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UMC Repository: Recent submissions

  • A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism 
    Rella, Lorenzo; Povoa, Euclides E.Fernandes; Mars, Jonas; Ebbing, Annabel L.P.; Schoppink, Luc; Betist, Marco C.; Korswagen, Hendrik C. (National Academy of Sciences, 2021-03-18)
    Members of the Wnt family of secreted glycoproteins regulate cell migration through distinct canonical and noncanonical signaling pathways. Studies of vertebrate development and disease have shown that these pathways can ...
  • Macrophages provide a transient muscle stem cell niche via NAMPT secretion 
    Ratnayake, Dhanushika; Nguyen, Phong D.; Rossello, Fernando J.; Wimmer, Verena C.; Tan, Jean L.; Galvis, Laura A.; Julier, Ziad; Wood, Alasdair J.; Boudier, Thomas; Isiaku, Abdulsalam I.; Berger, Silke; Oorschot, Viola; Sonntag, Carmen; Rogers, Kelly L.; Marcelle, Christophe; Lieschke, Graham J.; Martino, Mikaël M.; Bakkers, Jeroen; Currie, Peter D. (Nature Research, 2021-03-11)
    Skeletal muscle regenerates through the activation of resident stem cells. Termed satellite cells, these normally quiescent cells are induced to proliferate by wound-derived signals1. Identifying the source and nature of ...
  • Tissue regeneration: Reserve or reverse? 
    Shivdasani, Ramesh A.; Clevers, Hans; de Sauvage, Frederic J. (American Association for the Advancement of Science, 2021-02-19)
  • Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype 
    Hanemaaijer, Evelyn S.; Margaritis, Thanasis; Sanders, Karin; Bos, Frank L.; Candelli, Tito; Al-Saati, Hanin; van Noesel, Max M.; Meyer-Wentrup, Friederike A.G.; van de Wetering, Marc; Holstege, Frank C.P.; Clevers, Hans (National Academy of Sciences, 2021-02-02)
    Neuroblastoma is the most common extracranial solid tumor and accounts for ∼10% of pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is generally accepted that neuroblastoma derives ...
  • Mycobacteria–host interactions in human bronchiolar airway organoids 
    Iakobachvili, Nino; Leon-Icaza, Stephen Adonai; Knoops, Kèvin; Sachs, Norman; Mazères, Serge; Simeone, Roxane; Peixoto, Antonio; Bernard, Célia; Murris-Espin, Marlène; Mazières, Julien; Cam, Kaymeuang; Chalut, Christian; Guilhot, Christophe; López-Iglesias, Carmen; Ravelli, Raimond B.G.; Neyrolles, Olivier; Meunier, Etienne; Lugo-Villarino, Geanncarlo; Clevers, Hans; Cougoule, Céline; Peters, Peter J. (Wiley-Blackwell, 2022-03)
    Respiratory infections remain a major global health concern. Tuberculosis is one of the top 10 causes of death worldwide, while infections with Non-Tuberculous Mycobacteria are rising globally. Recent advances in human ...
  • High-content imaging-based pooled CRISPR screens in mammalian cells 
    Yan, Xiaowei; Stuurman, Nico; Ribeiro, Susana A.; Tanenbaum, Marvin E.; Horlbeck, Max A.; Liem, Christina R.; Jost, Marco; Weissman, Jonathan S.; Vale, Ronald D. (Rockefeller University Press, 2021-02-01)
    CRISPR (clustered regularly interspaced short palindromic repeats)-based gene inactivation provides a powerful means for linking genes to particular cellular phenotypes. CRISPR-based screening typically uses large genomic ...
  • A heterozygous mutation in cardiac troponin t promotes ca2+ dysregulation and adult cardiomyopathy in zebrafish 
    Kamel, Sarah M.; Koopman, Charlotte D.; Kruse, Fabian; Willekers, Sven; Chocron, Sonja; Bakkers, Jeroen (MDPI AG, 2021-04)
    Cardiomyopathies are a group of heterogeneous diseases that affect the muscles of the heart, leading to early morbidity and mortality in young and adults. Genetic forms of cardiomyopathy are caused predominantly by mutations ...
  • Author Correction: mRNA structural dynamics shape Argonaute-target interactions (Nature Structural & Molecular Biology, (2020), 27, 9, (790-801), 10.1038/s41594-020-0461-1) 
    Ruijtenberg, Suzan; Sonneveld, Stijn; Cui, Tao Ju; Logister, Ive; de Steenwinkel, Dion; Xiao, Yao; MacRae, Ian J.; Joo, Chirlmin; Tanenbaum, Marvin E. (Nature Research, 2021-06)
    In the version of this article initially published, the data in Fig. 6h and Extended Data Fig. 6j were incorrect due to errors in the simulation code. The correct figures are shown below. The Fig. 6h caption has been updated ...
  • Organoids and organs-on-chips: Insights into human gut-microbe interactions 
    Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Clevers, Hans (Cell Press, 2021-06-09)
    The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The difficulty of inferring causation from metagenomic microbiome sequencing studies and from mouse-human ...
  • Advancing lung organoids for COVID-19 research 
    van der Vaart, Jelte; Lamers, Mart M.; Haagmans, Bart L.; Clevers, Hans (Company of Biologists Ltd, 2021-06)
    The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus’ cellular environment, however, may impede research and waste resources. ...
  • Value of Targeted Biopsies and Combined PSMA PET/CT and mp-MRI Imaging in Locally Recurrent Prostate Cancer after Primary Radiotherapy 
    Rasing, Marnix; van Son, Marieke; Moerland, Marinus; de Keizer, Bart; Wessels, Frank; Jonges, Trudy; van de Pol, Sandrine; Eppinga, Wietse; Noteboom, Juus; Lagendijk, Jan; van der Voort van Zijp, Jochem; Peters, Max (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)
    Radiorecurrent prostate cancer is conventionally confirmed using systematic and/or targeted biopsies. The availability of multiparametric (mp) MRI and prostate specific membrane antigen (PSMA) PET/CT has increased diagnostic ...
