Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells

DSpace/Manakin Repository

Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells
 
Pouw, Juliëtte N; Olde Nordkamp, Michel A M; O'Toole, Tom G; Radstake, Timothy R D J; Leijten, Emmerik F A; Boes, Marianne
(2022) Lupus science & medicine, volume 9, issue 1, pp. 1 - 3
(Letter)
Abstract
INTRODUCTION: Plasmacytoid dendritic cells (pDCs) are the main producers of type I interferon (IFN) in SLE. pDCs express high secretory carrier membrane protein 5 (SCAMP5). Recent work in transfected HEK cells connects SCAMP5 to the type I IFN secretory pathway. To further study the role of SCAMP5 in IFNα secretion ... read more
Download/Full Text
Open Access version via Utrecht University Repository Publisher version
Version on publisher website for UU-students and staff
Version on publisher website
 
Keywords: autoimmunity, interferon type I, lupus erythematosus, systemic, Immunology, Letter
DOI: https://doi.org/10.1136/lupus-2022-000680
ISSN: 2053-8790
Publisher: BMJ Publishing Group
Note: Funding Information: Contributors TRDJR and MB were responsible for conception. JNP, EFAL and MB designed the experiments. JNP and MAMON performed the experiments. JNP and TGO'T were responsible for the analyses. JNP and MB primarily wrote the manuscript. All authors contributed to substantial discussion of content, and review and revision of the manuscript before submission. Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. Competing interests MB reports research grants from Actuate Therapeutics, Nutricia and Argenx, unrelated to the submitted work. All other authors state no conflict of interest and have no disclosures. Patient consent for publication Not required. Ethics approval This study involves human participants. At University Medical Center Utrecht, a cohort of healthy subjects is used from the Mini Donor Service (MDS). The MDS aims to collect blood from healthy volunteers to support scientific research and laboratory diagnosis at UMC Utrecht. Donors are volunteers who by means of a written declaration have indicated their willingness to donate small quantities of blood (100 mL maximum) four times a year without being reimbursed by financial or other means. The work has been carried out in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki). Provenance and peer review Not commissioned; externally peer reviewed. Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise. Publisher Copyright: © Author(s) (or their employer(s)) 2022.
(Peer reviewed)