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UMC Repository: Recent submissions

  • RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study 
    Raasveld, Senta Jorinde; Karami, Mina; van den Bergh, Walter M.; Oude Lansink-Hartgring, Annemieke; van der Velde, Franciska; Maas, Jacinta J.; van de Berg, Pablo; de Haan, Maarten; Lorusso, Roberto; Delnoij, Thijs S.R.; Dos Reis Miranda, Dinis; Mandigers, Loes; Scholten, Erik; Overmars, Martijn; Silvio Taccone, Fabio; Brasseur, Alexandre; Dauwe, Dieter F.; De Troy, Erwin; Hermans, Greet; Meersseman, Philippe; Pappalardo, Federico; Fominskiy, Evgeny; Ivancan, Višnja; Bojčić, Robert; de Metz, Jesse; van den Bogaard, Bas; Donker, Dirk W.; Meuwese, Christiaan L.; de Bakker, Martin; Reddi, Benjamin; de Bruin, Sanne; Lagrand, Wim K.; Henriques, José P.S.; Broman, Lars M.; Vlaar, Alexander P.J. (Lippincott Williams & Wilkins, 2022-02-01)
    OBJECTIVES: In the general critical care patient population, restrictive transfusion regimen of RBCs has been shown to be safe and is yet implemented worldwide. However, in patients on venovenous extracorporeal membrane ...
  • Sex Difference and Rupture Rate of Intracranial Aneurysms: An Individual Patient Data Meta-Analysis 
    Zuurbier, Charlotte C.M.; Molenberg, Rob; Mensing, Liselore A.; Wermer, Marieke J.H.; Juvela, Seppo; Lindgren, Antti E.; Jääskeläinen, Juha E.; Koivisto, Timo; Yamazaki, Tomosato; Uyttenboogaart, Maarten; van Dijk, J. Marc C.; Aalbers, Marlien W.; Morita, Akio; Tominari, Shinjiro; Arai, Hajime; Nozaki, Kazuhiko; Murayama, Yuichi; Ishibashi, Toshihiro; Takao, Hiroyuki; Gondar, Renato; Bijlenga, Philippe; Rinkel, Gabriel J.E.; Greving, Jacoba P.; Ruigrok, Ynte M. (Lippincott Williams & Wilkins, 2022-02)
    BACKGROUND AND PURPOSE: In previous studies, women had a higher risk of rupture of intracranial aneurysms than men, but female sex was not an independent risk factor. This may be explained by a higher prevalence of patient- ...
  • Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI) 
    EU-GEI WP2 Group (Oxford University Press, 2022-05)
    BACKGROUND AND HYPOTHESIS: Evidence suggests that childhood maltreatment (ie, childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and ...
  • Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis 
    EU-GEI High Risk Study (Elsevier, 2022-06)
    Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical ...
  • Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium 
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Springer Nature, 2022-04)
    Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread ...
  • Robotic Cardiac Surgery in Europe: Status 2020 
    Cerny, Stepan; Oosterlinck, Wouter; Onan, Burak; Singh, Sandeep; Segers, Patrique; Bolcal, Cengiz; Alhan, Cem; Navarra, Emiliano; Pettinari, Matteo; Van Praet, Frank; De Praetere, Herbert; Vojacek, Jan; Cebotaru, Theodor; Modi, Paul; Doguet, Fabien; Franke, Ulrich; Ouda, Ahmed; Melly, Ludovic; Malapert, Ghislain; Labrousse, Louis; Gianoli, Monica; Agnino, Alfonso; Philipsen, Tine; Jansens, Jean-Luc; Folliguet, Thierry; Palmen, Meindert; Pereda, Daniel; Musumeci, Francesco; Suwalski, Piotr; Cathenis, Koen; Van den Eynde, Jef; Bonatti, Johannes (Frontiers Media S. A., 2022-01-20)
    Background: European surgeons were the first worldwide to use robotic techniques in cardiac surgery and major steps in procedure development were taken in Europe. After a hype in the early 2000s case numbers decreased but ...
  • Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function 
    Bourgeois, Benjamin; Gui, Tianshu; Hoogeboom, Diana; Hocking, Henry G.; Richter, Gesa; Spreitzer, Emil; Viertler, Martin; Richter, Klaus; Madl, Tobias; Burgering, Boudewijn M.T. (Cell Press, 2021-07-27)
    Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity. Here, we present a ...
  • Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis 
    te Boekhorst, Veronika; Jiang, Liying; Mählen, Marius; Meerlo, Maaike; Dunkel, Gina; Durst, Franziska C.; Yang, Yanjun; Levine, Herbert; Burgering, Boudewijn M.T.; Friedl, Peter (Cell Press, 2022-01-24)
    Hypoxia, through hypoxia inducible factor (HIF), drives cancer cell invasion and metastatic progression in various cancer types. In epithelial cancer, hypoxia induces the transition to amoeboid cancer cell dissemination, ...
  • The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer 
    Wölfl, Benjamin; te Rietmole, Hedy; Salvioli, Monica; Kaznatcheev, Artem; Thuijsman, Frank; Brown, Joel S.; Burgering, Boudewijn; Staňková, Kateřina (Springer Science + Business Media, 2022-06)
    Evolutionary game theory mathematically conceptualizes and analyzes biological interactions where one’s fitness not only depends on one’s own traits, but also on the traits of others. Typically, the individuals are not ...
