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Now showing items 13161-13180 of 40729

Time interval between diagnostic excision-biopsy of a primary melanoma and sentinel node biopsy: effects on the sentinel node positivity rate and survival outcomes

El Sharouni, Mary-Ann; Scolyer, Richard A; van Gils, Carla H; Ch'ng, Sydney; Nieweg, Omgo E; Pennington, Thomas E; Saw, Robyn P M; Shannon, Kerwin; Spillane, Andrew; Stretch, Jonathan; Witkamp, Arjen J; Sigurdsson, Vigfús; Thompson, John F; van Diest, Paul J; Lo, Serigne N (Elsevier Limited, 2022-05)

INTRODUCTION: The optimal time interval between diagnostic excision of a primary cutaneous melanoma and sentinel node (SN) biopsy is unknown. The current study sought to determine whether this interval influenced the ...
Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

Koorman, Thijs; Jansen, Karin A; Khalil, Antoine; Haughton, Peter D; Visser, Daan; Rätze, Max A K; Haakma, Wisse E; Sakalauskaitè, Gabrielè; van Diest, Paul J; de Rooij, Johan; Derksen, Patrick W B (Nature Publishing Group, 2022-04-22)

The tumor micro-environment often contains stiff and irregular-bundled collagen fibers that are used by tumor cells to disseminate. It is still unclear how and to what extent, extracellular matrix (ECM) stiffness versus ...
Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study

The Polaris Observatory HCV Collaborators (Elsevier Limited, 2022-05)

Background: Since the release of the first global hepatitis elimination targets in 2016, and until the COVID-19 pandemic started in early 2020, many countries and territories were making progress toward hepatitis C virus ...
Changes in Inflammatory and Atherogenesis Biomarkers With the 2-Drug Regimen Dolutegravir Plus Lamivudine in Antiretroviral Therapy-Experienced, Virologically Suppressed People With HIV-1: A Systematic Literature Review

Llibre, Josep; Cahn, Pedro; Lo, Janet; Barber, Tristan; Mussini, Cristina; van Welzen, Berend; Hernadez, Beatriz; Donovan, Cynthia; Kisare, Michelle; Sithamparanathan, Myooran; Van Wyk, Jean (Oxford University Press, 2022-04)

Background. The 2-drug regimen dolutegravir plus lamivudine has demonstrated long-term noninferior efficacy vs 3-/4-drug regimens (3/4DRs) in phase 3 trials. This systematic literature review summarizes clinical trial and ...
Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells

Pouw, Juliëtte N; Olde Nordkamp, Michel A M; O'Toole, Tom G; Radstake, Timothy R D J; Leijten, Emmerik F A; Boes, Marianne (BMJ Publishing Group, 2022-03-16)

INTRODUCTION: Plasmacytoid dendritic cells (pDCs) are the main producers of type I interferon (IFN) in SLE. pDCs express high secretory carrier membrane protein 5 (SCAMP5). Recent work in transfected HEK cells connects ...
Genetic care in geographically isolated small island communities: 8 years of experience in the Dutch Caribbean

Verberne, Eline A; Westermann, Jonne M; de Vries, Tamar I; Ecury-Goossen, Ginette M; Lo-A-Njoe, Shirley M; Manshande, Meindert E; Faries, Sonja; Veenhuis, Hans D; Philippi, Patricia; Falix, Farah A; Rosina-Angelista, Irsa; Ponson-Wever, Maria; Rafael-Croes, Louise; Thorsen, Patricia; Arends, Eric; de Vroomen, Maartje; Nagelkerke, Sietse Q; Tilanus, Martijn; van der Veken, Lars T; Huijsdens-van Amsterdam, Karin; van der Kevie-Kersemaekers, Anne-Marie; Alders, Mariëlle; Mannens, Marcel M A M; van Haelst, Mieke M (John Wiley & Sons Inc., 2022-06)

Worldwide, there are large inequalities in genetic service delivery. In 2011, we established a bi-annual joint pediatric-genetics clinic with a visiting clinical geneticist in the Dutch Caribbean. This retrospective study ...
The perceived impact of an HIV cure by people living with HIV and key populations vulnerable to HIV in the Netherlands: A qualitative study

