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UMC Repository: Recent submissions

  • Optimal temperature management in aortic arch surgery: A systematic review and network meta-analysis 
    Abjigitova, Djamila; Notenboom, Maximiliaan L; Veen, Kevin M; van Tussenbroek, Gabriëlle; Bekkers, Jos A; Mokhles, Mostafa M; Bogers, Ad J J C (Wiley-Blackwell, 2022-12)
    OBJECTIVES: New temperature management concepts of moderate and mild hypothermic circulatory arrest during aortic arch surgery have gained weight over profound cooling. Comparisons of all temperature levels have rarely ...
  • Differential isoform expression of Allergin-1 during acute and chronic inflammation 
    Geerdink, Ruben J.; Pascoal Ramos, Maria Inês; van den Hoogen, Luuk L.; Radstake, Timothy R.D.J.; Shibayama, Shiro; Shibuya, Akira; Bont, Louis; Meyaard, Linde (John Wiley & Sons Inc., 2022-12)
    Introduction: Neutrophils are crucial to antimicrobial defense, but excessive neutrophilic inflammation elicits immune pathology. Currently, no effective treatment exists to curb neutrophil activation. However, neutrophils ...
  • Endoscopic management of patients with high-risk colorectal colitis-associated neoplasia: a Delphi study 
    Bak, Michiel T J; Albéniz, Eduardo; East, James E; Coelho-Prabhu, Nayantara; Suzuki, Noriko; Saito, Yutaka; Matsumoto, Takayuki; Banerjee, Rupa; Kaminski, Michal F; Kiesslich, Ralf; Coron, Emmanuel; de Vries, Annemarie C; van der Woude, C Janneke; Bisschops, Raf; Hart, Ailsa L; Itzkowitz, Steven H; Pioche, Mathieu; Moons, Leon M G; Oldenburg, Bas (Mosby Inc., 2023-04)
    BACKGROUND AND AIMS: Current guidelines recommend endoscopic resection of visible and endoscopically resectable colorectal colitis-associated neoplasia (CAN) in patients with inflammatory bowel disease (IBD). However, ...
  • Exercise and Nutritional Interventions in Patients with Advanced Gastroesophageal Cancer: A Systematic Review 
    Besseling, Joost; van Velzen, Merel; Wierdsma, Nicolette; Alonso-Duin, Kelly Silverio; Weijs, Peter; May, Anne M; van Laarhoven, Hanneke (Humana Press, 2023-09)
    PURPOSE: The quality of life and survival of patients with advanced gastroesophageal cancer can be improved. Positive effects of exercise and nutritional interventions on quality of life and potential effects on cancer ...
  • Transfusion burden in early childhood plays an important role in iron overload in Diamond-Blackfan anaemia 
    de Wilde, Jonathan R A; van Dooijeweert, Birgit; van Vuren, Annelies J; Huisman, Elise J; Smiers, Frans J; van der Veer, Arian; van Wijk, Richard; van Solinge, Wouter W; Nieuwenhuis, Edward E S; van Beers, Eduard J; Bartels, Marije (2022-11)
    In Diamond-Blackfan anaemia (DBA), iron overload (IO) is common in transfusion-dependent patients, yet has also been reported in non-transfusion-dependent patients. We explored the incidence of IO in transfusion-dependent ...
  • Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes 
    Feyen, Dries A M; McKeithan, Wesley L; Bruyneel, Arne A N; Spiering, Sean; Hörmann, Larissa; Ulmer, Bärbel; Zhang, Hui; Briganti, Francesca; Schweizer, Michaela; Hegyi, Bence; Liao, Zhandi; Pölönen, Risto-Pekka; Ginsburg, Kenneth S; Lam, Chi Keung; Serrano, Ricardo; Wahlquist, Christine; Kreymerman, Alexander; Vu, Michelle; Amatya, Prashila L; Behrens, Charlotta S; Ranjbarvaziri, Sara; Maas, Renee G C; Greenhaw, Matthew; Bernstein, Daniel; Wu, Joseph C; Bers, Donald M; Eschenhagen, Thomas; Metallo, Christian M; Mercola, Mark (Cell Press, 2020-07-21)
    Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and ...
  • Defining Textbook Outcome in liver surgery and assessment of hospital variation: A nationwide population-based study 
    for Dutch Hepato Biliary Audit Group, Collaborators (W.B. Saunders Ltd, 2022-12)
    INTRODUCTION: Textbook outcome (TO) is a composite outcome measure covering the surgical care process in a single outcome measure. TO has an advantage over single outcome parameters with low event rates, which have less ...
  • Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy 
    Korenblik, R; Olij, B; Aldrighetti, L A; Hilal, M Abu; Ahle, M; Arslan, B; van Baardewijk, L J; Baclija, I; Bent, C; Bertrand, C L; Björnsson, B; de Boer, M T; de Boer, S W; Bokkers, R P H; Rinkes, I H M Borel; Breitenstein, S; Bruijnen, R C G; Bruners, P; Büchler, M W; Camacho, J C; Cappelli, A; Carling, U; Chan, B K Y; Chang, D H; Choi, J; Font, J Codina; Crawford, M; Croagh, D; Cugat, E; Davis, R; De Boo, D W; De Cobelli, F; De Wispelaere, J F; van Delden, O M; Delle, M; Detry, O; Díaz-Nieto, R; Dili, A; Erdmann, J I; Fisher, O; Fondevila, C; Fretland, Å; Borobia, F Garcia; Gelabert, A; Gérard, L; Giuliante, F; Gobardhan, P D; Gómez, F; Grünberger, T; Grünhagen, D J; Guitart, J; Hagendoorn, J; Heil, J; Heise, D; Herrero, E; Hess, G F; Hoffmann, M H; Iezzi, R; Imani, F; Nguyen, J; Jovine, E; Kalff, J C; Kazemier, G; Kingham, T P; Kleeff, J; Kollmar, O; Leclercq, W K G; Ben, S Lopez; Lucidi, V; MacDonald, A; Madoff, D C; Manekeller, S; Martel, G; Mehrabi, A; Mehrzad, H; Meijerink, M R; Menon, K; Metrakos, P; Meyer, C; Moelker, A; Modi, S; Montanari, N; Navines, J; Neumann, U P; Peddu, P; Primrose, J N; Qu, X; Raptis, D; Ratti, F; Ridouani, F; Rogan, C; Ronellenfitsch, U; Ryan, S; Sallemi, C; Moragues, J Sampere; Sandström, P; Sarriá, L; Schnitzbauer, A; Serenari, M; Serrablo, A; Smits, M L J; Sparrelid, E; Spüntrup, E; Stavrou, G A; Sutcliffe, R P; Tancredi, I; Tasse, J C; Udupa, V; Valenti, D; Fundora, Y; Vogl, T J; Wang, X; White, S A; Wohlgemuth, W A; Yu, D; Zijlstra, I A J; Binkert, C A; Bemelmans, M H A; van der Leij, C; Schadde, E; van Dam, R M (Springer-Verlag, 2022-09)
    STUDY PURPOSE: The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients ...
  • Patterns of Hearing Loss in Irradiated Survivors of Head and Neck Rhabdomyosarcoma 
    Diepstraten, Franciscus A; Wiersma, Jan; Schoot, Reineke A; Knops, Rutger R G; Zuur, Charlotte L; Meijer, Annelot J M; Dávila Fajardo, Raquel; Pieters, Bradley R; Balgobind, Brian V; Westerveld, Henrike; Freling, Nicole; van Tinteren, Harm; Smeele, Ludwig E; Bel, Arjan; van den Heuvel-Eibrink, Marry M; Stokroos, Robert J; Merks, Johannes H M; Hoetink, Alexander E; Hol, Marinka L F (Multidisciplinary Digital Publishing Institute (MDPI), 2022-12)
    PURPOSE: The frequency and patterns of HL in a HNRMS survivor cohort were investigated. A dose-effect relationship between the dose to the cochlea and HL was explored. METHODS: Dutch survivors treated for HNRMS between ...
  • Leerdoelen over kinder- en jeugdpsychiatrie in de opleiding psychiatrie: een delphistudie 
    Deschamps, Peter; Roelofs, Susan; Klumpers, Ursula M.H.; van der Schaaf, Marieke; Hennus, Marije (Uitgeverij Boom, 2022-06-15)
    BACKGROUND: The new Dutch training plan for psychiatrists puts more emphasis on life course psychiatry. Subsequently, adjustments in the educational program regarding child and adolescent psychiatric knowledge, skills and ...
  • Professionals' adaptive expertise and adaptive performance in educational and workplace settings: an overview of reviews 
    Pelgrim, Els; Hissink, Elske; Kuijer-Siebelink, Wietske; Nieuwenhuis, Loek; Bus, Lotte; van der Schaaf, Marieke; van Tartwijk, Jan (Springer Netherlands, 2022-12)
    Professionals will increasingly be confronted with new insights and changes. This raises questions as to what kind of expertise professionals need, and how development of this expertise can be influenced within the contexts ...
