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Challenges for modelling interventions for future pandemics

Kretzschmar, Mirjam E.; Ashby, Ben; Fearon, Elizabeth; Overton, Christopher E.; Panovska-Griffiths, Jasmina; Pellis, Lorenzo; Quaife, Matthew; Rozhnova, Ganna; Scarabel, Francesca; Stage, Helena B.; Swallow, Ben; Thompson, Robin N.; Tildesley, Michael J.; Villela, Daniel (Elsevier, 2022-03)

Mathematical modelling and statistical inference provide a framework to evaluate different non-pharmaceutical and pharmaceutical interventions for the control of epidemics that has been widely used during the COVID-19 ...
Detection of sentinel lymph nodes by tilmanocept in oral squamous cell carcinoma

de Bree, Remco; Mahieu, Rutger; Donders, Dominique N V; de Keizer, Bart (Springer Netherlands, 2022-06)
Esophageal second primary tumors in patients with head and neck squamous cell carcinoma: incidence, risk factors and overall survival

Overwater, Anouk; Rueb, Kuna; Elias, Sjoerd G; de Bree, Remco; Weusten, Bas L A M (Wolters Kluwer Health, 2022-05-01)

INTRODUCTION: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous ...
A Comprehensive Overview of the Clinical Relevance and Treatment Options for Antibody-mediated Rejection Associated With Non-HLA Antibodies

Kardol-Hoefnagel, Tineke; Otten, Henny G. (Lippincott Williams & Wilkins, 2021-07-01)

Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the ...
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

BIOS Consortium (American Association for the Advancement of Science, 2022-02-23)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) exposures and disease progression, as well ...
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

KORA-Study Group (Nature Research, 2022-03-01)

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1.5, susceptibility genes remain largely unknown. ...
Cortical and subcortical changes in resting-state neuronal activity and connectivity in early symptomatic ALS and advanced frontotemporal dementia

Govaarts, Rosanne; Beeldman, Emma; Fraschini, Matteo; Griffa, Alessandra; Engels, Marjolein M A; van Es, Michael A; Veldink, Jan H; van den Berg, Leonard H; van der Kooi, Anneke J; Pijnenburg, Yolande A L; de Visser, Marianne; Stam, Cornelis J; Raaphorst, Joost; Hillebrand, Arjan (Elsevier, 2022-02-22)

The objective of this study was to examine if patterns of resting-state brain activity and functional connectivity in cortical and subcortical regions in patients with early symptomatic amyotrophic lateral sclerosis (ALS) ...
Right atrial and ventricular strain detects subclinical changes in right ventricular function in precapillary pulmonary hypertension

Vos, J. L.; Leiner, T.; van Dijk, A. P.J.; van der Zwaan, H. B.; Sieswerda, G. Tj; Snijder, R. J.; Post, M. C.; Vonk, M. C.; van Leuven, S.; Vart, P.; Snoeren, M.; Hirsch, A.; El Messaoudi, S.; Nijveldt, R.; Driessen, M. M.P. (Springer Netherlands, 2022-08)

Right ventricular (RV) ejection fraction (EF) by cardiac magnetic resonance (CMR) correlates to outcome in precapillary pulmonary hypertension (pPH) patients, but is insensitive to early changes. Strain might provide ...
Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial

REDUCE LAP-HF II investigators (Elsevier, 2022-03-19)

Background: Placement of an interatrial shunt device reduces pulmonary capillary wedge pressure during exercise in patients with heart failure and preserved or mildly reduced ejection fraction. We aimed to investigate ...
Acceptability and Satisfaction of Contraceptive Vaginal Rings in Clinical Studies: A Systematic Review and Narrative Synthesis

Delvaux, Thérèse; Jespers, Vicky; Benova, Lenka; van de Wijgert, Janneke (Frontiers Media S. A., 2021)

Introduction: Acceptability of and satisfaction with contraceptive methods are paramount for uptake and continuation. In the current context of multipurpose prevention of pregnancy and sexually transmitted diseases/HIV ...
Urine and vaginal microbiota compositions of postmenopausal and premenopausal women differ regardless of recurrent urinary tract infection and renal transplant status

Hugenholtz, Floor; van der Veer, Charlotte; Terpstra, Matty L; Borgdorff, Hanneke; van Houdt, Robin; Bruisten, Sylvia; Geerlings, Suzanne E; van de Wijgert, Janneke H H M (Nature Publishing Group, 2022-12)

Postmenopausal women and renal transplant recipients are at increased risk of recurrent urinary tract infections (RUTI). Urine and vaginal microbiota of premenopausal controls (N = 18) and RUTI cases (18), and of postmenopausal ...
Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study

Venekamp, Roderick P; Veldhuijzen, Irene K; Moons, Karel G M; van den Bijllaardt, Wouter; Pas, Suzan D; Lodder, Esther B; Molenkamp, Richard; Igloi, Zsofi; Wijers, Constantijn; Dos Santos, Claudy Oliveira; Debast, Sylvia B; Bruins, Marjan J; Polad, Khaled; Nagel-Imming, Carla R S; Han, Wanda G H; van de Wijgert, Janneke H H M; van den Hof, Susan; Schuit, Ewoud (BioMed Central Ltd., 2022-02-24)

