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Now showing items 13141-13160 of 40729

Performance Assessment of a Rapid Molecular Respiratory Syncytial Virus Point-of-Care Test: A Prospective Community Study in Older Adults

Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators (Oxford University Press, 2022-08-01)

Background. Respiratory syncytial virus (RSV) causes a substantial burden in older adults. Viral load in RSV-infected adults is generally lower compared to young children, which could result in suboptimal sensitivity of ...
Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age

Hulshof, Lianne A.; Frajmund, Leon A.; van Nuijs, Danny; van der Heijden, Denise C.N.; Middeldorp, Jinte; Hol, Elly M. (Elsevier, 2022-05)

Alzheimer's disease (AD) is the most common cause of dementia. Despite many years of research, very limited treatment options are available. Here we aim to establish a well-defined learning and memory performance test for ...
Publisher Correction: Microglial transcriptomics meets genetics: new disease leads

Hol, Elly M.; Pasterkamp, R. Jeroen (Nature Research, 2022-04)

Correction to: Nature Reviews Neurology https://doi.org/10.1038/s41582-022-00633-w, published online 28 February 2022.
The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients

de Jong, Corine; Chargi, Najiba; Herder, Gerarda J.M.; van Haarlem, Simone W.A.; van der Meer, Femke; van Lindert, Anne S.R.; ten Heuvel, Alexandra; Brouwer, Jan; de Jong, Pim A.; Devriese, Lot A.; Huitema, Alwin D.R.; Egberts, Toine C.G.; de Bree, Remco; Deneer, Vera H.M. (Wiley-Blackwell, 2022-06)

Background: Chemotherapy-induced toxicities frequently occur in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. Low skeletal muscle mass (SMM) has been associated with a higher incidence ...
Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract

Genomics England Research Consortium (Elsevier, 2022-05)

Congenital anomalies of the kidney and urinary tract (CAKUT) represent the most common cause of chronic kidney failure in children. Despite growing knowledge of the genetic causes of CAKUT, the majority of cases remain ...
Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: To WiN study

Heijdra, Jessica M.; Al Arashi, Wala; De Jager, Nico C.B.; Cloesmeijer, Michael E.; Bukkems, Laura H.; Zwaan, Christian M.; Leebeek, Frank W.G.; Mathôt, Ron A.A.; Cnossen, Marjon H.; Cnossen, M. H.; Leebeek, F. W.G.; Zwaan, Christian M.; Van Vliet, I.; Fijnvandraat, K.; Mathot, R. A.A.; Meijer, K.; Kruip, M. J.H.A.; S Polinder, Polinder; Coppens, M.; Tamminga, R. Y.J.; Meijer, K.; Laros-Van, B. A.P.; Brons, P.; Schols, S. E.M.; Van Der Meer, F. J.M.; Eikenboom, H. C.J.; Schutgens, R. E.G.; Fischer, K.; Heubel-Moenen, F.; Nieuwenhuizen, L.; Ypma, P.; Driessens, M. H.E.; Pw Collins, Collins; Liesner, R.; Chowdary, P.; Keeling, D. (BMJ Publishing Group, 2022-02-15)

Introduction Von Willebrand disease (VWD) is a bleeding disorder, caused by a deficiency or defect of von Willebrand factor (VWF). In case of medical procedures or bleeding, patients are treated with desmopressin and/or ...
NEXMIF encephalopathy: an X-linked disorder with male and female phenotypic patterns

NEXMIF (Lippincott Williams & Wilkins, 2021-02)

PURPOSE: Pathogenic variants in the X-linked gene NEXMIF (previously KIAA2022) are associated with intellectual disability (ID), autism spectrum disorder, and epilepsy. We aimed to delineate the female and male phenotypic ...
KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum

Bonardi, Claudia M; Heyne, Henrike O; Fiannacca, Martina; Fitzgerald, Mark P; Gardella, Elena; Gunning, Boudewijn; Olofsson, Kern; Lesca, Gaétan; Verbeek, Nienke; Stamberger, Hannah; Striano, Pasquale; Zara, Federico; Mancardi, Maria M; Nava, Caroline; Syrbe, Steffen; Buono, Salvatore; Baulac, Stephanie; Coppola, Antonietta; Weckhuysen, Sarah; Schoonjans, An-Sofie; Ceulemans, Berten; Sarret, Catherine; Baumgartner, Tobias; Muhle, Hiltrud; Portes, Vincent des; Toulouse, Joseph; Nougues, Marie-Christine; Rossi, Massimiliano; Demarquay, Geneviève; Ville, Dorothée; Hirsch, Edouard; Maurey, Hélène; Willems, Marjolaine; de Bellescize, Julitta; Altuzarra, Cecilia Desmettre; Villeneuve, Nathalie; Bartolomei, Fabrice; Picard, Fabienne; Hornemann, Frauke; Koolen, David A; Kroes, Hester Y; Reale, Chiara; Fenger, Christina D; Tan, Wen-Hann; Dibbens, Leanne; Bearden, David R; Møller, Rikke S; Rubboli, Guido (Oxford University Press, 2021-12-01)

Variants in KCNT1, encoding a sodium-gated potassium channel (subfamily T member 1), have been associated with a spectrum of epilepsies and neurodevelopmental disorders. These range from familial autosomal dominant or ...
Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage

van den Bosch, Aletta; Fransen, Nina; Mason, Matthew; Rozemuller, Annemieke Johanna; Teunissen, Charlotte; Smolders, Joost; Huitinga, Inge (Lippincott Williams & Wilkins, 2022-05-01)

BACKGROUND AND OBJECTIVES: To investigate whether white matter lesion activity, acute axonal damage, and axonal density in MS associate with CSF neurofilament light chain (NfL) levels. METHODS: Of 101 brain donors with MS ...
Genome-wide linkage analysis combined with genome sequencing in large families with intracranial aneurysms

Bakker, Mark K.; Cobyte, Suze; Hennekam, Frederic A.M.; Rinkel, Gabriel J.E.; Veldink, Jan H.; Ruigrok, Ynte M. (Springer Nature, 2022-07)

Rupture of an intracranial aneurysm (IA) leads to aneurysmal subarachnoid haemorrhage (ASAH), a severe type of stroke. Some rare variants that cause IA in families have been identified, but still, the majority of genetic ...
The predictive performance and impact of pediatric early warning systems in hospitalized pediatric oncology patients—A systematic review

Soeteman, Marijn; Lekkerkerker, Caroline W.; Kappen, Teus H.; Tissing, Wim J.; Nieuwenhuis, Edward E.; Wösten-van Asperen, Roelie M. (Wiley-Liss Inc., 2022-05)

Pediatric early warning systems (PEWS) arewidely used to identify clinically deteriorating patients. Hospitalized pediatric oncology patients are particularly prone to clinical deterioration. We assessed the PEWS performance ...
Health-Related Quality of Life in Adrenocortical Carcinoma: Development of the Disease-Specific Questionnaire ACC-QOL and Results from the PROFILES Registry

Steenaard, Rebecca V.; Kerkhofs, Thomas M.A.; Zijlstra, Myrte; Mols, Floortje; Kerstens, Michiel N.; Timmers, Henry J.L.M.; van Leeuwaarde, Rachel S.; Dreijerink, Koen M.A.; Eekhoff, Elisabeth M.W.; Nieveen van Dijkum, Els J.M.; Corssmit, Eleonora P.M.; Kapiteijn, Ellen; Kremers, Marjolein N.T.; Feelders, Richard A.; Haak, Harm R. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-03-08)

We aimed to develop a disease-specific adrenocortical carcinoma (ACC) health-related quality of life (HRQoL) questionnaire (ACC-QOL) and assess HRQoL in a population-based cohort of patients with ACC. Development was in ...
Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-γ signaling in dendritic cells: implications for the treatment of psoriasis and interferon-driven diseases

Vincken, Nanette L A; Welsing, Paco M J; Silva-Cardoso, Sandra C; Bekker, Cornelis P J; Lopes, Ana P; Nordkamp, Michel Olde; Leijten, Emmerik F A; Radstake, Timothy R D J; Angiolilli, Chiara (Wiley-Blackwell, 2022-06)

