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Now showing items 13261-13280 of 40729

Signal transduction pathway activity in high-grade serous carcinoma, its precursors and Fallopian tube epithelium

van der Ploeg, Phyllis; Uittenboogaard, Aniek; Bosch, Steven L; van Diest, Paul J; Wesseling-Rozendaal, Yvonne J W; van de Stolpe, Anja; Lambrechts, Sandrina; Bekkers, Ruud L M; Piek, Jurgen M J (Academic Press Inc., 2022-04)

OBJECTIVE: To determine the activity of key signal transduction pathways in serous tubal intraepithelial carcinoma (STIC) and concurrent high-grade serous carcinoma (HGSC) and compare this to pathway activity in normal ...
Effect of the time interval between melanoma diagnosis and sentinel node biopsy on the size of metastatic tumour deposits in node-positive patients

El Sharouni, Mary Ann; Scolyer, Richard A.; van Gils, Carla H.; Ch'ng, Sydney; Nieweg, Omgo E.; Pennington, Thomas E.; Saw, Robyn PM; Shannon, Kerwin; Spillane, Andrew; Stretch, Jonathan; Witkamp, Arjen J.; Sigurdsson, Vigfús; Thompson, John F.; van Diest, Paul J.; Lo, Serigne N. (Elsevier Limited, 2022-05)

Introduction: This study sought to assess whether the interval between diagnostic excision-biopsy of a primary melanoma and definitive wide excision with sentinel node biopsy (SNB) influenced the size of SN metastatic ...
A Multinational Pilot Study on Patients’ Perceptions of Advanced Neuroendocrine Neoplasms on the EORTC QLQ‐C30 and EORTC QLQ‐GINET21 Questionnaires

van Leeuwaarde, Rachel S.; González‐clavijo, Angélica M.; Pracht, Marc; Emelianova, Galina; Cheung, Winson Y.; Thirlwell, Christina; Öberg, Kjell; Spada, Francesca (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-25)

Among the available neuroendocrine neoplasm (NEN)‐specific HR‐QoL scales, only the EORTC QLQ‐C30 and EORTC QLQ‐G.I.NET21 questionnaires have been validated in several languages. We aim to assess patients’ perceptions of ...
Latent Classes of Substance Use in Young Adults - A Systematic Review

de Jonge, Martha Charlotta; Bukman, Andrea Johanna; van Leeuwen, Lonneke; Onrust, Simone Arianne; Kleinjan, Marloes (Informa Healthcare, 2022-04-16)

Background: This systematic review provides an overview of studies on latent classes related to the substance use among young adults (18-25 years). Identifying these classes helps to detect high-risk groups, setting a base ...
Value of routine cytokeratin immunohistochemistry in detecting low volume disease in cervical cancer

Baeten, I. G.T.; Hoogendam, J. P.; Jonges, G. N.; Jürgenliemk-Schulz, I. M.; Braat, A. J.A.T.; van Diest, P. J.; Gerestein, C. G.; Zweemer, R. P. (Academic Press Inc., 2022-05)

Objective: In cervical cancer, sentinel lymph nodes (SLNs) are processed according to the pathological ultrastaging protocol. According to current guidelines, immunohistochemistry with pancytokeratin antibodies is performed ...
Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study

van den Brink, Hilde; Kopczak, Anna; Arts, Tine; Onkenhout, Laurien; Siero, Jeroen C.W.; Zwanenburg, Jaco J.M.; Duering, Marco; Blair, Gordon W.; Doubal, Fergus N.; Stringer, Michael S.; Thrippleton, Michael J.; Kuijf, Hugo J.; de Luca, Alberto; Hendrikse, Jeroen; Wardlaw, Joanna M.; Dichgans, Martin; Biessels, Geert Jan; SVDs@target group (Elsevier, 2021-01)

Background: Cerebral small vessel diseases (SVDs) are a major cause of stroke and dementia. Yet, specific treatment strategies are lacking in part because of a limited understanding of the underlying disease processes. ...
Association of Early MRI Characteristics With Subsequent Epilepsy and Neurodevelopmental Outcomes in Children With Tuberous Sclerosis Complex