BACKGROUND: Rapid antigen diagnostic tests (Ag-RDTs) are the most widely used point-of-care tests for detecting SARS-CoV-2 infection. Since the accuracy may have altered by changes in SARS-CoV-2 epidemiology, indications ...
Editor's Choice - European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs

De Maeseneer, Marianne G; Kakkos, Stavros K; Aherne, Thomas; Baekgaard, Niels; Black, Stephen; Blomgren, Lena; Giannoukas, Athanasios; Gohel, Manjit; de Graaf, Rick; Hamel-Desnos, Claudine; Jawien, Arkadiusz; Jaworucka-Kaczorowska, Aleksandra; Lattimer, Christopher R; Mosti, Giovanni; Noppeney, Thomas; van Rijn, Marie Josee; Stansby, Gerry; Esvs Guidelines Committee, Guidelines Committee; Kolh, Philippe; Bastos Goncalves, Frederico; Chakfé, Nabil; Coscas, Raphael; de Borst, Gert J; Dias, Nuno V; Hinchliffe, Robert J; Koncar, Igor B; Lindholt, Jes S; Trimarchi, Santi; Tulamo, Riikka; Twine, Christopher P; Vermassen, Frank; Wanhainen, Anders; Document Reviewers, Reviewers; Björck, Martin; Labropoulos, Nicos; Lurie, Fedor; Mansilha, Armando; Nyamekye, Isaac K; Ramirez Ortega, Marta; Ulloa, Jorge H; Urbanek, Tomasz; van Rij, Andre M; Vuylsteke, Marc E (W.B. Saunders Ltd, 2022-02)
Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders, Lotte; Landsmeer, Lennart P L; Cui, Kai; Depuydt, Marie A C; Verwer, Maarten; Mekke, Joost; Timmerman, Nathalie; van den Dungen, Noortje A M; Kuiper, Johan; de Winther, Menno P J; Prange, Koen H M; Ma, Wei Feng; Miller, Clint L; Aherrahrou, Redouane; Civelek, Mete; de Borst, Gert J; de Kleijn, Dominique P V; Asselbergs, Folkert W; den Ruijter, Hester M; Boltjes, Arjan; Pasterkamp, Gerard; van der Laan, Sander W; Mokry, Michal (Oxford University Press, 2022-01)

Aims Genome-wide association studies (GWASs) have discovered hundreds of common genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of susceptibility loci into biological mechanisms ...
Negative symptoms in First-Episode Schizophrenia related to morphometric alterations in orbitofrontal and superior temporal cortex: the OPTiMiSE study

Demjaha, Arsime; Galderisi, Silvana; Glenthøj, Birthe; Arango, Celso; Mucci, Armida; Lawrence, Andrew; O'Daly, Owen; Kempton, Matthew; Ciufolini, Simone; Baandrup, Lone; Ebdrup, Bjørn H; Rodriguez-Jimenez, Roberto; Diaz-Marsa, Maria; Díaz-Caneja, Covadonga Martinez; Winter van Rossum, Inge; Kahn, Rene; Dazzan, Paola; McGuire, Philip (Cambridge University Press, 2023-06)

Background Negative symptoms are one of the most incapacitating features of Schizophrenia but their pathophysiology remains unclear. They have been linked to alterations in grey matter in several brain regions, but findings ...
Management of atherosclerotic extracranial carotid artery stenosis

Bonati, Leo H; Jansen, Olav; de Borst, Gert J; Brown, Martin M (Elsevier Limited, 2022-03)

Atherosclerosis leading to stenosis of the internal carotid artery is the underlying cause of 8-15% of ischaemic strokes (symptomatic carotid stenosis). 1-2% of the adult population have asymptomatic carotid stenosis. ...
Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum

Schutte, Maya J L; Voppel, Alban; Collin, Guusje; Abramovic, Lucija; Boks, Marco P M; Cahn, Wiepke; van Haren, Neeltje E M; Hugdahl, Kenneth; Koops, Sanne; Mandl, René C W; Sommer, Iris E C (Oxford University Press, 2022-05-07)

Functional connectome alterations, including modular network organization, have been related to the experience of hallucinations. It remains to be determined whether individuals with hallucinations across the psychosis ...
Meaningful Respect for the Autonomy of Persons with "Completed Life": An Analysis in Light of Empirical Research

Zomers, M L; van Wijngaarden, E J; van Delden, J J M; van Thiel, G J M W (Routledge, 2022-02-01)
Development of the Saudi Arabian trauma system

Chowdhury, Sharfuddin; Mok, Dennis; Leenen, Luke (Carol Davila University Press, 2022-01-01)

A dedicated network-based trauma system ensures optimal care to injured patients. Considering the significant burden of trauma, the Kingdom of Saudi Arabia is striving to develop a nationwide trauma system. This article ...
Physiology dictated treatment after severe trauma: timing is everything

van Wessem, Karlijn J P; Leenen, Luke P H; Hietbrink, Falco (Springer International Publishing AG, 2022-10)

INTRODUCTION: Damage control strategies in resuscitation and (fracture) surgery have become standard of care in the treatment of severely injured patients. It is suggested that damage control improves survival and decreases ...

Now showing items 13281-13300 of 40729