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Now showing items 11641-11660 of 40729

High-throughput total RNA sequencing in single cells using VASA-seq

Salmen, Fredrik; De Jonghe, Joachim; Kaminski, Tomasz S.; Alemany, Anna; Parada, Guillermo E.; Verity-Legg, Joe; Yanagida, Ayaka; Kohler, Timo N.; Battich, Nicholas; van den Brekel, Floris; Ellermann, Anna L.; Arias, Alfonso Martinez; Nichols, Jennifer; Hemberg, Martin; Hollfelder, Florian; van Oudenaarden, Alexander (Nature Research, 2022-12)

Most methods for single-cell transcriptome sequencing amplify the termini of polyadenylated transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes the detection of many long ...
Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

Solman, Maja; Blokzijl-Franke, Sasja; Piques, Florian; Yan, Chuan; Yang, Qiqi; Strullu, Marion; Kamel, Sarah M.; Ak, Pakize; Bakkers, Jeroen; Langenau, David M.; Cavé, Hélène; Den Hertog, Jeroen (eLife Sciences Publications, 2022-05-10)

Gain-of-function mutations in the protein-tyrosine phosphatase SHP2 are the most frequently occurring mutations in sporadic juvenile myelomonocytic leukemia (JMML) and JMML-like myeloproliferative neoplasm (MPN) associated ...
Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment

Huang, Dan; Guo, Yunlu; Guan, Xiaoyu; Pan, Lijun; Zhu, Ziyu; Chen, Zeng’ai; Dijkhuizen, Rick M.; Duering, Marco; Yu, Fang; Boltze, Johannes; Li, Peiying (SAGE Publications Inc., 2023-02)

Cognitive impairment (CI) is a major health concern in aging populations. It impairs patients’ independent life and may progress to dementia. Vascular cognitive impairment (VCI) encompasses all cerebrovascular pathologies ...
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Respiratory Virus Global Epidemiology Network; RESCEU Investigators (Elsevier, 2022-05-28)

Background: Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infection in young children. We previously estimated that in 2015, 33·1 million episodes of RSV-associated acute lower ...
Cost-effectiveness of Respiratory Syncytial Virus Disease Prevention Strategies: Maternal Vaccine Versus Seasonal or Year-Round Monoclonal Antibody Program in Norwegian Children

Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators (Oxford University Press, 2022-08-01)

BACKGROUND: Every winter, respiratory syncytial virus (RSV) disease results in thousands of cases in Norwegian children under 5 years of age. We aim to assess the RSV-related economic burden and the cost-effectiveness of ...
SOCIAL LISTENING AND GOOGLE TRENDS AS TOOLS FOR ESTIMATING PUBLIC AWARENESS OF RESPIRATORY SYNCYTIAL VIRUS

Schuurman, Gillian Samantha; Bont, Louis (Lippincott Williams & Wilkins, 2022-07)

Respiratory Syncytial Virus (RSV) imposes a large disease burden on a global level. Public awareness of RSV is important to support preventive interventions. In this study, Google Trends and a social listening tool, Brand24, ...
The assessment of future RSV immunizations: How to protect all infants?

Bont, Louis; Weil Olivier, Catherine; Herting, Egbert; Esposito, Susanna; Navarro Alonso, Jose Antonio; Lega, Federico; Mader, Silke; Morioka, Ichiro; Shen, Kunling; Syrogiannopoulos, George A.; Faust, Saul N.; Bozzola, Elena (Frontiers Media S. A., 2022-08-09)
Comparative performance of cardiovascular risk prediction models in people living with HIV

Tahir, Irtiza; Vos, Alinda; Damen, Johanna; Barth, Roos; Tempelman, Hugo; Grobbee, Diederick; Scheuermaier, Karine; Venter, Willem; Klipstein-Grobusch, Kerstin (AOSIS (Pty) Ltd, 2022-11-15)

Background: Current cardiovascular risk assessment in people living with HIV is based on general risk assessment tools; however, whether these tools can be applied in sub-Saharan African populations has been questioned.Objectives: ...
Reply: "Anti-TNF Withdrawal in Inflammatory Bowel Disease With Endoscopic Healing and the Risk of Relapse"

Mahmoud, R; Savelkoul, E H J; Jharap, B; Oldenburg, B (W.B. Saunders, 2023-07)
Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier

Jelinsky, Scott A; Derksen, Merel; Bauman, Eric; Verissimo, Carla S; van Dooremalen, Wies T M; Roos, Jamie Lee; Higuera Barón, Celia; Caballero-Franco, Celia; Johnson, Bryce G; Rooks, Michelle G; Pott, Johanna; Oldenburg, Bas; Vries, Robert G J; Boj, Sylvia F; Kasaian, Marion T; Pourfarzad, Farzin; Rosadini, Charles V (John Wiley & Sons Inc., 2023-02-01)

BACKGROUND: Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by inconsistencies with differentiation and functional characterization. ...
Epidemiology and management of nontuberculous mycobacterial disease in people with cystic fibrosis, the Netherlands

