchomegaly (Mounier-kuhn syndrome) in a 28-year-old zambian male: A case report 
    Shahin, Saifurrahman; Hoffman, Thijs; van Es, Wouter; Grutters, Jan; Mateyo, Kondwelani (Pan African Medical Journal, 2021-09-01)
    Congenital tracheobronchomegaly, also known as Mounier Kuhn Syndrome (MKS) is a rare respiratory disorder characterized by dilatation of the trachea and bronchi. We report a case of a 28-year-old male of African descent ...
  • Neutrophil count, lymphocyte count and neutrophil-to-lymphocyte ratio in relation to response to adjunctive dexamethasone treatment in community-acquired pneumonia 
    Santeon-CAP study group (Elsevier, 2022-02)
    Background: It is hypothesised that community-acquired pneumonia (CAP) patients with more severe disease or inflammation might benefit more from adjunctive corticosteroid treatment. Neutrophil count, lymphocyte count and ...
  • The use of online visual analogue scales in idiopathic pulmonary fibrosis 
    Moor, Catharina C.; Mostard, Remy L.M.; Grutters, Jan C.; Bresser, Paul; Wijsenbeek, Marlies S. (European Respiratory Society, 2022-01-01)
  • Thrombosis pathways in COVID-19 vs. influenza-associated ARDS: a targeted proteomics approach 
    Rademaker, Emma; Doorduijn, Dennis J; Kusadasi, Nuray; Maas, Coen; Drylewicz, Julia; Huisman, Albert; Hoefer, Imo E; Bonten, Marc J M; Derde, Lennie P G; Rooijakkers, Suzan H M; Cremer, Olaf L (Wiley-Blackwell, 2022-05)
    Background: Pulmonary embolism (PE) occurs in one-third of critically-ill COVID-19 patients. Although prior studies identified several pathways contributing to thrombogenicity, it is unknown whether this is COVID-19-specific ...
  • The association between patient satisfaction with information and adherence to oral anticancer agents 
    Melis, Eward J; Zwart-van Rijkom, Jeannette Ef; Egberts, Toine Cg; van den Bemt, Bart Jf; Witteveen, Petronella O; Gardarsdottir, Helga (SAGE Publications Ltd, 2023-04)
    INTRODUCTION: Adherence to anticancer agents is a critical factor in achieving adequate clinical response, and became a major challenge for patients and caregivers since the increased substitution of parenteral cytostatic ...
  • Mineralocorticoid receptor status in the human brain after dexamethasone treatment: a single case study 
    Koning, Anne Sophie C.A.M.; Habets, Philippe C.; Bogaards, Marit; Kroon, Jan; van Santen, Hanneke M.; de Bont, Judith M.; Meijer, Onno C. (BioScientifica Ltd., 2022-03-14)
    Background: Synthetic glucocorticoids like dexamethasone can cause severe neuropsychiatric effects. They preferentially bind to the glucocorticoid receptor (GR) over the mineralocorticoid receptor (MR). High dosages result ...
  • An update on the use of tolvaptan for autosomal dominant polycystic kidney disease: consensus statement on behalf of the ERA Working Group on Inherited Kidney Disorders, the European Rare Kidney Disease Reference Network and Polycystic Kidney Disease International 
    Müller, Roman-Ulrich; Messchendorp, A Lianne; Birn, Henrik; Capasso, Giovambattista; Gall, Emilie Cornec-Le; Devuyst, Olivier; van Eerde, Albertien; Guirchon, Patrick; Harris, Tess; Hoorn, Ewout J; Knoers, Nine V A M; Korst, Uwe; Mekahli, Djalila; Meur, Yannick Le; Nijenhuis, Tom; Ong, Albert C M; Sayer, John A; Schaefer, Franz; Servais, Aude; Tesar, Vladimir; Torra, Roser; Walsh, Stephen B; Gansevoort, Ron T (Oxford University Press, 2022-05-01)
    Approval of the vasopressin V2 receptor antagonist tolvaptan-based on the landmark TEMPO 3:4 trial-marked a transformation in the management of autosomal dominant polycystic kidney disease (ADPKD). This development has ...
  • Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study 
    Alberga, Anna J; Karthaus, Eleonora G; Wilschut, Janneke A; de Bruin, Jorg L; Akkersdijk, George P; Geelkerken, Robert H; Hamming, Jaap F; Wever, Jan J; Verhagen, Hence J M; Dutch Society of Vascular Surgery; de Borst, Gert Jan; van Hattum, Eline; van Herwaarden, Joost A.; Petri, Bart-Jeroen; Toorop, RJ (W.B. Saunders Ltd, 2022-02)
    Objective: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of ...