Romijnders, Kim A.G.J.; de Groot, Laura; Vervoort, Sigrid C.J.M.; Basten, Maartje G.J.; van Welzen, Berend J.; Kretzschmar, Mirjam E.; Reiss, Peter; Davidovich, Udi; Rozhnova, Ganna (Elsevier, 2022-03)

Introduction: When an HIV cure becomes available, it will have consequences for people living with HIV (PLHIV) and key populations who are vulnerable to HIV. This qualitative study aimed to explore the perceived impact of ...
Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-Mutant Melanoma

Schuler, Martin; Zimmer, Lisa; Kim, Kevin B; Sosman, Jeffrey A; Ascierto, Paolo A; Postow, Michael A; De Vos, Filip; van Herpen, Carla M L; Carlino, Matteo S; Johnson, Douglas B; Berking, Carola; Reddy, Micaela B; Harney, Allison S; Berlin, Jordan D; Amaria, Rodabe N (American Association for Cancer Research Inc., 2022-07-15)

Purpose: Enhanced MAPK pathway signaling and cell-cycle checkpoint dysregulation are frequent in NRAS-mutant melanoma and, as such, the regimen of the MEK inhibitor binimetinib and the selective CDK4/6 inhibitor ribociclib ...
Prognostic significance of DNA methylation profiles at MRI enhancing tumor recurrence: a report from the EORTC 26091 TAVAREC trial

Draaisma, Kaspar; Tesileanu, C Mircea S; de Heer, Iris; Klein, Martin; Smits, Marion; Reijneveld, Jaap C; Clement, Paul M; De Vos, Filip; Wick, Antje; Mulholland, Paul; Taphoorn, Martin; Weller, Michael; Chinot, Olivier L; Kros, Johan M; Verschuere, Tina; Coens, Corneel; Golfinopoulos, Vassilis; Gorlia, Thierry; Idbaih, Ahmed; Robe, Pierre A; van den Bent, Martin J; French, Pim J (American Association for Cancer Research Inc., 2022-06-01)

PURPOSE: Despite recent advances in the molecular characterization of gliomas, it remains unclear which patients benefit most from which second-line treatments. The TAVAREC trial was a randomized, open-label phase II trial ...
Feasibility of cardiac-synchronized quantitative T1 and T2 mapping on a hybrid 1.5 Tesla magnetic resonance imaging and linear accelerator system

Akdag, Osman; Mandija, Stefano; van Lier, Astrid L H M W; Borman, PTS; Schakel, Tim; Alberts, Eveline; van der Heide, Oscar; Hassink, Rutger J; Verhoeff, Joost J C; Mohamed Hoesein, Firdaus A A; Raaymakers, Bas W; Fast, Martin F (Elsevier, 2022-01)

Background and Purpose: The heart is important in radiotherapy either as target or organ at risk. Quantitative T1 and T2 cardiac magnetic resonance imaging (qMRI) may aid in target definition for cardiac radioablation, and ...
Adults with autism spectrum disorder and the criminal justice system: An investigation of prevalence of contact with the criminal justice system, risk factors and sex differences in a specialist assessment service

Blackmore, Charlotte E; Woodhouse, Emma L; Gillan, Nicola; Wilson, Ellie; Ashwood, Karen L; Stoencheva, Vladimira; Nolan, Alexandra; McAlonan, Grainne M; Robertson, Dene M; Whitwell, Susannah; Deeley, Quinton; Craig, Michael C; Zinkstok, Janneke; Wichers, Rob; Spain, Debbie; Roberts, Ged; Murphy, Declan Gm; Murphy, Clodagh M; Daly, Eileen (SAGE Publications Ltd, 2022-11)

The behavioural and cognitive difficulties of some adults with autism spectrum disorder (ASD) may increase their risk of contact with the criminal justice system (CJS) as a potential suspect. There has been limited ...
Editorial: Gone to Pot: Examining the Association Between Cannabis Use and Medical/Psychiatric Disorders

Radhakrishnan, Rajiv; Guloksuz, Sinan; D'Souza, Deepak C.; van Os, Jim (Frontiers Research Foundation, 2022-02-08)
HOSPITAL Score and LACE Index to Predict Mortality in Multimorbid Older Patients

