Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy

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Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy
 
Mo, Shaobo; Tang, Peiyuan; Luo, Wenqin; Zhang, Long; Li, Yaqi; Hu, Xiang; Ma, Xiaoji; Chen, Yikuan; Bao, Yichao; He, Xingfeng; Fu, Guoxiang; Xu, Xiaoya; Rao, Xinxin; Li, Xiaomeng; Guan, Ruoyu; Chen, Shengzhi; Deng, Yun; Lv, Tao; Mu, Peiyuan; Zheng, Qiang; Wang, Simin; Liu, Fangqi; Li, Yiwei; Sheng, Weiqi; Huang, Dan; Hu, Chen; Gao, Jianjun; Zhang, Zhen; Cai, Sanjun; Clevers, Hans; Peng, Junjie; Hua, Guoqiang
(2022) Advanced Science, volume 9, issue 31, pp. 1 - 16
(Article)
Abstract
There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient-derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors and paired liver metastatic lesions is successfully constructed. CRLM PDOs ... read more
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Keywords: chemotherapy response, colorectal cancer liver metastasis, patient-derived organoid, prognosis prediction, tumor heterogeneity, Medicine (miscellaneous), General Chemical Engineering, General Materials Science, Biochemistry, Genetics and Molecular Biology (miscellaneous), General Engineering, General Physics and Astronomy
DOI: https://doi.org/10.1002/advs.202204097
Publisher: Wiley-VCH Verlag
Note: Funding Information: National Natural Science Foundation of China; Grant numbers 82173461 (to G.H.), U1932145 (to J.P.), 81972244 (to X.H.), 82002946 (to Y.L.); Fudan University Shanghai Cancer Center Basic and Clinical Translational Research Seed Foundation; Grant Number: YJZZ201802 (to S.C.); Science and Technology Commission of Shanghai Municipality; Grant Number: 18401933402 (to J.P.); Shanghai Sailing Program; Grant Number: 22YF1408800 (to S.M.), 19YF1409500 (to Y.L.). The authors thank colleagues from Institute of Radiation Medicine, Fudan University for their help to this work. Publisher Copyright: © 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
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