  • Basal ganglia calcifications: No association with cognitive function 
    de Brouwer, Esther JM; Golüke, Nienke MS; Claus, Jules J; Staekenborg, Salka S; Emmelot-Vonk, Mariëlle H; de Jong, Pim A; Koek, Huiberdina L; De Jonghe, Annemarieke (Elsevier Masson, 2023-03)
    BACKGROUND AND PURPOSE: Basal ganglia calcifications (BGC), a form of vascular calcification, are a common brain computed tomography (CT) finding. We investigated whether BGC are associated with cognitive function and ...
  • Trends in Distal Esophageal and Gastroesophageal Junction Cancer Care: The Dutch Nationwide Ivory Study 
    Kalff, Marianne C; Henegouwen, Mark I van Berge; Baas, Peter C; Bahadoer, Renu R; Belt, Eric J T; Brattinga, Baukje; Claassen, Linda; Ćosović, Admira; Crull, David; Daams, Freek; van Dalsen, Annette D; Dekker, Jan Willem T; van Det, Marc J; Drost, Manon; van Duijvendijk, Peter; Eshuis, Wietse J; van Esser, Stijn; Gaspersz, Marcia P; Görgec, Burak; Groenendijk, Richard P R; Hartgrink, Henk H; van der Harst, Erwin; Haveman, Jan Willem; Heisterkamp, Joos; van Hillegersberg, Richard; Kelder, Wendy; Kingma, B Feike; Koemans, Willem J; Kouwenhoven, Ewout A; Lagarde, Sjoerd M; Lecot, Frederik; van der Linden, Philip P; Luyer, Misha D P; Nieuwenhuijzen, Grard A P; Olthof, Pim B; van der Peet, Donald L; Pierie, Jean-Pierre E N; Pierik, E G J M Robert; Plat, Victor D; Polat, Fatih; Rosman, Camiel; Ruurda, Jelle P; van Sandick, Johanna W; Scheer, Rene; Slootmans, Cettela A M; Sosef, Meindert N; Sosef, Odin V; de Steur, Wobbe O; Stockmann, Hein B A C; Stoop, Fanny J; Voeten, Daan M; Vugts, Guusje; Vijgen, Guy H E J; Weeda, Víola B; Wiezer, Marinus J; van Oijen, Martijn G H; Gisbertz, Suzanne S (Lippincott Williams & Wilkins, 2023-04)
    Objective: This study evaluated the nationwide trends in care and accompanied postoperative outcomes for patients with distal esophageal and gastro-esophageal junction cancer. Summary of Background Data: The introduction ...
  • Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke 
    Yanev, Pavel; van Tilborg, Geralda A.F.; van der Toorn, Annette; Kong, Xiangmei; Stowe, Ann M.; Dijkhuizen, Rick M. (SAGE Publications Inc., 2022-06)
    Injectable hydrogels can generate and support pro-repair environments in injured tissue. Here we used a slow-releasing drug carrying in situ-forming hydrogel to promote post-stroke recovery in a rat model. Release kinetics ...
  • Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis 
    Rowald, Andreas; Komi, Salif; Demesmaeker, Robin; Baaklini, Edeny; Hernandez-Charpak, Sergio Daniel; Paoles, Edoardo; Montanaro, Hazael; Cassara, Antonino; Becce, Fabio; Lloyd, Bryn; Newton, Taylor; Ravier, Jimmy; Kinany, Nawal; D'Ercole, Marina; Paley, Aurélie; Hankov, Nicolas; Varescon, Camille; McCracken, Laura; Vat, Molywan; Caban, Miroslav; Watrin, Anne; Jacquet, Charlotte; Bole-Feysot, Léa; Harte, Cathal; Lorach, Henri; Galvez, Andrea; Tschopp, Manon; Herrmann, Natacha; Wacker, Moïra; Geernaert, Lionel; Fodor, Isabelle; Radevich, Valentin; Van Den Keybus, Katrien; Eberle, Grégoire; Pralong, Etienne; Roulet, Maxime; Ledoux, Jean-Baptiste; Fornari, Eleonora; Mandija, Stefano; Mattera, Loan; Martuzzi, Roberto; Nazarian, Bruno; Benkler, Stefan; Callegari, Simone; Greiner, Nathan; Fuhrer, Benjamin; Froeling, Martijn; Buse, Nik; Denison, Tim; Buschman, Rik; Wende, Christian; Ganty, Damien; Bakker, Jurriaan; Delattre, Vincent; Lambert, Hendrik; Minassian, Karen; van den Berg, Cornelis A T; Kavounoudias, Anne; Micera, Silvestro; Van De Ville, Dimitri; Barraud, Quentin; Kurt, Erkan; Kuster, Niels; Neufeld, Esra; Capogrosso, Marco; Asboth, Leonie; Wagner, Fabien B; Bloch, Jocelyne; Courtine, Grégoire (Nature Research, 2022-02)
    Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were ...