Aubert, Carole E; Rodondi, Nicolas; Terman, Samuel W; Feller, Martin; Schneider, Claudio; Oberle, Jolanda; Dalleur, Olivia; Knol, Wilma; O'Mahony, Denis; Aujesky, Drahomir; Donzé, Jacques (Adis, 2022-03)

BACKGROUND: Estimating life expectancy of older adults informs whether to pursue future investigation and therapy. Several models to predict mortality have been developed but often require data not immediately available ...
Erratum to: Performance of a trigger tool for detecting drug-related hospital admissions in older people: analysis from the OPERAM trial

Zerah, Lorène; Henrard, Séverine; Thevelin, Stefanie; Feller, Martin; Meyer-Masetti, Carla; Knol, Wilma; Wilting, Ingeborg; O'Mahony, Denis; Crowley, Erin; Dalleur, Olivia; Spinewine, Anne (Oxford University Press, 2022-03-01)

In the originally published version of this manuscript, the following co-author's name should read: "Carla Meyer-Masetti"instead of "Carla Meyer-Maseti".This error has now been corrected online.
Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review

Mäkitie, Antti A; Alabi, Rasheed Omobolaji; Orell, Helena; Youssef, Omar; Almangush, Alhadi; Homma, Akihiro; Takes, Robert P; López, Fernando; de Bree, Remco; Rodrigo, Juan P; Ferlito, Alfio (Springer, 2022-04)

INTRODUCTION: Patients with head and neck cancer (HNC) are usually confronted with functional changes due to the malignancy itself or its treatment. These factors typically affect important structures involved in speech, ...
Sarcopenia and its impact in head and neck cancer treatment

de Bree, Remco; van Beers, Maartje A; Schaeffers, Anouk W M A (Lippincott Williams & Wilkins, 2022-04-01)

PURPOSE OF REVIEW: The aim of this review is to discuss recent studies on the assessment of sarcopenia and its predictive and prognostic value in head and neck cancer (HNC) patients. RECENT FINDINGS: There is increasing ...
Association of preoperative low skeletal muscle mass with postoperative complications after selective neck dissection

Ansari, E; Chargi, N; van Es, R J J; Dieleman, F J; Van Cann, E M; de Bree, R (Churchill Livingstone, 2022-11)

Skeletal muscle mass (SMM) is an emerging predictive and prognostic factor in head and neck cancer patients. The aim of this study was to investigate the predictive value of low SMM for postoperative complications in ...
Image-guided surgery in oral cancer: toward improved margin control

Noorlag, Rob; de Bree, Remco; Witjes, Max J H (Lippincott Williams & Wilkins, 2022-05-01)

PURPOSE OF REVIEW: The aim of this review is to discuss recent studies on the assessment of tumor extension and resection margins by different intraoperative techniques allowing for image-guided surgery of oral cancer. ...
Targeting Angiogenesis in Squamous Cell Carcinoma of the Head and Neck: Opportunities in the Immunotherapy Era

Saba, Nabil F; Vijayvargiya, Pooja; Vermorken, Jan B; Rodrigo, Juan P; Willems, Stefan M; Zidar, Nina; de Bree, Remco; Mäkitie, Antti; Wolf, Greg T; Argiris, Athanassios; Teng, Yong; Ferlito, Alfio (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-25)

Despite the lack of approved anti-angiogenic therapies in squamous cell carcinoma of the head and neck (SCCHN), preclinical and more recent clinical evidence support the role of targeting the vascular endothelial growth ...
Characteristics and time course of acute and chronic myocardial lesion formation after electroporation ablation in the porcine model

Neven, Kars; van Driel, Vincent J.H.M.; Vink, Aryan; du Pré, Bastiaan C.; van Wessel, Harry; Füting, Anna; Doevendans, Pieter A.; Wittkampf, Fred H.M.; van Es, René (Wiley-Blackwell, 2022-03)

Introduction: Electroporation ablation creates deep and wide myocardial lesions. No data are available on time course and characteristics of acute lesion formation. Methods: For the acute phase of myocardial lesion ...

Now showing items 13161-13180 of 40729