Dutch CF Registry Steering group (Elsevier, 2023-03)

Background: Nontuberculous mycobacteria (NTM) are opportunistic, difficult to treat pathogens. With increasing prevalence of NTM infections in people with cystic fibrosis (pwCF) and the improved life expectancy, the burden ...
Visualization of the inflammatory response to injury by neutrophil phenotype categories: Neutrophil phenotypes after trauma

de Fraiture, Emma J; Bongers, Suus H; Jukema, Bernard N; Koenderman, Leo; Vrisekoop, Nienke; van Wessem, Karlijn J P; Leenen, Luke P H; Hietbrink, Falco (Springer International Publishing AG, 2023-04)

PURPOSE: The risk of infectious complications after trauma is determined by the amount of injury-related tissue damage and the resulting inflammatory response. Recently, it became possible to measure the neutrophil phenotype ...
Value of multiparametric magnetic resonance imaging for local staging of invasive urinary bladder tumours.

Huele, Eline H.; Veenboer, Paul W.; Wessels, Frank J.; Jonges, Trudy N.; Meijer, Richard P. (Elsevier, 2023-01)

Background: Initial tumour staging in bladder cancer mainly relies on the histo-pathological outcome of the transurethral bladder tumour resection (TURBT) and imaging by means of a CT-scan (CT-intravenous urography; CT-IVU). ...
CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI

SVDs@target group (John Wiley & Sons Inc., 2023-01)

Objective: Cerebral small vessel diseases (cSVDs) are a major cause of stroke and dementia. We used cutting-edge 7T-MRI techniques in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and ...
The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysis

Lam, Bonnie Yk; Cai, Yuan; Akinyemi, Rufus; Biessels, Geert Jan; Brink, Hilde van den; Chen, Christopher Lh; Cheung, Chin Wai; Chow, King Ngai; Chung, Henry Kh; Duering, Marco; Fu, Siu Ting; Gustafson, Deborah; Hilal, Saima; Hui, Vincent Mh; Kalaria, Rajesh; Kim, SangYun; Lam, Maggie Lm; de Leeuw, Frank-Erik; Li, Ami Sm; Markus, Hugh S; Marseglia, Anna; Zheng, Huijing; O'brien, John; Pantoni, Leonardo; Sachdev, Perminder S; Smith, Eric Edward; Wardlaw, Joanna; Mok, Vincent Ct (SAGE Publications Ltd, 2023-01)

BACKGROUND: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries. Studies ...
Neuropsychiatric symptoms in patients with possible vascular cognitive impairment, does sex matter?

TRACE-VCI study group (Elsevier, 2022)

Background: Neuropsychiatric symptoms (NPS) are common in patients with vascular cognitive impairment (VCI). We aimed to establish sex differences in the manifestation of NPS in memory clinic patients with possible VCI and ...
Vascular Cognitive Impairment and cognitive decline; a longitudinal study comparing different types of vascular brain injury - The TRACE-VCI study

Boomsma, Jooske Mf; Exalto, Lieza G; Barkhof, Frederik; Leeuwis, Anna E; Prins, Niels D; Scheltens, Philip; Teunissen, Charlotte E; Weinstein, Henry C; Biessels, Geert Jan; van der Flier, Wiesje M; On-Behalf-Of-The-Trace-Vci-Study-Group (Elsevier, 2022)

Background: Little is known about the trajectories of cognitive decline in relation to different types of vascular brain injury in patients presenting at a memory clinic with Vascular Cognitive Impairment (VCI). Methods: ...
Value of diagnosing immunological phenomena in patients with suspected endocarditis

van der Vaart, Thomas W; Heerschop, Luca L; Bouma, Berto J; Freudenburg, Wieke; Bonten, Marc J M; Prins, Jan M; van der Meer, Jan T M (Urban und Vogel, 2023-06)

PURPOSE: Immunological phenomena are a minor criteria in the modified Duke Criteria for endocarditis. Given the changes in epidemiology and diagnostics, the added value of determining these phenomena in today's patients ...
Assessing social configurations in teacher learning groups the Dimensions of Social Learning Questionnaire

Vrieling, Emmy; de Vreugd, Lars (2023)

Increasingly, teacher learning groups (TLGs) are being deployed as a way to realise high-quality educational designs. There is a need for monitoring and for insights into the development of TLGs. Therefore, in the present ...
Methodological Recommendations for Studies on the Daily Life Implementation of Implantable Communication-Brain–Computer Interfaces for Individuals With Locked-in Syndrome

Vansteensel, Mariska J.; Branco, Mariana P.; Leinders, Sacha; Freudenburg, Zac F.; Schippers, Anouck; Geukes, Simon H.; Gaytant, Michael A.; Gosselaar, Peter H.; Aarnoutse, Erik J.; Ramsey, Nick F. (SAGE Publications Inc., 2022-11)

Implantable brain–computer interfaces (BCIs) promise to be a viable means to restore communication in individuals with locked-in syndrome (LIS). In 2016, we presented the world-first fully implantable BCI system that uses ...

Now showing items 11641-11660 of 40729