Hulshof, Hanna M; Kuijf, Hugo J; Kotulska, Katarzyna; Curatolo, Paolo; Weschke, Bernhard; Riney, Kate; Krsek, Pavel; Feucht, Martha; Nabbout, Rima; Lagae, Lieven; Jansen, Anna; Otte, Wim M; Lequin, Maarten H; Sijko, Kamil; Benvenuto, Arianna; Hertzberg, Christoph; Benova, Barbora; Scholl, Theresa; De Ridder, Jessie; Aronica, EleonoraM A; Kwiatkowski, David J; Jozwiak, Sergiusz; Jurkiewicz, Elzbieta; Braun, Kees; Jansen, Floor E; EPISTOP consortium (Lippincott Williams & Wilkins, 2022-03-22)

Background and ObjectivesMultiple factors have been found to contribute to the high risk of epilepsy in infants with tuberous sclerosis complex (TSC), including evolution of EEG abnormalities, TSC gene variant, and MRI ...
CeRebrUm and CardIac Protection with ALlopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass (CRUCIAL): study protocol of a phase III, randomized, quadruple-blinded, placebo-controlled, Dutch multicenter trial

CRUCIAL trial consortium (BioMed Central, 2022-02-23)

BACKGROUND: Neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result in adverse neurodevelopment. To date, no therapy ...
Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia

Dekker, Linde; Calkoen, Friso G.; Jiang, Yilin; Blok, Hilly; Veldkamp, Saskia R.; De Koning, Coco; Spoon, Maike; Admiraal, Rick; Hoogerbrugge, Peter; Vormoor, Britta; Vormoor, H. Josef; Visscher, Henk; Bierings, Marc; Van Der Vlugt, Marieke; Van Tinteren, Harm; Nijstad, A. Laura; Huitema, Alwin D.R.; Van Der Elst, Kim C.M.; Pieters, Rob; Lindemans, Caroline A.; Nierkens, Stefan (The American Society of Hematology, 2022-04-12)

The addition of fludarabine to cyclophosphamide as a lymphodepleting regimen prior to CD19 chimeric antigen receptor (CAR) T-cell therapy significantly improved outcomes in patients with relapsed/refractory (r/r) B-cell ...
Computer-Aided Assessment of Melanocytic Lesions by Means of a Mitosis Algorithm

Sturm, Bart; Creytens, David; Smits, Jan; Ooms, Ariadne H A G; Eijken, Erik; Kurpershoek, Eline; Küsters-Vandevelde, Heidi V N; Wauters, Carla; Blokx, Willeke A M; van der Laak, Jeroen A W M (MDPI AG, 2022-02-08)

An increasing number of pathology laboratories are now fully digitised, using whole slide imaging (WSI) for routine diagnostics. WSI paves the road to use artificial intelligence (AI) that will play an increasing role in ...
Leadership of PhD-prepared nurses working in hospitals and its influence on career development: A qualitative study

van Dongen, Lisa J.C.; Hafsteinsdóttir, Thóra B. (Wiley-Blackwell, 2022-12)

Aims and objectives: To explore leadership experiences and the influence of leadership on career development of PhD-prepared nurses working in hospitals. Background: The Doctor of Philosophy (PhD) represents the highest ...
Drug-induced Sleep Endoscopy: Are there Predictors for Failure of Oral Appliance Treatment?

Veugen, Christianne C.A.F.M.; Sanders, Rineke M.C.; Stokroos, Robert J.; Copper, Marcel P. (Thieme Medical Publishers Inc., 2022-07)

Introduction In the literature, evidence is lacking on the predictive value of drug-induced sleep endoscopy (DISE) for oral appliance treatment (OAT). Objectives The aim of the present study is to evaluate whether DISE ...
Technique failure in peritoneal dialysis: Modifiable causes and patient-specific risk factors

Bonenkamp, Anna A; der Sluijs, Anita van Eck van; Dekker, Friedo W; Struijk, Dirk G; de Fijter, Carola Wh; Vermeeren, Yolande M; van Ittersum, Frans J; Verhaar, Marianne C; van Jaarsveld, Brigit C; Abrahams, Alferso C (Multimed Inc., 2023-01)

