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Now showing items 13121-13140 of 40729

Substrate Stiffness Determines the Establishment of Apical-Basal Polarization in Renal Epithelial Cells but Not in Tubuloid-Derived Cells

Hagelaars, Maria J; Yousef Yengej, Fjodor A; Verhaar, Marianne C; Rookmaaker, Maarten B; Loerakker, Sandra; Bouten, Carlijn V C (Frontiers Media S. A., 2022-03-01)

Mechanical guidance of tissue morphogenesis is an emerging method of regenerative medicine that can be employed to steer functional kidney architecture for the purpose of bioartificial kidney design or renal tissue engineering ...
Prognostic impact of waiting time between diagnosis and treatment in patients with cervical cancer: A nationwide population-based study

Hack, Amy P.; Zweemer, Ronald P.; Jonges, Trudy N.; van der Leij, Femke; Gerestein, Cornelis G.; Peters, Max; Jürgenliemk-Schulz, Ina M.; van Rossum, Peter S.N. (Academic Press Inc., 2022-05)

Objective: Prior research underlined the importance of timely oncological care as longer waiting times from diagnosis to treatment may result in poorer survival outcomes. The aim of this study was to determine the impact ...
A population-based study on treatment and outcomes in patients with gastric adenocarcinoma diagnosed with distant interval metastases

Dijksterhuis, Willemieke P.M.; Kroese, Tiuri E.; Verhoeven, Rob H.A.; van Rossum, Peter S.N.; Mook, Stella; Haj Mohammad, Nadia; Hulshof, Maarten C.C.M.; Gisbertz, Suzanne S.; Ruurda, Jelle P.; van Oijen, Martijn G.H.; van Hillegersberg, Richard; van Laarhoven, Hanneke W.M. (W.B. Saunders Ltd, 2022-09)

Background: In patients with gastric or gastroesophageal junction (GEJ) cancer treated with curative intent, distant interval metastases may be detected after start of neoadjuvant chemotherapy or during surgery. The aim ...
ASO Author Reflections: Role of Local Treatment for Oligometastatic Esophagogastric Cancer

Kroese, Tiuri E; van Rossum, Peter S N; van Hillegersberg, Richard (Springer New York, 2022-08)
Hospital physicians' and older patients' agreement with individualised STOPP/START-based medication optimisation recommendations in a clinical trial setting

Huibers, C J A; Sallevelt, B T G M; Heij, J M J Op; O'Mahony, D; Rodondi, N; Dalleur, O; van Marum, R J; Egberts, A C G; Wilting, I; Knol, W (Springer Science and Business Media Deutschland GmbH, 2022-06)

OBJECTIVE: To evaluate the agreement of hospital physicians and older patients with individualised STOPP/START-based medication optimisation recommendations from a pharmacotherapy team. METHODS: This study was embedded ...
Increased mortality risk in multiple-myeloma patients with subsequent malignancies: a population-based study in the Netherlands

Brink, Mirian; Minnema, Monique C; Visser, Otto; Levin, Mark-David; Posthuma, Eduardus F M Ward; Broijl, Annemiek; Sonneveld, Pieter; van der Klift, Marjolein; Roeloffzen, Wilfried W H; Westerman, Matthijs; van Rooijen, Cleo R; Geerts, Paul A F; Zweegman, Sonja; van de Donk, Niels W C J; Dinmohamed, Avinash G (Nature Publishing Group, 2022-03-15)
Health-related quality of life in patients with light chain amyloidosis treated with bortezomib, cyclophosphamide, and dexamethasone ± daratumumab: results from the ANDROMEDA study

Sanchorawala, Vaishali; Palladini, Giovanni; Minnema, Monique C; Jaccard, Arnaud; Lee, Hans C; Gibbs, Simon; Mollee, Peter; Venner, Christopher; Lu, Jin; Schönland, Stefan; Gatt, Moshe; Suzuki, Kenshi; Kim, Kihyun; Cibeira, M Teresa; Beksac, Meral; Libby, Edward; Valent, Jason; Hungria, Vania; Wong, Sandy W; Rosenzweig, Michael; Bumma, Naresh; Chauveau, Dominique; Gries, Katharine S; Fastenau, John; Tran, Nam Phuong; Qin, Xiang; Vasey, Sandra Y; Weiss, Brendan M; Vermeulen, Jessica; Ho, Kai Fai; Merlini, Giampaolo; Comenzo, Raymond L; Kastritis, Efstathios; Wechalekar, Ashutosh D (John Wiley & Sons Inc., 2022-06-01)

In the phase 3 ANDROMEDA trial, patients treated with daratumumab, bortezomib, cyclophosphamide, and dexamethasone (D-VCd) had significantly higher rates of organ and hematologic response compared with patients who received ...
External validation of the MSKCC nomogram to estimate five-year overall survival after surgery for stage I–III colon cancer in a Dutch population