  • β-catenin regulates FOXP2 transcriptional activity via multiple binding sites 
    Richter, Gesa; Gui, Tianshu; Bourgeois, Benjamin; Koyani, Chintan N.; Ulz, Peter; Heitzer, Ellen; von Lewinski, Dirk; Burgering, Boudewijn M.T.; Malle, Ernst; Madl, Tobias (Wiley-Blackwell, 2021-05)
    The transcription factor forkhead box protein P2 (FOXP2) is a highly conserved key regulator of embryonal development. The molecular mechanisms of how FOXP2 regulates embryonal development, however, remain elusive. Using ...
  • A FOXO-dependent replication checkpoint restricts proliferation of damaged cells 
    Hornsveld, Marten; Feringa, Femke M.; Krenning, Lenno; van den Berg, Jeroen; Smits, Lydia M.M.; Nguyen, Nguyen B.T.; Rodríguez-Colman, Maria J.; Dansen, Tobias B.; Medema, René H.; Burgering, Boudewijn M.T. (Cell Press, 2021-01-26)
    DNA replication is challenged by numerous exogenous and endogenous factors that can interfere with the progression of replication forks. Substantial accumulation of single-stranded DNA during DNA replication activates the ...
  • Protocol to profile the bioenergetics of organoids using Seahorse 
    Ludikhuize, Marlies C.; Meerlo, Maaike; Burgering, Boudewijn M.T.; Rodríguez Colman, Maria J. (Cell Press, 2021-03-19)
    Addressing bioenergetics is key to evaluate the impact of metabolism on the regulation of biological processes and its alteration in disease. Organoids are in vitro grown self-organizing structures derived from healthy and ...
  • The human 2-cys peroxiredoxins form widespread, cysteine-dependent-and isoform-specific protein-protein interactions 
    van Dam, Loes; Pagès-Gallego, Marc; Polderman, Paulien E.; van Es, Robert M.; Burgering, Boudewijn M.T.; Vos, Harmjan R.; Dansen, Tobias B. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-04)
    Redox signaling is controlled by the reversible oxidation of cysteine thiols, a post-translational modification triggered by H2O2 acting as a second messenger. However, H2O2 actually reacts poorly with most cysteine thiols ...
  • DNA damage and oxidant stress activate p53 through differential upstream signaling pathways 
    Shi, Tao; van Soest, Daan M.K.; Polderman, Paulien E.; Burgering, Boudewijn M.T.; Dansen, Tobias B. (Elsevier, 2021-08-20)
    Stabilization and activation of the p53 tumor suppressor are triggered in response to various cellular stresses, including DNA damaging agents and elevated Reactive Oxygen Species (ROS) like H2O2. When cells are exposed ...
  • P53 forms redox-dependent protein–protein interactions through cysteine 277 
    Shi, Tao; Polderman, Paulien E.; Pagès-Gallego, Marc; van Es, Robert M.; Vos, Harmjan R.; Burgering, Boudewijn M.T.; Dansen, Tobias B. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-10)
    Reversible cysteine oxidation plays an essential role in redox signaling by reversibly altering protein structure and function. Cysteine oxidation may lead to intra-and intermolecular di-sulfide formation, and the latter ...
  • FOXOs: masters of the equilibrium 
    Gui, Tianshu; Burgering, Boudewijn M.T. (Wiley-Blackwell, 2022-12)
    Forkhead box O (FOXO) transcription factors (TFs) are a subclass of the larger family of forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6. The interest in FOXO function stems mostly from their ...
  • Sex- and age specific association of new-onset atrial fibrillation with in-hospital mortality in hospitalised COVID-19 patients 
    CAPACITY-COVID collaborative consortium (Elsevier, 2022-04)
    Background: Coronavirus disease 2019 (COVID-19) is a systemic disease with cardiovascular involvement, including cardiac arrhythmias. Notably, new-onset atrial fibrillation (AF) and atrial flutter (AFL) during hospitalisation ...
  • Identification of Risk Factors for Dupilumab-associated Ocular Surface Disease in Patients with Atopic Dermatitis 
    Achten, Roselie E; Van Luijk, Chantal; Van der Rijst, Lisa; Bakker, Daphne; Spekhorst, Lotte; Zuithoff, Nicolaas; Schuttelaar, Marie; Romeijn, Geertruida; Voorberg, Angelique; Kamsteeg, Marijke; Haeck, Inge; De Graaf, Marlies; Thijs, Judith; De Boer, Joke; De Bruin-Weller, Marjolein (Medical Journals Sweden AB, 2022-03-11)
    This study identified risk factors for the development of dupilumab-associated ocular surface disease in patients with moderate-to-severe atopic dermatitis in a large prospective daily practice cohort. Data from the Dutch ...
  • SCORE2 models allow consideration of sex-specific cardiovascular disease risks by region 
    Hageman, Steven; Pennells, Lisa; Ojeda, Francisco; Kaptoge, Stephen; Dorresteijn, Jannick; Angelantonio, Emanuele Di; SCORE2 working group and ESC Cardiovascular Risk Collaboration (Oxford University Press, 2022-01-14)
  • Population median imputation was noninferior to complex approaches for imputing missing values in cardiovascular prediction models in clinical practice 
    Berkelmans, G F N; Read, S H; Gudbjörnsdottir, S; Wild, S H; Franzen, S; van der Graaf, Y; Eliasson, B; Visseren, F L J; Paynter, N P; Dorresteijn, J A N (Elsevier, 2022-05)
    Objectives: To compare the validity and robustness of five methods for handling missing characteristics when using cardiovascular disease risk prediction models for individual patients in a real-world clinical setting. ...