BACKGROUND: Technique survival is a core outcome for peritoneal dialysis (PD), according to Standardized Outcomes in Nephrology-Peritoneal Dialysis. This study aimed to identify modifiable causes and risk factors of technique ...
Insight into the content of and experiences with follow-up conversations with bereaved parents in paediatrics: A systematic review

van Kempen, Merel M.; Kochen, Eline M.; Kars, Marijke C. (Wiley-Blackwell, 2022-04)

Aim: A follow-up conversation with bereaved parents is a relatively well-established intervention in paediatric clinical practice. Yet, the content and value of these conversations remain unclear. This review aims to provide ...
Community-acquired pneumonia subgroups and differential response to corticosteroids: a secondary analysis of controlled studies

Wittermans, Esther; van der Zee, Philip A.; Qi, Hongchao; van de Garde, Ewoudt M. W.; Blum, Claudine A.; Christ-Crain, Mirjam; Gommers, Diederik; Grutters, Jan C.; Voorn, G. Paul; Bos, Willem Jan W.; Endeman, Henrik (European Respiratory Society, 2022-01)

Background: Latent class analysis (LCA) has identified subgroups with meaningful treatment implications in acute respiratory distress syndrome. We performed a secondary analysis of three studies to assess whether LCA can ...
Characteristics and Outcome of Children with Wilms Tumor Requiring Intensive Care Admission in First Line Therapy

Steur, Anouk; Raymakers-Janssen, Paulien A.M.A.; Kneyber, Martin C.J.; Dijkstra, Sandra; van Woensel, Job B.M.; van Waardenburg, Dick A.; van de Ven, Cornelis P.; van der Steeg, Alida F.W.; Wijnen, Marc; Lilien, Marc R.; de Krijger, Ronald R.; van Tinteren, Harm; Littooij, Annemieke S.; Janssens, Geert O.; Peek, Annemarie M.L.; Tytgat, Godelieve A.M.; Mavinkurve-Groothuis, Annelies M.; van Grotel, Martine; van den Heuvel-Eibrink, Marry M.; Wösten-Van Asperen, Roelie M. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-14)

Survival rates are excellent for children with Wilms tumor (WT), yet tumor and treatment-related complications may require pediatric intensive care unit (PICU) admission. We assessed the frequency, clinical characteristics, ...
Safe transfer of pediatric patients from hematopoietic stem cell transplant unit into the pediatric intensive care unit: views of nurses and physicians

Nurses Group of the European Society for Blood and Marrow Transplantation (EBMT) (Springer Nature, 2022-05)

Sufficient communication between hematopoietic stem cell transplantation (HSCT) and pediatric intensive care unit (PICU) teams is pivotal for a successful advanced support in the PICU for HSCT-related complications. We ...
The role of cognitive and brain reserve in memory decline and atrophy rate in mid and late-life: The SMART-MR study

UCC-SMART Study Group (Masson SpA, 2022-03)

OBJECTIVE: Investigate associations of cognitive and brain reserve with trajectories of memory decline in mid-life and late-life, and whether the relationship of memory decline with atrophy differs as a function of reserve. ...
Interplay Between Risk Perception, Behavior, and COVID-19 Spread

Doenges, Philipp; Wagner, Joel; Contreras, Sebastian; Iftekhar, Emil; Bauer, Simon; Mohr, Sebastian; Dehning, Jonas; Calero Valdez, Andre; Kretzschmar, Mirjam; Maes, Michael; Nagel, Kai; Priesemann, Viola (Frontiers Media S. A., 2022-02-15)

Pharmaceutical and non-pharmaceutical interventions (NPIs) have been crucial for controlling COVID-19. They are complemented by voluntary health-protective behavior, building a complex interplay between risk perception, ...
Identifying Sexually Transmitted Infection Risk Groups Based on Behavioral and Psychological Characteristics Among Heterosexuals During the COVID-19 Pandemic

van Wees, Daphne A; Godijk, Noortje G; den Daas, Chantal; Kretzschmar, Mirjam E E; Heijne, Janneke C M (Lippincott Williams & Wilkins, 2022-02)

BACKGROUND: Measures to reduce coronavirus disease (COVID-19) transmission may impact sexual health. We aimed to examine the impact of COVID-19 on sexual behavior and sexually transmitted infection (STI) testing and to ...

Now showing items 13261-13280 of 40729