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Endoscopic surgery suturing techniques: a randomized study on learning

Voskens, F J; van der Schans, E M; Ruurda, J P; Broeders, I A M J (BioMed Central, 2022-02-17)

BACKGROUND: Surgeons have widely adopted endoscopic suturing techniques using conventional laparoscopic instruments and the more advanced robotic systems. The FlexDex is a novel articulating laparoscopic needle driver ...
Scrutinizing Privacy in Multi-Omics Research: How to Provide Ethical Grounding for the Identification of Privacy-Relevant Data Properties

Safarlou, C. W.; Bredenoord, A. L.; Vermeulen, R.; Jongsma, K. R. (Routledge, 2021-12-02)
Contribution of Age, Brain Region, Mood Disorder Pathology, and Interindividual Factors on the Methylome of Human Microglia

de Witte, Lot D.; Wang, Zhaoyu; Snijders, Gijsje L.J.L.; Mendelev, Natalia; Liu, Qingkun; Sneeboer, Marjolein A.M.; Boks, Marco P.M.; Ge, Yongchao; Haghighi, Fatemeh (Elsevier, 2022-03-15)

Background: Transcriptome studies have revealed age-, disease-, and region-associated microglial phenotypes reflecting changes in microglial function during development, aging, central nervous system homeostasis, and ...
Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Feklicheva, Inna; Boks, Marco P.; de Kloet, E. Ron; Chipeeva, Nadezda; Maslennikova, Ekaterina; Pashkov, Anton; Korobova, Svetlana; Komelkova, Mariia; Kuznetsova, Yulia; Platkovski, Pavel; Mamonova, Marina; Sidorenko, Olga; Vasilenko, Tatyana; Tseilikman, Olga; Tseilikman, Vadim (Elsevier Limited, 2022-04)

In the present study we measured the concentrations of cortisol, thyroid hormones, testosterone, and GABA (gamma aminobutyric acid) in am blood plasma samples of combatants with an at least 10 year history of military ...
Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

OMEC working group (Elsevier Limited, 2022-03)

Background: Consensus about the definition and treatment of oligometastatic oesophagogastric cancer is lacking. Objective: To assess the definition and treatment of oligometastatic oesophagogastric cancer across multidisciplinary ...
Physical and mental health impact of COVID-19 on children, adolescents, and their families

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Elsevier, 2022-02-15)

Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable ...
Relationship between 3D Morphologic Change and 2D and 3D Growth of Unruptured Intracranial Aneurysms

Timmins, Kimberley; Kuijf, Hugo; Vergouwen, Mervyn; Ruigrok, Ynte; Velthuis, Birgitta; van der Schaaf, Irene (American Society of Neuroradiology, 2022-03)

BACKGROUND AND PURPOSE: Untreated unruptured intracranial aneurysms are usually followed radiologically to detect aneurysm growth, which is associated with increased rupture risk. The ideal aneurysm size cutoff for defining ...
Representation and Outcomes of Individuals with Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials

Taipale, Heidi; Schneider-Thoma, Johannes; Pinzón-Espinosa, Justo; Radua, Joaquim; Efthimiou, Orestis; Vinkers, Christiaan H.; Mittendorfer-Rutz, Ellenor; Cardoner, Narcís; Pintor, Luis; Tanskanen, Antti; Tomlinson, Anneka; Fusar-Poli, Paolo; Cipriani, Andrea; Vieta, Eduard; Leucht, Stefan; Tiihonen, Jari; Luykx, Jurjen J. (American Medical Association, 2022-03-01)

Importance: Most evidence about efficacy and safety of antipsychotics in schizophrenia spectrum disorders relies on randomized clinical trials (RCTs). However, owing to their strict eligibility criteria, RCTs represent ...
Effects of childhood-onset systemic lupus erythematosus on academic achievements and employment in adult life

Groot, Noortje; Kardolus, Anne; Bijl, Marc; Dolhain, Radboud J.E.M.; Teng, Y. K.Onno; Zirkzee, Els; De Leeuw, Karina; Fritsch-Stork, Ruth; Burdorf, Alex; Bultink, Irene E.; Kamphuis, Sylvia (Journal of Rheumatology, 2021-06-01)

Objective. Long-term outcome data in adults with childhood-onset systemic lupus erythematosus (cSLE) are limited. Here, we report the effects of cSLE on education, vocation, and employment in a large cohort of adults with ...
Modification of the TRISS: simple and practical mortality prediction after trauma in an all-inclusive registry

Driessen, Mitchell L S; van Klaveren, David; de Jongh, Mariska A C; Leenen, Luke P H; Sturms, Leontien M (Springer International Publishing AG, 2022-10)

