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Now showing items 13401-13420 of 40729

Randomised, placebo-controlled trial of dexamethasone for quality of life in pulmonary sarcoidosis

Vis, Roeland; van de Garde, Ewoudt M.W.; Meek, Bob; Korenromp, Ingrid H.E.; Grutters, Jan C. (W.B. Saunders Ltd, 2020-04-01)

Background: Many patients with pulmonary sarcoidosis experience reduced quality of life. Although oral corticosteroids are the most common agents used in sarcoidosis, very little is known on the effects on quality of life. ...
Food Security, Dietary Diversity, Dietary Patterns and the Double Burden of Malnutrition among School-Aged Children and Adolescents in Two Nigerian States

Adeomi, Adeleye Abiodun; Fatusi, Adesegun; Klipstein-Grobusch, Kerstin (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-14)

Background: Little evidence exists on the relationship between diet-related factors and child/adolescent malnutrition in Nigeria. This study aimed to assess the associations between household food insecurity (HFI), dietary ...
The impact of maternal hyperglycaemia first detected in pregnancy on offspring blood pressure in Soweto, South Africa

Boerstra, Brittany A; Soepnel, Larske M; Nicolaou, Veronique; Kolkenbeck-Ruh, Andrea; Kagura, Juliana; Ware, Lisa J; Norris, Shane A; Klipstein-Grobusch, Kerstin (Lippincott Williams & Wilkins, 2022-05)

BACKGROUND: The long-term consequences for offspring born to mothers with hyperglycaemia first detected in pregnancy (HFDP) are not yet well understood and its influence on childhood blood pressure has not previously been ...
Hypertension determinants among Ghanaians differ according to location of residence: RODAM study

van der Linden, Eva L; Meeks, Karlijn A C; Klipstein-Grobusch, Kerstin; Bahendeka, Silver; Beune, Erik J A J; van den Born, Bert-Jan H; Agyemang, Charles (Lippincott Williams & Wilkins, 2022-05)

OBJECTIVE: Hypertension prevalence is high among African migrants, but the determinants of hypertension in migrants in Europe in relation to the population in the country of origin still needs to be elucidated. Therefore, ...
Patient expectations, experiences and satisfaction with nintedanib and pirfenidone in idiopathic pulmonary fibrosis: A quantitative study

Moor, C. C.; Mostard, R. L.M.; Grutters, J. C.; Bresser, P.; Aerts, J. G.J.V.; Dirksen, C. D.; Kimman, M. L.; Wijsenbeek, M. S. (BioMed Central Ltd., 2020-07-23)

Background: Two antifibrotic drugs, nintedanib and pirfenidone, are available for treatment of idiopathic pulmonary fibrosis (IPF). Although efficacy and adverse events have been well studied, little is known about patient ...
Simultaneous testing of immunological sensitization to multiple antigens in sarcoidosis reveals an association with inorganic antigens specifically related to a fibrotic phenotype

Beijer, E.; Kraaijvanger, R.; Roodenburg, C.; Grutters, J. C.; Meek, B.; Veltkamp, M. (Wiley-Blackwell, 2021-01)

Organic and inorganic antigens were studied simultaneously in the same cohort of sarcoidosis patients to investigate whether correlations between clinical characteristics and immunological sensitization could reveal new ...
Replication of a mortality prediction model in Dutch patients with COVID-19

Quanjel, Marian J.R.; van Holten, Thijs C.; Gunst-van der Vliet, Pieternel C.; Wielaard, Jette; Karakaya, Bekir; Söhne, Maaike; Moeniralam, Hazra S.; Grutters, Jan C. (Springer International Publishing, 2021-01)
Genetic disorders of the surfactant system: Focus on adult disease

van Moorsel, Coline H.M.; van der Vis, Joanne J.; Grutters, Jan C. (European Respiratory Society, 2021)

Genes involved in the production of pulmonary surfactant are crucial for the development and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a spectrum of severe monogenic pulmonary ...
Current View of Diagnosing Small Fiber Neuropathy

Raasing, Lisette R.M.; Vogels, Oscar J.M.; Veltkamp, Marcel; Van Swol, Christiaan F.P.; Grutters, Jan C. (IOS Press, 2021)

Small fiber neuropathy (SFN) is a disorder of the small myelinated Ad-fibers and unmyelinated C-fibers [5, 6]. SFN might affect small sensory fibers, autonomic fibers or both, resulting in sensory changes, autonomic ...
Patterns of healthcare resource utilization in patients with sarcoidosis: A cross-sectional study

Kampstra, Nynke A.; van der Nat, Paul B.; van Beek, Frouke T.; Grutters, Jan C.; van der Wees, Philip J. (Mattioli 1885 S.p.A., 2021-10-13)

Background: Limited data are available on healthcare resource use and costs in patients with sarcoidosis; Objectives: The primary aim of this study was to describe cost-drivers of the top 1% and top ≥1-5% high-cost patients ...
Elevated serum amyloid a levels are not specific for sarcoidosis but associate with a fibrotic pulmonary phenotype

Beijer, Els; Roodenburg-Benschop, Claudia; Schimmelpennink, Milou C.; Grutters, Jan C.; Meek, Bob; Veltkamp, Marcel (Multidisciplinary Digital Publishing Institute (MDPI), 2021-03)