Interleukin (IL)-12 and IL-23 are pro-inflammatory cytokines produced by dendritic cells (DCs) and associated with Psoriasis (Pso) and Psoriatic Arthritis (PsA) pathogenesis. Tofacitinib, a Janus kinase inhibitor, effectively ...
First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAF(V600)-mutant advanced melanoma patients: a propensity-matched survival analysis

van Breeschoten, Jesper; Wouters, Michel W J M; Hilarius, Doranne L; Haanen, John B; Blank, Christian U; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; de Groot, Jan-Willem B; Hospers, Geke A P; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Roos S; Suijkerbuijk, Karijn P M; Blokx, Willeke A M; Tije, Bert-Jan J Ten; Veldt, Astrid A M van der; Vreugdenhil, Art; Boers-Sonderen, Marye J; van den Eertwegh, Alfonsus J M (Springer Nature, 2022-05-18)

Correction to: British Journal of Cancer https://doi.org/10.1038/s41416-020-01229-1, published online 26 January 2021 The original version of this article unfortunately contained a mistake. During online publication of ...
The 3-Month Effectiveness of a Stratified Blended Physiotherapy Intervention in Patients With Nonspecific Low Back Pain: Cluster Randomized Controlled Trial

Koppenaal, Tjarco; Pisters, Martijn F.; Kloek, Corelien J.J.; Arensman, Remco M.; Ostelo, Raymond W.J.G.; Veenhof, Cindy (Journal of medical Internet Research, 2022-02-25)

Background: Patient education, home-based exercise therapy, and advice on returning to normal activities are established physiotherapeutic treatment options for patients with nonspecific low back pain (LBP). However, the ...
Atypical fibroxanthoma and pleomorphic dermal sarcoma: Is superficial infiltration in subcutaneous tissue acceptable in AFX?

van Midden, Dominique; Flucke, Uta E; Amir, Avital L; Bonenkamp, Johannes J; Lubeek, Satish F K; Blokx, Willeke A M (W.B. Saunders, 2022-06)

BACKGROUND: Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous neoplasms forming a spectrum. Case reports with recurrences and metastasis have been published despite the current view that ...
Improving robotic skills by video review

van der Leun, Josephine A; Siem, Gabriel; Meijer, Richard P; Brinkman, Willem M (Mary Ann Liebert Inc., 2022-08-04)

Background: Since the transition of surgical robot systems into the medical field, physicians have had to develop new dexterity skills. The ideal learning environment for robotic surgery has yet to be discovered. Virtual ...
Rebleeding After Aneurysmal Subarachnoid Hemorrhage in Two Centers Using Different Blood Pressure Management Strategies

Calviere, Lionel; Gathier, Celine; Rafiq, Marie; Koopman, Inez; Rousseau, Vanessa; Raposo, Nicolas; Albucher, Jean François; Viguier, Alain; Geeraerts, Thomas; Cognard, Christophe; Rinkel, Gabriel J E; Vergouwen, Mervyn D I; Olivot, Jean-Marc (Frontiers Media S. A., 2022)

Background: High systolic blood pressure (SBP) after aneurysmal subarachnoid hemorrhage (aSAH) has been associated with an increased risk of rebleeding. It remains unclear if an SBP lowering strategy before aneurysm treatment ...
The Feasibility of Implementing Mainstream Germline Genetic Testing in Routine Cancer Care—A Systematic Review

Bokkers, Kyra; Vlaming, Michiel; Engelhardt, Ellen G.; Zweemer, Ronald P.; van Oort, Inge M.; Kiemeney, Lambertus A.L.M.; Bleiker, Eveline M.A.; Ausems, Margreet G.E.M. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-02)

Background: Non-genetic healthcare professionals can provide pre-test counseling and order germline genetic tests themselves, which is called mainstream genetic testing. In this systematic review, we determined whether ...
Ocular surface disease is common in moderate-to-severe atopic dermatitis patients

Achten, Roselie E; Bakker, Daphne S; van Luijk, Chantal M; van der Wal, M Marlot; de Graaf, Marlies; van Wijk, Femke; Zuithoff, Nicolaas P A; van der Rijst, Lisa P; Boesjes, Celeste M; Thijs, Judith L; de Boer, Joke H; de Bruin-Weller, Marjolein S (Wiley-Blackwell, 2022-06)

Now showing items 13141-13160 of 40729