PURPOSE: Numerous studies have modified the Trauma Injury and Severity Score (TRISS) to improve its predictive accuracy for specific trauma populations. The aim of this study was to develop and validate a simple and practical ...
Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease: The updated SMART2 algorithm

UCC-SMART Study Group and the ESC Cardiovascular Risk Collaboration (Oxford University Press, 2022-05-07)

Aims: The 10-year risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events in patients with established ASCVD can be estimated with the Secondary Manifestations of ARTerial disease (SMART) risk score, and ...
Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

Undiagnosed Diseases Network (Lippincott Williams & Wilkins, 2021-10)
The self-fulfilling prophecy of post-hoc power calculations

Christogiannis, Christos; Nikolakopoulos, Stavros; Pandis, Nikolaos; Mavridis, Dimitris (Elsevier, 2022-02)
Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome

Gray, Belinda; Baruteau, Alban-Elouen; Antolin, Albert A; Pittman, Alan; Sarganas, Giselle; Molokhia, Mariam; Blom, Marieke T; Bastiaenen, Rachel; Bardai, Abdenasser; Priori, Silvia G; Napolitano, Carlo; Weeke, Peter E; Shakir, Saad A; Haverkamp, Wilhelm; Mestres, Jordi; Winkel, Bo; Witney, Adam A; Chis-Ster, Irina; Sangaralingam, Ajanthah; Camm, A John; Tfelt-Hansen, Jacob; Roden, Dan M; Tan, Hanno L; Garbe, Edeltraut; Sturkenboom, Miriam; Behr, Elijah R (Lippincott Williams & Wilkins, 2022-02-03)

Background: Acquired long QT syndrome (aLQTS) is a serious unpredictable adverse drug reaction. Pharmacogenomic markers may predict risk. Methods: Among 153 aLQTS patients (mean age 58 years [range, 14-88], 98.7% White, ...
A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease

Kuipers, Sanne; Overmars, L Malin; van Es, Bram; de Bresser, Jeroen; Bron, Esther E; Hoefer, Imo E; Kappelle, L Jaap; Teunissen, Charlotte E; Biessels, Geert Jan; Haitjema, Saskia (SAGE Publications Inc., 2022-07-01)

Biological processes underlying cerebral small vessel disease (cSVD) are largely unknown. We hypothesized that identification of clusters of inter-related bood-based biomarkers that are associated with the burden of cSVD ...
Does livestreaming surgical education have the future? Development and participant evaluation of a national COVID-19 livestreaming initiative

NVvH Livestream Collaborative Group (Springer New York, 2022-08)

Backgrounds: COVID-19 related reduction of surgical procedures jeopardizes learning on the job of surgical residents. Many educators resorted to digital resources in the search for alternatives. However, these resources ...
Nationwide oncological networks for resection of colorectal liver metastases in the Netherlands: Differences and postoperative outcomes

Dutch Hepato Biliary Audit Group (W.B. Saunders Ltd, 2022-02)

Introduction: Widespread differences in patient demographics and disease burden between hospitals for resection of colorectal liver metastases (CRLM) have been described. In the Netherlands, networks consisting of at least ...
Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy

Poghosyan, Susanna; Frenkel, Nicola; Lentzas, Aristeidis; Laoukili, Jamila; Rinkes, Inne Borel; Kranenburg, Onno; Hagendoorn, Jeroen (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)

Neuropilin-2 (Nrp2), an important regulator of lymphangiogenesis and lymphatic metastasis, has been associated with progression in colorectal cancer (CRC). However, the tumor cell-intrinsic role of Nrp2 in cancer progression ...
Unequal prescription of anticoagulants among females and males with atrial fibrillation and similar stroke risk: Should we omit sex category from the CHA2DS2-VASc score?

Seelig, Jaap; Chu, Gordon; Trinks-Roerdink, Emmy M.; Pisters, Ron; de Vries, Tim A.C.; ten Cate, Hugo; Geersing, Geert Jan; Rutten, Frans H.; Huisman, Menno V.; Hemels, Martin E.W. (Elsevier, 2022-05)
Scout - sarcoidosis outcomes taskforce. A systematic review of outcomes to inform the development of a core outcome set for pulmonary sarcoidosis

Harman, Nicola L; Gorst, Sarah L; Williamson, Paula R; Barnathan, Elliot S; Baughman, Robert P; Judson, Marc A; Junk, Heidi; Kampstra, Nynke A; Sullivan, Eugene J; Victorson, David E; Walton, Marc; Al-Hakim, Tamara; Nabulsi, Hana; Singh, Noopur; Grutters, Jan C; Culver, Daniel A (Mattioli 1885 S.p.A., 2021)

Background: Clinical trials evaluating different management strategies for pulmonary sarcoidosis may measure different outcomes. This heterogeneity in outcomes can lead to waste in research due to the inability to compare ...

Now showing items 13361-13380 of 40729