Bond, Marinde J.G.; Hamers, Patricia A.H.; Vink, Geraldine R.; van Grevenstein, Wilhelmina M.U.; Laclé, Miangela M.; van Smeden, Maarten; Koopman, Miriam; Roodhart, Jeanine M.L.; Punt, Cornelis J.A.; May, Anne M. (Informa Healthcare, 2022-05-04)

Introduction: The Memorial Sloan Kettering Cancer Centre (MSKCC) nomogram has been developed to estimate five-year overall survival (OS) after curative-intent surgery of colon cancer based on age, sex, T stage, differentiation ...
Early Speech Sound Production and Its Trajectories in Very Preterm Children From 2 to 4 Years of Age

van Noort-van der Spek, Inge L; Dudink, Jeroen; Reiss, Irwin K; Franken, Marie-Christine J P (American Speech-Language-Hearing Association (ASHA), 2022-04-04)

Purpose: Very preterm (VPT) children are at risk for speech and language problems throughout school age. However, little is known about early speech sound production in these children. This study aims to present a detailed ...
Modified Delphi procedure-based expert consensus on endpoints for an international disease registry for Metachromatic Leukodystrophy: The European Metachromatic Leukodystrophy initiative (MLDi)

Schoenmakers, Daphne H.; Beerepoot, Shanice; van den Berg, Sibren; Adang, Laura; Bley, Annette; Boelens, Jaap Jan; Fumagalli, Francesca; Goettsch, Wim G.; Grønborg, Sabine; Groeschel, Samuel; van Hasselt, Peter M.; Hollak, Carla E.M.; Lindemans, Caroline; Mochel, Fanny; Mol, Peter G.M.; Sevin, Caroline; Zerem, Ayelet; Schöls, Ludger; Wolf, Nicole I. (BioMed Central, 2022-02-14)

Background: Metachromatic Leukodystrophy (MLD) is a rare lysosomal disorder. Patients suffer from relentless neurological deterioration leading to premature death. Recently, new treatment modalities, including gene therapy ...
Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts

Chang, Kai Ti; Jezek, Jan; Campbell, Alicia N.; Stieg, David C.; Kiss, Zachary A.; Kemper, Kevin; Jiang, Ping; Lee, Hyung Ok; Kruger, Warren D.; van Hasselt, Peter M.; Strich, Randy (Elsevier, 2022-02-18)

MED13L syndrome is a haploinsufficiency developmental disorder characterized by intellectual disability, heart malformation, and hypotonia. MED13L controls transcription by tethering the cyclin C-Cdk8 kinase module (CKM) ...
MutationalPatterns: the one stop shop for the analysis of mutational processes

Manders, Freek; Brandsma, Arianne M; de Kanter, Jurrian; Verheul, Mark; Oka, Rurika; van Roosmalen, Markus J; van der Roest, Bastiaan; van Hoeck, Arne; Cuppen, Edwin; van Boxtel, Ruben (BioMed Central, 2022-12)

BACKGROUND: The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. These processes can be investigated by extracting relevant mutational patterns ...
Different responses to DNA damage determine ageing differences between organs

Vougioukalaki, Maria; Demmers, Joris; Vermeij, Wilbert P; Baar, Marjolein; Bruens, Serena; Magaraki, Aristea; Kuijk, Ewart; Jager, Myrthe; Merzouk, Sarra; Brandt, Renata M C; Kouwenberg, Janneke; van Boxtel, Ruben; Cuppen, Edwin; Pothof, Joris; Hoeijmakers, Jan H J (Wiley-Blackwell, 2022-04)

Organs age differently, causing wide heterogeneity in multimorbidity, but underlying mechanisms are largely elusive. To investigate the basis of organ-specific ageing, we utilized progeroid repair-deficient Ercc1Δ /- mouse ...
Calcium signaling in individual APP/PS1 mouse dentate gyrus astrocytes increases ex vivo with Aβ pathology and age without affecting astrocyte network activity

Huffels, Christiaan F M; Osborn, Lana M; Cappaert, Natalie L M; Hol, Elly M (Wiley-Liss Inc., 2022-06)

