A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism

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A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism
 
Rella, Lorenzo; Povoa, Euclides E.Fernandes; Mars, Jonas; Ebbing, Annabel L.P.; Schoppink, Luc; Betist, Marco C.; Korswagen, Hendrik C.
(2021) Proceedings of the National Academy of Sciences of the United States of America, volume 118, issue 12, pp. 1 - 12
(Article)
Abstract
Members of the Wnt family of secreted glycoproteins regulate cell migration through distinct canonical and noncanonical signaling pathways. Studies of vertebrate development and disease have shown that these pathways can have opposing effects on cell migration, but the mechanism of this functional interplay is not known. In the nematode Caenorhabditis ... read more
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Keywords: C. elegans, Cell migration, Pathway interactions, Slt-Robo, Wnt, General
DOI: https://doi.org/10.1073/PNAS.2013239118
ISSN: 0027-8424
Publisher: National Academy of Sciences
Note: Funding Information: ACKNOWLEDGMENTS. We thank Stefan van der Elst from the Flow Cytometry Core facility and the Hubrecht Imaging Center (Hubrecht Institute) for technical support, and Guangshuo Ou (Tsinghua University, Beijing, China) and Barbara Conradt (University College London, United Kingdom) for reagents. Part of this work was funded by the research program (14NOISE01) of the Foundation for Fundamental Research on Matter, which is financially supported by the Netherlands Organization for Scientific Research. Some strains were provided by the Caenorhabditis Genetics Center (CGC), which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). We are grateful to members of the Korswagen and Galli groups for helpful discussions and critical reading of the manuscript. Publisher Copyright: © 2021 National Academy of Sciences. All rights reserved.
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