  • Turnover of Murine Cytomegalovirus-Expanded CD8+ T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response 
    Baliu-Piqué, Mariona; Drylewicz, Julia; Zheng, Xiaoyan; Borkner, Lisa; Swain, Arpit C.; Otto, Sigrid A.; de Boer, Rob J.; Tesselaar, Kiki; Cicin-Sain, Luka; Borghans, José A.M. (American Association of Immunologists, 2022-02-15)
    The potential of memory T cells to provide protection against reinfection is beyond question. Yet, it remains debated whether long-term T cell memory is due to long-lived memory cells. There is ample evidence that blood-derived ...
  • Clinical and Molecular Diagnosis of Osteocraniostenosis in Fetuses and Newborns: Prenatal Ultrasound, Clinical, Radiological and Pathological Features 
    Rosato, Simonetta; Unger, Sheila; Campos-Xavier, Belinda; Caraffi, Stefano Giuseppe; Beltrami, Laura; Pollazzon, Marzia; Ivanovski, Ivan; Castori, Marco; Bonasoni, Maria Paola; Comitini, Giuseppina; Nikkels, Peter G.J.; Lindstrom, Kristin; Umandap, Christine; Superti-Furga, Andrea; Garavelli, Livia (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02)
    Osteocraniostenosis (OCS, OMIM #602361) is a severe, usually lethal condition characterized by gracile bones with thin diaphyses, a cloverleaf-shaped skull and splenic hypo/aplasia. The condition is caused by heterozygous ...
  • How age and infection history shape the antigen-specific CD8+ T-cell repertoire: Implications for vaccination strategies in older adults 
    Lanfermeijer, Josien; Borghans, José A.M.; van Baarle, Debbie (Wiley-Blackwell, 2020-11)
    Older adults often show signs of impaired CD8+ T-cell immunity, reflected by weaker responses against new infections and vaccinations, and decreased protection against reinfection. This immune impairment is in part thought ...
  • Latent CMV Infection Is Associated With Lower Influenza Virus-Specific Memory T-Cell Frequencies, but Not With an Impaired T-Cell Response to Acute Influenza Virus Infection 
    van den Berg, Sara P.H.; Lanfermeijer, Josien; Jacobi, Ronald H.J.; Hendriks, Marion; Vos, Martijn; van Schuijlenburg, Roos; Nanlohy, Nening M.; Borghans, José A.M.; van Beek, Josine; van Baarle, Debbie; de Wit, Jelle (Frontiers Media S. A., 2021-05-05)
    Latent infection with cytomegalovirus (CMV) is assumed to contribute to the age-associated decline of the immune system. CMV induces large changes in the T-cell pool and may thereby affect other immune responses. CMV is ...
  • Longitudinal characterization of the mumps-specific HLA-A2 restricted T-cell response after mumps virus infection 
    Lanfermeijer, Josien; Nühn, Marieke M.; Emmelot, Maarten E.; Poelen, Martien C.M.; van Els, Cécile A.C.M.; Borghans, José A.M.; van Baarle, Debbie; Kaaijk, Patricia; de Wit, Jelle (Multidisciplinary Digital Publishing Institute, 2021-12)
    Waning of the mumps virus (MuV)-specific humoral response after vaccination has been suggested as a cause for recent mumps outbreaks in vaccinated young adults, although it cannot explain all cases. Moreover, CD8+ T cells ...
  • Impact of the SARS-CoV-2 pandemic on trauma care: a nationwide observational study 
    Driessen, Mitchell L S; van Ditshuizen, Jan C; Waalwijk, Job F; van den Bunt, Gerrita; IJpma, Frank F A; Reininga, Inge H F; Fiddelers, Audrey A; Habets, Karin; Homma, Paulien C M; van den Berg, Marleen H; Bloemers, Frank W; Schipper, Inger B; Leenen, Luke P H; de Jongh, Mariska A C (Springer International Publishing AG, 2022-08)
    PURPOSE: The SARS-CoV-2 pandemic severely disrupted society and the health care system. In addition to epidemiological changes, little is known about the pandemic's effects on the trauma care chain. Therefore, in addition ...
  • The effect of shared decision-making on recovery from non-chronic aspecific low back pain in primary care; a post-hoc analysis from the patient, physician and observer perspectives 
    Sanders, Ariëtte R.J.; de Wit, Niek J.; Zuithoff, Nicolaas P.A.; van Dulmen, Sandra (BioMed Central Ltd., 2022-02-02)
    BACKGROUND: Although shared decision-making (SDM) is increasingly accepted in healthcare and has demonstrated merits for several psychological outcomes, the effect on recovery from somatic conditions is still subject to ...
  • The pace of a trauma resuscitation: experience matters 
    Maarseveen, Oscar E C van; Ham, Wietske H W; Huijsmans, Roel L N; Leenen, Luke P H (Springer International Publishing AG, 2022-06)
    Purpose: Resuscitation quality and pace depend on effective team coordination, which can be facilitated by adequate leadership. Our primary aim was to assess the influence of trauma team leader experience on resuscitation ...