  • The generic skills learning systematic: Evaluating university students’ learning after complex problem-solving 
    van Ravenswaaij, Heleen; Bouwmeester, Rianne A.M.; van der Schaaf, Marieke F.; Dilaver, Gönül; van Rijen, Harold V.M.; de Kleijn, Renske A.M. (Frontiers Media S. A., 2022-11-03)
    Professionals are increasingly confronted with complex problems that require generic skills. These generic skills are important for a variety of domains and contexts. As the evaluation of such skills can be difficult, this ...
  • A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet 
    Mandemaker, Imke K.; Mattiroli, Francesca (Cell Press, 2022-11-17)
    Soman, A., Wong, S.Y., et al. find that telomeric DNA assembles into a new high-order chromatin structure resembling a columnar stack of nucleosomes with dynamic properties. This raises new questions on telomere biology ...
  • Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models 
    Beumer, Joep; Bauzá-Martinez, Julia; Veth, Tim S.; Geurts, Veerle; Boot, Charelle; Gilliam-Vigh, Hannah; Poulsen, Steen S.; Knop, Filip K.; Wu, Wei; Clevers, Hans (National Academy of Sciences, 2022-11-15)
    Enteroendocrine cells (EECs) secrete hormones in response to ingested nutrients to control physiological processes such as appetite and insulin release. EEC hormones are synthesized as large proproteins that undergo ...
  • Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2 
    Solman, Maja; Woutersen, Daniëlle T.J.; den Hertog, Jeroen (Frontiers Media S. A., 2022-11-04)
    Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a highly conserved protein tyrosine phosphatase (PTP), which is encoded by PTPN11 and is indispensable during embryonic development. Mutations ...
  • Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy 
    Mo, Shaobo; Tang, Peiyuan; Luo, Wenqin; Zhang, Long; Li, Yaqi; Hu, Xiang; Ma, Xiaoji; Chen, Yikuan; Bao, Yichao; He, Xingfeng; Fu, Guoxiang; Xu, Xiaoya; Rao, Xinxin; Li, Xiaomeng; Guan, Ruoyu; Chen, Shengzhi; Deng, Yun; Lv, Tao; Mu, Peiyuan; Zheng, Qiang; Wang, Simin; Liu, Fangqi; Li, Yiwei; Sheng, Weiqi; Huang, Dan; Hu, Chen; Gao, Jianjun; Zhang, Zhen; Cai, Sanjun; Clevers, Hans; Peng, Junjie; Hua, Guoqiang (Wiley-VCH Verlag, 2022-11-03)
    There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient-derived organoid (PDO) has become an important preclinical model. ...
  • Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis 
    Klaasen, Sjoerd J.; Kops, Geert J.P.L. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-11)
    Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing ...
  • In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed 
    Bonanini, Flavio; Kurek, Dorota; Previdi, Sara; Nicolas, Arnaud; Hendriks, Delilah; de Ruiter, Sander; Meyer, Marine; Clapés Cabrer, Maria; Dinkelberg, Roelof; García, Silvia Bonilla; Kramer, Bart; Olivier, Thomas; Hu, Huili; López-Iglesias, Carmen; Schavemaker, Frederik; Walinga, Erik; Dutta, Devanjali; Queiroz, Karla; Domansky, Karel; Ronden, Bob; Joore, Jos; Lanz, Henriette L.; Peters, Peter J.; Trietsch, Sebastiaan J.; Clevers, Hans; Vulto, Paul (Springer Netherlands, 2022-11)
    With recent progress in modeling liver organogenesis and regeneration, the lack of vasculature is becoming the bottleneck in progressing our ability to model human hepatic tissues in vitro. Here, we introduce a platform ...
  • A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression 
    Vrij, Erik J.; Scholte Op Reimer, Yvonne S.; Fuentes, Laury Roa; Guerreiro, Isabel Misteli; Holzmann, Viktoria; Aldeguer, Javier Frias; Sestini, Giovanni; Koo, Bon Kyoung; Kind, Jop; van Blitterswijk, Clemens A.; Rivron, Nicolas C. (Company of Biologists Ltd, 2022-10-15)
    Embryogenesis is supported by dynamic loops of cellular interactions. Here, we create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn). We trigger ...
  • Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements 
    Luquette, Lovelace J.; Miller, Michael B.; Zhou, Zinan; Bohrson, Craig L.; Zhao, Yifan; Jin, Hu; Gulhan, Doga; Ganz, Javier; Bizzotto, Sara; Kirkham, Samantha; Hochepied, Tino; Libert, Claude; Galor, Alon; Kim, Junho; Lodato, Michael A.; Garaycoechea, Juan I.; Gawad, Charles; West, Jay; Walsh, Christopher A.; Park, Peter J. (Nature Research, 2022-10)
    Accurate somatic mutation detection from single-cell DNA sequencing is challenging due to amplification-related artifacts. To reduce this artifact burden, an improved amplification technique, primary template-directed ...