Astrocytes are critical for healthy brain function. In Alzheimer's disease, astrocytes become reactive, which affects their signaling properties. Here, we measured spontaneous calcium transients ex vivo in hippocampal ...
Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Taj, Tahir; Poulsen, Aslak Harbo; Andersen, Zorana J; Bellander, Tom; Brandt, Jørgen; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Verschuren, W M Monique; Jørgensen, Jeanette T; Katsouyanni, Klea; Ketzel, Matthias; Lager, Anton; Leander, Karin; Liu, Shuo; Ljungman, Petter; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Magnusson, Patrik K E; Nagel, Gabriele; Pershagen, Göran; Peters, Annette; Rizzuto, Debora; van der Schouw, Yvonne T; Samoli, Evangelia; Sørensen, Mette; Stafoggia, Massimo; Tjønneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Brunekreef, Bert; Raaschou-Nielsen, Ole; Hoek, Gerard (Springer Nature, 2022-06-01)

BACKGROUND: The evidence linking ambient air pollution to bladder cancer is limited and mixed. METHODS: We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen ...
Correction to: To what extent do dietary costs explain socio-economic differences in dietary behavior? (Nutrition Journal, (2020), 19, 1, (88), 10.1186/s12937-020-00608-x)

Hoenink, Jody; Beulens, Joline W J; Harbers, Marjolein C; Boer, Jolanda M A; Dijkstra, S Coosje; Nicolaou, Mary; van der Schouw, Yvonne T; Sluijs, Ivonne; Verschuren, W M Monique; Waterlander, Wilma; Mackenbach, Joreintje D (BioMed Central, 2022-03-17)
Long-term Air Pollution Exposure and Pneumonia Related Mortality in a Large Pooled European Cohort

Liu, Shuo; Lim, Youn-Hee; Chen, Jie; Strak, Maciek; Wolf, Kathrin; Weinmayr, Gudrun; Rodopolou, Sophia; de Hoogh, Kees; Bellander, Tom; Brandt, Jørgen; Concin, Hans; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla A; Verschuren, W M Monique; Jöckel, Karl-Heinz; Jørgensen, Jeanette T; So, Rina; Amini, Heresh; Cole-Hunter, Thomas; Mehta, Amar J; Mortensen, Laust H; Ketzel, Matthias; Lager, Anton; Leander, Karin; Ljungman, Petter; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Magnusson, Patrik K E; Nagel, Gabriele; Pershagen, Göran; Peters, Annette; Raaschou-Nielsen, Ole; Rizzuto, Debora; van der Schouw, Yvonne T; Schramm, Sara; Sørensen, Mette; Stafoggia, Massimo; Tjønneland, Anne; Katsouyanni, Klea; Huang, Wei; Samoli, Evangelia; Brunekreef, Bert; Hoek, Gerard; Andersen, Zorana J (American Thoracic Society, 2022-06-15)

Rationale: Ambient air pollution exposure has been linked to mortality from chronic cardiorespiratory diseases, while evidence on respiratory infections remains more limited. Objectives: We examined the association between ...
Efficacy and safety of durvalumab with olaparib in metastatic or recurrent endometrial cancer (phase II DOMEC trial)

Post, C C B; Westermann, A M; Boere, I A; Witteveen, P O; Ottevanger, P B; Sonke, G S; Lalisang, R I; Putter, H; Meershoek-Klein Kranenbarg, E; Braak, J P B M; Creutzberg, C L; Bosse, T; Kroep, J R (Academic Press Inc., 2022-05)

BACKGROUND: Patients with advanced endometrial cancer have a poor prognosis, and treatment options are limited. The investigator-initiated, multicenter, phase II DOMEC trial (NCT03951415) is the first trial to report data ...
Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women

Verdiesen, Renée M G; van der Schouw, Yvonne T; van Gils, Carla H; Verschuren, W M Monique; Broekmans, Frank J M; Borges, Maria C; Gonçalves Soares, Ana L; Lawlor, Deborah A; Eliassen, A Heather; Kraft, Peter; Sandler, Dale P; Harlow, Siobán D; Smith, Jennifer A; Santoro, Nanette; Schoemaker, Minouk J; Swerdlow, Anthony J; Murray, Anna; Ruth, Katherine S; Onland-Moret, N Charlotte (Oxford University Press, 2022-05-03)

STUDY QUESTION: Can additional genetic variants for circulating anti-Müllerian hormone (AMH) levels be identified through a genome-wide association study (GWAS) meta-analysis including a large sample of premenopausal women? ...
Systematic review and non-inferiority meta-analysis of randomised phase II/III trials on S-1-based therapy versus 5-fluorouracil- or capecitabine-based therapy in the treatment of patients with metastatic colorectal cancer

Derksen, Jeroen W G; Smit, Karel C; May, Anne M; Punt, Cornelis J A (Elsevier Limited, 2022-05)

BACKGROUND: S-1 is an oral fluoropyrimidine that is increasingly used in Western countries for the treatment of metastatic colorectal cancer (mCRC). We conducted a non-inferiority meta-analysis on the efficacy of S-1-based ...

Now showing items 13121-13140 of 40729