Elevated Serum Amyloid A (SAA) levels have been found in several inflammatory diseases, including sarcoidosis. SAA is suggested to be involved in sarcoidosis pathogenesis by involvement in granuloma formation and maintenance. ...
World Association for Sarcoidosis and Other Granulomatous Disease (WASOG) Centers of Excellence

Baughman, Robert P; Grutters, Jan C; Wells, Athol U; Azuma, Arata; Costabel, Ulrich; Drent, Marjolein; Lower, Elyse E; Culver, Daniel A (Mattioli 1885 S.p.A., 2021)
Potential therapeutic targets to prevent organ damage in chronic pulmonary sarcoidosis

Nienhuis, Wa; Grutters, Jc (Informa Healthcare, 2022-01)

Introduction: Sarcoidosis is a granulomatous inflammatory disease with high chances of reduced quality of life, irreversible organ damage, and reduced life expectancy when vital organs are involved. Any organ system can ...
ERS clinical practice guidelines on treatment of sarcoidosis

Baughman, Robert P.; Valeyre, Dominique; Korsten, Peter; Mathioudakis, Alexander G.; Wuyts, Wim A.; Wells, Athol; Rottoli, Paola; Nunes, Hiliaro; Lower, Elyse E.; Judson, Marc A.; Israel-Biet, Dominique; Grutters, Jan C.; Drent, Marjolein; Culver, Daniel A.; Bonella, Francesco; Antoniou, Katerina; Martone, Filippo; Quadder, Bernd; Spitzer, Ginger; Nagavci, Blin; Tonia, Thomy; Rigau, David; Ouellette, Daniel R. (European Respiratory Society, 2021-12-01)

BACKGROUND: The major reasons to treat sarcoidosis are to lower the morbidity and mortality risk or to improve quality of life (QoL). The indication for treatment varies depending on which manifestation is the cause of ...
Adjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: A randomised clinical trial

Santeon-CAP study group (European Respiratory Society, 2021-08-01)

Background Adjunctive intravenous corticosteroid treatment has been shown to reduce length of stay (LOS) in adults hospitalised with community-acquired pneumonia (CAP). We aimed to assess the effect of oral dexamethasone ...
A polymorphism in C-C chemokine receptor 5 (CCR5) associates with löfgren’s syndrome and alters receptor expression as well as functional response

Karakaya, Bekir; van Moorsel, Coline H.M.; Veltkamp, Marcel; Roodenburg-Benschop, Claudia; Kazemier, Karin M.; van der Helm-Mil, Annette H.M.; Huizinga, Tom W.J.; Grutters, Jan C.; Rijkers, Ger T. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-08)

C-C chemokine receptor 5 (CCR5) and polymorphisms in CCR5 gene are associated with sarcoidosis and Löfgren’s syndrome. Löfgren’s syndrome is an acute and usually self-remitting phenotype of sarcoidosis. We investigated ...
Presence of propionibacterium acnes in granulomas associates with a chronic disease course in dutch sarcoidosis patients

Beijer, Els; Seldenrijk, Kees; Eishi, Yoshinobu; Uchida, Keisuke; Damen, Jan; Grutters, Jan C.; Veltkamp, Marcel (European Respiratory Society, 2021-01-01)

Several studies demonstrated that Propionibacterium acnes may be involved in sarcoidosis pathogenesis. Presence of P. acnes was found in granulomas of the majority of Japanese sarcoidosis patients. However, presence of P. ...
Humoral Immune Status in Relation to Outcomes in Patients with Idiopathic Pulmonary Fibrosis

Hoffman, T. W.; van Moorsel, C. H.M.; Kazemier, K. M.; Biesma, D. H.; Grutters, J. C.; van Kessel, D. A. (Springer New York, 2021-12)

Purpose: Idiopathic pulmonary fibrosis (IPF) is a severe fibrotic lung disease, in which inflammation is thought to only play a secondary role. Several factors associated with acute exacerbations of IPF (AE-IPF) have been ...
The MUC5B Promoter Polymorphism Associates With Severe COVID-19 in the European Population

van Moorsel, Coline H.M.; van der Vis, Joanne J.; Duckworth, Anna; Scotton, Chris J.; Benschop, Claudia; Ellinghaus, David; Ruven, Henk J.T.; Quanjel, Marian J.R.; Grutters, Jan C. (Frontiers Media S. A., 2021-11-23)

Background: Diversity in response on exposure to severe acute respiratory syndrome coronavirus 2 may be related to the innate immune response in the elderly. The mucin MUC5B is an important component of the innate immune ...
Activation of downstream mTORC1 target ribosomal protein S6 kinase (S6K) can be found in a subgroup of Dutch patients with granulomatous pulmonary disease

Kraaijvanger, Raisa; Seldenrijk, Kees; Beijer, Els; Damen, Jan; Wilson, Jayne Louise; Weichhart, Thomas; Grutters, Jan C.; Veltkamp, Marcel (Multidisciplinary Digital Publishing Institute (MDPI), 2021-12)

Mechanistic target of rapamycin complex 1 (mTORC1) has been linked to different diseases. The mTORC1 signaling pathway is suggested to play a role in the granuloma formation of sarcoidosis. Recent studies demonstrated ...

Now showing items 13401-13420 of 40729