  • Spatial transcriptomics of the nematode Caenorhabditis elegans using RNA tomography 
    Schild, Erik S.; Mars, Jonas; Ebbing, Annabel; Vivié, Judith; Betist, Marco; Korswagen, Hendrik C. (Cell Press, 2021-06-18)
    RNA tomography or tomo-seq combines mRNA sequencing and cryo-sectioning to spatially resolve gene expression. We have adapted this method for the nematode Caenorhabditis elegans to generate anteroposterior gene expression ...
  • Short term effect and effect on rate of lung function decline after surgery for neuromuscular or syndromic scoliosis 
    Veldhoen, Esther S; de Vries, Anneloes; Schlosser, Tom P C; Kruyt, Moyo C; van Eijk, Ruben P A; Tersmette, Joyce M; Hulzebos, Erik H; van der Pol, Ludo W; Wösten-van Asperen, Roelie M; van der Ent, Cornelis K (John Wiley & Sons Inc., 2022-05)
    Introduction: Understanding the impact of scoliosis surgery on lung function is important for counseling patients about risks and benefits of surgery. We prospectively compared the trends in lung function test (LFT) results ...
  • Clinical trials in pediatric ALS: a TRICALS feasibility study 
    Answer ALS Foundation (Informa Healthcare, 2022-11)
    Background: Pediatric investigation plans (PIPs) describe how adult drugs can be studied in children. In 2015, PIPs for Amyotrophic Lateral Sclerosis (ALS) became mandatory for European marketing-authorization of adult ...
  • Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis 
    Al Khleifat, Ahmad; Iacoangeli, Alfredo; van Vugt, Joke J F A; Bowles, Harry; Moisse, Matthieu; Zwamborn, Ramona A J; van der Spek, Rick A A; Shatunov, Aleksey; Cooper-Knock, Johnathan; Topp, Simon; Byrne, Ross; Gellera, Cinzia; López, Victoria; Jones, Ashley R; Opie-Martin, Sarah; Vural, Atay; Campos, Yolanda; van Rheenen, Wouter; Kenna, Brendan; Van Eijk, Kristel R; Kenna, Kevin; Weber, Markus; Smith, Bradley; Fogh, Isabella; Silani, Vincenzo; Morrison, Karen E; Dobson, Richard; van Es, Michael A; McLaughlin, Russell L; Vourc'h, Patrick; Chio, Adriano; Corcia, Philippe; de Carvalho, Mamede; Gotkine, Marc; Panades, Monica P; Mora, Jesus S; Shaw, Pamela J; Landers, John E; Glass, Jonathan D; Shaw, Christopher E; Basak, Nazli; Hardiman, Orla; Robberecht, Wim; Van Damme, Philip; van den Berg, Leonard H; Veldink, Jan H; Al-Chalabi, Ammar (Nature Publishing Group, 2022-01-28)
    There is a strong genetic contribution to Amyotrophic lateral sclerosis (ALS) risk, with heritability estimates of up to 60%. Both Mendelian and small effect variants have been identified, but in common with other conditions, ...
  • Functional Loss and Mortality in Randomized Clinical Trials for Amyotrophic Lateral Sclerosis: To Combine, or Not to Combine-That is the Estimand 
    van Eijk, Ruben P A; Roes, Kit C B; de Greef-van der Sandt, Inez; van den Berg, Leonard H; Lu, Ying (Wiley-Blackwell, 2022-04)
    Amyotrophic lateral sclerosis is a rapidly progressive disease leading to death in, on average, 3-5 years after first symptom onset. Consequently, there are frequently a non-negligible number of patients who die during the ...
  • Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (Nature Genetics, (2021), 53, 12, (1636-1648), 10.1038/s41588-021-00973-1) 
    SLALOM Consortium (Nature Research, 2022-03)
    In the version of this article initially published, the affiliation for Nazli Başak appeared incorrectly. Nazli Başak is at Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey, and not Bogazici University. ...
  • Home-monitoring of vital capacity in people with a motor neuron disease 
    Helleman, Jochem; Bakers, Jaap N E; Pirard, Evelien; van den Berg, Leonard H; Visser-Meily, Johanna M A; Beelen, Anita (Springer Science and Business Media Deutschland GmbH, 2022-07)
    BACKGROUND: Home-monitoring of spirometry has the potential to improve care for patients with a motor neuron disease (MND) by enabling early detection of respiratory dysfunction and reducing travel burden. Our aim was to ...
  • The influence of smoking and HIV infection on pulmonary function 
    Sussenbach, Annelotte; Gijzel, Sjors van; Lalla-Edward, Samanta; Venter, Willem; Shaddock, Erica; Feldman, Charles; Klipstein-Grobusch, Kerstin; Vos, Alinda (AOSIS (Pty) Ltd, 2022-02-21)
    Background: Prevalence of HIV, smoking, and pulmonary infections in South Africa are high.Objectives: We investigated the role of smoking and HIV status on lung function.Methods: This is a secondary analysis of a cross-sectional ...
  • Individual and contextual factors associated with under- and over-nutrition among school-aged children and adolescents in two Nigerian states: a multi-level analysis 
    Adeomi, Adeleye Abiodun; Fatusi, Adesegun; Klipstein-Grobusch, Kerstin (Cambridge University Press, 2022-08-24)
    Objective: This study aimed to identify individual and contextual factors that are associated with under- and over-nutrition among school-aged children and adolescents in two Nigerian states. Design: Community-based ...